Published in Cell on November 16, 2007
A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans. PLoS Biol (2008) 3.00
The presynaptic active zone. Neuron (2012) 2.35
In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. Proc Natl Acad Sci U S A (2011) 2.27
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron (2010) 1.57
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol (2013) 1.41
CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions. Proc Natl Acad Sci U S A (2009) 1.26
Remote homology between Munc13 MUN domain and vesicle tethering complexes. J Mol Biol (2009) 1.24
Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron (2009) 1.24
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron (2009) 1.23
A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Neuron (2011) 1.14
Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion. J Cell Biol (2012) 1.14
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci (2011) 1.11
Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. EMBO J (2012) 1.11
Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion. J Biol Chem (2010) 1.00
Two distinct secretory vesicle-priming steps in adrenal chromaffin cells. J Cell Biol (2010) 0.99
Intrinsic variability in Pv, RRP size, Ca(2+) channel repertoire, and presynaptic potentiation in individual synaptic boutons. Front Synaptic Neurosci (2013) 0.97
Neurobeachin regulates neurotransmitter receptor trafficking to synapses. J Cell Biol (2012) 0.97
Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. Proc Natl Acad Sci U S A (2010) 0.95
DGKι regulates presynaptic release during mGluR-dependent LTD. EMBO J (2010) 0.94
Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am J Physiol Endocrinol Metab (2008) 0.94
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2012) 0.93
ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. J Cell Biol (2017) 0.92
Analysis of neurotransmitter release mechanisms by photolysis of caged Ca²⁺ in an autaptic neuron culture system. Nat Protoc (2012) 0.90
CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. Mol Biol Cell (2013) 0.89
Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Mol Cell Biol (2012) 0.89
CAPS and Munc13: CATCHRs that SNARE Vesicles. Front Endocrinol (Lausanne) (2013) 0.89
Dendritic position is a major determinant of presynaptic strength. J Cell Biol (2012) 0.89
Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. J Biol Chem (2010) 0.88
Role of PI(4,5)P(2) in vesicle exocytosis and membrane fusion. Subcell Biochem (2012) 0.87
Role of phosphoinositides at the neuronal synapse. Subcell Biochem (2012) 0.87
Vesicle pools: lessons from adrenal chromaffin cells. Front Synaptic Neurosci (2011) 0.86
CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation. J Biol Chem (2009) 0.85
Ca-dependent nonsecretory vesicle fusion in a secretory cell. J Gen Physiol (2008) 0.85
mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron (2013) 0.84
A comparison of electrically evoked and channel rhodopsin-evoked postsynaptic potentials in the pharyngeal system of Caenorhabditis elegans. Invert Neurosci (2009) 0.84
Two Rab2 interactors regulate dense-core vesicle maturation. Neuron (2014) 0.84
UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics (2011) 0.83
RIC-7 promotes neuropeptide secretion. PLoS Genet (2012) 0.82
Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1. J Biol Chem (2013) 0.81
Imaging the recruitment and loss of proteins and lipids at single sites of calcium-triggered exocytosis. Mol Biol Cell (2016) 0.79
A new approach to the molecular analysis of docking, priming, and regulated membrane fusion. J Chem Biol (2011) 0.79
Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Elife (2015) 0.77
CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. Elife (2015) 0.77
Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone. Front Synaptic Neurosci (2016) 0.77
Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability. FASEB J (2015) 0.77
Phosphatidylinositol 4,5-bisphosphate regulation of SNARE function in membrane fusion mediated by CAPS. Adv Enzyme Regul (2009) 0.77
Resident CAPS on dense-core vesicles docks and primes vesicles for fusion. Mol Biol Cell (2015) 0.76
CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus. Sci Rep (2016) 0.76
The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis. J Biol Chem (2016) 0.75
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons. Elife (2017) 0.75
Vesicle priming in a SNAP. Neuron (2010) 0.75
CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Rep (2016) 0.75
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. Neuron (2016) 0.75
Molecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion. PLoS Comput Biol (2012) 0.75
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder. J Clin Invest (2017) 0.75
Endosomal Phosphatidylinositol-3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses. J Biol Chem (2016) 0.75
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A (2008) 3.74
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17
Neuroligin 2 is exclusively localized to inhibitory synapses. Eur J Cell Biol (2004) 3.15
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A (2002) 2.91
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron (2002) 2.52
