Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.

PubWeight™: 1.78‹?› | Rank: Top 3%

🔗 View Article (PMID 18078439)

Published in Mol Microbiol on January 01, 2008

Authors

Sameera Sayeed1, Francisco A Uzal, Derek J Fisher, Juliann Saputo, Jorge E Vidal, Yue Chen, Phalguni Gupta, Julian I Rood, Bruce A McClane

Author Affiliations

1: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Articles citing this

Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev (2013) 1.91

Sporulation and enterotoxin (CPE) synthesis are controlled by the sporulation-specific sigma factors SigE and SigK in Clostridium perfringens. J Bacteriol (2009) 1.45

Contact with enterocyte-like Caco-2 cells induces rapid upregulation of toxin production by Clostridium perfringens type C isolates. Cell Microbiol (2009) 1.38

Use of an EZ-Tn5-based random mutagenesis system to identify a novel toxin regulatory locus in Clostridium perfringens strain 13. PLoS One (2009) 1.34

Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon. Infect Immun (2008) 1.32

A novel small acid soluble protein variant is important for spore resistance of most Clostridium perfringens food poisoning isolates. PLoS Pathog (2008) 1.27

The Agr-like quorum-sensing system regulates sporulation and production of enterotoxin and beta2 toxin by Clostridium perfringens type A non-food-borne human gastrointestinal disease strain F5603. Infect Immun (2011) 1.23

Genetic characterization of type A enterotoxigenic Clostridium perfringens strains. PLoS One (2009) 1.16

Characterization of virulence plasmid diversity among Clostridium perfringens type B isolates. Infect Immun (2009) 1.14

Sequencing and diversity analyses reveal extensive similarities between some epsilon-toxin-encoding plasmids and the pCPF5603 Clostridium perfringens enterotoxin plasmid. J Bacteriol (2008) 1.11

Development and application of new mouse models to study the pathogenesis of Clostridium perfringens type C Enterotoxemias. Infect Immun (2009) 1.10

Toxin plasmids of Clostridium perfringens. Microbiol Mol Biol Rev (2013) 1.07

Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease. Future Microbiol (2014) 1.07

Characterization of toxin plasmids in Clostridium perfringens type C isolates. Infect Immun (2010) 1.05

Sialidases affect the host cell adherence and epsilon toxin-induced cytotoxicity of Clostridium perfringens type D strain CN3718. PLoS Pathog (2011) 1.03

Clostridium Perfringens Toxins Involved in Mammalian Veterinary Diseases. Open Toxinology J (2010) 1.01

Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685. Mol Microbiol (2011) 1.01

Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity. Infect Immun (2008) 0.99

EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting. RNA (2009) 0.98

Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections. Vet Microbiol (2011) 0.98

Clostridium perfringens beta-toxin induces necrostatin-inhibitable, calpain-dependent necrosis in primary porcine endothelial cells. PLoS One (2013) 0.97

TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714. Infect Immun (2011) 0.95

The VirS/VirR two-component system regulates the anaerobic cytotoxicity, intestinal pathogenicity, and enterotoxemic lethality of Clostridium perfringens type C isolate CN3685. MBio (2011) 0.94

Rapid cytopathic effects of Clostridium perfringens beta-toxin on porcine endothelial cells. Infect Immun (2010) 0.94

Role of the Agr-like quorum-sensing system in regulating toxin production by Clostridium perfringens type B strains CN1793 and CN1795. Infect Immun (2012) 0.92

Epsilon-toxin production by Clostridium perfringens type D strain CN3718 is dependent upon the agr operon but not the VirS/VirR two-component regulatory system. MBio (2011) 0.92

Genotypic and phenotypic characterization of Clostridium perfringens isolates from Darmbrand cases in post-World War II Germany. Infect Immun (2012) 0.91

Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis. Mob DNA (2014) 0.91

Synergistic effects of Clostridium perfringens enterotoxin and beta toxin in rabbit small intestinal loops. Infect Immun (2014) 0.90

Organization of the cpe locus in CPE-positive clostridium perfringens type C and D isolates. PLoS One (2010) 0.89

Host cell-induced signaling causes Clostridium perfringens to upregulate production of toxins important for intestinal infections. Gut Microbes (2013) 0.87

NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens. Toxins (Basel) (2010) 0.87

The effect of Clostridium perfringens type C strain CN3685 and its isogenic beta toxin null mutant in goats. Vet Microbiol (2012) 0.86

Use of aminoglycoside 3' adenyltransferase as a selection marker for Chlamydia trachomatis intron-mutagenesis and in vivo intron stability. BMC Res Notes (2015) 0.84

The p38 MAPK and JNK pathways protect host cells against Clostridium perfringens beta-toxin. Infect Immun (2013) 0.84

