Published in J Biol Chem on September 11, 2009
Lipid droplets and cellular lipid metabolism. Annu Rev Biochem (2012) 4.02
Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. J Lipid Res (2011) 1.79
Packaging of fat: an evolving model of lipid droplet assembly and expansion. J Biol Chem (2011) 1.73
The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J Cell Biol (2011) 1.51
PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization. Blood (2010) 1.46
Perilipin 5-Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21. Diabetes (2015) 1.45
Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. J Cell Biol (2014) 1.45
Biogenesis and functions of lipid droplets in plants: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man. J Lipid Res (2011) 1.38
Dual function lipin proteins and glycerolipid metabolism. Trends Endocrinol Metab (2011) 1.36
Lipid droplet biogenesis. Curr Opin Cell Biol (2014) 1.35
The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol (2012) 1.31
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem (2011) 1.17
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. J Cell Biol (2013) 1.11
Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation. Proc Natl Acad Sci U S A (2011) 1.11
Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression. Mol Biol Cell (2010) 1.09
Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection. Biochimie (2013) 1.06
The life cycle of lipid droplets. Curr Opin Cell Biol (2015) 1.00
Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology. Mol Biol Cell (2014) 0.97
The lipid droplet-a well-connected organelle. Front Cell Dev Biol (2015) 0.96
Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization. Curr Opin Lipidol (2014) 0.96
Distinct cellular pools of perilipin 5 point to roles in lipid trafficking. Biochim Biophys Acta (2011) 0.91
Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte (2013) 0.90
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab (2013) 0.89
A conserved family of proteins facilitates nascent lipid droplet budding from the ER. J Cell Biol (2015) 0.88
Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue. Neurogenetics (2014) 0.83
High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins. Am J Physiol Endocrinol Metab (2011) 0.82
Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in lipid homeostasis. Eukaryot Cell (2011) 0.82
Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions. Lipid Insights (2014) 0.81
Imaging of neutral lipids and neutral lipid associated proteins. Methods Cell Biol (2013) 0.81
A single centrifugation method for isolating fat droplets from cells and tissues. J Lipid Res (2012) 0.80
Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun (2016) 0.78
Surface features of the lipid droplet mediate perilipin 2 localization. Biochem Biophys Res Commun (2014) 0.78
Higher PLIN5 but not PLIN3 content in isolated skeletal muscle mitochondria following acute in vivo contraction in rat hindlimb. Physiol Rep (2014) 0.77
Protein kinase Cη is targeted to lipid droplets. Histochem Cell Biol (2013) 0.76
Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly. J Cell Biol (2017) 0.76
Perilipins: a diversity of intracellular lipid droplet proteins. Lipids Health Dis (2017) 0.75
Adipose tissue depot specific differences of PLIN protein content in endurance trained rats. Adipocyte (2016) 0.75
The Lipid Droplet Associated Protein Perilipin 3 facilitates hepatitis C Virus-Driven Hepatic Steatosis. J Lipid Res (2016) 0.75
Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. Sci Rep (2017) 0.75
The collaborative work of droplet assembly. Biochim Biophys Acta (2017) 0.75
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. Biochem Biophys Res Commun (1986) 7.96
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res (2007) 6.03
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem (2004) 4.89
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature (2008) 4.70
Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem (2003) 3.90
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci U S A (1982) 3.73
A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett (2006) 3.25
Coat proteins: shaping membrane transport. Nat Rev Mol Cell Biol (2003) 3.10
Mechanisms of lipid-body formation. Trends Biochem Sci (1999) 2.96
Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum. Plant Cell (2006) 2.81
OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes (2006) 2.77
Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res (1995) 2.53
Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic (2007) 2.49
Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem (2002) 2.49
COPI complex is a regulator of lipid homeostasis. PLoS Biol (2008) 2.47
S3-12, Adipophilin, and TIP47 package lipid in adipocytes. J Biol Chem (2005) 2.46
Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics (2006) 2.23
Arf family GTP loading is activated by, and generates, positive membrane curvature. Biochem J (2008) 2.20
TIP47 associates with lipid droplets. J Biol Chem (2000) 2.13
