Published in Blood on November 27, 2007
A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. PLoS One (2011) 3.39
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell (2011) 2.79
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell (2009) 2.27
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell (2011) 2.11
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat Biotechnol (2012) 1.94
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood (2010) 1.88
Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol (2010) 1.72
Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res (2010) 1.67
High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells (2010) 1.61
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Genes Dev (2011) 1.55
The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47
The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell (2016) 1.46
A simple tool to improve pluripotent stem cell differentiation. Nat Methods (2013) 1.42
Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol (2013) 1.38
Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. Proc Natl Acad Sci U S A (2013) 1.27
Hematopoietic development from human induced pluripotent stem cells. Ann N Y Acad Sci (2009) 1.22
Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev (2011) 1.17
Diverse hematopoietic potentials of five human embryonic stem cell lines. Exp Cell Res (2008) 1.17
Role of mechanical factors in fate decisions of stem cells. Regen Med (2011) 1.15
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood (2013) 1.14
TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy. Cell Res (2011) 1.12
From notochord formation to hereditary chordoma: the many roles of Brachyury. Biomed Res Int (2013) 1.12
DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci (2012) 1.11
Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems. Cell Transplant (2010) 1.11
BMP4 regulates vascular progenitor development in human embryonic stem cells through a Smad-dependent pathway. J Cell Biochem (2010) 1.08
BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state. Development (2013) 1.07
Cell sources for the regeneration of articular cartilage: the past, the horizon and the future. Int J Exp Pathol (2012) 1.06
Model systems for studying trophoblast differentiation from human pluripotent stem cells. Cell Tissue Res (2012) 1.05
Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF. PLoS One (2013) 1.05
Efficient derivation of lateral plate and paraxial mesoderm subtypes from human embryonic stem cells through GSKi-mediated differentiation. Stem Cells Dev (2013) 1.03
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells Dev (2012) 1.01
Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. Cell Cycle (2012) 0.99
Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. Stem Cells Dev (2011) 0.96
Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem (2013) 0.94
no tail integrates two modes of mesoderm induction. Development (2010) 0.94
TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner. Stem Cells (2012) 0.92
Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Dev Biol (2013) 0.91
Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells. Stem Cells (2012) 0.91
Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. PLoS One (2012) 0.91
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network. Cell Mol Life Sci (2015) 0.90
DNA methyltransferase inhibition induces mouse embryonic stem cell differentiation into endothelial cells. Exp Cell Res (2009) 0.90
Coaxial electrospray of liquid core-hydrogel shell microcapsules for encapsulation and miniaturized 3D culture of pluripotent stem cells. Integr Biol (Camb) (2014) 0.89
The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function. J Cell Sci (2014) 0.88
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling. PLoS One (2012) 0.88
BMP4 regulation of human trophoblast development. Int J Dev Biol (2014) 0.86
Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas. Placenta (2013) 0.85
Microfluidic-based patterning of embryonic stem cells for in vitro development studies. Lab Chip (2013) 0.85
Vascular potential of human pluripotent stem cells. Arterioscler Thromb Vasc Biol (2010) 0.85
AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning. Cell Res (2012) 0.84
Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84
Induced pluripotent stem cells in cardiovascular medicine. Stem Cells Int (2011) 0.83
Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools. Biomed Res Int (2014) 0.83
The balance of positive and negative effects of TGF-β signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells. Stem Cells Dev (2013) 0.82
Efficient differentiation of human pluripotent stem cells into mesenchymal stem cells by modulating intracellular signaling pathways in a feeder/serum-free system. Stem Cells Dev (2011) 0.82
Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application. Cell Mol Life Sci (2014) 0.82
Activin A promotes hematopoietic fated mesoderm development through upregulation of brachyury in human embryonic stem cells. Stem Cells Dev (2012) 0.81
Generating cartilage repair from pluripotent stem cells. Tissue Eng Part B Rev (2013) 0.81
Recreating kidney progenitors from pluripotent cells. Pediatr Nephrol (2013) 0.80
Endoglin is a novel endothelial cell specification gene. Stem Cell Res (2011) 0.80
Mesenchymal stem cell-conditioned medium enhances osteogenic and chondrogenic differentiation of human embryonic stem cells and human induced pluripotent stem cells by mesodermal lineage induction. Tissue Eng Part A (2013) 0.80
Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells. Skelet Muscle (2015) 0.79
Derivation of hair-inducing cell from human pluripotent stem cells. PLoS One (2015) 0.79
Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem (2015) 0.79
Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS One (2015) 0.78
Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A (2016) 0.78
A synthetic substrate to support early mesodermal differentiation of human embryonic stem cells. Biomaterials (2011) 0.78
Extracellular matrices decellularized from embryonic stem cells maintained their structure and signaling specificity. Tissue Eng Part A (2013) 0.78
Both BMP4 and serum have significant roles in differentiation of embryonic stem cells to primitive and definitive endoderm. Cytotechnology (2015) 0.78
Characterization of human bone morphogenetic protein gene variants for possible roles in congenital heart disease. Mol Med Rep (2016) 0.77
Temporal and contextual orchestration of cardiac fate by WNT-BMP synergy and threshold. J Cell Mol Med (2010) 0.77
Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation. Tissue Eng Part B Rev (2015) 0.77
Fibromodulin reprogrammed cells: A novel cell source for bone regeneration. Biomaterials (2016) 0.77
Comparison of cell viability and embryoid body size of two embryonic stem cell lines after different exposure times to bone morphogenetic protein 4. Iran J Med Sci (2015) 0.76
Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives. Stem Cells Transl Med (2015) 0.76
A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production. Stem Cell Reports (2016) 0.76
MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell Res (2015) 0.75
Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells. Development (2016) 0.75
