Published in Nat Immunol on November 04, 2007
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell (2009) 5.22
Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol (2012) 3.41
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (2013) 2.42
Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol (2008) 2.39
Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol (2014) 2.28
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res (2010) 2.25
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol (2010) 2.19
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med (2015) 1.98
CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction. Proc Natl Acad Sci U S A (2011) 1.91
The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol (2012) 1.84
Macrophages as mediators of tumor immunosurveillance. Trends Immunol (2010) 1.80
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med (2011) 1.78
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma. Clin Exp Metastasis (2009) 1.71
Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A (2011) 1.71
Human hemato-lymphoid system mice: current use and future potential for medicine. Annu Rev Immunol (2013) 1.70
Current advances in humanized mouse models. Cell Mol Immunol (2012) 1.65
BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection. Blood (2013) 1.57
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity (2015) 1.56
Macrophage heterogeneity in tissues: phenotypic diversity and functions. Immunol Rev (2014) 1.55
Renaissance for mouse models of human hematopoiesis and immunobiology. Nat Immunol (2009) 1.54
Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice. Hum Immunol (2009) 1.53
Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. J Clin Invest (2012) 1.52
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A (2011) 1.44
Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A (2011) 1.35
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet (2011) 1.33
Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood (2010) 1.32
Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells Mol Dis (2010) 1.31
Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell (2013) 1.30
Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One (2010) 1.29
Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice. J Immunol (2012) 1.27
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med (2012) 1.24
Engineering humanized mice for improved hematopoietic reconstitution. Cell Mol Immunol (2012) 1.18
Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function. Curr Opin Immunol (2009) 1.18
Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma. MAbs (2015) 1.16
Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation (2012) 1.16
Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood (2012) 1.16
Human cancer growth and therapy in immunodeficient mouse models. Cold Spring Harb Protoc (2014) 1.12
SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. J Exp Med (2013) 1.11
IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice. Mucosal Immunol (2012) 1.09
Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis. Am J Pathol (2010) 1.09
Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology. Sci Rep (2014) 1.09
Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods (2014) 1.08
The counterbalance theory for evolution and function of paired receptors. Immunity (2008) 1.08
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature (2017) 1.07
Non-self recognition by monocytes initiates allograft rejection. J Clin Invest (2014) 1.06
Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood (2008) 1.05
HIV-1 immunopathogenesis in humanized mouse models. Cell Mol Immunol (2012) 1.03
Nonirradiated NOD,B6.SCID Il2rγ-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells. Stem Cell Reports (2015) 1.01
Hepatitis C virus infection and related liver disease: the quest for the best animal model. Front Microbiol (2013) 0.99
Mouse models with human immunity and their application in biomedical research. J Cell Mol Med (2008) 0.99
Development of a humanized mouse model to study the role of macrophages in allograft injury. Transplantation (2009) 0.98
Humanized hemato-lymphoid system mice. Haematologica (2016) 0.98
Use of nonobese diabetic mice to understand human type 1 diabetes. Endocrinol Metab Clin North Am (2010) 0.97
Establishing humanized mice using stem cells: maximizing the potential. Clin Exp Immunol (2008) 0.97
Macrophage tolerance: CD47-SIRP-alpha-mediated signals matter. Nat Immunol (2007) 0.97
CD47 is required for suppression of allograft rejection by donor-specific transfusion. J Immunol (2010) 0.96
Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci (2010) 0.94
Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1. Mol Ther Nucleic Acids (2013) 0.93
Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells. Immunology (2014) 0.92
Full reconstitution of human platelets in humanized mice after macrophage depletion. Blood (2012) 0.91
Heterogeneity in the CD200R paired receptor family. Immunogenetics (2009) 0.91
Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47. J Biol Chem (2014) 0.90
Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol (2010) 0.88
Development of humanized mouse models to study human malaria parasite infection. Future Microbiol (2012) 0.87
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement. J Cell Sci (2012) 0.87
Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders? J Neuroimmune Pharmacol (2012) 0.87
Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nat Rev Cancer (2017) 0.87
"Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis. J Biol Chem (2015) 0.86
Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice. J Biomed Biotechnol (2011) 0.85
The innate immune system in transplantation. Semin Immunol (2011) 0.84
Loss of quiescence and impaired function of CD34(+)/CD38(low) cells one year following autologous stem cell transplantation. Haematologica (2013) 0.84
SIRPα/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen. J Immunol (2012) 0.84
Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections. Cell Microbiol (2014) 0.84
Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. Curr Opin Immunol (2015) 0.83
Human allograft rejection in humanized mice: a historical perspective. Cell Mol Immunol (2012) 0.83
Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II. Blood (2014) 0.83
CD47 in xenograft rejection and tolerance induction. Xenotransplantation (2010) 0.83
Murine Models of Transplantation Tolerance through Mixed Chimerism: Advances and Roadblocks. Clin Exp Immunol (2017) 0.83
Stem cell transplantation for muscular dystrophy: the challenge of immune response. Biomed Res Int (2014) 0.83
Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo. PLoS One (2016) 0.82
Evaluation of five candidate genes from GWAS for association with oligozoospermia in a Han Chinese population. PLoS One (2013) 0.82
Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells. Cell Mol Immunol (2012) 0.82
Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver cancer. J Cell Commun Signal (2015) 0.82
Immunobiology of liver xenotransplantation. Expert Rev Clin Immunol (2012) 0.81
Innate allorecognition. Immunol Rev (2014) 0.81
Association of a FGFR-4 gene polymorphism with bronchopulmonary dysplasia and neonatal respiratory distress. Dis Markers (2013) 0.81
Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPα capable of binding to human CD47. Cell Transplant (2011) 0.81
Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases. Inflamm Bowel Dis (2015) 0.80
CD47: a new player in phagocytosis and xenograft rejection. Cell Mol Immunol (2011) 0.80
The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47. J Biol Chem (2010) 0.80
Assessing the therapeutic potential of lab-made hepatocytes. Hepatology (2016) 0.80
Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice. Genes Immun (2014) 0.78
Increasing hematopoietic stem cell yield to develop mice with human immune systems. Biomed Res Int (2013) 0.78
Effect of glycyrrhizin on pseudomonal skin infections in human-mouse chimeras. PLoS One (2014) 0.78
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature (2011) 6.39
Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med (2006) 5.92
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science (2013) 5.75
Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med (2011) 5.24
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol (2004) 5.10
Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal Chem (2009) 4.95
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science (2012) 4.92
Cancer stem cells: lessons from leukemia. Trends Cell Biol (2005) 3.90
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science (2011) 3.89
Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol (2010) 3.27
Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Cancer (2007) 3.10
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med (2012) 3.03
The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med (2011) 2.96
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell (2010) 2.95
Modeling the initiation and progression of human acute leukemia in mice. Science (2007) 2.90
Hematopoiesis: a human perspective. Cell Stem Cell (2012) 2.87
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68
Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat Immunol (2006) 2.60
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell (2009) 2.60
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med (2005) 2.42
Comment on "Tumor growth need not be driven by rare cancer stem cells". Science (2007) 2.41
Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells. Blood (2005) 2.41
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol (2013) 2.34
Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med (2003) 2.31
Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood (2010) 2.19
Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood (2002) 2.15
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood (2009) 1.99
Cancer stem cells in solid tumors: an overview. Semin Radiat Oncol (2009) 1.98
The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell (2003) 1.90
Looking ahead in cancer stem cell research. Nat Biotechnol (2009) 1.89
Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. Sci Transl Med (2010) 1.84
Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgc-null recipients. Blood (2010) 1.78
ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell (2012) 1.70
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun (2012) 1.67
Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. Blood (2003) 1.60
Concepts of human leukemic development. Oncogene (2004) 1.56
Problems with co-funding in Canada. Science (2005) 1.48
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood (2011) 1.36
The evolution of cellular deficiency in GATA2 mutation. Blood (2013) 1.36
PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev (2009) 1.35
The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nat Immunol (2013) 1.35
Attenuation of miR-126 activity expands HSC in vivo without exhaustion. Cell Stem Cell (2012) 1.35
Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. Haematologica (2008) 1.25
Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med (2012) 1.24
Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. Blood (2009) 1.22
Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. Blood (2010) 1.21
Stem cells: Self-renewal writ in blood. Nature (2003) 1.18
ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev (2006) 1.15
ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes. Blood (2006) 1.13
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol (2009) 1.12
Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population. Blood (2006) 1.11
SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. J Exp Med (2013) 1.11
Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp Hematol (2005) 1.09
Cancer patient perceptions on the ethical and legal issues related to biobanking. BMC Med Genomics (2013) 1.08
Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells. Exp Hematol (2007) 1.08
Human solid tumor xenografts in immunodeficient mice are vulnerable to lymphomagenesis associated with Epstein-Barr virus. PLoS One (2012) 1.07
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. Blood (2009) 1.06
Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J Clin Invest (2012) 1.04
Chromosomal reinsertion of broken RSS ends during T cell development. J Exp Med (2007) 1.03
Human acute myeloid leukemia stem cells. Arch Med Res (2004) 1.01
Hematopoietic cell fate and the initiation of leukemic properties in primitive primary human cells are influenced by Ras activity and farnesyltransferase inhibition. Mol Cell Biol (2004) 1.00
Molecular and functional characterization of early human hematopoiesis. Ann N Y Acad Sci (2012) 1.00
Generation and analysis of a mouse intestinal metatranscriptome through Illumina based RNA-sequencing. PLoS One (2012) 0.99
A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. Blood (2011) 0.99
Susceptibility to lymphoid neoplasia in immunodeficient strains of nonobese diabetic mice. Cancer Res (2002) 0.95
γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model. J Immunol (2013) 0.92
Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B', in differentiated human neuronal cells. Cell Stress Chaperones (2010) 0.92
Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse. J Immunol (2005) 0.91
Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice. J Immunol (2006) 0.90
Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors. Blood (2010) 0.88
Auger electron radioimmunotherapeutic agent specific for the CD123+/CD131- phenotype of the leukemia stem cell population. J Nucl Med (2011) 0.87
Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Int J Cancer (2013) 0.87
The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice. Diabetes (2006) 0.86
p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res (2006) 0.86