Published in Blood on December 20, 2007
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity (2012) 6.29
Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells. Int J Parasitol (2011) 0.88
Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3. PLoS Pathog (2011) 0.86
Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J Biol Chem (2010) 0.84
Apoptosis Induction by the Total Flavonoids from Arachniodes exilis in HepG2 Cells through Reactive Oxygen Species-Mediated Mitochondrial Dysfunction Involving MAPK Activation. Evid Based Complement Alternat Med (2014) 0.81
Cytotoxic proteins and therapeutic targets in severe cutaneous adverse reactions. Toxins (Basel) (2014) 0.76
Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells. Blood (2009) 0.75
T cell responses are better correlates of vaccine protection in the elderly. J Immunol (2006) 4.38
Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol (2002) 3.01
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol (2010) 1.97
Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol (2004) 1.75
Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine (2009) 1.69
Granzyme B: a natural born killer. Immunol Rev (2003) 1.61
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol (2011) 1.57
Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension. J Mol Med (Berl) (2011) 1.56
The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine (2012) 1.54
The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. J Exp Med (2002) 1.39
Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition. Immunity (2003) 1.20
Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection. Am J Transplant (2005) 1.16
Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate. Mol Biol Cell (2005) 1.15
B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators. Nat Rev Immunol (2008) 1.14
Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism. J Virol (2011) 1.03
A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B. J Immunol Methods (2003) 1.02
Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults. Vaccine (2005) 1.01
Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells. J Immunol (2006) 1.00
Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. Biochem Biophys Res Commun (2007) 0.97
Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis. Biochemistry (2002) 0.97
Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia. Proc Natl Acad Sci U S A (2013) 0.96
The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Blood (2004) 0.92
The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity. Mol Cancer Res (2009) 0.91
Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice. Cell Transplant (2008) 0.90
Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity. J Immunol (2011) 0.90
A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity. Int Immunol (2006) 0.88
Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes. Int J Biochem Cell Biol (2004) 0.88
Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes. J Immunol (2008) 0.88
Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis. J Cell Sci (2006) 0.87
Bim is reversibly phosphorylated but plays a limited role in paclitaxel cytotoxicity of breast cancer cell lines. Biochem Biophys Res Commun (2008) 0.87
Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3. PLoS Pathog (2011) 0.86
Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. Am J Transplant (2005) 0.85
The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes. Exp Cell Res (2010) 0.84
Impaired cytolytic activity in calreticulin-deficient CTLs. J Immunol (2005) 0.82
Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B. Am J Transplant (2004) 0.81
Isolation and characterization of novel single-chain Fv specific for human granzyme B. Hybrid Hybridomics (2004) 0.81
Caspase 12 in calnexin-deficient cells. Biochemistry (2006) 0.80
Mitochondria at the heart of the cytotoxic attack. Biochem Biophys Res Commun (2003) 0.79
A novel lineage-specific hypersensitive site is essential for position independent granzyme B expression in transgenic mice. Biochem Biophys Res Commun (2008) 0.78
Protection of porcine islet xenografts in mice using sertoli cells and monoclonal antibodies. Transplantation (2011) 0.78
PPP1R9B (Neurabin 2): involvement and dynamics in the NK immunological synapse. Eur J Immunol (2009) 0.78
CD4+CD25+CD127dimFoxp3+ T cells are cytotoxic for human neurons. J Leukoc Biol (2011) 0.77
Evaluating antigen-specific cytotoxic T lymphocyte responses by a novel mouse granzyme B ELISPOT assay. J Immunol Methods (2005) 0.76
Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation. Mol Immunol (2013) 0.76