Published in Diabetes on December 10, 2007
The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes (2009) 1.90
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat Med (2014) 1.85
Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet (2009) 1.80
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol (2009) 1.72
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes (2012) 1.61
TCF1 links GIPR signaling to the control of beta cell function and survival. Nat Med (2015) 1.52
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res (2011) 1.50
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes (2014) 1.37
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia (2012) 1.24
Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. J Clin Endocrinol Metab (2009) 1.17
Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care (2011) 1.17
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab (2010) 1.16
The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Diabetes (2012) 1.16
TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet (2014) 1.10
Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne) (2013) 1.07
TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia (2008) 1.05
Type 2 diabetes and obesity: genomics and the clinic. Hum Genet (2011) 1.04
Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies. Int J Endocrinol (2014) 1.04
TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program. PLoS One (2011) 1.04
Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. PLoS One (2010) 1.02
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass. Hum Mol Genet (2014) 1.02
Animal models of GWAS-identified type 2 diabetes genes. J Diabetes Res (2013) 1.01
Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample. PLoS One (2012) 0.99
Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes (2009) 0.98
Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets. Transplantation (2008) 0.97
In vitro scan for enhancers at the TCF7L2 locus. Diabetologia (2012) 0.95
The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective. Cell Biosci (2012) 0.93
The search for genetic risk factors of type 2 diabetes mellitus. Diabetes Metab J (2011) 0.92
The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis. Am J Physiol Endocrinol Metab (2012) 0.91
Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study. Am J Epidemiol (2012) 0.90
Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146. PLoS One (2013) 0.90
An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. BMC Dev Biol (2011) 0.90
Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? Curr Diab Rep (2014) 0.89
Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort. Diabetes (2011) 0.89
TCF7L2 and glucose metabolism: time to look beyond the pancreas. Diabetes (2013) 0.87
TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver. PLoS Genet (2012) 0.87
Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3. Cell Cycle (2016) 0.86
Importance of β-Catenin in glucose and energy homeostasis. Sci Rep (2012) 0.86
Expression of the diabetes-associated gene TCF7L2 in adult mouse brain. J Comp Neurol (2009) 0.86
Beta cell connectivity in pancreatic islets: a type 2 diabetes target? Cell Mol Life Sci (2014) 0.85
Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice. Int J Biol Sci (2012) 0.85
The role of the Wnt signaling pathway in incretin hormone production and function. Front Physiol (2012) 0.84
COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways. PLoS One (2012) 0.84
Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Hum Mol Genet (2014) 0.83
Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin. Diabetologia (2014) 0.82
Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. Hum Mol Genet (2012) 0.82
Ileal interposition surgery-induced improvement of hyperglycemia and insulin resistance in Goto-Kakizaki rats by upregulation of TCF7L2 expression. Exp Ther Med (2013) 0.81
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies. PLoS One (2008) 0.81
The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis. Mol Metab (2015) 0.81
From mice to humans. Curr Diab Rep (2012) 0.80
Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. PLoS One (2013) 0.80
Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146. Sci Rep (2014) 0.80
Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents. Pharmgenomics Pers Med (2016) 0.79
Sequence variants of ADIPOQ and association with type 2 diabetes mellitus in Taiwan Chinese Han population. ScientificWorldJournal (2014) 0.79
Association of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and Peroxisome Proliferator-Activated Receptors- γ 2 with Type 2 Diabetes Mellitus and is Interaction with Obesity Status in Emirati Population. J Diabetes Res (2015) 0.79
Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China. Int J Environ Res Public Health (2015) 0.79
Profiling of embryonic stem cell differentiation. Rev Diabet Stud (2014) 0.79
Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population. PLoS One (2013) 0.79
Genetics of Insulin Resistance and the Metabolic Syndrome. Curr Cardiol Rep (2016) 0.78
Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion. Mol Metab (2013) 0.77
Predicting diabetes: our relentless quest for genomic nuggets. Diabetes Care (2012) 0.77
Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies? PPAR Res (2015) 0.77
Novel phenotypes of prediabetes? Diabetologia (2016) 0.76
Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas. Sci Rep (2016) 0.75