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron (2009) 2.44
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23. Cell (2003) 2.25
A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron (2006) 2.25
Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol (2006) 2.17
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin. Neuropharmacology (2004) 2.13
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science (2010) 2.12
Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell (2009) 2.06
Fast vesicle fusion in living cells requires at least three SNARE complexes. Science (2010) 2.06
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron (2004) 2.04
CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron (2005) 1.94
Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol (2005) 1.93
A common molecular basis for membrane docking and functional priming of synaptic vesicles. Eur J Neurosci (2009) 1.91
Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter. Neuron (2007) 1.89
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell (2004) 1.85
Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Cell (2004) 1.80
Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling. Neuron (2013) 1.79
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A (2008) 1.78
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice. J Neurosci (2011) 1.73
Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci (2005) 1.71
Dissecting docking and tethering of secretory vesicles at the target membrane. EMBO J (2006) 1.70
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A (2008) 1.68
Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells. Proc Natl Acad Sci U S A (2008) 1.63
Vesicle docking in regulated exocytosis. Traffic (2008) 1.63
CaMKII binding to GluN2B is critical during memory consolidation. EMBO J (2012) 1.62
Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43. J Neurosci (2003) 1.59
The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses. Curr Opin Neurobiol (2012) 1.58
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron (2010) 1.57
Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Neuron (2003) 1.55
Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J Neurosci (2007) 1.50
EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron (2007) 1.48
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci (2010) 1.48
The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics. Proc Natl Acad Sci U S A (2008) 1.46
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. J Cell Biol (2010) 1.43
Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion. J Neurosci (2007) 1.42
A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles. Nat Neurosci (2009) 1.39
Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. J Neurosci (2006) 1.37
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc Natl Acad Sci U S A (2011) 1.37
Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse. J Neurosci (2009) 1.36
Molecular mechanisms of active zone function. Curr Opin Neurobiol (2003) 1.35
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. J Biol Chem (2006) 1.34
Identification of the minimal protein domain required for priming activity of Munc13-1. Curr Biol (2005) 1.32
Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc Natl Acad Sci U S A (2009) 1.31
Protein kinase C-dependent phosphorylation of synaptosome-associated protein of 25 kDa at Ser187 potentiates vesicle recruitment. J Neurosci (2002) 1.30
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell (2009) 1.29
Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C. J Neurosci (2008) 1.29
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. Proc Natl Acad Sci U S A (2008) 1.29
Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Proc Natl Acad Sci U S A (2008) 1.28
An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells. Neuron (2013) 1.26
N-glycosylation is essential for vesicular targeting of synaptotagmin 1. Neuron (2004) 1.25
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A (2011) 1.23
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes (2006) 1.22
Role of the synaptobrevin C terminus in fusion pore formation. Proc Natl Acad Sci U S A (2010) 1.20
Differential abilities of SNAP-25 homologs to support neuronal function. J Neurosci (2007) 1.20
Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Mol Cell Neurosci (2004) 1.20
Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms. Arch Gen Psychiatry (2010) 1.17
SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Neuron (2010) 1.16
CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. J Neurosci (2008) 1.15
The role of ubiquitylation in nerve cell development. Nat Rev Neurosci (2011) 1.14
Erythropoietin enhances hippocampal long-term potentiation and memory. BMC Biol (2008) 1.14
Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb Cortex (2010) 1.13
Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2. J Biol Chem (2006) 1.12
A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. J Biol Chem (2003) 1.12
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci (2011) 1.11
Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice. J Neurosci (2006) 1.10
Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse. Mol Cell Biol (2005) 1.10