Extracellular Matrix and Integrins in Embryonic Stem Cell Differentiation. Biochem Insights (2015) 0.75
Activin A Modulates CRIPTO-1/HNF4α(+) Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells. Stem Cells Int (2017) 0.75
Activin/Smad2-induced H3K27me3 Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells. J Biol Chem (2016) 0.75
Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation. Sci Rep (2016) 0.75
Human fetal liver stromal cells expressing erythropoietin promote hematopoietic development from human embryonic stem cells. Cell Reprogram (2012) 0.75
Overexpression of the BMP4/SMAD signaling pathway in skull base chordomas is associated with poor prognosis. Int J Clin Exp Pathol (2015) 0.75
Cyclosporin A induces cardiac differentiation but inhibits hemato-endothelial differentiation of P19 cells. PLoS One (2015) 0.75
Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells. Stem Cells Int (2017) 0.75
A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells. PLoS One (2017) 0.75
Induced Pluripotent Stem Cell for the Study and Treatment of Sickle Cell Anemia. Stem Cells Int (2017) 0.75
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Mapping and sequencing of structural variation from eight human genomes. Nature (2008) 30.28
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev (2005) 8.95
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
High-throughput DNA methylation profiling using universal bead arrays. Genome Res (2006) 8.05
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
The genome of a songbird. Nature (2010) 5.90
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell (2008) 5.04
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell (2008) 4.63
Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Nat Biotechnol (2011) 4.56
DNA binding site sequence directs glucocorticoid receptor structure and activity. Science (2009) 4.48
Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution. Nat Neurosci (2007) 4.28
A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res (2008) 4.06
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Neural correlates of behavioral preference for culturally familiar drinks. Neuron (2004) 3.80
Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol (2003) 3.69
A burst of segmental duplications in the genome of the African great ape ancestor. Nature (2009) 3.63
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens. Clin Infect Dis (2013) 3.49
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res (2009) 3.44
Evolutionary toggling of the MAPT 17q21.31 inversion region. Nat Genet (2008) 3.42
Analyses and comparison of accuracy of different genotype imputation methods. PLoS One (2008) 3.41
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. N Engl J Med (2016) 3.40
Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg Am (2003) 3.36
Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell (2003) 3.36
Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology (2007) 3.29
Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. J Am Coll Cardiol (2012) 3.19
Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma. N Engl J Med (2015) 3.18
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother (2007) 3.15
Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell (2008) 3.15
Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle (2009) 3.14
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol Cell Biol (2008) 3.11
Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi Metallo-β-lactamase. Clin Infect Dis (2011) 3.06
Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell (2005) 3.04
Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. Antimicrob Agents Chemother (2010) 3.03
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03
Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa. Antimicrob Agents Chemother (2006) 2.95
Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood (2009) 2.92
Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic (2004) 2.91
Colistin hetero-resistance in multidrug-resistant Acinetobacter baumannii clinical isolates from the Western Pacific region in the SENTRY antimicrobial surveillance programme. J Infect (2008) 2.88
Pharmacokinetics of intravenous polymyxin B in critically ill patients. Clin Infect Dis (2008) 2.79
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res (2009) 2.74
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol (2010) 2.68
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry. Mol Cell (2004) 2.55
Retracted CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy. Sci Transl Med (2013) 2.51
Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med (2003) 2.50
Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/progenitor cells in adult human liver. Hepatology (2012) 2.47
Central and autonomic nervous system interaction is altered by short-term meditation. Proc Natl Acad Sci U S A (2009) 2.45
Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003-11): a national observational cohort study. Lancet (2012) 2.41
Temporal dissection of tumorigenesis in primary cancers. Cancer Discov (2011) 2.40
Prognosis of patients taking selective serotonin reuptake inhibitors before coronary artery bypass grafting. Am J Cardiol (2006) 2.40
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity (2013) 2.39
Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet (2011) 2.35
Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. J Biol Chem (2004) 2.35
Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res (2011) 2.31
Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proc Natl Acad Sci U S A (2004) 2.29
In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res (2007) 2.28
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med (2012) 2.20
Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systemic review and meta-analysis. Tumour Biol (2014) 2.19
Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol (2008) 2.19
The role of the striatum in aversive learning and aversive prediction errors. Philos Trans R Soc Lond B Biol Sci (2008) 2.17
CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol (2006) 2.15
The price of racial bias: intergroup negotiations in the ultimatum game. Psychol Sci (2013) 2.15
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients. Proc Natl Acad Sci U S A (2013) 2.09
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation (2009) 2.09
Intelligent urban public transportation for accessibility dedicated to people with disabilities. Sensors (Basel) (2012) 2.06
Comparative studies of de novo assembly tools for next-generation sequencing technologies. Bioinformatics (2011) 2.05
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Efficacy of platelet-rich plasma combined with allograft bone in the management of displaced intra-articular calcaneal fractures: a prospective cohort study. J Orthop Res (2012) 2.04
Structure--activity relationships of polymyxin antibiotics. J Med Chem (2010) 2.03
Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China. Am J Trop Med Hyg (2005) 2.02
Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: role of endostatin and oxidative stress. Ann Thorac Surg (2006) 2.02
What's in a smile? Maternal brain responses to infant facial cues. Pediatrics (2008) 2.02