PubRank

John E Dick

Author PubWeight™ 177.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2006 24.52
2 Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006 17.42
3 The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012 9.89
4 Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 2011 6.39
5 Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006 5.92
6 Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med 2011 5.24
7 Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004 5.10
8 Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal Chem 2009 4.95
9 Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 2012 4.92
10 Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 2007 4.22
11 Cancer stem cells: lessons from leukemia. Trends Cell Biol 2005 3.90
12 Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011 3.89
13 Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol 2010 3.27
14 Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 2012 3.03
15 The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med 2011 2.96
16 A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 2010 2.95
17 Modeling the initiation and progression of human acute leukemia in mice. Science 2007 2.90
18 Hematopoiesis: a human perspective. Cell Stem Cell 2012 2.87
19 Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell 2011 2.68
20 Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat Immunol 2006 2.60
21 Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell 2009 2.60
22 Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med 2005 2.42
23 Comment on "Tumor growth need not be driven by rare cancer stem cells". Science 2007 2.41
24 Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells. Blood 2005 2.41
25 Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med 2003 2.31
26 Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 2010 2.19
27 Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood 2002 2.15
28 Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood 2009 1.99
29 Cancer stem cells in solid tumors: an overview. Semin Radiat Oncol 2009 1.98
30 Looking ahead in cancer stem cell research. Nat Biotechnol 2009 1.89
31 Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. Sci Transl Med 2010 1.84
32 Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgc-null recipients. Blood 2010 1.78
33 ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell 2012 1.70
34 Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 2012 1.67
35 Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. Blood 2003 1.60
36 Concepts of human leukemic development. Oncogene 2004 1.56
37 Problems with co-funding in Canada. Science 2005 1.48
38 Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood 2011 1.36
39 The evolution of cellular deficiency in GATA2 mutation. Blood 2013 1.36
40 PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev 2009 1.35
41 The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nat Immunol 2013 1.35
42 Attenuation of miR-126 activity expands HSC in vivo without exhaustion. Cell Stem Cell 2012 1.35
43 Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. Haematologica 2008 1.25
44 Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med 2012 1.24
45 Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. Blood 2009 1.22
46 Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. Blood 2010 1.21
47 Stem cells: Self-renewal writ in blood. Nature 2003 1.18
48 Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population. Blood 2006 1.11
49 Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp Hematol 2005 1.09
50 Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells. Exp Hematol 2007 1.08
51 Human solid tumor xenografts in immunodeficient mice are vulnerable to lymphomagenesis associated with Epstein-Barr virus. PLoS One 2012 1.07
52 Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. Blood 2009 1.06
53 Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J Clin Invest 2012 1.04
54 Human acute myeloid leukemia stem cells. Arch Med Res 2004 1.01
55 Hematopoietic cell fate and the initiation of leukemic properties in primitive primary human cells are influenced by Ras activity and farnesyltransferase inhibition. Mol Cell Biol 2004 1.00
56 Molecular and functional characterization of early human hematopoiesis. Ann N Y Acad Sci 2012 1.00
57 A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. Blood 2011 0.99
58 Auger electron radioimmunotherapeutic agent specific for the CD123+/CD131- phenotype of the leukemia stem cell population. J Nucl Med 2011 0.87
59 Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Int J Cancer 2013 0.87
60 miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell 2016 0.80
61 Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint. J Rheumatol 2010 0.79
62 Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc Natl Acad Sci U S A 2013 0.78
63 Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc(-/-) mouse model, while long-term treatment is ineffective. Blood 2002 0.77
64 Characterization of cord blood hematopoietic stem cells. Ann N Y Acad Sci 2003 0.77
65 Erratum: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns. Nature 2016 0.75