Published in Cell Metab on December 01, 2007
A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes (2010) 3.04
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36
Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab (2009) 2.27
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03
Leptin and the central nervous system control of glucose metabolism. Physiol Rev (2011) 1.94
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology (2009) 1.92
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab (2010) 1.64
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab (2009) 1.59
PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab (2010) 1.57
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med (2009) 1.55
Hormone and glucose signalling in POMC and AgRP neurons. J Physiol (2009) 1.48
Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol (2013) 1.21
Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology (2008) 1.18
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell (2015) 1.11
Leptin signaling and leptin resistance. Front Med (2013) 1.08
Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway. Neuroendocrinology (2011) 1.05
Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects. Cell Metab (2013) 1.05
Structure, production and signaling of leptin. Metabolism (2014) 0.98
Central regulation of metabolism by protein tyrosine phosphatases. Front Neurosci (2013) 0.96
Metabolic regulation by protein tyrosine phosphatases. J Biomed Res (2014) 0.95
Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology (2009) 0.95
A chromatin perspective of adipogenesis. Organogenesis (2010) 0.92
Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase. J Neurosci (2015) 0.88
Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling. Am J Physiol Regul Integr Comp Physiol (2011) 0.87
Metabolic actions of hypothalamic SIRT1. Trends Endocrinol Metab (2012) 0.86
Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature. Proc Natl Acad Sci U S A (2012) 0.85
The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. PLoS Genet (2016) 0.83
Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin. Clin Auton Res (2012) 0.82
PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin. Mol Metab (2013) 0.82
Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis. Am J Physiol Endocrinol Metab (2016) 0.79
Thyroid hormones induce browning of white fat. J Endocrinol (2016) 0.77
Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential. Channels (Austin) (2016) 0.76
Whole-body and hepatic insulin resistance in obese children. PLoS One (2014) 0.75
Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci (2016) 0.75
PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges. Mol Cell Endocrinol (2016) 0.75
Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. J Clin Invest (2017) 0.75
The Leptin Receptor Complex: Heavier Than Expected? Front Endocrinol (Lausanne) (2017) 0.75
Orangutan cultures and the evolution of material culture. Science (2003) 6.06
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (2004) 5.98
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods (2005) 5.59
Mechanisms of leptin action and leptin resistance. Annu Rev Physiol (2008) 4.72
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest (2011) 4.17
Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell (2010) 4.16
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity (2011) 3.40
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot (2010) 3.11
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev (2008) 2.76
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med (2006) 2.72
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity (2010) 2.71
The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab (2009) 2.69
STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol (2009) 2.67
Neurobiology of feeding and energy expenditure. Annu Rev Neurosci (2007) 2.64
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57
Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54
Central insulin action in energy and glucose homeostasis. J Clin Invest (2006) 2.51
A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Nicotine decreases food intake through activation of POMC neurons. Science (2011) 2.41
Modeling human cortical development in vitro using induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 2.41
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol (2011) 2.38
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36
A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity. Proc Natl Acad Sci U S A (2007) 2.36
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 2.29
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab (2010) 2.26
ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J Neurosci (2002) 2.25
Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes (2005) 2.24
A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest (2013) 2.23
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature (2013) 2.19
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Major issues and challenges of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2008) 2.16
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet (2009) 2.16
Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci (2003) 2.14
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci (2004) 2.13
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell (2013) 2.11
Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci (2005) 2.06