Published in Proc Natl Acad Sci U S A on December 11, 2007
Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature (2010) 3.68
Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A (2008) 1.43
Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J Immunol (2010) 1.43
HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes. J Clin Invest (2010) 1.18
Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin Immunol (2011) 1.05
The specificity of T cell regulation that enables self-nonself discrimination in the periphery. Proc Natl Acad Sci U S A (2008) 0.90
Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase. Int Immunol (2011) 0.86
Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity. Curr Opin Immunol (2010) 0.86
CD8+ regulatory T cells induced by T cell vaccination protect against autoimmune nephritis. J Am Soc Nephrol (2012) 0.86
An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. J Immunol (2011) 0.78
PFA-fixed Hsp60sp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis. Cell Mol Immunol (2013) 0.77
Comeback kids: CD8(+) suppressor T cells are back in the game. J Clin Invest (2010) 0.76
FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell (1994) 7.66
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity (2001) 4.16
T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature (1985) 3.71
Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol (2004) 3.41
T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity (2006) 3.02
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science (1992) 2.60
Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science (1992) 2.57
Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest (2006) 2.53
Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Cell (1994) 1.92
Regulation of immune responses by T cells. N Engl J Med (2006) 1.76
T cell responses to Gram-negative intracellular bacterial pathogens: a role for CD8+ T cells in immunity to Salmonella infection and the involvement of MHC class Ib molecules. J Immunol (1999) 1.72
Somatic hypermutation of immunoglobulin genes. Annu Rev Immunol (1996) 1.72
Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing V beta 8 TCR: a role of the Qa-1 molecule. Immunity (1995) 1.72
Characterization of an anti-H-2 monoclonal antibody and its use in large-scale antigen purification. J Immunol (1981) 1.70
The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1. Annu Rev Immunol (2000) 1.68
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med (2002) 1.67
DNA sequence of the mouse H-2Dd transplantation antigen gene. Proc Natl Acad Sci U S A (1985) 1.65
Negative selection during the peripheral immune response to antigen. J Exp Med (2001) 1.59
Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes. J Clin Invest (2005) 1.42
CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Natl Acad Sci U S A (2001) 1.41
Heat shock proteins can regulate expression of the Tla region-encoded class Ib molecule Qa-1. Proc Natl Acad Sci U S A (1991) 1.33
Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2003) 1.27
T cell recognition of QA-1b antigens on cells lacking a functional Tap-2 transporter. J Immunol (1992) 1.24
A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site. J Immunol (1993) 1.16
Qa-1b binds conserved class I leader peptides derived from several mammalian species. J Exp Med (1998) 1.12
Induction of TCR Vbeta-specific CD8+ CTLs by TCR Vbeta-derived peptides bound to HLA-E. J Immunol (2001) 1.11
Human CD8+ T lymphocyte clones specific for T cell receptor V beta families expressed on autologous CD4+ T cells. Immunity (1995) 1.06
A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm. J Immunol (2003) 1.00
Analysis of T cell receptors specific for recognition of class IB antigens. J Immunol (1993) 0.99
Qa-1 interaction and T cell recognition of the Qa-1 determinant modifier peptide. Eur J Immunol (1997) 0.98
An affinity/avidity model of peripheral T cell regulation. J Clin Invest (2005) 0.92
Constitutive and regulated expression of the class IB molecule Qa-1 in pancreatic beta cells. Immunology (1998) 0.89
Functional analysis of the molecular factors controlling Qa1-mediated protection of target cells from NK lysis. J Immunol (2001) 0.87
Anti-ergotypic immunoregulation. Scand J Immunol (2006) 0.86
The class I-b molecule Qa-1 forms heterodimers with H-2Ld and a novel 50-kD glycoprotein encoded centromeric to I-E beta. J Exp Med (1995) 0.78
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Global desertification: building a science for dryland development. Science (2007) 10.15
Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy. Mol Cell (2002) 4.44
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2006) 4.43
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med (2011) 4.07
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Sex differences in application, success, and funding rates for NIH extramural programs. Acad Med (2011) 3.30
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell (2012) 3.21
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet (2010) 3.02
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 2.81
Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain (2011) 2.80
Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem (2012) 2.42
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med (2007) 2.41
Dexmedetomidine versus remifentanil sedation during awake fiberoptic nasotracheal intubation: a double-blinded randomized controlled trial. J Anesth (2012) 2.40
TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell (2010) 2.33
Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet (2002) 2.27
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Proc Natl Acad Sci U S A (2013) 2.25
Interactions between atrial electrical remodeling and autonomic remodeling: how to break the vicious cycle. Heart Rhythm (2011) 2.24
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J Biol Chem (2004) 2.19
Short telomeres and prognosis of hypertension in a chinese population. Hypertension (2009) 2.18
Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease. Neurology (2013) 2.15
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron (2009) 2.03
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet (2012) 2.02
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest (2008) 2.01
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. J Clin Invest (2004) 2.00
Sex differences in career development awardees' subsequent grant attainment. Ann Intern Med (2010) 1.93
