PubRank

James H Naismith

Author PubWeight™ 135.95‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity. Mol Cell 2012 3.41
2 An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol. BMC Biotechnol 2008 3.27
3 Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature 2012 2.86
4 Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE). J Biol Chem 2011 2.86
5 Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein. Nature 2006 2.77
6 The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution. Science 2008 2.21
7 Structure of the DNA repair helicase XPD. Cell 2008 2.16
8 Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science 2005 2.10
9 TarO: a target optimisation system for structural biology. Nucleic Acids Res 2008 1.89
10 SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol 2006 1.89
11 Pivotal roles of the outer membrane polysaccharide export and polysaccharide copolymerase protein families in export of extracellular polysaccharides in gram-negative bacteria. Microbiol Mol Biol Rev 2009 1.82
12 Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature 2004 1.70
13 The Scottish Structural Proteomics Facility: targets, methods and outputs. J Struct Funct Genomics 2010 1.66
14 A simple and efficient expression and purification system using two newly constructed vectors. Protein Expr Purif 2008 1.64
15 Mechanism of the Class I KDPG aldolase. Bioorg Med Chem 2006 1.62
16 Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol 2011 1.59
17 Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein. EMBO J 2003 1.58
18 The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain. Nat Struct Mol Biol 2012 1.53
19 Wzi is an outer membrane lectin that underpins group 1 capsule assembly in Escherichia coli. Structure 2013 1.51
20 The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J 2006 1.49
21 Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J 2005 1.48
22 CRISPR interference: a structural perspective. Biochem J 2013 1.48
23 Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance. Nucleic Acids Res 2009 1.38
24 The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. J Mol Biol 2007 1.38
25 Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza. J Biol Chem 2003 1.37
26 The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli. Proc Natl Acad Sci U S A 2007 1.36
27 MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL. Appl Magn Reson 2012 1.34
28 Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. J Biol Chem 2005 1.34
29 Structural aspects of non-ribosomal peptide biosynthesis. Curr Opin Struct Biol 2004 1.34
30 Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J Mol Biol 2005 1.30
31 Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis. Bioorg Med Chem Lett 2003 1.25
32 Adenylate-forming enzymes. Curr Opin Struct Biol 2009 1.23
33 Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains. J Biol Chem 2007 1.21
34 Structure of the heterotrimeric PCNA from Sulfolobus solfataricus. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 1.21
35 Three-dimensional structure of Wza, the protein required for translocation of group 1 capsular polysaccharide across the outer membrane of Escherichia coli. J Biol Chem 2004 1.21
36 AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nat Chem Biol 2009 1.21
37 The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction. Angew Chem Int Ed Engl 2013 1.20
38 The fluorinase from Streptomyces cattleya is also a chlorinase. Angew Chem Int Ed Engl 2006 1.13
39 Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules. J Biol Chem 2005 1.11
40 PELDOR spectroscopy distance fingerprinting of the octameric outer-membrane protein Wza from Escherichia coli. Angew Chem Int Ed Engl 2009 1.10
41 RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol 2006 1.09
42 Toward a structural understanding of the dehydratase mechanism. Structure 2002 1.08
43 NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond. Angew Chem Int Ed Engl 2010 1.06
44 Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure 2002 1.06
45 Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. J Mol Biol 2007 1.04
46 Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy. Proc Natl Acad Sci U S A 2012 1.03
47 The discovery of new cyanobactins from Cyanothece PCC 7425 defines a new signature for processing of patellamides. Chembiochem 2012 1.02
48 Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate. Biochemistry 2003 1.02
49 Structural, mechanistic and regulatory studies of serine palmitoyltransferase. Biochem Soc Trans 2012 1.02
50 Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site. J Am Chem Soc 2005 1.02
51 A novel outer membrane protein, Wzi, is involved in surface assembly of the Escherichia coli K30 group 1 capsule. J Bacteriol 2003 1.01
52 An efficient method for the in vitro production of azol(in)e-based cyclic peptides. Angew Chem Int Ed Engl 2014 0.99
53 Mechanism of enzymatic fluorination in Streptomyces cattleya. J Am Chem Soc 2007 0.98
54 The chemical basis of serine palmitoyltransferase inhibition by myriocin. J Am Chem Soc 2013 0.98
55 Structural insights into regioselectivity in the enzymatic chlorination of tryptophan. J Mol Biol 2009 0.98
56 New insights into the mechanism of enzymatic chlorination of tryptophan. Angew Chem Int Ed Engl 2008 0.97
57 The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 0.97
58 The structure of NADH in the enzyme dTDP-d-glucose dehydratase (RmlB). J Am Chem Soc 2003 0.97
59 Periplasmic export machines for outer membrane assembly. Curr Opin Struct Biol 2008 0.96
60 A dimeric Rep protein initiates replication of a linear archaeal virus genome: implications for the Rep mechanism and viral replication. J Virol 2010 0.96
61 Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria. Org Biomol Chem 2009 0.95
62 Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30. Acta Crystallogr D Biol Crystallogr 2004 0.95
63 Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly. J Mol Biol 2009 0.94
