Published in Traffic on December 11, 2007
Lipid droplets finally get a little R-E-S-P-E-C-T. Cell (2009) 4.58
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Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell (2013) 2.39
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Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum. J Biol Chem (2011) 1.30
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Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife (2014) 1.23
Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice. J Lipid Res (2010) 1.20
Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogens. PLoS One (2010) 1.19
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Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation. J Biol Chem (2010) 1.13
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. J Cell Biol (2013) 1.11
Evidence that diacylglycerol acyltransferase 1 (DGAT1) has dual membrane topology in the endoplasmic reticulum of HepG2 cells. J Biol Chem (2011) 1.10
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. J Lipid Res (2009) 1.09
Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression. Mol Biol Cell (2010) 1.09
The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics. Biol Cell (2011) 1.07
Quantitative electron microscopy shows uniform incorporation of triglycerides into existing lipid droplets. Histochem Cell Biol (2009) 1.04
The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Mol Cell Biol (2009) 1.03
Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J Biol Chem (2011) 1.03
Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem (2011) 1.00
Emerging role of lipid droplets in host/pathogen interactions. J Biol Chem (2011) 1.00
Structure-function analysis of diacylglycerol acyltransferase sequences from 70 organisms. BMC Res Notes (2011) 0.99
Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles. PLoS Pathog (2013) 0.98
Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes. Mol Biol Cell (2012) 0.98
Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology. Mol Biol Cell (2014) 0.97
Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin. J Biol Chem (2010) 0.96
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity. PLoS One (2011) 0.94
Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. PLoS One (2012) 0.93
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Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes. Am J Physiol Endocrinol Metab (2010) 0.91
The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography. PLoS One (2013) 0.91
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Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell (2015) 0.90
The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix. Elife (2015) 0.88
Expression of tung tree diacylglycerol acyltransferase 1 in E. coli. BMC Biotechnol (2011) 0.86
The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage. J Cell Sci (2013) 0.86
Dietary restriction during development enlarges intestinal and hypodermal lipid droplets in Caenorhabditis elegans. PLoS One (2012) 0.86
An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Cell Rep (2013) 0.85
High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. J Lipid Res (2014) 0.85
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Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity. J Lipid Res (2014) 0.84
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. PLoS One (2015) 0.83
Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes. J Physiol (2009) 0.83
Unraveling the complexity of lipid body organelles in human eosinophils. J Leukoc Biol (2014) 0.82
Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation. PLoS One (2013) 0.82
Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism. J Lipid Res (2014) 0.82
Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions. Lipid Insights (2014) 0.81
Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation. Biosci Rep (2013) 0.81
Rab GTPases associate with isolated lipid droplets (LDs) and show altered content after ethanol administration: potential role in alcohol-impaired LD metabolism. Alcohol Clin Exp Res (2013) 0.81
Reorganization of cellular retinol-binding protein type 1 and lecithin:retinol acyltransferase during retinyl ester biosynthesis. Biochim Biophys Acta (2012) 0.81
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Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus. J Biol Chem (2014) 0.81
Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion. PLoS One (2013) 0.80
Long-term live cell microscopy studies of lipid droplet fusion dynamics in adipocytes. J Lipid Res (2013) 0.80
A Lys49 phospholipase A2, isolated from Bothrops asper snake venom, induces lipid droplet formation in macrophages which depends on distinct signaling pathways and the C-terminal region. Biomed Res Int (2012) 0.80
Bovine dedifferentiated adipose tissue (DFAT) cells: DFAT cell isolation. Adipocyte (2013) 0.80
DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling. Cell Mol Life Sci (2015) 0.80
Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis. J Biol Chem (2014) 0.80
Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J (2016) 0.79
Dictyostelium lipid droplets host novel proteins. Eukaryot Cell (2013) 0.79
