Published in Am J Med Genet B Neuropsychiatr Genet on September 05, 2008
An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings. BMC Genet (2010) 1.96
TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica (2009) 1.95
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol Aging (2013) 1.37
The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res (2012) 1.16
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry (2013) 1.16
Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease. PLoS One (2011) 1.07
Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction. Curr Alzheimer Res (2012) 0.92
A multi-center study of ACE and the risk of late-onset Alzheimer's disease. J Alzheimers Dis (2011) 0.89
Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and intervention. Front Psychiatry (2014) 0.86
Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease. Brain Res (2012) 0.84
BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. PLoS One (2013) 0.83
Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Mol Neurodegener (2014) 0.82
Genomic Characteristics of Genetic Creutzfeldt-Jakob Disease Patients with V180I Mutation and Associations with Other Neurodegenerative Disorders. PLoS One (2016) 0.75
Plasma Dickkopf-related Protein 1, an antagonist of the Wnt pathway, is associated with HIV-associated neurocognitive impairment. AIDS (2017) 0.75
Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk. Med Sci Monit (2016) 0.75
Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease. J Pathol (2017) 0.75
AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein. Exp Brain Res (2017) 0.75
A protein interaction map of Drosophila melanogaster. Science (2003) 20.06
An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome. N Engl J Med (1992) 18.11
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53
Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs. Cell (1979) 12.83
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology (1996) 12.33
Stromal gene signatures in large-B-cell lymphomas. N Engl J Med (2008) 11.34
Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet (2001) 11.06
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell (1982) 9.27
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue. Virology (1978) 8.28
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science (2001) 8.14
GPs in principle but not in practice: a study of vocationally trained doctors not currently working as principals. BMJ (1995) 8.09
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell (1997) 7.47
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (2000) 7.03
A quantitative approach to perceived health status: a validation study. J Epidemiol Community Health (1980) 6.29
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J (1996) 6.08
The prevalence of frontotemporal dementia. Neurology (2002) 5.73
High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry (1999) 5.54
Variations in breast cancer management between a teaching and a non-teaching district. Eur J Cancer (1992) 5.54
Prenatal screening for Down's syndrome with use of maternal serum markers. N Engl J Med (1992) 5.21
The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med A (1981) 5.02
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry (2011) 4.91
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med (2001) 4.83
Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. Am J Hum Genet (2000) 4.72
Influence of substrate wettability on the attachment of marine bacteria to various surfaces. Appl Microbiol (1975) 4.70
Host-range mutants of adenovirus type 5 defective for growth in HeLa cells. Virology (1977) 4.40
Primary structure of human transferrin receptor deduced from the mRNA sequence. Nature (1984) 4.04
The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet (2005) 4.02
Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology (1999) 3.95
Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry (2003) 3.87
Change in use of asthma as a diagnostic label for wheezing illness in schoolchildren. BMJ (1989) 3.80
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection. J Virol (1997) 3.79
The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection. J Virol (1997) 3.77
The influence of dominance rank on the reproductive success of female chimpanzees. Science (1997) 3.74
The prevalence of dementia in Europe: a collaborative study of 1980-1990 findings. Eurodem Prevalence Research Group. Int J Epidemiol (1991) 3.70
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry (2009) 3.59
Defective transforming capacity of adenovirus type 5 host-range mutants. Virology (1978) 3.52
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev (2001) 3.43
Physical mapping of temperature-sensitive mutations of adenoviruses. Cold Spring Harb Symp Quant Biol (1975) 3.42
Do general practitioners know when living wills are legal? J R Coll Physicians Lond (1998) 3.39
Spiral Tube Assembly for High-Speed Countercurrent Chromatography: Choice of Elution Modes for Four Typical Two-Phase Solvent Systems. J Liq Chromatogr Relat Technol (2008) 3.33
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res (1994) 3.22
Cell-cycle arrest versus cell death in cancer therapy. Nat Med (1997) 3.18
Generic inhalers for asthma. BMJ (1994) 3.09
A multirater validation study to assess the reliability of acne lesion counting. J Am Acad Dermatol (1996) 3.09
Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription. Nucleic Acids Res (1990) 3.08
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry (2008) 3.01
Discriminating between normal and glaucomatous eyes using the Heidelberg Retina Tomograph, GDx Nerve Fiber Analyzer, and Optical Coherence Tomograph. Arch Ophthalmol (2001) 2.99
Biosynthesis of HLA-A and HLA-B antigens in vivo. J Biol Chem (1980) 2.94
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro. J Clin Invest (1995) 2.91
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science (1992) 2.90
Role of alginate and its O acetylation in formation of Pseudomonas aeruginosa microcolonies and biofilms. J Bacteriol (2001) 2.87
Purchasing for all: an alternative to fundholding. BMJ (1994) 2.86
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ (2009) 2.85
Acute compartment syndromes. Br J Surg (2002) 2.81
Fixation of fractures of the shaft of the humerus by dynamic compression plate or intramedullary nail. A prospective, randomised trial. J Bone Joint Surg Br (2000) 2.81
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature (1990) 2.80
Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen. Proc Natl Acad Sci U S A (1986) 2.76
T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol (1997) 2.76
Behavioral engineering: the reduction of smoking behavior by a conditioning apparatus and procedure. J Appl Behav Anal (1968) 2.71
'Ending up a GP': a qualitative study of junior doctors' perceptions of general practice as a career. Fam Pract (1997) 2.70
Interaction and dose equivalence of salbutamol and salmeterol in patients with asthma. BMJ (1993) 2.70
An economic appraisal of screening for Down's syndrome in pregnancy using maternal age and serum alpha fetoprotein concentration. Soc Sci Med (1987) 2.69
Physical mapping of temperature-sensitive mutations of adenoviruses. J Mol Biol (1975) 2.69
Cognitive impairment and dementia in neurocysticercosis: a cross-sectional controlled study. Neurology (2010) 2.66
Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5. Cold Spring Harb Symp Quant Biol (1975) 2.65
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ (2008) 2.65
DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behav Genet (1997) 2.64
The genetic basis of complex human behaviors. Science (1994) 2.62
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry (2010) 2.59
Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J Exp Med (1999) 2.58
International differences in understanding recovery: systematic review. Epidemiol Psychiatr Sci (2012) 2.57
Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma. Lancet (1990) 2.52
Susceptibility locus for Alzheimer's disease on chromosome 10. Science (2000) 2.49
Structural brain abnormalities associated with deletion at chromosome 22q11: quantitative neuroimaging study of adults with velo-cardio-facial syndrome. Br J Psychiatry (2001) 2.49
Improved spiral tube assembly for high-speed counter-current chromatography. J Chromatogr A (2008) 2.48
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev (1996) 2.47
The endurance shuttle walk: a new field test for the assessment of endurance capacity in chronic obstructive pulmonary disease. Thorax (1999) 2.45
Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia. Antimicrob Agents Chemother (1997) 2.43
Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH-A). Depress Anxiety (2001) 2.42
Concurrent validity of the OPCRIT diagnostic system. Comparison of OPCRIT diagnoses with consensus best-estimate lifetime diagnoses. Br J Psychiatry (1996) 2.42
beta A4 amyloid protein deposition in brain after head trauma. Lancet (1991) 2.41