Published in Nat Rev Mol Cell Biol on January 01, 2008
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation. Proc Natl Acad Sci U S A (2008) 5.06
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature (2011) 4.60
Mutations in GNAL cause primary torsion dystonia. Nat Genet (2012) 3.66
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev (2010) 3.27
Structural insights into RNA recognition by RIG-I. Cell (2011) 3.25
Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature (2012) 2.88
Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors in ligand-free basal state. Nat Struct Mol Biol (2013) 2.06
Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia. N Engl J Med (2013) 2.05
The HTLV-1 Tax interactome. Retrovirology (2008) 2.02
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins. Chem Rev (2010) 1.98
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annu Rev Pharmacol Toxicol (2009) 1.97
Microbial and animal rhodopsins: structures, functions, and molecular mechanisms. Chem Rev (2013) 1.93
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A (2009) 1.81
Signal transduction by protease-activated receptors. Br J Pharmacol (2010) 1.64
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Sci Signal (2015) 1.61
Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer. PLoS One (2011) 1.51
Lifting the lid on GPCRs: the role of extracellular loops. Br J Pharmacol (2012) 1.50
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc Natl Acad Sci U S A (2010) 1.49
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. Nat Med (2014) 1.46
Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol (2008) 1.45
The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev (2011) 1.39
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem (2010) 1.32
SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science (2015) 1.29
Structural basis of G protein-coupled receptor-G protein interactions. Nat Chem Biol (2010) 1.27
Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G-protein action. Mol Syst Biol (2010) 1.23
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. J Exp Med (2009) 1.21
Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. Cancer Metastasis Rev (2011) 1.21
Universal allosteric mechanism for Gα activation by GPCRs. Nature (2015) 1.21
Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Curr Pharm Des (2010) 1.20
Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis. J Biol Chem (2008) 1.19
Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3. J Biol Chem (2008) 1.19
Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal (2012) 1.16
Anaphylactic shock depends on endothelial Gq/G11. J Exp Med (2009) 1.16
Regulation of Ca(V)2 calcium channels by G protein coupled receptors. Biochim Biophys Acta (2012) 1.15
The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. PLoS One (2011) 1.14
Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications. IUBMB Life (2010) 1.14
Shuttling and translocation of heterotrimeric G proteins and Ras. Trends Pharmacol Sci (2009) 1.10
Heterotrimeric G protein-coupled signaling in plants. Annu Rev Plant Biol (2013) 1.08
Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem (2008) 1.08
Non-canonical signaling and localizations of heterotrimeric G proteins. Cell Signal (2011) 1.07
Structural basis of GDP release and gating in G protein coupled Fe2+ transport. EMBO J (2009) 1.05
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling. Nat Commun (2012) 1.05
Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. J Biol Chem (2013) 1.05
G-protein betagamma-complex is crucial for efficient signal amplification in vision. J Neurosci (2011) 1.05
Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Mol Pharmacol (2011) 1.04
The experimental power of FR900359 to study Gq-regulated biological processes. Nat Commun (2015) 1.04
Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface. Proc Natl Acad Sci U S A (2009) 1.03
The information highways of a biotechnological workhorse--signal transduction in Hypocrea jecorina. BMC Genomics (2008) 1.03
Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem (2011) 1.03
Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry (2008) 1.03
G protein modulation of CaV2 voltage-gated calcium channels. Channels (Austin) (2010) 1.02
Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry (2009) 1.02
Redefining metamorphosis in spiny lobsters: molecular analysis of the phyllosoma to puerulus transition in Sagmariasus verreauxi. Sci Rep (2015) 1.00
Evidence for multiple phototransduction pathways in a reef-building coral. PLoS One (2012) 1.00
Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate. J Am Chem Soc (2010) 0.99
H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury. Proc Natl Acad Sci U S A (2012) 0.98
Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels. Br J Pharmacol (2012) 0.98
A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer. J Biol Chem (2011) 0.98
The fifth class of Galpha proteins. Proc Natl Acad Sci U S A (2009) 0.98
The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics (2009) 0.98
Membrane-localized extra-large G proteins and Gbg of the heterotrimeric G proteins form functional complexes engaged in plant immunity in Arabidopsis. Plant Physiol (2015) 0.98
