Peptide translocation by variants of the transporter associated with antigen processing.

PubWeight™: 1.71‹?› | Rank: Top 3%

🔗 View Article (PMID 8266106)

Published in Science on December 24, 1993

Authors

M T Heemels1, T N Schumacher, K Wonigeit, H L Ploegh

Author Affiliations

1: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Articles citing this

Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. EMBO J (1996) 2.64

Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J Exp Med (1997) 2.38

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J (1996) 2.26

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. Proc Natl Acad Sci U S A (1994) 2.08

Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene. J Virol (1997) 1.88

Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J Exp Med (1994) 1.69

The peptide-binding motif for the human transporter associated with antigen processing. J Exp Med (1995) 1.56

Analysis and prediction of affinity of TAP binding peptides using cascade SVM. Protein Sci (2004) 1.55

Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries. Proc Natl Acad Sci U S A (1997) 1.53

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J (1994) 1.37

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling. J Exp Med (1994) 1.36

Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP. J Virol (1998) 1.33

The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J Exp Med (1996) 1.28

Purification and reconstitution of the antigen transport complex TAP: a prerequisite for determination of peptide stoichiometry and ATP hydrolysis. J Biol Chem (2009) 1.24

Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen. Proc Natl Acad Sci U S A (1995) 1.16

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides. Proc Natl Acad Sci U S A (1996) 1.15

Inhibition of major histocompatibility complex class I antigen presentation in pig and primate cells by herpes simplex virus type 1 and 2 ICP47. J Virol (1998) 1.14

Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region. Am J Hum Genet (1995) 1.13

Cloning and functional characterization of a subunit of the transporter associated with antigen processing. Proc Natl Acad Sci U S A (1997) 1.09

A detailed analysis of the murine TAP transporter substrate specificity. PLoS One (2008) 1.00

Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation. Proc Natl Acad Sci U S A (1994) 0.95

Assembly and peptide binding of major histocompatibility complex class II heterodimers in an in vitro translation system. Proc Natl Acad Sci U S A (1994) 0.90

Conformation of peptides bound to the transporter associated with antigen processing (TAP). Proc Natl Acad Sci U S A (2011) 0.88

Targeted degradation of ABC transporters in health and disease. J Bioenerg Biomembr (2007) 0.87

Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides. Proc Natl Acad Sci U S A (1994) 0.86

Using the TAP component of the antigen-processing machinery as a molecular adjuvant. PLoS Pathog (2005) 0.84

Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat. PLoS Genet (2014) 0.80

Surrogate antigen processing mediated by TAP-dependent antigenic peptide secretion. J Cell Biol (1998) 0.79

Structure and Dynamics of Antigenic Peptides in Complex with TAP. Front Immunol (2017) 0.75

Articles by these authors

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell (1996) 8.25

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature (1996) 7.90

Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med (2001) 6.19

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature (1991) 5.90

Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. Cell (1981) 5.81

Viral subversion of the immune system. Annu Rev Immunol (2000) 5.76

Empty MHC class I molecules come out in the cold. Nature (1990) 5.53

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol (1986) 4.30

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell (1990) 4.18

CD27 is required for generation and long-term maintenance of T cell immunity. Nat Immunol (2000) 3.84

Isolation and characterization of the intracellular MHC class II compartment. Nature (1994) 3.50

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell (1990) 3.44

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J (2001) 3.42

Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A (1983) 3.42

Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. Proc Natl Acad Sci U S A (1979) 3.29

Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc Natl Acad Sci U S A (1996) 3.17

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J Immunol (1987) 3.09

Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity (1999) 3.01

Molecular cloning of a human histocompatibility antigen cDNA fragment. Proc Natl Acad Sci U S A (1980) 2.99

Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity (1996) 2.93

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity (1997) 2.93

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med (1999) 2.77

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A (1998) 2.75

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature (1987) 2.72

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell (1993) 2.43

Immunotherapy through TCR gene transfer. Nat Immunol (2001) 2.41

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J Immunol (1993) 2.40

The WD-40 repeat. FEBS Lett (1992) 2.37

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. EMBO J (1996) 2.26

Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J (2000) 2.24

How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol (1995) 2.24

The alpha chain of the T cell antigen receptor is degraded in the cytosol. Immunity (1997) 2.20