A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis. Oncotarget (2016) 0.75
Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro. Chin Med (2014) 0.75
TCF7L2 rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population. World J Gastroenterol (2016) 0.75
PAX4 R192H and P321H polymorphisms in type 2 diabetes and their functional defects. J Hum Genet (2016) 0.75
Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. BMC Genet (2013) 0.75
Effect of Wnt Signaling on the Differentiation of Islet β-Cells from Adipose-Derived Stem Cells. Biomed Res Int (2017) 0.75
Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes. Sci Rep (2017) 0.75
TOSO promotes β-cell proliferation and protects from apoptosis. Mol Metab (2012) 0.75
Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146. Metabolism (2016) 0.75
Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain. J Chem Neuroanat (2012) 0.75
Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs. Pharmacogenomics J (2016) 0.75
Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab (2015) 0.75
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Res (2017) 0.75
Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance. Sci Rep (2016) 0.75
Role of GNB3, NET, KCNJ11, TCF7L2 and GRL genes single nucleotide polymorphism in the risk prediction of type 2 diabetes mellitus. 3 Biotech (2016) 0.75
Restoring Mitochondrial Function: A Small Molecule-mediated Approach to Enhance Glucose Stimulated Insulin Secretion in Cholesterol Accumulated Pancreatic beta cells. Sci Rep (2016) 0.75
Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway. Cell Death Dis (2015) 0.75
Pharmacogenetics of posttransplant diabetes mellitus. Pharmacogenomics J (2017) 0.75
From genotype to human β cell phenotype and beyond. Islets (2012) 0.75
Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. Diabetologia (2017) 0.75
The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity. Diabetes Care (2017) 0.75
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest (2002) 5.52
Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology (2011) 4.99
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes (2003) 2.62
Mechanisms of beta-cell death in type 2 diabetes. Diabetes (2005) 2.50
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet (2009) 2.29
Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med (Berl) (2003) 2.10
Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma. Liver Transpl (2004) 1.80
FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication. Proc Natl Acad Sci U S A (2002) 1.72
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology (2008) 1.68
CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab (2009) 1.55
Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1. Diabetes (2006) 1.47
Concern Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes (2006) 1.47
Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes. Mol Ther (2002) 1.46
Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS One (2009) 1.44
Hilar early division of the hepatic duct in living donor right hepatectomy: the probe-and-clamp technique. Liver Transpl (2006) 1.44
Staged approach for abdominal wound closure following combined liver and intestinal transplantation from living donors in pediatric patients. Pediatr Transplant (2008) 1.43
Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J Biol Rhythms (2011) 1.36
Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. Cell Metab (2013) 1.35
Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes (2004) 1.31
TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Hum Mol Genet (2011) 1.20
Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes (2013) 1.12
XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model. Endocrinology (2010) 1.11
Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J (2008) 1.10
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes (2010) 1.10
Long-term metabolic and immunological follow-up of nonimmunosuppressed patients with type 1 diabetes treated with microencapsulated islet allografts: four cases. Diabetes Care (2011) 1.08
The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 1.08
β-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes (2013) 1.06
The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1. Hum Mol Genet (2007) 1.01
In vitro proliferation of adult human beta-cells. PLoS One (2012) 0.99
Encapsulation of human islets in novel inhomogeneous alginate-ca2+/ba2+ microbeads: in vitro and in vivo function. Artif Cells Blood Substit Immobil Biotechnol (2008) 0.97
Cost analysis of human islet transplantation for the treatment of type 1 diabetes in the Swiss-French Consortium GRAGIL. Diabetes Care (2004) 0.97
The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization. J Clin Endocrinol Metab (2013) 0.96
Arantius' ligament approach to the left hepatic vein and to the common trunk. J Am Coll Surg (2002) 0.95
Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. J Hepatol (2005) 0.95
Routine left robotic-assisted laparoscopic donor nephrectomy is safe and effective regardless of the presence of vascular anomalies. Transpl Int (2006) 0.94
An unusual, presumably hepatic mass. Lancet (2002) 0.93
Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations. Am J Physiol Gastrointest Liver Physiol (2009) 0.93
Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. Biochem Biophys Res Commun (2006) 0.92
Successful rescue of refractory, severe antibody mediated rejection with splenectomy. Transplantation (2007) 0.92
Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase. Free Radic Biol Med (2006) 0.90
Intra-portal injection of 400- microm microcapsules in a large-animal model. Transpl Int (2003) 0.89
Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? Curr Diab Rep (2014) 0.89
Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes. Hepatology (2013) 0.88
UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS One (2008) 0.88
Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility. Cell Transplant (2005) 0.88
Retracted Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization. J Biol Chem (2011) 0.88
Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat. Am J Physiol Endocrinol Metab (2009) 0.87
Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes. Am J Physiol Endocrinol Metab (2012) 0.85
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. PLoS One (2013) 0.84
COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways. PLoS One (2012) 0.84
Increased albumin concentration reduces apoptosis and improves functionality of human islets. Artif Cells Blood Substit Immobil Biotechnol (2008) 0.84
State of the art of robotic surgery in organ transplantation. World J Surg (2013) 0.84
Efficient gene delivery and silencing of mouse and human pancreatic islets. BMC Biotechnol (2010) 0.83
Islet transplantation: current status and future directions. Curr Diab Rep (2005) 0.83
TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6. Diabetologia (2014) 0.83
Prostaglandin E(1) protects human liver sinusoidal endothelial cell from apoptosis induced by hypoxia reoxygenation. Microvasc Res (2002) 0.82
Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+. Xenotransplantation (2012) 0.82
Activation of Melatonin Signaling Promotes β-Cell Survival and Function. Mol Endocrinol (2015) 0.82
Overexpression of E2F3 promotes proliferation of functional human β cells without induction of apoptosis. Cell Cycle (2013) 0.82
Imaging of the β-cells of the islets of Langerhans. Diabetes Res Clin Pract (2012) 0.82
Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression. Obesity (Silver Spring) (2013) 0.82
Living related segmental bowel transplantation: from experimental to standardized procedure. Ann Surg (2006) 0.82
Molecular detection of circulating beta-cells after islet transplantation. Diabetes (2002) 0.81
Robotic-assisted kidney transplantation. Surg Clin North Am (2013) 0.80
Alcohol-induced suppression of gluconeogenesis is greater in ethanol fed female rat hepatocytes than males. Alcohol (2007) 0.80
Glucose intolerance and lipid metabolic adaptations in response to intrauterine and postnatal calorie restriction in male adult rats. Endocrinology (2012) 0.80
Increased risk of post-transplant diabetes mellitus despite early steroid discontinuation in Hispanic kidney transplant recipients. Clin Transplant (2005) 0.79
Sex differences in hepatic gluconeogenic capacity after chronic alcohol consumption. Clin Med Res (2007) 0.79
Activation of human macrophages by allogeneic islets preparations: inhibition by AOP-RANTES and heparinoids. Immunology (2004) 0.79
Opposing effects of chronic alcohol consumption on hepatic gluconeogenesis for female versus male rats. Alcohol Clin Exp Res (2005) 0.79
Reduction in carotid intima-media thickness after pancreatic islet transplantation in patients with type 1 diabetes. Diabetes Care (2012) 0.78
The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. PLoS One (2013) 0.78
Expression of Fas but not Fas ligand on fetal pig beta cells. Xenotransplantation (2004) 0.78
Insulin independence after conversion to tacrolimus and sirolimus-based immunosuppression in islet-kidney recipients. Transplantation (2003) 0.78
Perioperative risk assessment in robotic general surgery: lessons learned from 884 cases at a single institution. Arch Surg (2012) 0.78
Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient. Am J Transplant (2003) 0.78
Microfluidic array with integrated oxygenation control for real-time live-cell imaging: effect of hypoxia on physiology of microencapsulated pancreatic islets. Anal Chem (2013) 0.78
Implication of mitochondrial cytoprotection in human islet isolation and transplantation. Biochem Res Int (2012) 0.77
Dual microfluidic perifusion networks for concurrent islet perifusion and optical imaging. Biomed Microdevices (2012) 0.77
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet (2015) 0.77
Cadaver iliac vein outflow reconstruction in living donor right lobe liver transplantation. J Am Coll Surg (2004) 0.77
Application of microfluidic technology to pancreatic islet research: first decade of endeavor. Bioanalysis (2010) 0.77
CXCL10- a path to β-cell death. Islets (2010) 0.76
Are criteria for islet and pancreas donors sufficiently different to minimize competition? Am J Transplant (2004) 0.76
Robotic pancreas transplantation in a type 1 diabetic patient with morbid obesity: A case report. Medicine (Baltimore) (2017) 0.75
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest (2017) 0.75
Systematic prevention of bubble formation and accumulation for long-term culture of pancreatic islet cells in microfluidic device. Biomed Microdevices (2012) 0.75
Neutralizing interleukin 1β (IL-1β) induces β-cell survival by maintaining PDX1 protein nuclear localization. J Biol Chem (2015) 0.75
'Prope' tolerance in a noncompliant living related small bowel transplant recipient after severe rejection. Transplantation (2007) 0.75