Published in Proteins on June 01, 2008
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood (2008) 2.22
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Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature (2008) 4.09
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Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. Blood (2005) 2.37
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In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood (2008) 1.94
Assessing research participants' perceptions of their clinical research experiences. Clin Transl Sci (2011) 1.88
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
Adjuvant treatment with a glycoprotein IIb/IIIa receptor inhibitor increases the therapeutic window for low-dose tissue plasminogen activator administration in a rat model of embolic stroke. Circulation (2003) 1.77
Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates. J Bacteriol (2006) 1.63
The Rockefeller University Navigation Program: a structured multidisciplinary protocol development and educational program to advance translational research. Clin Transl Sci (2014) 1.37
Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. Proc Natl Acad Sci U S A (2004) 1.36
Use of an EZ-Tn5-based random mutagenesis system to identify a novel toxin regulatory locus in Clostridium perfringens strain 13. PLoS One (2009) 1.34
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci U S A (2013) 1.34
Virulence plasmid diversity in Clostridium perfringens type D isolates. Infect Immun (2007) 1.30
Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood (2010) 1.29
Modern homology modeling of G-protein coupled receptors: which structural template to use? J Med Chem (2009) 1.26
Assessing participant-centered outcomes to improve clinical research. N Engl J Med (2013) 1.26
Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood (2011) 1.20
Development of a research participants' perception survey to improve clinical research. Clin Transl Sci (2012) 1.16
Genetic characterization of type A enterotoxigenic Clostridium perfringens strains. PLoS One (2009) 1.16
Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading. Blood (2007) 1.15
Characterization of virulence plasmid diversity among Clostridium perfringens type B isolates. Infect Immun (2009) 1.14
Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry (2011) 1.13
Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques. PLoS Comput Biol (2011) 1.12
Clostridium perfringens toxin genotypes in the feces of healthy North Americans. Anaerobe (2008) 1.12
Sequencing and diversity analyses reveal extensive similarities between some epsilon-toxin-encoding plasmids and the pCPF5603 Clostridium perfringens enterotoxin plasmid. J Bacteriol (2008) 1.11
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (2010) 1.09
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Sci Transl Med (2012) 1.07
Modeling activated states of GPCRs: the rhodopsin template. J Comput Aided Mol Des (2006) 1.06
Reflections on being a Chair of Medicine, 1993 to 2001 - Part 2. Am J Med (2004) 1.06
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Characterization of toxin plasmids in Clostridium perfringens type C isolates. Infect Immun (2010) 1.05
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics (2007) 1.04
Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics. Biochemistry (2009) 1.03
Membrane driven spatial organization of GPCRs. Sci Rep (2013) 1.03
Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors. Biochemistry (2011) 1.03
Assessing the relative stability of dimer interfaces in g protein-coupled receptors. PLoS Comput Biol (2012) 1.02
Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin. PLoS One (2011) 1.01
A novel cost-effective technology to convert sucrose and homocelluloses in sweet sorghum stalks into ethanol. Biotechnol Biofuels (2013) 1.01
Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy. PLoS One (2013) 1.00
Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy. Proc Natl Acad Sci U S A (2013) 0.99
TRAJELIX: a computational tool for the geometric characterization of protein helices during molecular dynamics simulations. J Comput Aided Mol Des (2006) 0.99
Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China. FEMS Microbiol Lett (2012) 0.97
Identification of novel Clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene. PLoS One (2011) 0.97
Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis. Blood (2002) 0.97
Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding. Blood (2013) 0.96
Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. J Chem Inf Model (2013) 0.96
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood (2009) 0.96
Lessons from free energy simulations of delta-opioid receptor homodimers involving the fourth transmembrane helix. Biochemistry (2010) 0.95
Creating an ontology-based human phenotyping system: The Rockefeller University bleeding history experience. Clin Transl Sci (2009) 0.95
Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics. Biophys J (2010) 0.94
Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain. J Biol Chem (2005) 0.93
In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1. PLoS One (2009) 0.93
Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease. J Mol Biol (2011) 0.93
Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3. J Biol Chem (2010) 0.93
Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors. Curr Opin Struct Biol (2011) 0.93
Structural biology: How opioid drugs bind to receptors. Nature (2012) 0.92
Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3. Thromb Haemost (2007) 0.92
Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation. Blood (2007) 0.92
Genotypic and phenotypic characterization of Clostridium perfringens isolates from Darmbrand cases in post-World War II Germany. Infect Immun (2012) 0.91
A data-rich recruitment core to support translational clinical research. Clin Transl Sci (2014) 0.91
Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry (2014) 0.91
High expression of transgene protein in Spirodela. Plant Cell Rep (2007) 0.90
DNA sequence analysis of the triose phosphate isomerase gene from isolates of Giardia lamblia. Chin Med J (Engl) (2002) 0.90
Morphological and functional platelet abnormalities in Berkeley sickle cell mice. Blood Cells Mol Dis (2008) 0.90
Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. Proteins (2009) 0.88
Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy. Blood (2003) 0.87
Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophys J (2008) 0.86
Monocyte-derived tissue factor contributes to stent thrombosis in an in vitro system. J Am Coll Cardiol (2004) 0.85
alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan. Blood (2005) 0.84
Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity. BMC Gastroenterol (2013) 0.84
Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation. J Biol Chem (2013) 0.84
Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates. J Am Coll Cardiol (2002) 0.83
Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group. Circulation (2012) 0.83
Enterotoxigenic Clostridium perfringens: detection and identification. Microbes Environ (2012) 0.83
Clostridium perfringens type A enterotoxin damages the rabbit colon. Infect Immun (2014) 0.83
Identification of a lambda toxin-negative Clostridium perfringens strain that processes and activates epsilon prototoxin intracellularly. Anaerobe (2012) 0.82
Influence of oligomerization on the dynamics of G-protein coupled receptors as assessed by normal mode analysis. Proteins (2008) 0.82
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis. Arch Med Res (2010) 0.82
RGD-modified endostatin peptide 30 derived from endostatin suppresses invasion and migration of HepG2 cells through the αvβ3 pathway. Cancer Biother Radiopharm (2011) 0.82
Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors. Expert Opin Drug Discov (2008) 0.81
Virulence Plasmids of Spore-Forming Bacteria. Microbiol Spectr (2014) 0.81