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol (1998) 2.16

HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. Int Immunol (1990) 2.12

Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association. Eur J Immunol (1988) 2.03

Peptide selection by MHC class I molecules. Nature (1991) 2.01

A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface. EMBO J (1997) 1.98

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell (1993) 1.96

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proc Natl Acad Sci U S A (1979) 1.94

Biosynthesis and cell surface localization of nonglycosylated human histocompatibility antigens. J Immunol (1981) 1.91

How MHC class II molecules reach the endocytic pathway. EMBO J (1995) 1.80

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (1996) 1.76

Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest (1998) 1.76

A proteolytic system that compensates for loss of proteasome function. Nature (1998) 1.76

The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol (1999) 1.74

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J Exp Med (1994) 1.73

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. EMBO J (1992) 1.72

Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell (2001) 1.69

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J Exp Med (1994) 1.69

An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. Hum Immunol (1986) 1.67

Phenotype and histological distribution of interstitial dendritic cells in the rat pancreas, liver, heart, and kidney. Transplantation (1984) 1.65

Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. J Exp Med (2001) 1.62

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc Natl Acad Sci U S A (2001) 1.60

A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J Biol Chem (1993) 1.58

Selective expansion of cross-reactive CD8(+) memory T cells by viral variants. J Exp Med (1999) 1.58

Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol (1999) 1.58

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes. J Exp Med (1995) 1.57

Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex. Nature (1982) 1.56

A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet (2000) 1.54

Proteases involved in MHC class II antigen presentation. Immunol Rev (1999) 1.54

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chem Biol (2001) 1.52

The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains. J Exp Med (1997) 1.51

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes. Chem Biol (1998) 1.51

Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses. Eur J Immunol (1991) 1.51

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J Exp Med (2000) 1.49

Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity (1998) 1.46

Purification, cDNA-cloning and expression of human diacylglycerol kinase. FEBS Lett (1990) 1.45

Experiences with liver transplantation in Hannover. Hepatology (1984) 1.45

In vitro translation and assembly of a complete T cell receptor-CD3 complex. J Exp Med (1997) 1.45

Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression. Clin Chem (1994) 1.43

Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: evolutionary aspects. Immunogenetics (1987) 1.41

Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. Blood (2001) 1.40

Bioactive and nuclease-resistant L-DNA ligand of vasopressin. Proc Natl Acad Sci U S A (1997) 1.40

Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. J Exp Med (1980) 1.39

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J Biol Chem (2000) 1.38

Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. J Exp Med (1995) 1.38

The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues. J Exp Med (1997) 1.37

Systemic T cell expansion during localized viral infection. Eur J Immunol (1999) 1.37

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J (1994) 1.37

Expression patterns of leukocyte adhesion ligand molecules on human liver endothelia. Lack of ELAM-1 and CD62 inducibility on sinusoidal endothelia and distinct distribution of VCAM-1, ICAM-1, ICAM-2, and LFA-3. Am J Pathol (1993) 1.36

The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. Proc Natl Acad Sci U S A (1999) 1.35

The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat. Nat Med (1999) 1.35

N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. J Exp Med (1990) 1.34

Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med (1994) 1.32

Proteolysis in MHC class II antigen presentation: who's in charge? Immunity (2000) 1.32

Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses. Eur J Immunol (1992) 1.30

Signs of hyperacute rejection of liver grafts in rhesus monkeys after donor-specific presensitization. Transplant Proc (1987) 1.30

Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. Mol Immunol (1998) 1.29

Altered natural killer cell repertoire in Tap-1 mutant mice. Proc Natl Acad Sci U S A (1994) 1.28

Redundancy of direct priming and cross-priming in tumor-specific CD8+ T cell responses. J Immunol (2001) 1.27

Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med (1997) 1.25

Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem (1993) 1.25

Patterns of donor-type microchimerism after heart transplantation. Lancet (1994) 1.25

Intracellular transport of MHC class II molecules. Immunol Today (1992) 1.24

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. EMBO J (2001) 1.24