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. J Biol Chem (2005) 1.91
Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy. Am J Physiol Heart Circ Physiol (2009) 1.90
Identification of human fetal liver miRNAs by a novel method. FEBS Lett (2005) 1.88
Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst (2003) 1.86
A PARALIND decomposition-based coherent two-dimensional direction of arrival estimation algorithm for acoustic vector-sensor arrays. Sensors (Basel) (2013) 1.84
Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A (2007) 1.83
Targeted discovery of novel human exons by comparative genomics. Genome Res (2007) 1.79
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem (2007) 1.79
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med (2011) 1.78
Regulation of immune responses by T cells. N Engl J Med (2006) 1.76
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem (2006) 1.75
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71
An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest (2004) 1.69
The impacts of climate change and human activities on biogeochemical cycles on the Qinghai-Tibetan Plateau. Glob Chang Biol (2013) 1.69
Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J Am Coll Cardiol (2012) 1.64
Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. J Hepatol (2010) 1.63
Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med (2003) 1.62
Quality of life and cost for patients with premature ventricular contractions by radiofrequency catheter ablation. Pacing Clin Electrophysiol (2006) 1.62
Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease. Arch Neurol (2005) 1.59
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell (2004) 1.55
A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial. EuroIntervention (2013) 1.53
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. J Neurosci (2011) 1.53
Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo. J Surg Res (2013) 1.52
Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry (2009) 1.51
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proc Natl Acad Sci U S A (2005) 1.51
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc Natl Acad Sci U S A (2013) 1.50
Neuronal activity regulates extracellular tau in vivo. J Exp Med (2014) 1.48
Pediatric video laryngoscope versus direct laryngoscope: a meta-analysis of randomized controlled trials. Paediatr Anaesth (2014) 1.42
GPU-based Monte Carlo simulation for light propagation in complex heterogeneous tissues. Opt Express (2010) 1.42
Plaque volume compression ratio, a novel biomechanical index, is independently associated with ischemic cerebrovascular events. J Hypertens (2009) 1.41
The utilization status of aspirin for the secondary prevention of ischemic stroke. Chin Med J (Engl) (2009) 1.41
Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction. Hypertension (2010) 1.39
Activation of Rap1B by G(i) family members in platelets. J Biol Chem (2002) 1.39
Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload. Proc Natl Acad Sci U S A (2010) 1.38
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Mol Neurodegener (2014) 1.36
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother (2007) 1.34
Transparent active matrix organic light-emitting diode displays driven by nanowire transistor circuitry. Nano Lett (2007) 1.31
Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L. Hum Genet (2004) 1.30
Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord (2010) 1.30
Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing. Circ Arrhythm Electrophysiol (2008) 1.29
Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol (2010) 1.28
Group intervention for children bereaved by the suicide of a relative. J Am Acad Child Adolesc Psychiatry (2002) 1.28
Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells. Circulation (2006) 1.27
Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer. World J Surg Oncol (2011) 1.26
Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem (2012) 1.26
Dielectrophoretic separation of colorectal cancer cells. Biomicrofluidics (2010) 1.25
Methods for generating shotgun and mixed shotgun/paired-end libraries for the 454 DNA sequencer. Curr Protoc Hum Genet (2009) 1.24
Video-assisted thoracoscopic surgery lobectomy for lung cancer: the learning curve. World J Surg (2010) 1.23
Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. Blood (2010) 1.21
Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther (2008) 1.21
Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma. Oncol Rep (2007) 1.20
Low-level vagosympathetic nerve stimulation inhibits atrial fibrillation inducibility: direct evidence by neural recordings from intrinsic cardiac ganglia. J Cardiovasc Electrophysiol (2010) 1.20
HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes. J Clin Invest (2010) 1.18
Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi. Cardiovasc Res (2009) 1.18
Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem (2002) 1.17
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Mol Neurodegener (2013) 1.17
The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist (2008) 1.17
Salivary cortisol and psychopathology in children bereaved by the september 11, 2001 terror attacks. Biol Psychiatry (2006) 1.16
Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med (2005) 1.16
Historical reconstruction reveals recovery in Hawaiian coral reefs. PLoS One (2011) 1.16
Modified bacterial artificial chromosomes for zebrafish transgenesis. Methods (2006) 1.16
Disrupted small-world brain networks in moderate Alzheimer's disease: a resting-state FMRI study. PLoS One (2012) 1.15
Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res (2006) 1.15
A novel method to monitor the expression of microRNAs. Mol Biotechnol (2006) 1.15
Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. Free Radic Biol Med (2009) 1.14
Soil CO₂ flux dynamics in the two main plantation forest types in subtropical China. Sci Total Environ (2012) 1.14
Nucleotide sequence and genomic organization of a newly isolated densovirus infecting Dendrolimus punctatus. J Gen Virol (2005) 1.14
Does the kidney play an important role in the generation of ventricular arrhythmias and sudden cardiac death? Clin Res Cardiol (2014) 1.14
Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res (2007) 1.12
Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst (2005) 1.12
Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol (2003) 1.12