Published in J Lipid Res on September 15, 2011
Peroxisomes: a nexus for lipid metabolism and cellular signaling. Cell Metab (2014) 1.18
Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet (2013) 1.11
Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochim Biophys Acta (2013) 0.99
Lysosome: regulator of lipid degradation pathways. Trends Cell Biol (2014) 0.99
Biodiesel versus diesel exposure: enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung. Toxicol Appl Pharmacol (2013) 0.89
Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases. PLoS One (2013) 0.88
Bioanalysis of eukaryotic organelles. Chem Rev (2013) 0.86
Lipid accumulation during the establishment of kleptoplasty in Elysia chlorotica. PLoS One (2014) 0.85
Quantitative dynamics of adipose cells. Adipocyte (2012) 0.81
Plant natural products as an anti-lipid droplets accumulation agent. J Nat Med (2014) 0.80
As the fat flies: The dynamic lipid droplets of Drosophila embryos. Biochim Biophys Acta (2015) 0.79
Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations. Free Radic Biol Med (2014) 0.78
Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction. Mol Cell Biol (2014) 0.78
Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets. Cell Death Discov (2017) 0.75
Lipopolysaccharide challenge significantly influences lipid metabolism and proteome of white adipose tissue in growing pigs. Lipids Health Dis (2015) 0.75
Waist Gain Is Associated with a Higher Incidence of Nonalcoholic Fatty Liver Disease in Korean Adults: A Cohort Study. PLoS One (2016) 0.75
Stress-responsive HILPDA is necessary for thermoregulation during fasting. J Endocrinol (2017) 0.75
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature (2003) 7.80
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res (2007) 6.03
The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res (2001) 5.00
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature (2008) 4.70
Lipid droplets finally get a little R-E-S-P-E-C-T. Cell (2009) 4.58
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med (2011) 3.96
The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr Biol (2006) 3.93
Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem (1991) 3.93
Adipose triglyceride lipase contributes to cancer-associated cachexia. Science (2011) 3.70
The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet (2006) 3.17
The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest (2011) 3.12
The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci U S A (2007) 3.11
Lipid droplets in lipogenesis and lipolysis. Endocrinology (2008) 3.02
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol (2008) 2.85
Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res (2007) 2.76
The life of lipid droplets. Biochim Biophys Acta (2008) 2.75
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab (2010) 2.58
Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog (2009) 2.52
Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic (2007) 2.49
Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein. J Biol Chem (2001) 2.49
COPI complex is a regulator of lipid homeostasis. PLoS Biol (2008) 2.47
Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics (2006) 2.23
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab (2009) 2.19
Proteins under new management: lipid droplets deliver. Trends Cell Biol (2007) 2.12
The gregarious lipid droplet. J Biol Chem (2008) 2.10
Not just fat: the structure and function of the lipid droplet. Cold Spring Harb Perspect Biol (2011) 2.07
SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds. Plant Cell (2006) 1.96
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem (2008) 1.94
Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta (2008) 1.89
Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med (2009) 1.80
Perilipin A and the control of triacylglycerol metabolism. Mol Cell Biochem (2008) 1.80
Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. Mol Biol Cell (2006) 1.67
Perilipin deficiency and autosomal dominant partial lipodystrophy. N Engl J Med (2011) 1.61
Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells. Electrophoresis (2000) 1.55
Demonstrated and inferred metabolism associated with cytosolic lipid droplets. J Lipid Res (2009) 1.43
Lipid droplets: size matters. J Electron Microsc (Tokyo) (2011) 1.35
New insights into Chlamydia intracellular survival mechanisms. Cell Microbiol (2009) 1.34
Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. J Immunol (1983) 1.33
Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab (2011) 1.27
Fat on the move: intracellular motion of lipid droplets. Biochem Soc Trans (2009) 1.21
Lipid bodies in inflammatory cells: structure, function, and current imaging techniques. J Histochem Cytochem (2011) 1.17
Intracellular origin and secretion of milk fat globules. Eur J Cell Biol (2005) 1.13
The contribution of the Drosophila model to lipid droplet research. Prog Lipid Res (2011) 1.07
Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase. Biochem J (1999) 1.06
Expanding roles for lipid droplets. Trends Endocrinol Metab (2011) 0.80
Lipin, a lipodystrophy and obesity gene. Cell Metab (2005) 3.16
Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem (2006) 3.02
Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A (2004) 2.89
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem (2006) 2.89
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet (2007) 2.60
Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem (2005) 2.42
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A (2004) 2.39
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J (2011) 2.36
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab (2007) 2.32
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J Biol Chem (2004) 2.25
Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A (2011) 2.13
The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet (2012) 2.02
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell (2011) 1.86
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. Am J Physiol Endocrinol Metab (2009) 1.85
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res (2006) 1.68
Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res (2006) 1.62
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol (2013) 1.61
Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metab (2009) 1.56
Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem (2003) 1.51
Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes (2006) 1.48
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes (2009) 1.46
Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice. J Lipid Res (2008) 1.44
Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome (2012) 1.43
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. J Biol Chem (2009) 1.40
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. J Lipid Res (2008) 1.39
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases. Biochim Biophys Acta (2009) 1.38
NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol (2010) 1.32
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. J Lipid Res (2008) 1.29
Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum Mol Genet (2005) 1.25
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically. J Lipid Res (2008) 1.25
Lipins: multifunctional lipid metabolism proteins. Annu Rev Nutr (2010) 1.24
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab (2013) 1.22
Cell nuclei spin in the absence of lamin b1. J Biol Chem (2007) 1.22
Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. J Clin Endocrinol Metab (2007) 1.21
Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxid Redox Signal (2010) 1.21
Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes (2006) 1.19
Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. J Biol Chem (2009) 1.19
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem (2011) 1.17
ABCC6 localizes to the mitochondria-associated membrane. Circ Res (2012) 1.14
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res (2013) 1.12
Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. J Biol Chem (2010) 1.11
Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis. J Biol Chem (2011) 1.11
Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Hum Mol Genet (2009) 1.09
GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res (2011) 1.08
Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol (2012) 1.08
A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res (2002) 1.08
HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes (2013) 1.07
Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res (2013) 1.06
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab (2013) 1.03
Metabolic impact of sex chromosomes. Adipocyte (2013) 1.00
Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol (2011) 0.99
Metabolic differences in breast cancer stem cells and differentiated progeny. Breast Cancer Res Treat (2014) 0.98
X and Y chromosome complement influence adiposity and metabolism in mice. Endocrinology (2013) 0.98
Cell-autonomous sex determination outside of the gonad. Dev Dyn (2013) 0.97
Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol (2010) 0.93
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc Natl Acad Sci U S A (2012) 0.92
Biphasic expression of lipin suggests dual roles in adipocyte development. Drug News Perspect (2005) 0.92
PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab (2013) 0.90
The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. J Biol Chem (2001) 0.89
Ulcerative dermatitis in C57BL/6 mice exhibits an oxidative stress response consistent with normal wound healing. Comp Med (2012) 0.89
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res (2012) 0.88
Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res (2014) 0.83
Response to Pomozi et al's research commentary. Circ Res (2013) 0.79
Hoofbeats, zebras, and insights into insulin resistance. J Clin Invest (2009) 0.79
RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. J Clin Invest (2017) 0.75
Lipin-1 flexes its muscle in autophagy. Cell Cycle (2014) 0.75
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J (2016) 0.75
Women in Metabolism: Part 3. Cell Metab (2015) 0.75