Published in Pflugers Arch on May 12, 2005
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Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes. Oncogene (2007) 2.91
TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol (2006) 1.90
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
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The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades. Pflugers Arch (2008) 1.46
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TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch (2008) 1.24
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3. Br J Pharmacol (2011) 1.18
Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells. Kidney Blood Press Res (2008) 1.13
Polycystins and renovascular mechanosensory transduction. Nat Rev Nephrol (2010) 1.13
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A polycystin-1 controls postcopulatory reproductive selection in mice. Proc Natl Acad Sci U S A (2008) 1.08
STAM and Hrs down-regulate ciliary TRP receptors. Mol Biol Cell (2007) 1.07
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Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol (2008) 1.06
Ciliar functions in the nephron. Pflugers Arch (2009) 0.99
Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol (2008) 0.99
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Flow modulates centriole movements in tubular epithelial cells. Pflugers Arch (2008) 0.91
Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell (2010) 0.90
Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci (2011) 0.88
Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. J Cardiovasc Pharmacol (2009) 0.81
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet (2003) 13.33
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
Molecular basis of mechanotransduction in living cells. Physiol Rev (2001) 5.78
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell (2000) 5.73
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol (2002) 5.58
Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol (2001) 5.42
Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell (2003) 4.73
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature (2004) 4.50
Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol (2002) 4.37
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature (2001) 4.28
TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol (2005) 3.92
Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell (1998) 3.84
Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat Med (2003) 3.78
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature (1999) 3.74
Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol (2002) 3.55
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med (2004) 3.09
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell (2002) 3.09
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Identification and characterization of polycystin-2, the PKD2 gene product. J Biol Chem (1999) 2.74
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci U S A (2001) 2.62
Removal of the MDCK cell primary cilium abolishes flow sensing. J Membr Biol (2003) 2.46
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The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem (1999) 2.37
The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol (2002) 2.36
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int (2003) 2.32
Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci U S A (2002) 2.29
The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol (2001) 2.27
Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J Biol Chem (2004) 2.26
Cell adhesion system and human cancer morphogenesis. Cancer Sci (2003) 2.18
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature (1999) 2.17
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J (2005) 2.12
Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci U S A (1999) 2.09
The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens (2003) 1.80
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol (2003) 1.67
Genetic models of mechanotransduction: the nematode Caenorhabditis elegans. Physiol Rev (2004) 1.66
The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. J Cell Biol (1996) 1.61
Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. J Biol Chem (2004) 1.60
Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins. J Biol Chem (2002) 1.58
Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J Biol Chem (2002) 1.57
A flagellar polycystin-2 homolog required for male fertility in Drosophila. Curr Biol (2003) 1.56
Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology. J Lab Clin Med (2003) 1.56
Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J Biol Chem (2002) 1.56
The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro. Biochem Biophys Res Commun (1998) 1.55
Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. Biochem Biophys Res Commun (2001) 1.48
Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res (2004) 1.43
Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J (2004) 1.43
Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest (1999) 1.41
Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J Am Soc Nephrol (2000) 1.41
A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells. Mol Biol Cell (2004) 1.39
Polycystic kidney disease--the ciliary connection. Lancet (2003) 1.37
The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proc Natl Acad Sci U S A (2000) 1.36
LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors. Trends Biochem Sci (2000) 1.34
Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway. J Biol Chem (2004) 1.26
Polycystins: from mechanosensation to gene regulation. Cell (2004) 1.25
PKD2 cation channel is required for directional sperm movement and male fertility. Curr Biol (2003) 1.23
Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells. Hum Mol Genet (2000) 1.20
New TRP channels in hearing and mechanosensation. Neuron (2003) 1.20
Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. Mol Genet Metab (2000) 1.17
Polycystins, calcium signaling, and human diseases. Biochem Biophys Res Commun (2004) 1.14
Polycystin-1 activates and stabilizes the polycystin-2 channel. J Biol Chem (2002) 1.12
Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. Genomics (2003) 1.09
Interaction between RGS7 and polycystin. Proc Natl Acad Sci U S A (1999) 1.09
Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells. Kidney Int (2001) 1.08
Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun (2001) 1.06
Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa. Mol Reprod Dev (2004) 1.05
Polycystin-1L2 is a novel G-protein-binding protein. Genomics (2004) 1.04
Polycystin-2 associates with tropomyosin-1, an actin microfilament component. J Mol Biol (2003) 1.04
Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells. Am J Physiol Renal Physiol (2004) 1.02
Autosomal dominant polycystic kidney disease. Nefrologia (2003) 1.02
Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected. J Biol Chem (2004) 1.00
Polycystin-1 interacts with intermediate filaments. J Biol Chem (2001) 0.97
The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. FEBS Lett (2002) 0.94
New insights into ciliary function: kidney cysts and photoreceptors. Proc Natl Acad Sci U S A (2003) 0.84
Assembly and gating of TRPC channels in signalling microdomains. Novartis Found Symp (2004) 0.81
High molecular mass egg fucose sulfate polymer is required for opening both Ca2+ channels involved in triggering the sea urchin sperm acrosome reaction. J Biol Chem (2001) 0.80
Altered distribution and co-localization of polycystin-2 with polycystin-1 in MDCK cells after wounding stress. Exp Cell Res (2004) 0.79
suREJ proteins: new signalling molecules in sea urchin spermatozoa. Zygote (2000) 0.79