Dynamics of the lipid droplet proteome of the Oleaginous yeast rhodosporidium toruloides. Eukaryot Cell (2015) 0.79
Overexpression of full-length cholesteryl ester transfer protein in SW872 cells reduces lipid accumulation. J Lipid Res (2015) 0.78
Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage. BMC Cell Biol (2014) 0.78
Spatiotemporal dynamics of triglyceride storage in unilocular adipocytes. Mol Biol Cell (2014) 0.78
Lipotubuloids in ovary epidermis of Ornithogalum umbellatum act as metabolons: suggestion of the name 'lipotubuloid metabolon'. J Exp Bot (2014) 0.78
GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions. J Cell Sci (2014) 0.77
Lipidome analysis of rotavirus-infected cells confirms the close interaction of lipid droplets with viroplasms. J Gen Virol (2013) 0.77
Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond) (2016) 0.76
Cell-autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques. Endocrinology (2015) 0.76
Identification of the Relationship between Oil Body Morphology and Oil Content by Microstructure Comparison Combining with QTL Analysis in Brassica napus. Front Plant Sci (2017) 0.76
Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function. Mol Biol Cell (2014) 0.76
Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storage. Biochim Biophys Acta (2013) 0.76
Dictyostelium discoideum Dgat2 can substitute for the essential function of Dgat1 in triglyceride production but not in ether lipid synthesis. Eukaryot Cell (2014) 0.76
Protein kinase Cη is targeted to lipid droplets. Histochem Cell Biol (2013) 0.76
Diacylglycerol acyltransferase 2 (DGAT2) links glucose utilization to fatty acid oxidation in the brown adipocytes. J Lipid Res (2016) 0.75
Defective triglyceride biosynthesis in CETP-deficient SW872 cells. J Lipid Res (2015) 0.75
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol (2003) 4.71
Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature (2005) 4.38
Automated identification and quantification of glycerophospholipid molecular species by multiple precursor ion scanning. Anal Chem (2006) 3.01
Polyene-lipids: a new tool to image lipids. Nat Methods (2004) 2.30
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells. Nat Methods (2005) 2.24
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
A physical and functional link between cholesterol and tetraspanins. Eur J Immunol (2003) 1.54
Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: a role for caveolar endocytosis. Traffic (2006) 1.48
Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature (2012) 1.42
Live cell multicolor imaging of lipid droplets with a new dye, LD540. Traffic (2009) 1.36
Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. PLoS Biol (2004) 1.34
Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. J Biol Chem (2011) 1.27
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Biochem J (2007) 1.20
The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake. J Lipid Res (2012) 1.16
StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein. J Biol Chem (2005) 1.15
Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles--a role of the endocytic-exocytic pathway. EMBO Mol Med (2011) 1.12
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. J Lipid Res (2009) 1.09
Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region. J Biol Chem (2010) 1.09
Protein networks supporting AP-3 function in targeting lysosomal membrane proteins. Mol Biol Cell (2008) 1.09
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia. J Neurosci (2006) 1.05
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med (Berl) (2009) 1.02
Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine. Cell Tissue Res (2006) 0.99
Phospholipids and lipid droplets. Biochim Biophys Acta (2012) 0.99
Protein-sphingolipid interactions within cellular membranes. J Lipid Res (2007) 0.96
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci U S A (2009) 0.95
A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization. J Lipid Res (2013) 0.93
Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol. FEBS Lett (2009) 0.93
Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering. J Biol Chem (2012) 0.93
Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludin. Exp Cell Res (2007) 0.91
Functional characterization of the MENTAL domain. J Biol Chem (2005) 0.91
Systematic screening for novel lipids by shotgun lipidomics. Anal Chem (2014) 0.88
Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays. J Lipid Res (2013) 0.87
Aberrant receptor-mediated endocytosis of Schistosoma mansoni glycoproteins on host lipoproteins. PLoS Med (2006) 0.84
Monotopic topology is required for lipid droplet targeting of ancient ubiquitous protein 1. J Lipid Res (2012) 0.84
siRNA screening reveals JNK2 as an evolutionary conserved regulator of triglyceride homeostasis. J Lipid Res (2008) 0.84
Exogenous ether lipids predominantly target mitochondria. PLoS One (2012) 0.81
Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis. Biometals (2015) 0.80
Monoubiquitination of ancient ubiquitous protein 1 promotes lipid droplet clustering. PLoS One (2013) 0.80
GLTP mediated non-vesicular GM1 transport between native membranes. PLoS One (2013) 0.76
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Mutual recognition of sphingolipid molecular species in membranes. Biochim Biophys Acta (2012) 0.75