Published in J Biol Chem on August 17, 2005
Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev (2008) 5.97
An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell (2009) 1.68
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating. J Biol Chem (2008) 1.62
Structural arrangement of the transmission interface in the antigen ABC transport complex TAP. Proc Natl Acad Sci U S A (2009) 1.27
ABC proteins in antigen translocation and viral inhibition. Nat Chem Biol (2010) 1.22
Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding. Mol Cell (2007) 1.21
A comparative electron paramagnetic resonance study of the nucleotide-binding domains' catalytic cycle in the assembled maltose ATP-binding cassette importer. Biophys J (2008) 1.08
Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations. Proc Natl Acad Sci U S A (2012) 1.06
PfMDR1: mechanisms of transport modulation by functional polymorphisms. PLoS One (2011) 0.98
Intracellular peptide transporters in human--compartmentalization of the "peptidome". Pflugers Arch (2006) 0.98
The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues. Biochemistry (2010) 0.96
Molecular-dynamics simulations of the ATP/apo state of a multidrug ATP-binding cassette transporter provide a structural and mechanistic basis for the asymmetric occluded state. Biophys J (2011) 0.92
The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state. Biochem J (2006) 0.91
Targeted degradation of ABC transporters in health and disease. J Bioenerg Biomembr (2007) 0.87
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains. Protein Sci (2010) 0.83
Assembly and function of the major histocompatibility complex (MHC) I peptide-loading complex are conserved across higher vertebrates. J Biol Chem (2014) 0.83
Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach. Protein Sci (2009) 0.81
Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor. Biochim Biophys Acta (2011) 0.80
Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. J Biol Chem (2015) 0.78
A Computational Approach towards the Understanding of Plasmodium falciparum Multidrug Resistance Protein 1. ISRN Bioinform (2013) 0.76
Efficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studies. Front Mol Biosci (2014) 0.75
Geno3D: automatic comparative molecular modelling of protein. Bioinformatics (2002) 3.19
euHCVdb: the European hepatitis C virus database. Nucleic Acids Res (2006) 2.41
A new bioinformatic approach to detect common 3D sites in protein structures. Proteins (2003) 1.62
Multiple GTPases participate in the assembly of the large ribosomal subunit in Bacillus subtilis. J Bacteriol (2006) 1.41
The SuMo server: 3D search for protein functional sites. Bioinformatics (2005) 1.41
The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA. J Biol Chem (2003) 1.40
Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. Cancer Res (2005) 1.33
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis. FEMS Microbiol Lett (2004) 1.33
HCVDB: hepatitis C virus sequences database. Appl Bioinformatics (2004) 1.21
Three-dimensional structure by cryo-electron microscopy of YvcC, an homodimeric ATP-binding cassette transporter from Bacillus subtilis. J Mol Biol (2002) 1.20
Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis. Biochemistry (2004) 1.14
Hepatitis C databases, principles and utility to researchers. Hepatology (2006) 1.13
Insights into early extracellular matrix evolution: spongin short chain collagen-related proteins are homologous to basement membrane type IV collagens and form a novel family widely distributed in invertebrates. Mol Biol Evol (2006) 1.13
Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth. Cancer Res (2012) 1.12
Functional reconstitution of an ABC transporter in nanodiscs for use in electron paramagnetic resonance spectroscopy. J Am Chem Soc (2010) 1.11
Integrated databanks access and sequence/structure analysis services at the PBIL. Nucleic Acids Res (2003) 1.11
Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1. Cancer Res (2004) 1.10
Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations. Proc Natl Acad Sci U S A (2012) 1.06
Staphylococcus aureus operates protein-tyrosine phosphorylation through a specific mechanism. J Biol Chem (2006) 1.06
ABCG2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem (2010) 1.06
Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2). Anticancer Drugs (2006) 1.05
Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors. J Med Chem (2007) 1.02
GeneFarm, structural and functional annotation of Arabidopsis gene and protein families by a network of experts. Nucleic Acids Res (2005) 1.01
Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance. Chem Rev (2014) 1.00
Crenarchaeal CdvA forms double-helical filaments containing DNA and interacts with ESCRT-III-like CdvB. PLoS One (2011) 0.98
Anticancer multidrug resistance mediated by MRP1: recent advances in the discovery of reversal agents. Med Res Rev (2005) 0.98
Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance. Med Res Rev (2002) 0.97
Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein. J Med Chem (2012) 0.94
Optimized purification of a heterodimeric ABC transporter in a highly stable form amenable to 2-D crystallization. PLoS One (2011) 0.94
PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones. Biochemistry (2012) 0.93
