Published in Cell on March 02, 2012
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. Cell Stem Cell (2014) 2.44
DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell (2014) 2.18
Understanding immunosenescence to improve responses to vaccines. Nat Immunol (2013) 2.09
Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med (2014) 2.05
Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet (2014) 1.94
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun (2014) 1.72
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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol (2014) 1.41
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature (2016) 1.38
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature (2014) 1.37
Impact of genomic damage and ageing on stem cell function. Nat Cell Biol (2014) 1.33
Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood (2014) 1.32
Mechanisms of BRCA1 tumor suppression. Cancer Discov (2012) 1.32
Quality control: Genome maintenance in pluripotent stem cells. J Cell Biol (2014) 1.27
Chronic inflammation and aging: DNA damage tips the balance. Curr Opin Immunol (2012) 1.13
Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell (2015) 1.13
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer. Cell Stem Cell (2015) 1.11
Hematopoietic stem cell injury induced by ionizing radiation. Antioxid Redox Signal (2014) 1.09
Reactive oxygen species in normal and tumor stem cells. Adv Cancer Res (2014) 1.06
Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance. J Exp Med (2013) 1.06
Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell (2014) 1.04
Understanding telomere diseases through analysis of patient-derived iPS cells. Curr Opin Genet Dev (2013) 1.03
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Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance. J Biol Chem (2014) 1.00
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Leukemia and benzene. Int J Environ Res Public Health (2012) 0.93
The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint. Cell Cycle (2012) 0.92
DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT. Stem Cell Reports (2013) 0.91
BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid. J Exp Med (2013) 0.91
Notch is a direct negative regulator of the DNA-damage response. Nat Struct Mol Biol (2015) 0.90
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells. Stem Cell Reports (2014) 0.90
Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation. Proc Natl Acad Sci U S A (2014) 0.90
Concise review: hematopoietic stem cell aging, life span, and transplantation. Stem Cells Transl Med (2012) 0.89
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Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell Death Differ (2016) 0.88
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. J Exp Med (2014) 0.88
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun (2015) 0.87
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Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA? Exp Hematol (2013) 0.87
Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells. Exp Hematol (2013) 0.85
Genome instability of ageing stem cells--Induction and defence mechanisms. Ageing Res Rev (2015) 0.84
Rictor is required for early B cell development in bone marrow. PLoS One (2014) 0.84
Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Biol Open (2015) 0.83
DNA-damage-induced differentiation in hematopoietic stem cells. Cell (2012) 0.83
Aging and neoteny in the B lineage. Blood (2012) 0.81
Epigenetic regulation of hematopoietic stem cell aging. Exp Cell Res (2014) 0.81
Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. J Exp Med (2013) 0.80
Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment. PLoS One (2012) 0.80
DNA damage response, redox status and hematopoiesis. Blood Cells Mol Dis (2013) 0.80
Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Nat Cell Biol (2016) 0.80
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Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging. Ageing Res Rev (2016) 0.80
Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem Cells (2015) 0.79
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The mortal strand hypothesis: non-random chromosome inheritance and the biased segregation of damaged DNA. Semin Cell Dev Biol (2013) 0.79
SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity. Nucleic Acids Res (2014) 0.79
DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia. Int J Mol Sci (2015) 0.79
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Tumor promoting role of the DNA damage response. Cell Cycle (2014) 0.78
The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells. Stem Cell Reports (2015) 0.78
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BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell (2016) 0.77
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival. Stem Cells (2016) 0.77
Stem cells: the pursuit of genomic stability. Int J Mol Sci (2014) 0.77
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice. Blood (2014) 0.77
Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells. Cell Death Differ (2015) 0.77
Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells. Gene (2015) 0.77
Potential relationship between inadequate response to DNA damage and development of myelodysplastic syndrome. Int J Mol Sci (2015) 0.76
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Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis. Oncotarget (2016) 0.75
SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress. Oncotarget (2017) 0.75
Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical. Oxid Med Cell Longev (2017) 0.75
SNEV(hPrp19/hPso4) Regulates Adipogenesis of Human Adipose Stromal Cells. Stem Cell Reports (2016) 0.75
Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation. Cell Rep (2016) 0.75
In Vivo RNAi Screen Unveils PPARγ as a Regulator of Hematopoietic Stem Cell Homeostasis. Stem Cell Reports (2017) 0.75
Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation. Nucleic Acids Res (2016) 0.75
The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion. Leukemia (2016) 0.75
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. Cell Death Dis (2016) 0.75
Cellular senescence impact on immune cell fate and function. Aging Cell (2016) 0.75
TOPOISOMERASE1α Acts through Two Distinct Mechanisms to Regulate Stele and Columella Stem Cell Maintenance. Plant Physiol (2016) 0.75
Epigenomics of human CD8 T cell differentiation and aging. Sci Immunol (2017) 0.75
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Novel regulators in hematopoietic stem cells can be revealed by a functional approach under leukemic condition. Leukemia (2016) 0.75
Agent-Based Deterministic Modeling of the Bone Marrow Homeostasis. Adv Bioinformatics (2016) 0.75
Measuring the aging process in stem cells. Methods Mol Biol (2015) 0.75
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Muscle gets stressed? p53 represses and protects. Cell Death Differ (2015) 0.75
Accumulation of DNA damage in the aged hematopoietic stem cell compartment. Semin Hematol (2016) 0.75
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