Published in Proc Natl Acad Sci U S A on November 02, 2007
The enigmatic LEA proteins and other hydrophilins. Plant Physiol (2008) 2.65
Chaperone activity of ERD10 and ERD14, two disordered stress-related plant proteins. Plant Physiol (2008) 1.54
ABA signaling in stress-response and seed development. Plant Cell Rep (2013) 1.39
Vitrification is essential for anhydrobiosis in an African chironomid, Polypedilum vanderplanki. Proc Natl Acad Sci U S A (2008) 1.27
Intrinsically disordered proteins as molecular shields. Mol Biosyst (2011) 1.05
Cryoprotective mechanism of a small intrinsically disordered dehydrin protein. Protein Sci (2011) 1.02
Identification of anhydrobiosis-related genes from an expressed sequence tag database in the cryptobiotic midge Polypedilum vanderplanki (Diptera; Chironomidae). J Biol Chem (2010) 0.99
Germination of conidia of Aspergillus niger is accompanied by major changes in RNA profiles. Stud Mycol (2012) 0.97
Late embryogenesis abundant proteins protect human hepatoma cells during acute desiccation. Proc Natl Acad Sci U S A (2012) 0.95
Sweetpotato late embryogenesis abundant 14 (IbLEA14) gene influences lignification and increases osmotic- and salt stress-tolerance of transgenic calli. Planta (2010) 0.95
Late Embryogenesis Abundant (LEA) proteins in legumes. Front Plant Sci (2013) 0.95
Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance. Proc Natl Acad Sci U S A (2010) 0.94
Discovering genes associated with dormancy in the monogonont rotifer Brachionus plicatilis. BMC Genomics (2009) 0.94
JcLEA, a novel LEA-like protein from Jatropha curcas, confers a high level of tolerance to dehydration and salinity in Arabidopsis thaliana. PLoS One (2013) 0.93
Sweeping away protein aggregation with entropic bristles: intrinsically disordered protein fusions enhance soluble expression. Biochemistry (2012) 0.90
The Arabidopsis metacaspase9 degradome. Plant Cell (2013) 0.88
Proteome analysis of Physcomitrella patens exposed to progressive dehydration and rehydration. J Exp Bot (2011) 0.88
RNA sequencing and proteogenomics reveal the importance of leaderless mRNAs in the radiation-tolerant bacterium Deinococcus deserti. Genome Biol Evol (2014) 0.87
Expression profiling and cross-species RNA interference (RNAi) of desiccation-induced transcripts in the anhydrobiotic nematode Aphelenchus avenae. BMC Mol Biol (2010) 0.87
Disordered plant LEA proteins as molecular chaperones. Plant Signal Behav (2008) 0.87
Trehalose transporter from African chironomid larvae improves desiccation tolerance of Chinese hamster ovary cells. Cryobiology (2011) 0.86
Disordered proteinaceous machines. Chem Rev (2014) 0.86
Two novel heat-soluble protein families abundantly expressed in an anhydrobiotic tardigrade. PLoS One (2012) 0.85
Stress response in tardigrades: differential gene expression of molecular chaperones. Cell Stress Chaperones (2009) 0.85
TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae. Mol Biol Cell (2012) 0.84
Understanding protein aggregation from the view of monomer dynamics. Mol Biosyst (2012) 0.83
Novel mitochondria-targeted heat-soluble proteins identified in the anhydrobiotic Tardigrade improve osmotic tolerance of human cells. PLoS One (2015) 0.82
Comparative functional analysis of six drought-responsive promoters in transgenic rice. Planta (2013) 0.82
Isolation, cloning, and characterization of a novel Sorghum dehydrin (SbDhn2) protein. Protoplasma (2015) 0.81
The effect of natamycin on the transcriptome of conidia of Aspergillus niger. Stud Mycol (2012) 0.81
Group 1 LEA proteins contribute to the desiccation and freeze tolerance of Artemia franciscana embryos during diapause. Cell Stress Chaperones (2014) 0.81
A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags. BMC Res Notes (2012) 0.81
Different Forms of Selenoprotein M Differentially Affect Aβ Aggregation and ROS Generation. Int J Mol Sci (2013) 0.80
The STF2p hydrophilin from Saccharomyces cerevisiae is required for dehydration stress tolerance. PLoS One (2012) 0.79
Drought-Responsive Mechanisms in Plant Leaves Revealed by Proteomics. Int J Mol Sci (2016) 0.79
Responses to acute and chronic desiccation stress in Enchytraeus (Oligochaeta: Enchytraeidae). J Comp Physiol B (2008) 0.79
Membrane-Induced Folding of the Plant Stress Dehydrin Lti30. Plant Physiol (2016) 0.79
A molecular physiological review of vegetative desiccation tolerance in the resurrection plant Xerophyta viscosa (Baker). Planta (2015) 0.78
Drought Stress Predominantly Endures Arabidopsis thaliana to Pseudomonas syringae Infection. Front Plant Sci (2016) 0.78
Molecular approaches for improving desiccation tolerance: insights from the brine shrimp Artemia franciscana. Planta (2015) 0.78
Ectopic Expression of an Atypical Hydrophobic Group 5 LEA Protein from Wild Peanut, Arachis diogoi Confers Abiotic Stress Tolerance in Tobacco. PLoS One (2016) 0.77
