PubRank

David A Wink

Author PubWeight™ 126.96‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The emerging biology of the nitrite anion. Nat Chem Biol 2005 2.88
2 The chemical biology of nitric oxide: implications in cellular signaling. Free Radic Biol Med 2008 2.72
3 Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am J Physiol Regul Integr Comp Physiol 2004 2.61
4 CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. J Biol Chem 2006 2.23
5 Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc Natl Acad Sci U S A 2005 2.17
6 Increasing survival of ischemic tissue by targeting CD47. Circ Res 2007 2.16
7 Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A 2002 2.04
8 Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci U S A 2004 1.87
9 A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system. Proc Natl Acad Sci U S A 2003 1.78
10 Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling. Proc Natl Acad Sci U S A 2003 1.76
11 Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood 2007 1.73
12 Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol 2010 1.56
13 Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res 2006 1.56
14 Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood 2006 1.56
15 Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci U S A 2005 1.55
16 Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. Proc Natl Acad Sci U S A 2002 1.53
17 Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest 2010 1.52
18 Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species. Chem Res Toxicol 2012 1.51
19 Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling. Sci Transl Med 2009 1.47
20 The reduction potential of nitric oxide (NO) and its importance to NO biochemistry. Proc Natl Acad Sci U S A 2002 1.45
21 Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses. Cardiovasc Res 2006 1.43
22 The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO. Pharmacol Ther 2006 1.41
23 Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem 2007 1.41
24 Oxidative stress, redox, and the tumor microenvironment. Semin Radiat Oncol 2004 1.38
25 Inflammation and IGF-I activate the Akt pathway in breast cancer. Int J Cancer 2007 1.38
26 The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biol Chem 2004 1.37
27 Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide. Proc Natl Acad Sci U S A 2002 1.33
28 The biphasic nature of nitric oxide responses in tumor biology. Antioxid Redox Signal 2006 1.32
29 Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res 2008 1.30
30 Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Radic Biol Med 2003 1.28
31 CD47 deficiency confers cell and tissue radioprotection by activation of autophagy. Autophagy 2012 1.27
32 Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. Am J Pathol 2008 1.26
33 Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci U S A 2007 1.26
34 Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo. J Med Chem 2005 1.26
35 Nitroxyl (HNO): chemistry, biochemistry, and pharmacology. Annu Rev Pharmacol Toxicol 2005 1.25
36 Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death. Free Radic Biol Med 2011 1.24
37 Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. Ann Surg 2008 1.24
38 The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide. Chem Res Toxicol 2005 1.24
39 Superoxide fluxes limit nitric oxide-induced signaling. J Biol Chem 2006 1.22
40 Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH. J Am Chem Soc 2005 1.22
41 Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. Biochim Biophys Acta 2009 1.20
42 Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. Methods Enzymol 2002 1.20
43 Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity. J Pharmacol Exp Ther 2005 1.18
44 Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species. Free Radic Biol Med 2003 1.16
45 Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms. Proc Natl Acad Sci U S A 2002 1.15
46 Molecular mechanisms for discrete nitric oxide levels in cancer. Nitric Oxide 2008 1.14
47 Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infect Immun 2003 1.14
48 Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med 2010 1.12
49 Nitric oxide in wound-healing. Microsurgery 2005 1.10
50 Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity. Clin Cancer Res 2012 1.09
51 Peroxynitrite and myocardial contractility: in vivo versus in vitro effects. Free Radic Biol Med 2006 1.08
52 Ingress and reactive chemistry of nitroxyl-derived species within human cells. Free Radic Biol Med 2002 1.07
53 Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function. Antioxid Redox Signal 2011 1.07
54 Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class. J Am Chem Soc 2010 1.05
55 Blockade of CD47 increases survival of mice exposed to lethal total body irradiation. Sci Rep 2013 1.05
56 A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Ann N Y Acad Sci 2002 1.04
57 The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxid Redox Signal 2011 1.04
58 Discriminating formation of HNO from other reactive nitrogen oxide species. Free Radic Biol Med 2005 1.03
59 Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. Breast Cancer Res 2012 1.02
60 Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res 2012 1.02
61 Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxid Redox Signal 2003 1.02
62 Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression. Proc Natl Acad Sci U S A 2014 1.01
63 S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer. Mol Cancer Res 2012 1.01
64 Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. J Inorg Biochem 2003 1.00
65 Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations. Inorg Chem 2006 1.00
66 COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. BMC Cancer 2010 0.99
67 Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radic Biol Med 2008 0.99
68 The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 2008 0.99
69 The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO). Arch Biochem Biophys 2007 0.99
70 The emergence of nitroxyl (HNO) as a pharmacological agent. Biochim Biophys Acta 2009 0.98
71 Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. Arch Biochem Biophys 2002 0.98
72 Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis. Clin Cancer Res 2007 0.96
73 Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells. Eur J Pharmacol 2010 0.95
74 Biological nitric oxide signalling: chemistry and terminology. Br J Pharmacol 2013 0.95
75 Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. J Neuroinflammation 2011 0.95
76 Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Trends Pharmacol Sci 2011 0.94
77 A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide. Clin Cancer Res 2009 0.94
78 Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice. Magn Reson Med 2008 0.93
79 Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow. Neoplasia 2008 0.92
80 Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. PLoS One 2012 0.91
81 Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications. Free Radic Biol Med 2009 0.90
82 Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. Lung Cancer 2009 0.89
83 Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 2012 0.89
84 Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. Curr Drug Targets 2008 0.88
85 The chemical dynamics of NO and reactive nitrogen oxides: a practical guide. Curr Mol Med 2004 0.87
86 Mother was right: eat your vegetables and do not spit! When oral nitrate helps with high blood pressure. Hypertension 2008 0.86
87 Neurotoxicity of nitroxyl: insights into HNO and NO biochemical imbalance. Free Radic Biol Med 2005 0.86
88 β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radic Biol Med 2012 0.85
89 Comparing the chemical biology of NO and HNO. Arch Pharm Res 2009 0.85
90 The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation. Free Radic Biol Med 2009 0.85
91 Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. PLoS One 2012 0.85
92 Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin. J Proteome Res 2008 0.85
93 Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Med Hypotheses 2010 0.83
94 The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxid Redox Signal 2006 0.83
95 Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. J Med Chem 2013 0.83
96 Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones 2009 0.83
97 Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer. Cancer Res 2012 0.83
98 Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients. Free Radic Biol Med 2005 0.82
99 The shy Angeli and his elusive creature: the HNO route to vasodilation. Am J Physiol Heart Circ Physiol 2009 0.81
100 Ion implicated in blood pact. Nat Med 2003 0.81
101 Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells. Br J Pharmacol 2012 0.80
102 Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells. Clin Cancer Res 2009 0.80
103 Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation. J Biol Chem 2009 0.80
104 Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite. Cancer Res 2006 0.77
105 The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well. J Biol Chem 2010 0.77
106 The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment. Mol Neurodegener 2014 0.76
107 S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer. For Immunopathol Dis Therap 2012 0.76
108 Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. Exp Neurol 2004 0.75