Published in J Biol Chem on September 13, 2004
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 8.44
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med (2008) 2.19
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy. Genes Cancer (2010) 1.80
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev (2013) 1.79
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev (2008) 1.78
Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div (2007) 1.64
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol (2008) 1.35
Notch signaling: switching an oncogene to a tumor suppressor. Blood (2014) 1.32
MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem (2010) 1.26
Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev (2008) 1.25
Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways. PLoS Pathog (2010) 1.23
Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci U S A (2005) 1.15
p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle (2012) 1.15
An integrated view of cyclin E function and regulation. Cell Cycle (2012) 1.15
Constitutive turnover of cyclin E by Cul3 maintains quiescence. Mol Cell Biol (2007) 1.10
Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation. Cancer Res (2009) 1.04
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell (2012) 1.03
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem (2008) 1.03
FBXW7 is involved in Aurora B degradation. Cell Cycle (2012) 0.98
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. J Biol Chem (2009) 0.97
Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Mol Cell Biol (2011) 0.94
The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol (2011) 0.94
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol Cell Biol (2013) 0.93
The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Dev Biol (2007) 0.92
A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron. J Biol Chem (2008) 0.91
Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol (2013) 0.91
Coordination of cell growth and division by the ubiquitin-proteasome system. Semin Cell Dev Biol (2012) 0.89
C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs. Dev Biol (2010) 0.87
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis. Neural Dev (2010) 0.85
GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms. Cell Div (2010) 0.85
DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase. Cell Death Dis (2015) 0.84
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron. Genes Dev (2012) 0.83
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development (2010) 0.83
Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1. J Biol Chem (2012) 0.82
Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. J Biol Chem (2015) 0.81
Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes. Blood (2012) 0.79
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. Front Mol Biosci (2017) 0.79
E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation. J Biol Chem (2015) 0.78
Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination. Dev Biol (2011) 0.78
ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun (2015) 0.78
Dysregulation of zinc finger protein, X-linked (ZFX) impairs cell proliferation and induces apoptosis in human oral squamous cell carcinorma. Tumour Biol (2015) 0.78
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med (2015) 0.76
Towards the computational design of protein post-translational regulation. Bioorg Med Chem (2015) 0.76
Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3). J Biol Chem (2015) 0.76
p53-dependent up-regulation of CDKN1A and down-regulation of CCNE2 in response to beryllium. Cell Prolif (2016) 0.76
The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation. Mol Cell Biol (2017) 0.75
The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ. PLoS One (2012) 0.75
Dysregulation of ubiquitin ligases in cancer. Drug Resist Updat (2015) 0.75
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
Dicer is essential for mouse development. Nat Genet (2003) 15.87
A map of the interactome network of the metazoan C. elegans. Science (2004) 15.60
Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44
The DNA damage response: ten years after. Mol Cell (2007) 11.80
Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39
Network organization of the human autophagy system. Nature (2010) 11.38
Principles of cancer therapy: oncogene and non-oncogene addiction. Cell (2009) 10.96
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50
MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11
A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer (2008) 7.93
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods (2007) 7.56
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol (2004) 5.47
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell (2003) 5.31
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00
RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93
Haploid genetic screens in human cells identify host factors used by pathogens. Science (2009) 4.91
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature (2003) 4.79
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75
Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell (2002) 4.57
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell (2007) 3.97
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol (2009) 3.95
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell (2003) 3.91
Global protein stability profiling in mammalian cells. Science (2008) 3.91
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J (2003) 3.72
Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol (2002) 3.66
The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature (2013) 3.57
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell (2010) 3.51
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (2011) 3.49
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell (2005) 3.47
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab (2005) 3.43
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43
Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (2012) 3.41
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40
Sortagging: a versatile method for protein labeling. Nat Chem Biol (2007) 3.39
A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A (2009) 3.37
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol (2004) 3.33
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A (2010) 3.31
Drug discovery in the ubiquitin-proteasome system. Nat Rev Drug Discov (2006) 3.27
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell (2011) 3.27
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog (2011) 3.26
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26