Targeted degradation of ABC transporters in health and disease.

Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines. Proc Natl Acad Sci U S A (2009) 1.35

Location of the beta 4 transmembrane helices in the BK potassium channel. J Neurosci (2009) 1.14

Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1. Biochem Biophys Res Commun (2010) 0.80

Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). J Biol Chem (2012) 0.80

Development of CFTR Structure. Front Pharmacol (2012) 0.77

Degradation of CFTR by the ubiquitin-proteasome pathway. Cell (1995) 7.88

Structure of a bacterial multidrug ABC transporter. Nature (2006) 7.76

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature (2001) 7.59

ERAD: the long road to destruction. Nat Cell Biol (2005) 7.46

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science (2002) 7.21

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell (1995) 5.61

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell (2006) 5.54

The human ATP-binding cassette (ABC) transporter superfamily. Genome Res (2001) 5.47

A membrane protein required for dislocation of misfolded proteins from the ER. Nature (2004) 5.39

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol Cell (2002) 4.79

Viral strategies of immune evasion. Science (1998) 4.48

Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science (1983) 3.88

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol (2002) 3.77

The ATP switch model for ABC transporters. Nat Struct Mol Biol (2004) 3.58

Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science (2003) 3.48

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J (1996) 3.34

Structure of an ABC transporter in complex with its binding protein. Nature (2007) 3.19

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature (1991) 3.12

Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science (1993) 3.06

A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep (2001) 2.96

An inward-facing conformation of a putative metal-chelate-type ABC transporter. Science (2006) 2.80

Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Annu Rev Genomics Hum Genet (2005) 2.80

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J Cell Biol (2007) 2.53

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell (1993) 2.43

A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity (1994) 2.26

MHC class I ubiquitination by a viral PHD/LAP finger protein. Immunity (2001) 2.21

A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. Science (1997) 2.18

Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Science (2007) 2.14

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression. Mol Cell Biol (1982) 2.03

MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding. Nature (1994) 1.93

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220. Immunity (1998) 1.90

Structure and mechanism of ABC transporters. Curr Opin Struct Biol (2002) 1.84

Peptide translocation by variants of the transporter associated with antigen processing. Science (1993) 1.71

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants. J Biol Chem (2006) 1.69

Virus subversion of the MHC class I peptide-loading complex. Immunity (2003) 1.60

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin. Mol Cell Biol (2005) 1.58

Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein. FASEB J (2007) 1.57

Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries. Proc Natl Acad Sci U S A (1997) 1.53

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem (2003) 1.52

Structure and function of ABC transporters. Physiology (Bethesda) (2007) 1.52

Viral degradation of the MHC class I peptide loading complex. Immunity (2004) 1.51

The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing. Physiology (Bethesda) (2004) 1.51

A structural analysis of asymmetry required for catalytic activity of an ABC-ATPase domain dimer. EMBO J (2006) 1.48

Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP). J Biol Chem (2003) 1.42

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket. Biochem J (2006) 1.40

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett (2004) 1.40

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc Natl Acad Sci U S A (2005) 1.36

The role of p97/Cdc48p in endoplasmic reticulum-associated degradation: from the immune system to yeast. Curr Top Microbiol Immunol (2005) 1.34

Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunol Lett (1997) 1.28

Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway. Cancer Res (2001) 1.25

Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation. Mol Biol Cell (2006) 1.24

ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly. EMBO J (1998) 1.24

p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation. EMBO J (2006) 1.24

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket. Biochem J (2006) 1.23

Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal. Mol Biol Cell (2007) 1.21

Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP. Proc Natl Acad Sci U S A (2001) 1.21

A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. Eur J Immunol (2003) 1.19

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading. J Immunol (2002) 1.18

Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Mdl1 from Saccharomyces cerevisiae. J Biol Chem (2006) 1.18

HLA class I deficiencies due to mutations in subunit 1 of the peptide transporter TAP1. J Clin Invest (1999) 1.18

Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing. J Biol Chem (2003) 1.08

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels. Am J Physiol Cell Physiol (2005) 1.08

Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein. J Biol Chem (2007) 1.07

The Q-loop disengages from the first intracellular loop during the catalytic cycle of the multidrug ABC transporter BmrA. J Biol Chem (2005) 1.06