64 Structural and mechanistic basis of bacterial sugar nucleotide-modifying enzymes. Biochemistry 2003 0.93
65 Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries. Org Biomol Chem 2011 0.93
66 Structure of PatF from Prochloron didemni. Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 0.92
67 Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis. Angew Chem Int Ed Engl 2011 0.92
68 The structural basis of chain length control in Rv1086. J Mol Biol 2008 0.91
69 Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli. PLoS One 2011 0.91
70 Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales. Proc Natl Acad Sci U S A 2011 0.90
71 Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing. Biochem J 2013 0.90
72 An enzymatic route to selenazolines. Chembiochem 2013 0.90
73 Low resolution structure of a bacterial SLC26 transporter reveals dimeric stoichiometry and mobile intracellular domains. J Biol Chem 2011 0.90
74 Structure of the archaeal Cascade subunit Csa5: relating the small subunits of CRISPR effector complexes. RNA Biol 2013 0.90
75 The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics. J Biol Chem 2009 0.89
76 Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity. J Mol Biol 2009 0.89
77 Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a. Mol Microbiol 2012 0.88
78 Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa. J Mol Biol 2012 0.88
79 A snapshot of carnitine acetyltransferase. Trends Biochem Sci 2003 0.88
80 The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step. J Biol Chem 2001 0.87
81 Two-step purification of outer membrane proteins. Int J Biol Macromol 2006 0.87
82 Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus. J Mol Biol 2010 0.87
83 Salt bridges regulate both dimer formation and monomeric flexibility in HdeB and may have a role in periplasmic chaperone function. J Mol Biol 2011 0.87
84 High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme. Structure 2003 0.86
85 Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a. Acta Crystallogr D Biol Crystallogr 2012 0.85
86 Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chem Commun (Camb) 2008 0.84
87 The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein. Biopolymers 2010 0.84
88 Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa. ACS Chem Biol 2013 0.84
89 The respiratory arsenite oxidase: structure and the role of residues surrounding the rieske cluster. PLoS One 2013 0.83
90 Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation. Blood 2014 0.83
91 Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens. Acta Crystallogr D Biol Crystallogr 2004 0.83
92 Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog. Angew Chem Int Ed Engl 2008 0.83
93 The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme. J Biol Chem 2004 0.83
94 Characterization and crystal structure of Escherichia coli KDPGal aldolase. Bioorg Med Chem 2007 0.82
95 Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation. Mol Biosyst 2010 0.82
96 Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates. Org Biomol Chem 2006 0.81
97 Preliminary crystallographic characterization of PrnB, the second enzyme in the pyrrolnitrin biosynthetic pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.81
98 Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.81
99 Crystallization and preliminary diffraction analysis of Wzi, a member of the capsule export and assembly pathway in Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.81
100 The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily. J Biol Chem 2010 0.81
101 Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.81
102 Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). Chembiochem 2009 0.80
103 Crystallization and X-ray diffraction of 5'-fluoro-5'-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya. Acta Crystallogr D Biol Crystallogr 2003 0.80
104 Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.80
105 Crystallization of Ranasmurfin, a blue-coloured protein from Polypedates leucomystax. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.80
106 The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily. Biochemistry 2007 0.80
107 Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis. J Struct Biol 2009 0.79
108 Chemical synthesis of UDP-Glc-2,3-diNAcA, a key intermediate in cell surface polysaccharide biosynthesis in the human respiratory pathogens B. pertussis and P. aeruginosa. Org Biomol Chem 2009 0.79
109 Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD. J Mol Biol 2011 0.79
110 Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining. Chembiochem 2014 0.78
111 The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism. Protein Sci 2010 0.78
112 Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway. Acta Crystallogr D Biol Crystallogr 2002 0.78
113 Crystallization and preliminary crystallographic analysis of the bacterial capsule assembly-regulating tyrosine phosphatases Wzb of Escherichia coli and Cps4B of Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.77
114 Purification, crystallization and preliminary crystallographic analysis of WsaF, an essential rhamnosyltransferase from Geobacillus stearothermophilus. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.77
115 A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model. J Am Chem Soc 2011 0.77
116 Halomethane biosynthesis: structure of a SAM-dependent halide methyltransferase from Arabidopsis thaliana. Angew Chem Int Ed Engl 2010 0.76
117 Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. ACS Chem Biol 2012 0.76
118 Overexpression, purification, crystallization and data collection of Sulfolobus solfataricus Sso6206, a novel highly conserved protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.75
119 Chemistry's prodigal child: enzyme mechanism. Curr Opin Chem Biol 2008 0.75
120 A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions. Angew Chem Int Ed Engl 2014 0.75
121 Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase. Biochemistry 2017 0.75