Coatomer-dependent protein delivery to lipid droplets. J Cell Sci (2009) 2.01
C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochim Biophys Acta (2006) 1.98
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem (2008) 1.94
Diacylglycerol, when simplicity becomes complex. Trends Biochem Sci (2006) 1.86
Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. Traffic (2006) 1.82
Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. J Biochem (2006) 1.71
Arf GAPs and membrane traffic. J Cell Sci (2006) 1.67
Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Mol Pharmacol (2002) 1.66
Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J Biol Chem (2001) 1.64
Adipocyte protein S3-12 coats nascent lipid droplets. J Biol Chem (2003) 1.63
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267. J Biol Chem (1982) 1.59
Structure-function relationships in the adipose cell. I. Ultrastructure of the isolated adipose cell. J Cell Biol (1970) 1.58
OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis. J Lipid Res (2005) 1.58
The central role of perilipin a in lipid metabolism and adipocyte lipolysis. IUBMB Life (2004) 1.45
Aluminum fluoride acts on the reversibility of ARF1-dependent coat protein binding to Golgi membranes. J Biol Chem (1994) 1.45
Post-translational regulation of perilipin expression. Stabilization by stored intracellular neutral lipids. J Biol Chem (1997) 1.45
The fusome mediates intercellular endoplasmic reticulum connectivity in Drosophila ovarian cysts. Mol Biol Cell (2004) 1.36
Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100. J Cell Sci (2008) 1.34
A simple and rapid method to assay triacylglycerol in cells and tissues. J Lipid Res (2007) 1.30
Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein. Biochem J (2001) 1.30
Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting. J Cell Biol (1997) 1.22
ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane. Mol Biol Cell (2000) 1.20
Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. J Biol Chem (1999) 1.19
Arf1-dependent PLD1 is localized to oleic acid-induced lipid droplets in NIH3T3 cells. Biochem Biophys Res Commun (2005) 1.11
Protein kinase C regulates Fas (CD95/APO-1) expression. J Immunol (1998) 1.05
Membrane topology and sequence requirements for oil body targeting of oleosin. Plant J (2004) 1.03
ADRP is dissociated from lipid droplets by ARF1-dependent mechanism. Biochem Biophys Res Commun (2004) 1.02
Mechanisms regulating adipocyte lipolysis. Adv Exp Med Biol (1998) 0.94
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature (2012) 3.35
Identification of a central role for complement in osteoarthritis. Nat Med (2011) 3.11
OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes (2006) 2.77
S3-12, Adipophilin, and TIP47 package lipid in adipocytes. J Biol Chem (2005) 2.46
Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis (2013) 2.39
Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest (2002) 2.30
CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest (2005) 2.04
CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem (2007) 2.02
Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet (2008) 1.98
DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem (2002) 1.90
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways. J Lipid Res (2008) 1.80
Evidence against the presence of an anandamide transporter. Proc Natl Acad Sci U S A (2003) 1.76
Packaging of fat: an evolving model of lipid droplet assembly and expansion. J Biol Chem (2011) 1.73
Isolation of lipid droplets from cells by density gradient centrifugation. Curr Protoc Cell Biol (2006) 1.71
Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab (2009) 1.70
CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology (2006) 1.67
Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology (2010) 1.64
Adipocyte protein S3-12 coats nascent lipid droplets. J Biol Chem (2003) 1.63
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes (2008) 1.61
The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J Lipid Res (2011) 1.60
OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis. J Lipid Res (2005) 1.58
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet (2004) 1.56
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J Biol Chem (2007) 1.53
Role of CD36 in membrane transport of long-chain fatty acids. Curr Opin Clin Nutr Metab Care (2002) 1.51
Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu Rev Nutr (2002) 1.42
CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem (2008) 1.41
CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue. Diabetes (2007) 1.41
Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum Mol Genet (2010) 1.40
A simple and rapid method to assay triacylglycerol in cells and tissues. J Lipid Res (2007) 1.30
Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem (2011) 1.30
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem (2009) 1.28
Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes (2006) 1.25
Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes (2005) 1.24
Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J Biol Chem (2008) 1.22
Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. J Biol Chem (2010) 1.22
FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. J Biol Chem (2005) 1.17
CD36 protein is involved in store-operated calcium flux, phospholipase A2 activation, and production of prostaglandin E2. J Biol Chem (2011) 1.17
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem (2008) 1.16
CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related to cell lipid and insulin responsiveness. Diabetes (2004) 1.15
Brief report: citrullination within the atherosclerotic plaque: a potential target for the anti-citrullinated protein antibody response in rheumatoid arthritis. Arthritis Rheum (2013) 1.12
A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. J Lipid Res (2010) 1.12
Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice. J Lipid Res (2009) 1.12
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology (2004) 1.10
Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation. J Biol Chem (2010) 1.08
CD36 genetics and the metabolic complications of obesity. Curr Opin Clin Nutr Metab Care (2011) 1.08
Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism. Annu Rev Nutr (2014) 1.06
Pharmacological activation of PPARbeta promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2008) 1.06
Differential association of adipophilin and TIP47 proteins with cytoplasmic lipid droplets in mouse enterocytes during dietary fat absorption. Biochim Biophys Acta (2009) 1.05
Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages. J Biol Chem (2013) 1.04
Cold-sensitive mutants of Taq DNA polymerase provide a hot start for PCR. Nucleic Acids Res (2003) 1.02
Changes in taste perception and eating behavior after bariatric surgery-induced weight loss in women. Obesity (Silver Spring) (2013) 1.02
CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J (2012) 0.99
CD36 protein influences myocardial Ca2+ homeostasis and phospholipid metabolism: conduction anomalies in CD36-deficient mice during fasting. J Biol Chem (2012) 0.98
Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse. Hepatology (2011) 0.97
Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase. J Lipid Res (2012) 0.97
Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids. Proc Natl Acad Sci U S A (2003) 0.97
New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36. Biochem J (2002) 0.95
CD36 level and trafficking are determinants of lipolysis in adipocytes. FASEB J (2012) 0.95
Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One (2011) 0.95
Insulin sensitivity is not associated with palmitoleate availability in obese humans. J Lipid Res (2011) 0.95
Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol (2013) 0.95
Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice. J Biol Chem (2010) 0.94
Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone. J Biol Chem (2002) 0.94
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation. PLoS One (2011) 0.93
Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte (2013) 0.90
ADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes. Am J Physiol Cell Physiol (2010) 0.89
Increased CD36 expression signals monocyte activation among patients with type 2 diabetes. Diabetes Care (2010) 0.89
CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice. J Lipid Res (2013) 0.89
Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice. PLoS One (2010) 0.87
CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis. J Lipid Res (2013) 0.86
Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. J Biol Chem (2004) 0.85
Multilayer nanofilms as substrates for hepatocellular applications. Biomaterials (2008) 0.83
An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice. PLoS One (2010) 0.83
High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins. Am J Physiol Endocrinol Metab (2011) 0.82
Long-term ritonavir exposure increases fatty acid and glycerol recycling in 3T3-L1 adipocytes as compensatory mechanisms for increased triacylglycerol hydrolysis. Endocrinology (2010) 0.82
Imaging of neutral lipids and neutral lipid associated proteins. Methods Cell Biol (2013) 0.81
The Whole Genome Expression Analysis using Two Microarray Technologies to Identify Gene Networks That Mediate the Myocardial Phenotype of CD36 Deficiency. Bioinformation (2013) 0.80
A single centrifugation method for isolating fat droplets from cells and tissues. J Lipid Res (2012) 0.80
Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring) (2011) 0.79
Update on the pathophysiology of obesity. Curr Opin Clin Nutr Metab Care (2010) 0.79
Genome-wide associations and metabolic disease: the big revolution. Curr Opin Clin Nutr Metab Care (2008) 0.77
Thyroid hormone transport by the rat fatty acid translocase. Endocrinology (2003) 0.75
The metabolism of cancer cells: moonlighting proteins and growth control. Curr Opin Clin Nutr Metab Care (2006) 0.75