Recognition and delivery of ERAD substrates to the proteasome and alternative paths for cell survival. Curr Top Microbiol Immunol (2005) 1.04

Mechanism of substrate sensing and signal transmission within an ABC transporter: use of a Trojan horse strategy. J Biol Chem (2006) 1.03

The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins. J Biol Chem (2006) 1.01

Assembly, maturation, and turnover of K(ATP) channel subunits. J Biol Chem (2003) 0.99

Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival. Cancer Res (2005) 0.98

The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. J Biol Chem (2006) 0.97

The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation. Cell Mol Life Sci (2006) 0.97

Membrane topology of the transporter associated with antigen processing (TAP1) within an assembled functional peptide-loading complex. J Biol Chem (2006) 0.96

Bovine herpesvirus 1 UL49.5 protein inhibits the transporter associated with antigen processing despite complex formation with glycoprotein M. J Virol (2006) 0.94

The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding. FEBS Lett (2006) 0.92

Modulation of the antigen transport machinery TAP by friends and enemies. FEBS Lett (2005) 0.92

Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). J Biol Chem (2005) 0.91

Multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing TAP2 subunit. J Biol Chem (2007) 0.91

Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP). Proc Natl Acad Sci U S A (2001) 0.88

Viral evasion of the MHC class I antigen-processing machinery. Pflugers Arch (2005) 0.87

Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2. J Biol Chem (2006) 0.86

Subcellular trafficking of the yeast plasma membrane ABC transporter, Pdr5, is impaired by a mutation in the N-terminal nucleotide-binding fold. Mol Microbiol (2007) 0.86

Thermodynamics of peptide binding to the transporter associated with antigen processing (TAP). J Mol Biol (2002) 0.85

Functional cysteine-less subunits of the transporter associated with antigen processing (TAP1 and TAP2) by de novo gene assembly. FEBS Lett (2003) 0.84

Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations. J Neurochem (2007) 0.81

Caught in the act: an ABC transporter on the move. Structure (2007) 0.78

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol (2008) 3.08

Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density. Biophys J (2010) 2.65

Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells. Nat Immunol (2004) 2.18

Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens. Proc Natl Acad Sci U S A (2003) 2.09

High-affinity adaptors for switchable recognition of histidine-tagged proteins. J Am Chem Soc (2005) 2.06

Structure and mechanism of ABC transporters. Curr Opin Struct Biol (2002) 1.84

Stochastic sensing of proteins with receptor-modified solid-state nanopores. Nat Nanotechnol (2012) 1.82

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions. Nat Cell Biol (2012) 1.66

Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A (2009) 1.61

Specific and stable fluorescence labeling of histidine-tagged proteins for dissecting multi-protein complex formation. J Am Chem Soc (2006) 1.53

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem (2003) 1.52

The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing. Physiology (Bethesda) (2004) 1.51

Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP). J Biol Chem (2003) 1.42

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc Natl Acad Sci U S A (2005) 1.36

The transporter associated with antigen processing: function and implications in human diseases. Physiol Rev (2002) 1.33

Structural arrangement of the transmission interface in the antigen ABC transport complex TAP. Proc Natl Acad Sci U S A (2009) 1.27

Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1. Proc Natl Acad Sci U S A (2011) 1.26

Fabs enable single particle cryoEM studies of small proteins. Structure (2012) 1.25

Purification and reconstitution of the antigen transport complex TAP: a prerequisite for determination of peptide stoichiometry and ATP hydrolysis. J Biol Chem (2009) 1.24

Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1. J Biol Chem (2007) 1.22

ABC proteins in antigen translocation and viral inhibition. Nat Chem Biol (2010) 1.22

Structural and functional fingerprint of the mitochondrial ATP-binding cassette transporter Mdl1 from Saccharomyces cerevisiae. J Biol Chem (2006) 1.18

Mitochondrial ABC proteins in health and disease. Biochim Biophys Acta (2009) 1.17

The binding specificity of OppA determines the selectivity of the oligopeptide ATP-binding cassette transporter. J Biol Chem (2004) 1.11

High-affinity chelator thiols for switchable and oriented immobilization of histidine-tagged proteins: a generic platform for protein chip technologies. Chemistry (2005) 1.10

Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing. J Biol Chem (2003) 1.08

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP. PLoS Pathog (2008) 1.08

Functional non-equivalence of ATP-binding cassette signature motifs in the transporter associated with antigen processing (TAP). J Biol Chem (2004) 1.06

The MHC I loading complex: a multitasking machinery in adaptive immunity. Trends Biochem Sci (2013) 1.04

Mechanism of substrate sensing and signal transmission within an ABC transporter: use of a Trojan horse strategy. J Biol Chem (2006) 1.03

How do ABC transporters drive transport? Biol Chem (2004) 1.01

Structure and dynamics of membrane-associated ICP47, a viral inhibitor of the MHC I antigen-processing machinery. J Biol Chem (2006) 1.00

Functional properties and modulation of extracellular epitope-tagged Ca(V)2.1 voltage-gated calcium channels. Channels (Austin) (2008) 0.99

The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding. J Biol Chem (2012) 0.98

Intracellular peptide transporters in human--compartmentalization of the "peptidome". Pflugers Arch (2006) 0.98

Identification of two interaction sites in SecY that are important for the functional interaction with SecA. J Mol Biol (2006) 0.97

Native protein nanolithography that can write, read and erase. Nat Nanotechnol (2007) 0.97

Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9). J Biol Chem (2005) 0.97

In situ assembly of macromolecular complexes triggered by light. Proc Natl Acad Sci U S A (2010) 0.96

Membrane topology of the transporter associated with antigen processing (TAP1) within an assembled functional peptide-loading complex. J Biol Chem (2006) 0.96

Identification of a lysosomal peptide transport system induced during dendritic cell development. J Biol Chem (2007) 0.95

TAP and TAP-like--brothers in arms? Naunyn Schmiedebergs Arch Pharmacol (2006) 0.94

Modulation of the antigen transport machinery TAP by friends and enemies. FEBS Lett (2005) 0.92

The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding. FEBS Lett (2006) 0.92

Kinetics of the ATP hydrolysis cycle of the nucleotide-binding domain of Mdl1 studied by a novel site-specific labeling technique. J Biol Chem (2005) 0.92

Two-substrate association with the 20S proteasome at single-molecule level. EMBO J (2004) 0.92

Single residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation. Proc Natl Acad Sci U S A (2010) 0.92

Engineering ATPase activity in the isolated ABC cassette of human TAP1. J Biol Chem (2006) 0.91

Asymmetric ATP hydrolysis cycle of the heterodimeric multidrug ABC transport complex TmrAB from Thermus thermophilus. J Biol Chem (2010) 0.90

Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion. J Biol Chem (2008) 0.89

The transporter associated with antigen processing (TAP) is active in a post-ER compartment. J Cell Sci (2010) 0.89

Multicolour fluorescence-detection size-exclusion chromatography for structural genomics of membrane multiprotein complexes. PLoS One (2013) 0.88

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J Cell Sci (2012) 0.88

Conformation of peptides bound to the transporter associated with antigen processing (TAP). Proc Natl Acad Sci U S A (2011) 0.88

Peptide trafficking and translocation across membranes in cellular signaling and self-defense strategies. Curr Opin Cell Biol (2009) 0.88

The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex. J Immunol (2008) 0.88

ABC transporters and immunity: mechanism of self-defense. Biochemistry (2012) 0.87

Viral evasion of the MHC class I antigen-processing machinery. Pflugers Arch (2005) 0.87

Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane. J Biol Chem (2012) 0.87

Tying up loose ends: ribosome recycling in eukaryotes and archaea. Trends Biochem Sci (2012) 0.86

Inhibition of HIV-1 by a peptide ligand of the genomic RNA packaging signal Psi. ChemMedChem (2008) 0.86

Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex. Cell Mol Life Sci (2012) 0.86

Metal-chelating amino acids as building blocks for synthetic receptors sensing metal ions and histidine-tagged proteins. Chembiochem (2003) 0.86

Differential protein assembly on micropatterned surfaces with tailored molecular and surface multivalency. Chembiochem (2006) 0.86

Specific lipids modulate the transporter associated with antigen processing (TAP). J Biol Chem (2011) 0.86

Thermodynamics of peptide binding to the transporter associated with antigen processing (TAP). J Mol Biol (2002) 0.85

