Published in Proc Natl Acad Sci U S A on November 19, 2007
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One (2011) 1.62
Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Apoptosis (2010) 1.33
Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J (2008) 1.33
The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci (2009) 1.31
Neuroglobin expression in ischemic stroke. Stroke (2010) 1.09
Pharmacological induction of neuroglobin expression. Pharmacology (2011) 0.97
Forever young: mechanisms of natural anoxia tolerance and potential links to longevity. Oxid Med Cell Longev (2010) 0.97
Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders. Int J Mol Sci (2012) 0.94
DNA methylation, a hand behind neurodegenerative diseases. Front Aging Neurosci (2013) 0.94
Ligand migration through the internal hydrophobic cavities in human neuroglobin. Proc Natl Acad Sci U S A (2009) 0.94
Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. J Neurotrauma (2010) 0.93
Hypoxia-inducible factor-1 and neuroglobin expression. Neurosci Lett (2012) 0.93
Neuroglobin and Alzheimer's dementia: genetic association and gene expression changes. Neurobiol Aging (2008) 0.91
An antiapoptotic neuroprotective role for neuroglobin. Int J Mol Sci (2010) 0.89
Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons. Neurobiol Dis (2013) 0.88
Mitochondrial mechanisms of neuroglobin's neuroprotection. Oxid Med Cell Longev (2013) 0.88
Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin (2009) 0.88
Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis. Cell Mol Neurobiol (2010) 0.87
Identification of neuroglobin-interacting proteins using yeast two-hybrid screening. Neuroscience (2011) 0.86
Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons. Neuroscience (2012) 0.84
Hemoglobin Control of Cell Survival/Death Decision Regulates in Vitro Plant Embryogenesis. Plant Physiol (2014) 0.84
The anti-apoptotic role of neuroglobin. Cells (2012) 0.83
Transcriptional regulation of mouse neuroglobin gene by cyclic AMP responsive element binding protein (CREB) in N2a cells. Neurosci Lett (2012) 0.81
Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci (2012) 0.80
Comparative genomics of neuroglobin reveals its early origins. PLoS One (2012) 0.79
Interaction of apoNeuroglobin with heme-Aβ complexes relevant to Alzheimer's disease. J Biol Inorg Chem (2015) 0.78
Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice. Mol Ther (2014) 0.78
Electrochemical Evidence for Neuroglobin Activity on NO at Physiological Concentrations. J Biol Chem (2016) 0.77
Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobin. PLoS One (2012) 0.77
Comparative protein interactomics of neuroglobin and myoglobin. J Neurochem (2012) 0.77
Treating Alzheimer's disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe. Neural Regen Res (2014) 0.76
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease. PLoS Genet (2016) 0.76
Brain globins in physiology and pathology. Med Gas Res (2016) 0.76
Neuroglobin, a Factor Playing for Nerve Cell Survival. Int J Mol Sci (2016) 0.76
Expression and cell distribution of neuroglobin in the brain tissue after experimental subarachnoid hemorrhage in rats: a pilot study. Cell Mol Neurobiol (2013) 0.76
Heme orientation modulates histidine dissociation and ligand binding kinetics in the hexacoordinated human neuroglobin. J Biol Inorg Chem (2012) 0.75
Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin. PLoS One (2015) 0.75
Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels. FEBS Lett (2017) 0.75
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J (1995) 7.60
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A (1999) 5.75
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A (1995) 4.84
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol (2003) 4.71
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 3.50
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proc Natl Acad Sci U S A (1973) 3.14
Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc Natl Acad Sci U S A (2001) 3.12
The neurobiological basis of spontaneous alternation. Neurosci Biobehav Rev (2002) 2.81
GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. Nat Med (1995) 2.77
Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci U S A (2003) 2.42
Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A (2006) 2.05
Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem (2005) 1.98
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci (2004) 1.92
Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes. Proc Natl Acad Sci U S A (2005) 1.85
Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. J Biol Chem (2003) 1.82
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. Science (2003) 1.77
Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects. J Neuropathol Exp Neurol (2000) 1.66
Heterotrimeric G-protein betagamma-dimers in growth and differentiation. Oncogene (2001) 1.61
Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death. Neurosci Lett (2006) 1.50
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci (2003) 1.44
Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling. J Neurobiol (2006) 1.31
Does my mouse have Alzheimer's disease? Genes Brain Behav (2002) 1.28
Neuroglobin, seven years after. Cell Mol Life Sci (2007) 1.19
RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. J Biol Chem (2005) 1.17
Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. Biochem Biophys Res Commun (2004) 1.05
Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects. Pharmacol Ther (2006) 1.01
A neuroglobin-overexpressing transgenic mouse. Gene (2007) 0.99
Transgenic mouse models of Alzheimer's disease. Biochim Biophys Acta (2000) 0.99
Reduction in cholesterol and sialic acid content protects cells from the toxic effects of beta-amyloid peptides. J Biol Chem (2001) 0.99
GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: endogenous seed for Alzheimer amyloid. Neuroscientist (2005) 0.94
Histological staining of amyloid-beta in mouse brains. Methods Mol Biol (2005) 0.88
Alpha4beta2 nicotinic acetylcholine receptor activation ameliorates impairment of spontaneous alternation behavior in stroke-prone spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder. J Pharmacol Exp Ther (2002) 0.83
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A (2002) 5.09
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest (2003) 4.74
Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 3.52
Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci (2003) 2.68
From angiogenesis to neuropathology. Nature (2005) 2.56
Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci U S A (2006) 2.55
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A (2006) 2.45
Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci U S A (2003) 2.42
Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. Aging Cell (2003) 2.27
Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A (2004) 2.20
Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A (2006) 2.05
NOS1AP is a genetic modifier of the long-QT syndrome. Circulation (2009) 2.00
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells. Stroke (2003) 1.70
Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proc Natl Acad Sci U S A (2010) 1.69
Stem cell factor stimulates neurogenesis in vitro and in vivo. J Clin Invest (2002) 1.63
Non-replication of association studies: "pseudo-failures" to replicate? Genet Med (2007) 1.62
Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am J Hum Genet (2003) 1.59
Neuroglobin: an endogenous neuroprotectant. Curr Opin Pharmacol (2007) 1.53
HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity. Am J Hum Genet (2002) 1.51
Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse. Dev Dyn (2009) 1.51
Quantification of type I error probabilities for heterogeneity LOD scores. Genet Epidemiol (2002) 1.50
Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. J Neurosci (2003) 1.49
FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A (2005) 1.46
Pathogenic EFHC1 mutations are tolerated in healthy individuals dependent on reported ancestry. Epilepsia (2014) 1.46
Neuroglobin expression in neurogenesis. Neurosci Lett (2013) 1.42
Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc Natl Acad Sci U S A (2003) 1.41
A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. Thyroid (2002) 1.41
Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo. J Neurosci (2002) 1.40
Hemin induces neuroglobin expression in neural cells. Blood (2002) 1.40
Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4). Eur J Hum Genet (2009) 1.37
The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem (2004) 1.37
Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice. Mol Pharmacol (2004) 1.34
Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. Neurobiol Dis (2005) 1.34
Centralizing the non-central chi-square: A new method to correct for population stratification in genetic case-control association studies. Genet Epidemiol (2006) 1.33
Increased severity of stroke in CB1 cannabinoid receptor knock-out mice. J Neurosci (2002) 1.33
Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J (2008) 1.33
Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J Neurosci (2007) 1.33
Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling. J Neurobiol (2006) 1.31
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J (2003) 1.30
Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Dev Biol (2005) 1.28
Vascular endothelial growth factors (VEGFs) and stroke. Cell Mol Life Sci (2013) 1.26
BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. Am J Hum Genet (2003) 1.25
Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab (2009) 1.24
VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. J Neurosci Res (2007) 1.23
HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. Arthritis Rheum (2011) 1.23
Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain. Aging Cell (2004) 1.21
Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study). Hum Hered (2004) 1.20
Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis. J Autoimmun (2007) 1.18
Familial risk factors for microvascular complications and differential male-female risk in a large cohort of American families with type 1 diabetes. J Clin Endocrinol Metab (2007) 1.18
Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases. J Clin Endocrinol Metab (2002) 1.17
Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. J Clin Endocrinol Metab (2005) 1.16
Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis. FASEB J (2004) 1.16
Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease. Thyroid (2006) 1.15
Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain (2009) 1.15
Neuroglobin protects against nitric oxide toxicity. Neurosci Lett (2007) 1.14