Published in Dev Biol on October 10, 2007
The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol (2009) 0.89
Diverse modes of Drosophila tracheal fusion cell transcriptional regulation. Mech Dev (2010) 0.88
Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila. Nat Commun (2012) 0.88
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Dev Biol (2009) 0.87
Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev (2009) 0.84
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development (2010) 0.83
Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor. PLoS One (2009) 0.82
The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Development (2013) 0.81
The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression. PLoS Genet (2013) 0.77
Drosophila Jing is part of the breathless fibroblast growth factor receptor positive feedback loop. Dev Genes Evol (2010) 0.76
dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E. PLoS One (2011) 0.76
The Drosophila jing gene is a downstream target in the Trachealess/Tango tracheal pathway. Dev Genes Evol (2010) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol (2004) 6.61
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science (2001) 6.29
Inactivation of hCDC4 can cause chromosomal instability. Nature (2004) 5.71
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J (2004) 4.95
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev (1998) 4.58
Tube morphogenesis: making and shaping biological tubes. Cell (2003) 4.54
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc Natl Acad Sci U S A (1988) 4.21
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med (2007) 4.04
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell (2003) 3.91
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell (2004) 3.85
branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell (1996) 3.75
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature (2001) 3.50
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell (2005) 3.47
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab (2005) 3.43
Genetic control of branching morphogenesis. Science (1999) 3.37
breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells. Genes Dev (1992) 2.90
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem (2001) 2.89
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science (2004) 2.83
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol (2001) 2.56
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res (2005) 2.54
Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol (2003) 2.50
Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol Cell (2006) 2.22
trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes Dev (1996) 2.21
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Tubulogenesis in Drosophila: a requirement for the trachealess gene product. Genes Dev (1996) 2.05
The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development (1993) 2.00
Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res (2007) 1.98
Genetic control of epithelial tube fusion during Drosophila tracheal development. Development (1996) 1.95
Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle (2005) 1.88
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res (2007) 1.85
The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol (2004) 1.80
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem (2004) 1.74
The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. Proc Natl Acad Sci U S A (2005) 1.71
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol (2003) 1.68
Cadherin-mediated cell adhesion and cell motility in Drosophila trachea regulated by the transcription factor Escargot. Development (1996) 1.61
Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev Cell (2005) 1.53
Regulation of Drosophila tracheal system development by protein kinase B. Dev Cell (2001) 1.53
Dual function of the region-specific homeotic gene spalt during Drosophila tracheal system development. Development (1996) 1.50
The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. Development (1997) 1.50
Generating lineage-specific markers to study Drosophila development. Dev Genet (1991) 1.37
Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea. Development (1997) 1.36
Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system. Genes Dev (1996) 1.35
Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem (2006) 1.35
Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system. Mech Dev (1999) 1.22
Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development. Genes Dev (2003) 1.22
Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea. Development (1999) 1.18
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability. Oncogene (2007) 1.16
FBXW7/hCDC4 controls glioma cell proliferation in vitro and is a prognostic marker for survival in glioblastoma patients. Cell Div (2007) 1.13
Targeted expression of dominant negative proteasome mutants in Drosophila melanogaster. Genesis (2002) 1.13
Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. J Biol Chem (2004) 1.11
The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein. Mol Cell Biol (2003) 1.07
Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Mech Dev (2002) 1.04
A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea. Dev Biol (2005) 1.02
Salivary duct determination in Drosophila: roles of the EGF receptor signalling pathway and the transcription factors fork head and trachealess. Development (1996) 0.99
Dysfusion transcriptional control of Drosophila tracheal migration, adhesion, and fusion. Mol Cell Biol (2006) 0.96
Function of the Drosophila POU domain transcription factor drifter as an upstream regulator of breathless receptor tyrosine kinase expression in developing trachea. Development (1996) 0.93
Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade. Dev Biol (1999) 0.92
Ischaemia-induced expression of bFGF in normal skeletal muscle: a potential paracrine mechanism for mediating angiogenesis in ischaemic skeletal muscle. Nat Med (1995) 0.90
Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila. Genes Dev (2000) 0.88
The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells. EMBO Rep (2005) 0.85
NPAS1 regulates branching morphogenesis in embryonic lung. Am J Respir Cell Mol Biol (2006) 0.81
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol (2010) 3.08
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Proc Natl Acad Sci U S A (2011) 1.11
Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer. Gynecol Oncol (2005) 1.07
UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. Dis Model Mech (2010) 1.00
A Drosophila melanogaster model of classic galactosemia. Dis Model Mech (2010) 0.96
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell (2011) 0.94
The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol (2009) 0.89
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Dev Biol (2009) 0.87
A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length. RNA (2014) 0.87
Cell-cell junctions: α-catenin and E-cadherin help fence in Yap1. Curr Biol (2011) 0.84
Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. Mech Dev (2012) 0.83
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development (2010) 0.83
Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. Cell Cycle (2011) 0.83
Stable isotope labeling with amino acids in Drosophila for quantifying proteins and modifications. J Proteome Res (2012) 0.82
Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor. PLoS One (2009) 0.82
Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors. PLoS One (2009) 0.80
ESCRTing cell proliferation off the beaten path: lessons from the drosophila eye. Cell Cycle (2006) 0.78
Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model. Cell Microbiol (2011) 0.78
The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression. PLoS Genet (2013) 0.77