Published in J Mol Biol on March 31, 2011
A transmembrane domain and GxxxG motifs within L2 are essential for papillomavirus infection. J Virol (2012) 1.10
Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry (2013) 1.07
Assessing the relative stability of dimer interfaces in g protein-coupled receptors. PLoS Comput Biol (2012) 1.02
Cholesterol as a co-solvent and a ligand for membrane proteins. Protein Sci (2013) 0.97
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase. J Am Chem Soc (2013) 0.93
Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site. Nat Commun (2014) 0.92
Impact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 protein. J Am Chem Soc (2014) 0.85
Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins. J Am Chem Soc (2011) 0.85
Structural heterogeneity in transmembrane amyloid precursor protein homodimer is a consequence of environmental selection. J Am Chem Soc (2014) 0.84
Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. PLoS One (2014) 0.80
Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease. PLoS One (2012) 0.78
Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein. Proc Natl Acad Sci U S A (2016) 0.78
Screening for transmembrane association in divisome proteins using TOXGREEN, a high-throughput variant of the TOXCAT assay. Biochim Biophys Acta (2016) 0.76
Extension of a protein docking algorithm to membranes and applications to amyloid precursor protein dimerization. Proteins (2015) 0.75
Backbone hydrogen bond strengths can vary widely in transmembrane helices. J Am Chem Soc (2017) 0.75
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites. J Biol Chem (2017) 0.75
Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61
Tissue sulfhydryl groups. Arch Biochem Biophys (1959) 61.89
GROMACS: fast, flexible, and free. J Comput Chem (2005) 27.22
Alzheimer's disease: genes, proteins, and therapy. Physiol Rev (2001) 19.19
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature (1991) 16.77
Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria. Methods Enzymol (1975) 16.73
The MARTINI force field: coarse grained model for biomolecular simulations. J Phys Chem B (2007) 9.56
A transmembrane helix dimer: structure and implications. Science (1997) 6.46
The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol (2000) 5.09
Fluorescence resonance energy transfer. Methods Enzymol (1995) 4.71
Reconstitution of gamma-secretase activity. Nat Cell Biol (2003) 4.66
Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry (1992) 4.19
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science (1991) 4.09
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature (1991) 3.86
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A (2006) 3.30
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci U S A (2000) 3.13
Interhelical hydrogen bonding drives strong interactions in membrane proteins. Nat Struct Biol (2000) 3.12
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem (2006) 3.03
Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci (1998) 3.03
The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A (2001) 2.97
gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci (2002) 2.85
TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc Natl Acad Sci U S A (1999) 2.76
Non-random distribution of amino acids in the transmembrane segments of human type I single span membrane proteins. J Mol Biol (1993) 2.70
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A (2001) 2.47
Insights into the recognition and association of transmembrane alpha-helices. The free energy of alpha-helix dimerization in glycophorin A. J Am Chem Soc (2005) 2.36
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci U S A (2002) 2.29
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum Mutat (2006) 2.29
The single transmembrane domains of ErbB receptors self-associate in cell membranes. J Biol Chem (2001) 2.25
Purification and characterization of the human gamma-secretase complex. Biochemistry (2004) 2.18
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A (2002) 2.16
Setting up and running molecular dynamics simulations of membrane proteins. Methods (2007) 2.02
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry (2002) 1.93
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator. J Mol Biol (1996) 1.86
The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues. Protein Sci (1998) 1.81
Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching. Proteins (1996) 1.75
Statistical analysis of predicted transmembrane alpha-helices. Biochim Biophys Acta (1998) 1.70
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem (2004) 1.65
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios. J Neurochem (2005) 1.61
gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J Biol Chem (2005) 1.61
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem (2008) 1.54
Reconstructing the equilibrium Boltzmann distribution from well-tempered metadynamics. J Comput Chem (2009) 1.54
Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J (1994) 1.52
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci (2000) 1.50
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin. J Biol Chem (2003) 1.50
The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Appl Pathol (1984) 1.49
Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem (2004) 1.45
Standardizing the free energy change of transmembrane helix-helix interactions. J Mol Biol (2002) 1.41
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc Natl Acad Sci U S A (2009) 1.30
Efficient reconstruction of complex free energy landscapes by multiple walkers metadynamics. J Phys Chem B (2006) 1.29
Sequence-specific dimerization of the transmembrane domain of the "BH3-only" protein BNIP3 in membranes and detergent. J Biol Chem (2003) 1.26
Interaction of transmembrane helices by a knobs-into-holes packing characteristic of soluble coiled coils. Proteins (1998) 1.26
Genetic neurodegenerative diseases: the human illness and transgenic models. Science (1998) 1.25
Helix-helix interactions in membrane proteins: coarse-grained simulations of glycophorin a helix dimerization. Biochemistry (2008) 1.18
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. BMC Neurosci (2008) 1.17
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Hum Mol Genet (2000) 1.15
Reconstruction of atomistic details from coarse-grained structures. J Comput Chem (2010) 1.10
Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations. J Am Chem Soc (2009) 1.04
Molecular dynamics simulations of the dimerization of transmembrane alpha-helices. Acc Chem Res (2010) 1.03
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry (2003) 1.02
Sequence context strongly modulates association of polar residues in transmembrane helices. J Mol Biol (2003) 1.02
Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett (2005) 0.99
Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene. Arch Neurol (2000) 0.98