Modulation of the antigenic peptide transporter TAP by recombinant antibodies binding to the last five residues of TAP1. J Mol Biol (2007) 0.85

Multiplexed parallel single transport recordings on nanopore arrays. Nano Lett (2010) 0.84

The transporter associated with antigen processing: a key player in adaptive immunity. Biol Chem (2015) 0.84

Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain. Traffic (2010) 0.84

Control of nanomolar interaction and in situ assembly of proteins in four dimensions by light. Angew Chem Int Ed Engl (2013) 0.84

Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL). J Biol Chem (2008) 0.84

Molecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing. FASEB J (2012) 0.84

The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms. J Bioenerg Biomembr (2005) 0.84

Specific orientation and two-dimensional crystallization of the proteasome at metal-chelating lipid interfaces. J Biol Chem (2002) 0.84

Native laser lithography of His-tagged proteins by uncaging of multivalent chelators. J Am Chem Soc (2010) 0.84

Functional cysteine-less subunits of the transporter associated with antigen processing (TAP1 and TAP2) by de novo gene assembly. FEBS Lett (2003) 0.84

Molecular printboards as a general platform for protein immobilization: a supramolecular solution to nonspecific adsorption. Angew Chem Int Ed Engl (2007) 0.83

Piezo dispensed microarray of multivalent chelating thiols for dissecting complex protein-protein interactions. Anal Chem (2006) 0.83

Epstein-Barr viral BNLF2a protein hijacks the tail-anchored protein insertion machinery to block antigen processing by the transport complex TAP. J Biol Chem (2011) 0.83

Quantum-yield-optimized fluorophores for site-specific labeling and super-resolution imaging. J Am Chem Soc (2011) 0.83

Exploring the minimal functional unit of the transporter associated with antigen processing. FEBS Lett (2005) 0.82

Chemical tags mediate the orthogonal self-assembly of DNA duplexes into supramolecular structures. Small (2010) 0.82

The TAP translocation machinery in adaptive immunity and viral escape mechanisms. Essays Biochem (2011) 0.82

Anchoring of histidine-tagged proteins to molecular printboards: self-assembly, thermodynamic modeling, and patterning. Chemistry (2008) 0.82

Self-assembled monolayers with latent aldehydes for protein immobilization. Bioconjug Chem (2007) 0.82

The peptide-loading complex--antigen translocation and MHC class I loading. Biol Chem (2009) 0.82

Self-assembled monolayers containing terminal mono-, bis-, and tris-nitrilotriacetic acid groups: characterization and application. Langmuir (2008) 0.82

Detection of metal binding sites on functional S-layer nanoarrays using single molecule force spectroscopy. J Struct Biol (2009) 0.82

Thermodynamics of the ATPase cycle of GlcV, the nucleotide-binding domain of the glucose ABC transporter of sulfolobus solfataricus. Biochemistry (2006) 0.81

Conformation of receptor adopted upon interaction with virus revealed by site-specific fluorescence quenchers and FRET analysis. J Am Chem Soc (2009) 0.80

Live-cell targeting of his-tagged proteins by multivalent N-nitrilotriacetic acid carrier complexes. J Am Chem Soc (2014) 0.80

Protein-resistant self-assembled monolayers on gold with latent aldehyde functions. Langmuir (2007) 0.80

Activation of G-protein-coupled receptors in cell-derived plasma membranes supported on porous beads. J Am Chem Soc (2011) 0.80

Selectivity of competitive multivalent interactions at interfaces. Chembiochem (2009) 0.80

Three-dimensional protein networks assembled by two-photon activation. Angew Chem Int Ed Engl (2014) 0.79

Highly parallel transport recordings on a membrane-on-nanopore chip at single molecule resolution. Nano Lett (2014) 0.79

Oriented binding of the His6-tagged carboxyl-tail of the L-type Ca2+ channel alpha1-subunit to a new NTA-functionalized self-assembled monolayer. Langmuir (2004) 0.79

Controlling the activity of the 20S proteasome complex by synthetic gatekeepers. Angew Chem Int Ed Engl (2006) 0.78

Characterization of a transport activity for long-chain peptides in barley mesophyll vacuoles. J Exp Bot (2011) 0.78