Recent insights into Clostridium perfringens beta-toxin. Toxins (Basel) (2015) 0.82

Structure-function analysis of peptide signaling in the Clostridium perfringens Agr-like quorum sensing system. J Bacteriol (2015) 0.80

NanI Sialidase, CcpA, and CodY Work Together To Regulate Epsilon Toxin Production by Clostridium perfringens Type D Strain CN3718. J Bacteriol (2015) 0.80

The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis. Vet Res (2016) 0.79

Binding studies on isolated porcine small intestinal mucosa and in vitro toxicity studies reveal lack of effect of C. perfringens beta-toxin on the porcine intestinal epithelium. Toxins (Basel) (2015) 0.79

Characterization of Clostridium perfringens TpeL toxin gene carriage, production, cytotoxic contributions, and trypsin sensitivity. Infect Immun (2015) 0.79

Animal models to study the pathogenesis of human and animal Clostridium perfringens infections. Vet Microbiol (2015) 0.79

Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel) (2015) 0.79

Clostridium perfringens type C isolates rapidly upregulate their toxin production upon contact with host cells: new insights into virulence? Virulence (2010) 0.79

Clostridium perfringens type A-E toxin plasmids. Res Microbiol (2014) 0.78

The interaction of Clostridium perfringens enterotoxin with receptor claudins. Anaerobe (2016) 0.78

Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets. Toxins (Basel) (2016) 0.77

Regulation of Toxin Production in Clostridium perfringens. Toxins (Basel) (2016) 0.77

The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms. Infect Immun (2015) 0.77

Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin. Pflugers Arch (2016) 0.76

Identification and characterization of Clostridium perfringens beta toxin variants with differing trypsin sensitivity and in vitro cytotoxicity activity. Infect Immun (2015) 0.75

Articles by these authors

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Toxin B is essential for virulence of Clostridium difficile. Nature (2009) 5.49

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature (2013) 5.35

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (2013) 5.10

JMJD6 is a histone arginine demethylase. Science (2007) 3.48

Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol (2010) 2.87

Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res (2006) 2.84

The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83

Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res (2007) 2.76

Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proc Natl Acad Sci U S A (2006) 2.71

Construction and analysis of chromosomal Clostridium difficile mutants. Mol Microbiol (2006) 2.65

Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers. Am J Respir Crit Care Med (2011) 2.64

Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour. CMAJ (2007) 2.60

Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada. Environ Health Perspect (2003) 2.55

Density interactions among Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in the nasopharynx of young Peruvian children. Pediatr Infect Dis J (2013) 2.47

Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS One (2008) 2.35

Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest (2004) 2.35

NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathog (2008) 2.23

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell (2013) 2.17

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10

Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene. Mol Microbiol (2005) 2.06

An intimate collaboration between peroxisomes and lipid bodies. J Cell Biol (2006) 2.04

Construction of an alpha toxin gene knockout mutant of Clostridium perfringens type A by use of a mobile group II intron. Appl Environ Microbiol (2005) 2.01

Chronic obstructive pulmonary disease is associated with lung cancer mortality in a prospective study of never smokers. Am J Respir Crit Care Med (2007) 1.85

Clostridial enteric infections in pigs. J Vet Diagn Invest (2005) 1.83

Comparison of time series and case-crossover analyses of air pollution and hospital admission data. Int J Epidemiol (2003) 1.79

Cancer mortality among US men and women with asthma and hay fever. Am J Epidemiol (2005) 1.70

Antimicrobial susceptibility and molecular determinants of quinolone resistance in Neisseria gonorrhoeae isolates from Shanghai. J Antimicrob Chemother (2006) 1.69

HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell (2006) 1.67

Detection of enterotoxigenic Clostridium perfringens type A isolates in American retail foods. Appl Environ Microbiol (2004) 1.66

Organization of the plasmid cpe Locus in Clostridium perfringens type A isolates. Infect Immun (2002) 1.63

Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates. J Bacteriol (2006) 1.63

Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens. Infect Immun (2006) 1.62

Gender-related differences in the association between socioeconomic status and self-reported diabetes. Int J Epidemiol (2003) 1.61

Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction. Proc Natl Acad Sci U S A (2005) 1.59

The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. J Clin Invest (2003) 1.58

The influence of ambient coarse particulate matter on asthma hospitalization in children: case-crossover and time-series analyses. Environ Health Perspect (2002) 1.57

Increased risk of depression in COPD patients with higher education and income. Chron Respir Dis (2005) 1.56

Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression. J Bacteriol (2002) 1.53

Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice. Int J Nanomedicine (2010) 1.51