Signal enhancement at the electron microscopic level using Nanogold and gold-based autometallography. Histochem Cell Biol (2000) 0.93
The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem (2003) 0.91
Calculating the free energy of association of transmembrane helices. Biophys J (2006) 0.90
Outer membrane phospholipase A is dimeric in phospholipid bilayers: a cross-linking and fluorescence resonance energy transfer study. Biochemistry (1999) 0.88
An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala). Neurology (2002) 0.87
Resonance energy transfer between catalytic sites of bovine liver uridine diphosphoglucose dehydrogenase. Biochemistry (1980) 0.87
More missense in amyloid gene. Nat Genet (1992) 0.83
Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature (2008) 4.09
Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J (2008) 2.99
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol. Proc Natl Acad Sci U S A (2004) 2.44
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A (2005) 2.33
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood (2012) 1.98
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci U S A (2013) 1.34
Conformational changes in the multidrug transporter EmrE associated with substrate binding. J Mol Biol (2003) 1.33
Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood (2010) 1.29
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nat Immunol (2013) 1.28
Modern homology modeling of G-protein coupled receptors: which structural template to use? J Med Chem (2009) 1.26
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell (2012) 1.19
A high-throughput strategy to screen 2D crystallization trials of membrane proteins. J Struct Biol (2007) 1.15
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood (2015) 1.14
Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry (2011) 1.13
Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniques. PLoS Comput Biol (2011) 1.12
Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Transl Med (2013) 1.09
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (2010) 1.09
Water Soluble Phosphane-Gold(I) Complexes. Applications as Recyclable Catalysts in a Three-component Coupling Reaction and as Antimicrobial and Anticancer Agents. Eur J Inorg Chem (2009) 1.07
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Sci Transl Med (2012) 1.07
Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. J Biol Chem (2011) 1.06
Modeling activated states of GPCRs: the rhodopsin template. J Comput Aided Mol Des (2006) 1.06
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics (2007) 1.04
Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics. Biochemistry (2009) 1.03
Membrane driven spatial organization of GPCRs. Sci Rep (2013) 1.03
Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors. Biochemistry (2011) 1.03
Assessing the relative stability of dimer interfaces in g protein-coupled receptors. PLoS Comput Biol (2012) 1.02
Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers. J Biol Chem (2010) 1.00
Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy. Proc Natl Acad Sci U S A (2013) 0.99
TRAJELIX: a computational tool for the geometric characterization of protein helices during molecular dynamics simulations. J Comput Aided Mol Des (2006) 0.99
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation. Blood (2012) 0.99
Automated electron microscopy for evaluating two-dimensional crystallization of membrane proteins. J Struct Biol (2010) 0.97
Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. J Chem Inf Model (2013) 0.96
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood (2009) 0.96
Lessons from free energy simulations of delta-opioid receptor homodimers involving the fourth transmembrane helix. Biochemistry (2010) 0.95
Putative active states of a prototypic g-protein-coupled receptor from biased molecular dynamics. Biophys J (2010) 0.94
Exploring the protein G helix free-energy surface by solute tempering metadynamics. Proteins (2008) 0.94
Effects of limiting extension at the alphaIIb genu on ligand binding to integrin alphaIIbbeta3. J Biol Chem (2010) 0.93
An automated pipeline to screen membrane protein 2D crystallization. J Struct Funct Genomics (2010) 0.93
Showcasing modern molecular dynamics simulations of membrane proteins through G protein-coupled receptors. Curr Opin Struct Biol (2011) 0.93
Structural biology: How opioid drugs bind to receptors. Nature (2012) 0.92
The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins. J Biol Chem (2003) 0.91
Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions. Biochemistry (2014) 0.91
Functional and computational studies of the ligand-associated metal binding site of beta3 integrins. Proteins (2008) 0.90
Design of HIV-1-PR inhibitors that do not create resistance: blocking the folding of single monomers. Protein Sci (2005) 0.88
HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia. J Clin Invest (2014) 0.88
Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. Proteins (2009) 0.88
Drug binding revealed by tandem mass spectrometry of a protein-micelle complex. J Am Chem Soc (2004) 0.87
Insight into the folding inhibition of the HIV-1 protease by a small peptide. Biophys J (2007) 0.87
The architecture of yeast DNA polymerase ζ. Cell Rep (2013) 0.87
Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophys J (2008) 0.86
Identification of an archaeal presenilin-like intramembrane protease. PLoS One (2010) 0.86
Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: insights into a functional role in intramembrane proteolysis. J Mol Biol (2006) 0.83
Influence of oligomerization on the dynamics of G-protein coupled receptors as assessed by normal mode analysis. Proteins (2008) 0.82
Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors. Expert Opin Drug Discov (2008) 0.81
Atomistic simulations of the HIV-1 protease folding inhibition. Biophys J (2008) 0.80
Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents. Biochemistry (2008) 0.80
Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand. J Comput Aided Mol Des (2012) 0.79
Two-dimensional crystallization of integral membrane proteins for electron crystallography. Methods Mol Biol (2010) 0.78
Early events in protein folding: Is there something more than hydrophobic burst? Protein Sci (2008) 0.78
The Dynamic Process of Drug-GPCR Binding at Either Orthosteric or Allosteric Sites Evaluated by Metadynamics. Methods Mol Biol (2015) 0.78
Bioactive conformations of two seminal delta opioid receptor penta-peptides inferred from free-energy profiles. Biopolymers (2014) 0.78
High-throughput methods for electron crystallography. Methods Mol Biol (2013) 0.76
Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods. Adv Exp Med Biol (2014) 0.75
Optical absorption of a green fluorescent protein variant: environment effects in a density functional study. J Phys Chem B (2007) 0.75
Preface. G Protein-Coupled Receptors in Drug Discovery. Methods Mol Biol (2015) 0.75