Highly efficient over-production in E. coli of YvcC, a multidrug-like ATP-binding cassette transporter from Bacillus subtilis. Biochim Biophys Acta (2002) 0.93
The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter. Biochim Biophys Acta (2009) 0.93
Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. Bioorg Med Chem (2007) 0.93
Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells. Biochem Biophys Res Commun (2008) 0.92
Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells. Clin Cancer Res (2011) 0.92
The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state. Biochem J (2006) 0.91
Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein. J Biol Chem (2002) 0.91
Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead. J Med Chem (2003) 0.90
Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity. J Med Chem (2012) 0.89
Small angle neutron scattering for the study of solubilised membrane proteins. Eur Phys J E Soft Matter (2013) 0.89
(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem (2007) 0.89
A new family of phosphotransferases with a P-loop motif. J Biol Chem (2002) 0.88
New model potentials for sulfur-copper(I) and sulfur-mercury(II) interactions in proteins: from ab initio to molecular dynamics. J Comput Chem (2006) 0.88
Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA. Biochemistry (2008) 0.88
Interactions of an essential Bacillus subtilis GTPase, YsxC, with ribosomes. J Bacteriol (2007) 0.88
The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. Microbiology (2009) 0.86
Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux. Antimicrob Agents Chemother (2006) 0.86
Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein. ACS Chem Biol (2011) 0.85
The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes. Biochim Biophys Acta (2010) 0.85
Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein. FEBS J (2014) 0.84
Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach. Eur J Pharm Sci (2009) 0.84
Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2. J Med Chem (2014) 0.84
ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity. Front Pharmacol (2013) 0.84
Molecular dynamics study of the metallochaperone Hah1 in its apo and Cu(I)-loaded states: role of the conserved residue M10. FEBS Lett (2005) 0.83
Tyrosine-kinase Wzc from Escherichia coli possesses an ATPase activity regulated by autophosphorylation. FEMS Microbiol Lett (2007) 0.83
Detection of unrelated proteins in sequences multiple alignments by using predicted secondary structures. Bioinformatics (2003) 0.83
Potassium acts as a GTPase-activating element on each nucleotide-binding domain of the essential Bacillus subtilis EngA. PLoS One (2012) 0.83
Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol (2009) 0.82
4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzyme. J Biol Chem (2011) 0.82
Structuring detergents for extracting and stabilizing functional membrane proteins. PLoS One (2011) 0.82
Phosphorylation of CpgA protein enhances both its GTPase activity and its affinity for ribosome and is crucial for Bacillus subtilis growth and morphology. J Biol Chem (2012) 0.82
Model peptides based on the binding loop of the copper metallochaperone Atx1: selectivity of the consensus sequence MxCxxC for metal ions Hg(II), Cu(I), Cd(II), Pb(II), and Zn(II). Inorg Chem (2006) 0.81
Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators. Org Biomol Chem (2008) 0.81
A synthetic chalcone as a potent inducer of glutathione biosynthesis. J Med Chem (2012) 0.81
MSX-3D: a tool to validate 3D protein models using mass spectrometry. Bioinformatics (2008) 0.81
Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer. Biochemistry (2005) 0.81
Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach. Protein Sci (2009) 0.81
Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A. J Med Chem (2004) 0.81
A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein. Eur J Pharm Sci (2008) 0.81
Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities. Br J Pharmacol (2013) 0.80
Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model. Fundam Clin Pharmacol (2013) 0.80
Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein. J Med Chem (2010) 0.80
ABCG2: recent discovery of potent and highly selective inhibitors. Future Med Chem (2013) 0.80
Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1. ChemMedChem (2011) 0.80
A new generation of cross-linkers for selective detection by MALDI MS. Proteomics (2009) 0.80
Copper(II)-complex directed regioselective mono-p-toluenesulfonylation of cyclomaltoheptaose at a primary hydroxyl group position: an NMR and molecular dynamics-aided design. J Phys Chem B (2011) 0.79
Regulation and mutational analysis of the HPr kinase/phosphorylase from Bacillus subtilis. Biochemistry (2003) 0.79
Insights into the functioning of Bacillus subtilis HPr kinase/phosphatase: affinity for its protein substrates and role of cations and phosphate. Biochemistry (2002) 0.79
Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones. J Med Chem (2014) 0.79
Structure prediction of GPCRs using piecewise homologs and application to the human CCR5 chemokine receptor: validation through agonist and antagonist docking. J Biomol Struct Dyn (2013) 0.79
New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity. Drug Des Devel Ther (2013) 0.78