GPCR mediated regulation of synaptic transmission. Prog Neurobiol (2012) 0.98
Regulators of AWC-mediated olfactory plasticity in Caenorhabditis elegans. PLoS Genet (2009) 0.97
A-kinase anchoring proteins: getting to the heart of the matter. Circulation (2010) 0.97
Novel insights on thyroid-stimulating hormone receptor signal transduction. Endocr Rev (2013) 0.97
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry (2009) 0.97
Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors. Synapse (2009) 0.96
Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry (2009) 0.96
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling. J Biol Chem (2012) 0.95
Structural determinants involved in the formation and activation of G protein betagamma dimers. Neurosignals (2009) 0.95
The pattern of expression of guanine nucleotide-binding protein beta3 in the retina is conserved across vertebrate species. Neuroscience (2010) 0.94
GPCR oligomers in pharmacology and signaling. Mol Brain (2011) 0.94
Structure determination of membrane proteins by nuclear magnetic resonance spectroscopy. Annu Rev Anal Chem (Palo Alto Calif) (2013) 0.93
Conventional and novel Gγ protein families constitute the heterotrimeric G-protein signaling network in soybean. PLoS One (2011) 0.93
A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction. Plant Signal Behav (2008) 0.93
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis. Front Neuroendocrinol (2011) 0.92
The evolution of the GPCR signaling system in eukaryotes: modularity, conservation, and the transition to metazoan multicellularity. Genome Biol Evol (2014) 0.92
Role and interrelationship of Gα protein, hydrogen peroxide, and nitric oxide in ultraviolet B-induced stomatal closure in Arabidopsis leaves. Plant Physiol (2013) 0.92
The alpha-subunit of the heterotrimeric G-protein affects jasmonate responses in Arabidopsis thaliana. J Exp Bot (2009) 0.92
G protein subunit dissociation and translocation regulate cellular response to receptor stimulation. PLoS One (2009) 0.92
Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev (2013) 0.92
Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor. Elife (2016) 0.92
Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling. Plant Physiol (2015) 0.92
The role of Arabidopsis heterotrimeric G-protein subunits in MLO2 function and MAMP-triggered immunity. Mol Plant Microbe Interact (2013) 0.92
Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol (2012) 0.92
The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. J Biol Chem (2011) 0.91
Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles. Cell Res (2011) 0.91
Quality control: quality control at the plasma membrane: one mechanism does not fit all. J Cell Biol (2014) 0.91
Probing Gαi1 protein activation at single-amino acid resolution. Nat Struct Mol Biol (2015) 0.91
The GPCR heterotetramer: challenging classical pharmacology. Trends Pharmacol Sci (2015) 0.91
Escaping the flatlands: new approaches for studying the dynamic assembly and activation of GPCR signaling complexes. Trends Pharmacol Sci (2011) 0.90
From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci (2013) 0.90
Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB. J Struct Biol (2010) 0.90
Arabidopsis heterotrimeric G-proteins play a critical role in host and nonhost resistance against Pseudomonas syringae pathogens. PLoS One (2013) 0.89
Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annu Rev Pharmacol Toxicol (2015) 0.89
Control of intracellular calcium signaling as a neuroprotective strategy. Molecules (2010) 0.89
Insights into G protein structure, function, and regulation. Endocr Rev (2003) 3.33
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nat Struct Mol Biol (2006) 2.68
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proc Natl Acad Sci U S A (2011) 2.10
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem (2005) 2.09
Structural basis of function in heterotrimeric G proteins. Q Rev Biophys (2006) 1.94
G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis. Nat Neurosci (2005) 1.69
Gbetagamma acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nat Neurosci (2005) 1.65
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci (2006) 1.58
Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway. Proc Natl Acad Sci U S A (2006) 1.33
Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med (2006) 1.31
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem (2006) 1.27
Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. EMBO J (2005) 1.26
RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons. Proc Natl Acad Sci U S A (2004) 1.26
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem (2002) 1.24
Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP. Blood (2005) 1.20
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J (2009) 1.18
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins. Proc Natl Acad Sci U S A (2007) 1.17
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J Cell Biol (2009) 1.15
DEP domains: More than just membrane anchors. Dev Cell (2006) 1.14
