Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMC 2841530)

Published in J Clin Endocrinol Metab on January 22, 2010

Authors

Ashis K Mondal1, Swapan K Das, Giulia Baldini, Winston S Chu, Neeraj K Sharma, Oksana G Hackney, Jianhua Zhao, Struan F A Grant, Steven C Elbein

Author Affiliations

1: or Swapan K. Das, Section on Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

Articles citing this

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res (2011) 1.50

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia (2012) 1.24

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism. Diabetes (2012) 1.10

TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet (2014) 1.10

Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials. Crit Rev Eukaryot Gene Expr (2011) 1.09

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass. Hum Mol Genet (2014) 1.02

Animal models of GWAS-identified type 2 diabetes genes. J Diabetes Res (2013) 1.01

Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects. J Clin Endocrinol Metab (2010) 0.96

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes. Nutr Metab Cardiovasc Dis (2012) 0.89

Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. World J Diabetes (2014) 0.85

Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice. Int J Biol Sci (2012) 0.85

Understanding the elusive mechanism of action of TCF7L2 in metabolism. Diabetes (2012) 0.81

A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia. Mol Genet Genomic Med (2014) 0.81

From mice to humans. Curr Diab Rep (2012) 0.80

Role of the single nucleotide polymorphism rs7903146 of TCF7L2 in inducing nonsense-mediated decay. Springerplus (2014) 0.78

Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data. BMJ Open Diabetes Res Care (2014) 0.77

Alternative splicing and the evolution of phenotypic novelty. Philos Trans R Soc Lond B Biol Sci (2017) 0.76

Regulation of alternative splicing in obesity and weight loss. Adipocyte (2013) 0.76

Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2. Cell Death Dis (2017) 0.75

Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico. BMC Genet (2016) 0.75

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. Diabetologia (2017) 0.75

KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment. BMC Med Genet (2017) 0.75

Articles cited by this

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med (2006) 7.75

Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet (2007) 7.42

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes (2006) 4.36

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia (2007) 3.34

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes (2006) 2.85

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes (2006) 2.67

Retracted Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes (2007) 2.25

Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab (2008) 2.07

Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms. J Biol Chem (2005) 1.85

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem (2008) 1.83

Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death Differ (2007) 1.80

Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet (2009) 1.80

The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res (2000) 1.77

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia (2007) 1.73

The Genetic Basis of Type 2 Diabetes. Cellscience (2006) 1.58

Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity (Silver Spring) (2008) 1.49

The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol (2008) 1.49

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes (2006) 1.45

The new type 2 diabetes gene TCF7L2. Curr Opin Clin Nutr Metab Care (2007) 1.41

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. Diabetologia (2009) 1.33

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins. J Clin Endocrinol Metab (2008) 1.20

Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab (2008) 1.15

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab (2007) 1.12

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men. Diabetologia (2007) 1.09

Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin. Biochem Biophys Res Commun (2008) 0.94

TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus. Metabolism (2008) 0.88

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res (2007) 19.07

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47

Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature (2007) 6.10

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45

High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications. Genome Res (2009) 4.32

Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18

Copy number variation at 1q21.1 associated with neuroblastoma. Nature (2009) 4.10

Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med (2008) 3.80

Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet (2008) 3.36

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19

From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes (2008) 2.90

A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet (2009) 2.47

Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet (2010) 2.47

The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) (2009) 2.34

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30

Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature (2010) 2.21

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15

Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab (2008) 2.07

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90

Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A (2010) 1.85

Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes. Hum Mol Genet (2011) 1.83

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81

Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.75

Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). PLoS Genet (2011) 1.75

Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol (2003) 1.64

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet (2011) 1.63

Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am J Hum Genet (2003) 1.62

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet (2011) 1.60

The Genetic Basis of Type 2 Diabetes. Cellscience (2006) 1.58

Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans. Hum Genet (2010) 1.54

Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression. Am J Physiol Endocrinol Metab (2005) 1.52

Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet (2012) 1.51

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. J Allergy Clin Immunol (2008) 1.46

ATOM: a powerful gene-based association test by combining optimally weighted markers. Bioinformatics (2008) 1.44

Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. Mol Genet Metab (2002) 1.44

Modeling genetic inheritance of copy number variations. Nucleic Acids Res (2008) 1.39

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab (2003) 1.38

A genome-wide study reveals copy number variants exclusive to childhood obesity cases. Am J Hum Genet (2010) 1.36

Real-time Raman spectroscopy for in vivo skin cancer diagnosis. Cancer Res (2012) 1.36

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. Diabetes (2009) 1.34

A genome-wide association study on obesity and obesity-related traits. PLoS One (2011) 1.33

Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population. J Hum Genet (2005) 1.31

Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes (2011) 1.31

Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes (2008) 1.27

Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. Clin Gastroenterol Hepatol (2007) 1.26

Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet (2013) 1.24

Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population. Am J Psychiatry (2010) 1.23

The genetics of human obesity. Ann N Y Acad Sci (2013) 1.22

The search for type 2 diabetes susceptibility loci: the chromosome 1q story. Curr Diab Rep (2007) 1.22

Ectopic fat accumulation and metabolic syndrome. Diabetes Obes Metab (2007) 1.22

Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans. Obesity (Silver Spring) (2011) 1.21

Enhancing the Curie temperature of ferromagnetic semiconductor (Ga,Mn)As to 200 K via nanostructure engineering. Nano Lett (2011) 1.20

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum Mol Genet (2013) 1.19

Detection of allelic imbalance in gene expression using pyrosequencing. Methods Mol Biol (2007) 1.19

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. BMC Med Genet (2010) 1.17

Multifunctional L1(0) -Mn(1.5)Ga films with ultrahigh coercivity, giant perpendicular magnetocrystalline anisotropy and large magnetic energy product. Adv Mater (2012) 1.16

Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab (2008) 1.15

Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab (2006) 1.15

Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis. Arthritis Rheum (2008) 1.13

Stimulation-dependent regulation of the pH, volume and quantal size of bovine and rodent secretory vesicles. J Physiol (2002) 1.12

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Diabetes (2012) 1.12

Advances in whole genome sequencing technology. Curr Pharm Biotechnol (2011) 1.12

An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. J Clin Endocrinol Metab (2011) 1.11

Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. Diabetes (2009) 1.10

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hum Mol Genet (2012) 1.09

Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture? Am J Hum Genet (2012) 1.09

Sequestration of mutated alpha1-antitrypsin into inclusion bodies is a cell-protective mechanism to maintain endoplasmic reticulum function. Mol Biol Cell (2007) 1.08

SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation. Hum Mutat (2009) 1.08

Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut (2007) 1.08

Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes (2007) 1.08

Large copy-number variations are enriched in cases with moderate to extreme obesity. Diabetes (2010) 1.07

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry. J Allergy Clin Immunol (2009) 1.06

Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers. Opt Lett (2008) 1.06

MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells. Gene (2013) 1.05

Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes (2006) 1.04

Constitutive traffic of melanocortin-4 receptor in Neuro2A cells and immortalized hypothalamic neurons. J Biol Chem (2006) 1.04