Published in Oncogene on December 17, 2007
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data. Biostatistics (2009) 4.31
Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer (2013) 2.02
Estimation of rearrangement phylogeny for cancer genomes. Genome Res (2011) 1.91
Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J (2012) 1.85
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J (2010) 1.36
Large duplications at reciprocal translocation breakpoints that might be the counterpart of large deletions and could arise from stalled replication bubbles. Genome Res (2011) 1.30
Characterising chromosome rearrangements: recent technical advances in molecular cytogenetics. Heredity (Edinb) (2011) 1.02
High-resolution array CGH clarifies events occurring on 8p in carcinogenesis. BMC Cancer (2008) 0.98
Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat (2011) 0.87
Array painting: a protocol for the rapid analysis of aberrant chromosomes using DNA microarrays. Nat Protoc (2009) 0.86
Are breast cancers driven by fusion genes? Breast Cancer Res (2012) 0.84
The relative timing of mutations in a breast cancer genome. PLoS One (2013) 0.84
Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes. BMC Genomics (2012) 0.83
Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control. Genes Cancer (2012) 0.82
RVD2: an ultra-sensitive variant detection model for low-depth heterogeneous next-generation sequencing data. Bioinformatics (2015) 0.82
Cancer gene discovery in mouse and man. Biochim Biophys Acta (2009) 0.81
Laser excitation power and the flow cytometric resolution of complex karyotypes. Cytometry A (2010) 0.79
Single-molecule analysis of genome rearrangements in cancer. Nucleic Acids Res (2011) 0.78
Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment. Int J Mol Sci (2016) 0.77
Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors. BMC Cancer (2012) 0.77
Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing. BMC Genomics (2013) 0.77
High-throughput analysis of chromosome translocations and other genome rearrangements in epithelial cancers. Genome Med (2010) 0.75
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science (2005) 39.06
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature (2007) 37.09
Cancer genes and the pathways they control. Nat Med (2004) 24.22
The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57
End-sequence profiling: sequence-based analysis of aberrant genomes. Proc Natl Acad Sci U S A (2003) 7.70
Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet (2004) 5.75
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat Genet (2004) 5.47
Forkhead transcription factors: key players in development and metabolism. Dev Biol (2002) 4.74
DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer (2003) 4.68
The cells and logic for mammalian sour taste detection. Nature (2006) 4.65
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
The critical role of chromosome translocations in human leukemias. Annu Rev Genet (1998) 3.49
Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res (2003) 3.42
Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. Mod Pathol (2007) 3.37
A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. In Vitro Cell Dev Biol (1987) 3.14
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer. Int J Cancer (1998) 3.12
Mutations truncating the EP300 acetylase in human cancers. Nat Genet (2000) 2.84
Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping. Cancer Genet Cytogenet (2005) 2.70
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev (2004) 2.33
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nat Genet (2007) 2.14
Recurrent chromosome aberrations in cancer. Mutat Res (2000) 2.09
Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. Genes Chromosomes Cancer (2002) 2.04
A set of BAC clones spanning the human genome. Nucleic Acids Res (2004) 2.00
Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Res (1978) 1.97
The complex nature of constitutional de novo apparently balanced translocations in patients presenting with abnormal phenotypes. J Med Genet (2005) 1.94
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A (2001) 1.85
The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci U S A (2005) 1.80
Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). Blood (1997) 1.63
Array painting: a method for the rapid analysis of aberrant chromosomes using DNA microarrays. J Med Genet (2003) 1.61
Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases. Proc Natl Acad Sci U S A (2004) 1.59
Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia. Blood (2000) 1.58
Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders. Genes Chromosomes Cancer (2005) 1.57
High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation. Oncogene (2006) 1.46
A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. Hum Genet (2002) 1.41
Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH. Oncogene (2006) 1.40
Polycystins: polymodal receptor/ion-channel cellular sensors. Pflugers Arch (2005) 1.37
Molecular cytogenetic analysis of breast cancer cell lines. Br J Cancer (2000) 1.36
Factors affecting flow karyotype resolution. Cytometry A (2006) 1.33
Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis. Genes Chromosomes Cancer (2005) 1.31
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). Genes Chromosomes Cancer (2000) 1.30
Ultra-high resolution array painting facilitates breakpoint sequencing. J Med Genet (2006) 1.25
Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines. Cancer Genet Cytogenet (2006) 1.08
A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene. Cancer Res (2004) 1.07
Chromosomal aberrations in breast cancer: a comparison between cytogenetics and comparative genomic hybridization. Genes Chromosomes Cancer (1999) 1.07
Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res (2007) 1.07
Pathways of chromosome alteration in human epithelial cancers. Adv Cancer Res (1995) 1.02
The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Genomics (2002) 0.95
Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. Int J Cancer (2001) 0.94
Cytogenetic analysis of three breast carcinoma cell lines using reverse chromosome painting. Genes Chromosomes Cancer (1997) 0.93
gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line. Oncogene (1999) 0.91
Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells. Int J Cancer (1997) 0.88
Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation. Oncogene (1999) 0.86
Spectral karyotyping and chromosome banding studies of primary breast carcinomas and their lymph node metastases. Int J Mol Med (2000) 0.85
Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. Genomics (1992) 9.06
The DNA sequence and comparative analysis of human chromosome 20. Nature (2002) 7.40
Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features. J Med Genet (2004) 5.76
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci U S A (1992) 5.53
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Array-based comparative genomic hybridisation identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders. J Med Genet (2006) 4.64
Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells. Cell (1984) 3.97
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci U S A (1990) 3.70
Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol (1994) 3.66
Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res (1991) 3.16
Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes. Genes Chromosomes Cancer (1992) 3.03
An SNP map of human chromosome 22. Nature (2000) 2.99
Experimental investigation of geologically produced antineutrinos with KamLAND. Nature (2005) 2.75
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res (1993) 2.65
Array-CGH detection of micro rearrangements in mentally retarded individuals: clinical significance of imbalances present both in affected children and normal parents. J Med Genet (2005) 2.60
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
Clonal genomic alterations in glioma malignancy stages. Cancer Res (1988) 2.39
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res (1994) 2.28
Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet (1994) 2.28
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene (2009) 2.26
Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci U S A (1989) 2.14
Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene (1996) 2.13
Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res (1992) 2.01
The complex nature of constitutional de novo apparently balanced translocations in patients presenting with abnormal phenotypes. J Med Genet (2005) 1.94
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet (1994) 1.81
A comparative study of karyotypes of muntjacs by chromosome painting. Chromosoma (1995) 1.81
Evaluation of the effect of diagnostic methodology on the reported incidence of ventilator-associated pneumonia. Thorax (2009) 1.81
Environmental stress response in plants: the role of mitogen-activated protein kinases. Trends Biotechnol (1997) 1.78
Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression. Proc Natl Acad Sci U S A (1997) 1.76
Global amplification of mRNA by template-switching PCR: linearity and application to microarray analysis. Nucleic Acids Res (2003) 1.76
CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines. Cancer Res (1994) 1.76
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q. Cancer Res (1998) 1.75
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res (2000) 1.74
The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. Nature (2001) 1.63
Prenatal detection of unbalanced chromosomal rearrangements by array CGH. J Med Genet (2005) 1.63
Array painting: a method for the rapid analysis of aberrant chromosomes using DNA microarrays. J Med Genet (2003) 1.61
Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma. Genes Chromosomes Cancer (1991) 1.61
Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification. Oncogene (1994) 1.58
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res (1994) 1.51
Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. Cancer Res (1996) 1.50
Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas. Brain Pathol (1999) 1.48
Measurement of neutrino oscillation with KamLAND: evidence of spectral distortion. Phys Rev Lett (2005) 1.46
High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation. Oncogene (2006) 1.46
Increased incidence of follicular lymphoma in the duodenum. Am J Surg Pathol (2000) 1.42
The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Mol Cell Biol (2005) 1.40
Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH. Oncogene (2006) 1.40
The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res (1999) 1.39
A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma. Leukemia (2009) 1.38
Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6. Plant Physiol (2001) 1.38
MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines. Oncogene (1999) 1.35
Formation and growth of multicellular spheroids of human origin. Int J Cancer (1983) 1.35
Reciprocal chromosome painting reveals detailed regions of conserved synteny between the karyotypes of the domestic dog (Canis familiaris) and human. Genomics (1999) 1.34
The DNA sequence and analysis of human chromosome 13. Nature (2004) 1.33
Identification of a possible MAP kinase cascade in Arabidopsis thaliana based on pairwise yeast two-hybrid analysis and functional complementation tests of yeast mutants. FEBS Lett (1998) 1.30
Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci U S A (1987) 1.30
Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2. Hum Mol Genet (1994) 1.29
Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ (2000) 1.29
Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. Genes Chromosomes Cancer (1998) 1.29
A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands. J Pathol (2009) 1.29
Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase. Plant Cell Physiol (2001) 1.27
Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. Am J Pathol (2001) 1.27
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts. J Neuropathol Exp Neurol (1999) 1.27
The response of neurons and microglia to blast injury in the rat brain. Neuropathol Appl Neurobiol (1995) 1.26
CD3- leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56++ population. Dev Immunol (1991) 1.26
Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors. Cancer Res (1991) 1.25
Ultra-high resolution array painting facilitates breakpoint sequencing. J Med Genet (2006) 1.25
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin. Br J Cancer (2012) 1.25
Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours. Oncogene (1997) 1.23
A YAC-based physical map of the mouse genome. Nat Genet (1999) 1.22
DNA sequence and analysis of human chromosome 9. Nature (2004) 1.21
Expression profiling of single cells using 3 prime end amplification (TPEA) PCR. Nucleic Acids Res (1998) 1.20
Deletion mapping in human renal cell carcinoma. Cancer Res (1989) 1.17
Inability of dendritic cells to prevent the blood transfusion effect in a mouse cardiac allograft model. Transplantation (1987) 1.17
Allelotyping of human prostatic adenocarcinoma. Genomics (1991) 1.16
Analysis of pilocytic astrocytoma by comparative genomic hybridization. Br J Cancer (2000) 1.16
The DNA sequence and comparative analysis of human chromosome 10. Nature (2004) 1.14
Molecular genetic analysis of chromosome 22 in 81 cases of meningioma. Cancer Res (1990) 1.13
Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Hum Genet (1993) 1.13
Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma. Cancer (1999) 1.13
Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss. Brain Res (2001) 1.12
The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene. Oncogene (2009) 1.12
1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas. Oncogene (2007) 1.12
NIPBL mutations and genetic heterogeneity in Cornelia de Lange syndrome. J Med Genet (2004) 1.11
Prenatal diagnosis by array-CGH. Eur J Med Genet (2005) 1.11
Multiple self-healing squamous epitheliomata (ESS1) mapped to chromosome 9q22-q31 in families with common ancestry. Nat Genet (1993) 1.10
Tetrasomy 15q: two marker chromosomes with no detectable alpha-satellite DNA. Am J Hum Genet (1994) 1.09