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol (2007) 1.13
Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins. J Mol Cell Cardiol (2004) 1.12
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell (2008) 1.11
Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation. Biochemistry (2002) 1.10
Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes. J Biol Chem (2002) 1.08
RACK1 regulates specific functions of Gbetagamma. J Biol Chem (2004) 1.08
Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction. Biophys J (2008) 1.07
Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. Mol Pharmacol (2007) 1.07
Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription. Curr Opin Genet Dev (2006) 1.05
Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective. J Mol Biol (2013) 1.05
G alpha COOH-terminal minigene vectors dissect heterotrimeric G protein signaling. Sci STKE (2002) 1.03
RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation. J Biol Chem (2005) 1.02
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J Biol Chem (2005) 1.01
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Sci Signal (2010) 1.01
Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway. Mol Pharmacol (2006) 1.00
Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol (2010) 0.99
How do receptors activate G proteins? Adv Protein Chem (2007) 0.99
G protein signaling: insights from new structures. Sci STKE (2004) 0.98
GPCR mediated regulation of synaptic transmission. Prog Neurobiol (2012) 0.98
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry (2009) 0.97
G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. J Biol Chem (2005) 0.97
Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling. J Biol Chem (2003) 0.97
Modeling the role of incisures in vertebrate phototransduction. Biophys J (2006) 0.96
Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One (2012) 0.93
Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets. Mol Pharmacol (2013) 0.93
Kinetics of rhodopsin deactivation and its role in regulating recovery and reproducibility of rod photoresponse. PLoS Comput Biol (2010) 0.93
G protein betagamma subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry. J Neurophysiol (2008) 0.93
The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution. Biochemistry (2003) 0.93
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins. Biochemistry (2008) 0.93
Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins. Methods Enzymol (2002) 0.92
Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2. J Biol Chem (2002) 0.92
A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. J Biol Chem (2003) 0.91
Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development (2013) 0.91
G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties. Proc Natl Acad Sci U S A (2006) 0.90
Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Mol Pharmacol (2009) 0.89
Coupling efficiency of rhodopsin and transducin in bicelles. Biochemistry (2011) 0.89
Dendritic molecular transporters provide control of delivery to intracellular compartments. Bioconjug Chem (2007) 0.88
Identification of key factors that reduce the variability of the single photon response. Proc Natl Acad Sci U S A (2011) 0.88
Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets. PLoS One (2013) 0.86
Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry (2012) 0.86
Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci (2014) 0.85
Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25. Mol Pharmacol (2012) 0.81
Differential localization of G protein βγ subunits. Biochemistry (2014) 0.80
Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen. J Biol Chem (2009) 0.80
Mathematical model of PAR1-mediated activation of human platelets. Mol Biosyst (2011) 0.79
Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions. J Pharmacol Exp Ther (2007) 0.79
Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective. Methods Mol Biol (2012) 0.78
Label-free detection of G protein-SNARE interactions and screening for small molecule modulators. ACS Chem Neurosci (2012) 0.78
Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo: procoagulant nature of osteosarcoma. Cancer (2011) 0.78
G-protein-coupled receptors: evolving views on physiological signalling: symposium on G-protein-coupled receptors: evolving concepts and new techniques. EMBO Rep (2006) 0.78
A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1. J Biol Chem (2014) 0.77
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Mol Pharmacol (2012) 0.77
Proteolytic fragmentation for epitope mapping. Methods Mol Biol (2009) 0.77
Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation. J Thromb Thrombolysis (2013) 0.76
Endothelial nitric-oxide synthase reveals a new face in G protein signaling. Mol Pharmacol (2005) 0.75
Dissecting receptor-G protein specificity using G alpha chimeras. Methods Enzymol (2002) 0.75
Defining G protein beta gamma specificity for effector recognition. Methods Enzymol (2002) 0.75
Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles. Methods Mol Biol (2015) 0.75
Structural characterization of intact G protein gamma subunits by mass spectrometry. Methods Enzymol (2002) 0.75