Late Embryogenesis Abundant (LEA) Constitutes a Large and Diverse Family of Proteins Involved in Development and Abiotic Stress Responses in Sweet Orange (Citrus sinensis L. Osb.). PLoS One (2015) 0.77
Plant dehydrins: shedding light on structure and expression patterns of dehydrin gene family in barley. J Plant Res (2017) 0.76
YSK2 Type Dehydrin (SbDhn1) from Sorghum bicolor Showed Improved Protection under High Temperature and Osmotic Stress Condition. Front Plant Sci (2017) 0.76
DR1769, a protein with N-terminal beta propeller repeats and a low-complexity hydrophilic tail, plays a role in desiccation tolerance of Deinococcus radiodurans. J Bacteriol (2013) 0.76
Seaweeds early development: detrimental effects of desiccation and attenuation by algal extracts. Planta (2011) 0.76
Spare PRELI gene loci: failsafe chromosome insurance? PLoS One (2012) 0.75
Triticum aestivum WRAB18 functions in plastids and confers abiotic stress tolerance when overexpressed in Escherichia coli and Nicotiania benthamiana. PLoS One (2017) 0.75
Xerotolerant bacteria: surviving through a dry spell. Nat Rev Microbiol (2017) 0.75
Boost protein expression through co-expression of LEA-like peptide in Escherichia coli. PLoS One (2013) 0.75
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem (2006) 5.39
The role of vitrification in anhydrobiosis. Annu Rev Physiol (1998) 4.80
Lessons from animal models of Huntington's disease. Trends Genet (2002) 2.54
Hsp26: a temperature-regulated chaperone. EMBO J (1999) 2.51
The continuing conundrum of the LEA proteins. Naturwissenschaften (2007) 2.44
LEA proteins prevent protein aggregation due to water stress. Biochem J (2005) 2.37
Structural disorder throws new light on moonlighting. Trends Biochem Sci (2005) 2.23
A molecular investigation of true dominance in Huntington's disease. J Med Genet (1999) 1.92
Cryptobiosis--a peculiar state of biological organization. Comp Biochem Physiol B Biochem Mol Biol (2001) 1.85
Anhydrobiosis: plant desiccation gene found in a nematode. Nature (2002) 1.84
Functional divergence of former alleles in an ancient asexual invertebrate. Science (2007) 1.82
Isolation and characterization of a D-7 LEA protein from pollen that stabilizes glasses in vitro. Biochim Biophys Acta (2001) 1.64
Transition from natively unfolded to folded state induced by desiccation in an anhydrobiotic nematode protein. J Biol Chem (2003) 1.55
Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding. Proc Natl Acad Sci U S A (2001) 1.44
Structure and function of a mitochondrial late embryogenesis abundant protein are revealed by desiccation. Plant Cell (2007) 1.34
Anhydrobiosis without trehalose in bdelloid rotifers. FEBS Lett (2003) 1.34
Resurrecting Van Leeuwenhoek's rotifers: a reappraisal of the role of disaccharides in anhydrobiosis. Philos Trans R Soc Lond B Biol Sci (2003) 1.33
Dehydration-specific induction of hydrophilic protein genes in the anhydrobiotic nematode Aphelenchus avenae. Eukaryot Cell (2004) 1.32
Dehydration-induced expression of LEA proteins in an anhydrobiotic chironomid. Biochem Biophys Res Commun (2006) 1.31
Cellular Concentrations and Uniformity of Cell-Type Accumulation of Two Lea Proteins in Cotton Embryos. Plant Cell (1993) 1.30
Sequence and characterization of 6 Lea proteins and their genes from cotton. Plant Mol Biol (1988) 1.27
An LEA group 3 family member is involved in survival of C. elegans during exposure to stress. FEBS Lett (2004) 1.13
Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. J Biol Chem (2002) 1.05
Gene induction by desiccation stress in the entomopathogenic nematode Steinernema carpocapsae reveals parallels with drought tolerance mechanisms in plants. Int J Parasitol (2007) 1.01
The Arabidopsis group 1 LATE EMBRYOGENESIS ABUNDANT protein ATEM6 is required for normal seed development. Plant Physiol (2005) 0.99
Desiccation stress of entomopathogenic nematodes induces the accumulation of a novel heat-stable protein. Parasitology (2000) 0.99
Trehalose in desiccated rotifers: a comparison between a bdelloid and a monogonont species. Comp Biochem Physiol A Mol Integr Physiol (2004) 0.98
Response of human cells to desiccation: comparison with hyperosmotic stress response. J Physiol (2004) 0.98
Dehydration-regulated processing of late embryogenesis abundant protein in a desiccation-tolerant nematode. FEBS Lett (2005) 0.96
Differential gene expression during desiccation stress in the insect-killing nematode Steinernema feltiae IS-6. J Parasitol (2003) 0.95
Intracellular trehalose is neither necessary nor sufficient for desiccation tolerance in yeast. FEMS Yeast Res (2006) 0.94
Desiccation survival of parasitic nematodes. Parasitology (1999) 0.91
Intracellular trehalose improves osmotolerance but not desiccation tolerance in mammalian cells. FEBS Lett (2000) 0.85
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87
Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol (2010) 6.41
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem (2006) 5.39
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol (2011) 4.96
In search of an "autophagomometer". Autophagy (2009) 4.31
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol (2010) 3.67
Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy (2008) 3.47
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic (2008) 3.18
Independently evolving species in asexual bdelloid rotifers. PLoS Biol (2007) 3.05
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol (2006) 3.02
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet (2002) 2.98
Transcriptional abnormalities in Huntington disease. Trends Genet (2003) 2.91
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett (2009) 2.58
Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet (2006) 2.57
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J Cell Sci (2008) 2.55
Huntington's disease: from pathology and genetics to potential therapies. Biochem J (2008) 2.41
Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet (2002) 2.41
Autophagosome precursor maturation requires homotypic fusion. Cell (2011) 2.39
Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol (2011) 2.38
LEA proteins prevent protein aggregation due to water stress. Biochem J (2005) 2.37
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet (2010) 2.22
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell (2012) 2.14
Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell (2013) 2.07
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet (2007) 2.03
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol (2011) 1.97
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol (2013) 1.97
POPP the question: what do LEA proteins do? Trends Plant Sci (2004) 1.93
Huntington's disease: degradation of mutant huntingtin by autophagy. FEBS J (2008) 1.89
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest (2011) 1.89
Anhydrobiosis: plant desiccation gene found in a nematode. Nature (2002) 1.84
Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease. J Nucl Med (2006) 1.83
Functional divergence of former alleles in an ancient asexual invertebrate. Science (2007) 1.82
Cytoprotective roles for autophagy. Curr Opin Cell Biol (2010) 1.81
The Hedgehog signalling pathway regulates autophagy. Nat Commun (2012) 1.80
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet (2006) 1.73
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation. J Biol Chem (2002) 1.70
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain (2009) 1.66
Transition from natively unfolded to folded state induced by desiccation in an anhydrobiotic nematode protein. J Biol Chem (2003) 1.55
Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell (2012) 1.55
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci (2004) 1.54
Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem (2010) 1.50
Lysosomal storage diseases as disorders of autophagy. Autophagy (2007) 1.46
Autophagy, a guardian against neurodegeneration. Semin Cell Dev Biol (2010) 1.45
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease. Hum Mol Genet (2005) 1.44
The so locus is required for vegetative cell fusion and postfertilization events in Neurospora crassa. Eukaryot Cell (2005) 1.42
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy (2006) 1.42
Small molecule enhancers of autophagy for neurodegenerative diseases. Mol Biosyst (2008) 1.39
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet (2010) 1.38
Autophagy in neurodegeneration and development. Biochim Biophys Acta (2008) 1.38
Protein misfolding disorders and macroautophagy. Curr Opin Cell Biol (2010) 1.36
Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy (2009) 1.36
Biochemical diversification through foreign gene expression in bdelloid rotifers. PLoS Genet (2012) 1.35
Anhydrobiosis without trehalose in bdelloid rotifers. FEBS Lett (2003) 1.34
Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors. Cell Stem Cell (2012) 1.33
Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum Mol Genet (2005) 1.32
Dehydration-specific induction of hydrophilic protein genes in the anhydrobiotic nematode Aphelenchus avenae. Eukaryot Cell (2004) 1.32
Can autophagy protect against neurodegeneration caused by aggregate-prone proteins? Neuroreport (2004) 1.31
Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Prog Neurobiol (2013) 1.31
Dehydration-induced expression of LEA proteins in an anhydrobiotic chironomid. Biochem Biophys Res Commun (2006) 1.31
Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet (2010) 1.30
Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes. Genome Biol (2015) 1.30
Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat Med (2005) 1.30
Autophagic clearance of aggregate-prone proteins associated with neurodegeneration. Methods Enzymol (2009) 1.28