Published in Nature on July 27, 2006
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci (2010) 4.28
Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol (2010) 4.07
Slicing across kingdoms: regeneration in plants and animals. Cell (2008) 2.18
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem Biol (2011) 2.07
Contribution of Candida albicans cell wall components to recognition by and escape from murine macrophages. Infect Immun (2010) 2.02
Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle. Cell Cycle (2009) 1.88
Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nat Rev Mol Cell Biol (2010) 1.73
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci (2012) 1.68
Electrical control of cell polarization in the fission yeast Schizosaccharomyces pombe. Curr Biol (2010) 1.67
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Dev Biol (2009) 1.62
Bioelectric mechanisms in regeneration: Unique aspects and future perspectives. Semin Cell Dev Biol (2009) 1.56
Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell (2014) 1.56
Molecular bioelectricity in developmental biology: new tools and recent discoveries: control of cell behavior and pattern formation by transmembrane potential gradients. Bioessays (2012) 1.42
Acanthamoeba migration in an electric field. Invest Ophthalmol Vis Sci (2013) 1.42
Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. PLoS Genet (2011) 1.41
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature (2010) 1.40
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS One (2008) 1.37
An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol (2013) 1.34
The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo. J Cell Biol (2010) 1.29
Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. Am J Physiol Heart Circ Physiol (2011) 1.25
Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis. Development (2011) 1.23
Interactive effects of surface topography and pulsatile electrical field stimulation on orientation and elongation of fibroblasts and cardiomyocytes. Biomaterials (2007) 1.23
The role of transcription-independent damage signals in the initiation of epithelial wound healing. Nat Rev Mol Cell Biol (2013) 1.23
Induction of vertebrate regeneration by a transient sodium current. J Neurosci (2010) 1.23
Imaging the electric field associated with mouse and human skin wounds. Wound Repair Regen (2008) 1.23
Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.22
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway. Dis Model Mech (2010) 1.17
Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Curr Opin Cell Biol (2014) 1.17
PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol (2010) 1.15
Modeling planarian regeneration: a primer for reverse-engineering the worm. PLoS Comput Biol (2012) 1.15
Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration. J Physiol (2014) 1.15
Tissue damage detection by osmotic surveillance. Nat Cell Biol (2013) 1.13
Effects of physiological electric fields on migration of human dermal fibroblasts. J Invest Dermatol (2010) 1.13
Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation. Commun Integr Biol (2013) 1.11
Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc Natl Acad Sci U S A (2009) 1.11
Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration. Dev Biol (2012) 1.10
Lymphocyte electrotaxis in vitro and in vivo. J Immunol (2008) 1.10
Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium. BMC Dev Biol (2009) 1.09
Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities. Wiley Interdiscip Rev Syst Biol Med (2013) 1.08
Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis. Curr Biol (2013) 1.08
Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. PLoS One (2008) 1.08
Electrically guiding migration of human induced pluripotent stem cells. Stem Cell Rev (2011) 1.08
The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila. Nat Cell Biol (2009) 1.06
Endogenous electric currents might guide rostral migration of neuroblasts. EMBO Rep (2013) 1.05
Cell blebbing and membrane area homeostasis in spreading and retracting cells. Biophys J (2010) 1.02
E-cadherin plays an essential role in collective directional migration of large epithelial sheets. Cell Mol Life Sci (2012) 1.02
The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes. J Cell Sci (2013) 1.01
Impedance sensing device enables early detection of pressure ulcers in vivo. Nat Commun (2015) 0.97
SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. J Cell Sci (2011) 0.96
Ion channels expression and function are strongly modified in solid tumors and vascular malformations. J Transl Med (2016) 0.96
Mechanisms of epithelial wound detection. Trends Cell Biol (2015) 0.96
A formative evaluation of two evidence-based psychotherapies for PTSD in VA residential treatment programs. J Trauma Stress (2013) 0.95
Electrical implications of corrosion for osseointegration of titanium implants. J Dent Res (2011) 0.95
Microfluidic device for studying cell migration in single or co-existing chemical gradients and electric fields. Biomicrofluidics (2012) 0.94
Electrohydrodynamic model of vesicle deformation in alternating electric fields. Biophys J (2009) 0.94
Inhibition of the phosphatase PTEN protects mice against oleic acid-induced acute lung injury. Br J Pharmacol (2009) 0.94
Control of patterns of corneal innervation by Pax6. Invest Ophthalmol Vis Sci (2008) 0.94
Local calcium elevation and cell elongation initiate guided motility in electrically stimulated osteoblast-like cells. PLoS One (2009) 0.93
Alignment and elongation of human adipose-derived stem cells in response to direct-current electrical stimulation. Conf Proc IEEE Eng Med Biol Soc (2009) 0.93
Improvement of human keratinocyte migration by a redox active bioelectric dressing. PLoS One (2014) 0.92
A multi-paradigm modeling framework to simulate dynamic reciprocity in a bioreactor. PLoS One (2013) 0.92
Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo. Phys Biol (2012) 0.92
Hyponatremia and bone: an emerging relationship. Nat Rev Endocrinol (2011) 0.91
Modulating endogenous electric currents in human corneal wounds--a novel approach of bioelectric stimulation without electrodes. Cornea (2011) 0.91
Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome. PLoS One (2012) 0.91
Ionic components of electric current at rat corneal wounds. PLoS One (2011) 0.90
Chloride channels and transporters in human corneal epithelium. Exp Eye Res (2010) 0.90
Electrical stimulation to accelerate wound healing. Diabet Foot Ankle (2013) 0.90
Therapeutic Application of Electric Fields in the Injured Nervous System. Adv Wound Care (New Rochelle) (2014) 0.90
PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration. Am J Physiol Lung Cell Mol Physiol (2011) 0.90
Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer. J Clin Exp Oncol (2013) 0.90
The role of electrical signals in murine corneal wound re-epithelialization. J Cell Physiol (2011) 0.89
PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol (2007) 0.89
Changes in gravity rapidly alter the magnitude and direction of a cellular calcium current. Planta (2011) 0.89
Electrochemical regulation of budding yeast polarity. PLoS Biol (2014) 0.88
Keratocyte fragments and cells utilize competing pathways to move in opposite directions in an electric field. Curr Biol (2013) 0.88
Skin cell proliferation stimulated by microneedles. J Am Coll Clin Wound Spec (2012) 0.88
Biomaterials-based electronics: polymers and interfaces for biology and medicine. Adv Healthc Mater (2012) 0.87
Electrical signaling in control of ocular cell behaviors. Prog Retin Eye Res (2011) 0.87
Electrical Stimulation Technologies for Wound Healing. Adv Wound Care (New Rochelle) (2014) 0.87
Controlled electromechanical cell stimulation on-a-chip. Sci Rep (2015) 0.86
Downregulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration. Invest Ophthalmol Vis Sci (2011) 0.86
Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone. Biomaterials (2013) 0.86
Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation. Adv Wound Care (New Rochelle) (2015) 0.86
Electrical stimulation of schwann cells promotes sustained increases in neurite outgrowth. Tissue Eng Part A (2013) 0.85
Gene expression of human lung cancer cell line CL1-5 in response to a direct current electric field. PLoS One (2011) 0.85
KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun (2015) 0.85
The influence of electric field and confinement on cell motility. PLoS One (2013) 0.85
GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxis. Cell Mol Life Sci (2011) 0.85
Electrotaxis of oral squamous cell carcinoma cells in a multiple-electric-field chip with uniform flow field. Biomicrofluidics (2012) 0.84
A role for PP1/NIPP1 in steering migration of human cancer cells. PLoS One (2012) 0.84
Cellular and molecular mechanisms of action of transcranial direct current stimulation: evidence from in vitro and in vivo models. Int J Neuropsychopharmacol (2014) 0.84
Superoxide mediates direct current electric field-induced directional migration of glioma cells through the activation of AKT and ERK. PLoS One (2013) 0.83
In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process. Biomicrofluidics (2012) 0.83
The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. Int J Neuropsychopharmacol (2014) 0.83
Passage-dependent relationship between mesenchymal stem cell mobilization and chondrogenic potential. Osteoarthritis Cartilage (2014) 0.83
Evaluation of EGFR and RTK signaling in the electrotaxis of lung adenocarcinoma cells under direct-current electric field stimulation. PLoS One (2013) 0.82
Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium. Mol Vis (2012) 0.82
Cerebral organoids model human brain development and microcephaly. Nature (2013) 9.07
The case for early detection. Nat Rev Cancer (2003) 6.96
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell (2003) 6.46
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Orangutan cultures and the evolution of material culture. Science (2003) 6.06
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
Overdiagnosis and overtreatment in cancer: an opportunity for improvement. JAMA (2013) 5.56
The gated gait of the processive molecular motor, myosin V. Nat Cell Biol (2002) 5.34
Regulation of cancer cell migration and bone metastasis by RANKL. Nature (2006) 5.27
Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 5.02
Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol (2004) 4.96
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Mitogen-activated protein kinases in apoptosis regulation. Oncogene (2004) 4.76
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol (2002) 4.64
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12
Identification of an organelle receptor for myosin-Va. Nat Cell Biol (2002) 4.06
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys (2010) 3.76
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72
Load-dependent kinetics of myosin-V can explain its high processivity. Nat Cell Biol (2005) 3.69
RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med (2005) 3.68
A critical review of the diagnosis and management of Barrett's esophagus: the AGA Chicago Workshop. Gastroenterology (2004) 3.50
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36
Controlling cell behavior electrically: current views and future potential. Physiol Rev (2005) 3.34
Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30
RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol (2001) 3.27
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19
AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol (2006) 3.12
Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot (2010) 3.11
Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med (2006) 3.09
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med (2013) 2.93
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol (2004) 2.90
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76
Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology (2009) 2.75
Para-inflammation in the aging retina. Prog Retin Eye Res (2009) 2.71
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57
Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A (2010) 2.54
PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet (2011) 2.47
Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science (2009) 2.47
Disparities in diabetes care: impact of mental illness. Arch Intern Med (2005) 2.45
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell (2009) 2.35
Selection of reliable reference genes for gene expression studies in peach using real-time PCR. BMC Mol Biol (2009) 2.35
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science (2013) 2.34
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Risk of pancreatic cancer in families with Lynch syndrome. JAMA (2009) 2.32
China's life satisfaction, 1990-2010. Proc Natl Acad Sci U S A (2012) 2.31
Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science (2009) 2.23
Neck length and processivity of myosin V. J Biol Chem (2003) 2.23
Navigating through models of chemotaxis. Curr Opin Cell Biol (2008) 2.19
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke (2012) 2.18