Revised nomenclature for transposable genetic elements. Plasmid (2008) 1.50

Epsilon-toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model. Infect Immun (2005) 1.49

Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model. Infect Immun (2006) 1.49

Effects of intracellular superoxide removal at acupoints with TAT-SOD on obesity. Free Radic Biol Med (2011) 1.46

An overview of the association between allergy and cancer. Int J Cancer (2006) 1.45

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res (2004) 1.44

Retracted catena-Poly[[[diaqua-thulium(III)]-μ-6-carboxy-nicotinato-μ-pyridine-2,5-di-carboxyl-ato] dihydrate]. Acta Crystallogr Sect E Struct Rep Online (2009) 1.44

Multiplex PCR genotyping assay that distinguishes between isolates of Clostridium perfringens type A carrying a chromosomal enterotoxin gene (cpe) locus, a plasmid cpe locus with an IS1470-like sequence, or a plasmid cpe locus with an IS1151 sequence. J Clin Microbiol (2004) 1.40

Fine particulate air pollution and all-cause mortality within the Harvard Six-Cities Study: variations in risk by period of exposure. Ann Epidemiol (2002) 1.39

Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39

Comprehensive profiling of protein lysine acetylation in Escherichia coli. J Proteome Res (2013) 1.39

Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol (2008) 1.39

Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens. J Bacteriol (2006) 1.39

Contact with enterocyte-like Caco-2 cells induces rapid upregulation of toxin production by Clostridium perfringens type C isolates. Cell Microbiol (2009) 1.38

Further comparison of temperature effects on growth and survival of Clostridium perfringens type A isolates carrying a chromosomal or plasmid-borne enterotoxin gene. Appl Environ Microbiol (2006) 1.38

The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives. Gut Microbes (2010) 1.37

Kinetics of non-structural protein 1, IgM and IgG antibodies in dengue type 1 primary infection. Virol J (2011) 1.35

Use of an EZ-Tn5-based random mutagenesis system to identify a novel toxin regulatory locus in Clostridium perfringens strain 13. PLoS One (2009) 1.34

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

A clean, more efficient method for in-solution digestion of protein mixtures without detergent or urea. J Proteome Res (2006) 1.33

Influence of bacterial interactions on pneumococcal colonization of the nasopharynx. Trends Microbiol (2012) 1.33

Perception measurement in clinical trials of schizophrenia: promising paradigms from CNTRICS. Schizophr Bull (2008) 1.32

Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets. J Clin Microbiol (2003) 1.32

Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. J Biol Chem (2007) 1.32

The alpha-toxin of Clostridium septicum is essential for virulence. Mol Microbiol (2005) 1.32

The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae. PLoS Pathog (2011) 1.32

Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon. Infect Immun (2008) 1.32

Development of a duplex PCR genotyping assay for distinguishing Clostridium perfringens type A isolates carrying chromosomal enterotoxin (cpe) genes from those carrying plasmid-borne enterotoxin (cpe) genes. J Clin Microbiol (2003) 1.31

Radon and lung cancer in the American Cancer Society cohort. Cancer Epidemiol Biomarkers Prev (2011) 1.30

Virulence plasmid diversity in Clostridium perfringens type D isolates. Infect Immun (2007) 1.30

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci (2013) 1.30

Binary toxin production in Clostridium difficile is regulated by CdtR, a LytTR family response regulator. J Bacteriol (2007) 1.29

Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection. J Virol (2011) 1.28

Revised nomenclature of Clostridium difficile toxins and associated genes. J Med Microbiol (2005) 1.28

The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile. PLoS Pathog (2011) 1.28

Subcompartmentalization of HIV-1 quasispecies between seminal cells and seminal plasma indicates their origin in distinct genital tissues. AIDS Res Hum Retroviruses (2002) 1.27

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. Mol Cell Proteomics (2007) 1.27

Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans. Clin Chim Acta (2009) 1.27

A novel small acid soluble protein variant is important for spore resistance of most Clostridium perfringens food poisoning isolates. PLoS Pathog (2008) 1.27

Association between ozone and respiratory admissions among children and the elderly in Vancouver, Canada. Inhal Toxicol (2003) 1.26

Coarse particulate matter and hospitalization for respiratory infections in children younger than 15 years in Toronto: a case-crossover analysis. Pediatrics (2005) 1.26

DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes. PLoS Pathog (2006) 1.25

Gaseous air pollutants and asthma hospitalization of children with low household income in Vancouver, British Columbia, Canada. Am J Epidemiol (2004) 1.25

Identification and verification of lysine propionylation and butyrylation in yeast core histones using PTMap software. J Proteome Res (2009) 1.25

Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nat Biotechnol (2007) 1.25

Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorporation. J Virol (2003) 1.24