Published in EMBO J on February 06, 2008
HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17
On the road to reading the RNA-interference code. Nature (2009) 4.33
Mechanisms and consequences of alternative polyadenylation. Mol Cell (2011) 3.96
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. Nature (2010) 3.65
Ending the message: poly(A) signals then and now. Genes Dev (2011) 3.47
Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation. Nucleic Acids Res (2009) 3.44
Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types. PLoS One (2009) 2.64
Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet (2013) 2.37
Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell (2012) 2.06
Alternative cleavage and polyadenylation: the long and short of it. Trends Biochem Sci (2013) 2.01
Alternative polyadenylation: new insights from global analyses. RNA (2012) 1.72
A physical and functional link between splicing factors promotes pre-mRNA 3' end processing. Nucleic Acids Res (2009) 1.60
Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation. Proc Natl Acad Sci U S A (2012) 1.54
Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing. Mol Cell Biol (2012) 1.49
A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence. EMBO J (2010) 1.49
Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage. Genes Dev (2011) 1.37
Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends Cell Biol (2009) 1.33
Phylogenetic analysis of mRNA polyadenylation sites reveals a role of transposable elements in evolution of the 3'-end of genes. Nucleic Acids Res (2008) 1.33
Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression. Genes Dev (2012) 1.33
Pre-mRNA 3'-end processing complex assembly and function. Wiley Interdiscip Rev RNA (2010) 1.30
Gene silencing by synthetic U1 adaptors. Nat Biotechnol (2009) 1.29
Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation. Nucleic Acids Res (2012) 1.23
RNA processing and export. Cold Spring Harb Perspect Biol (2010) 1.22
Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease. Mol Cell (2014) 1.21
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing. Genes Dev (2014) 1.17
The transcriptome of the baculovirus Autographa californica multiple nucleopolyhedrovirus in Trichoplusia ni cells. J Virol (2013) 1.16
Heterogeneity in mammalian RNA 3' end formation. Exp Cell Res (2010) 1.13
Transcriptome dynamics through alternative polyadenylation in developmental and environmental responses in plants revealed by deep sequencing. Genome Res (2011) 1.13
An unexpected ending: noncanonical 3' end processing mechanisms. RNA (2009) 1.13
A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination. Nucleic Acids Res (2010) 1.10
Tissue-specific mechanisms of alternative polyadenylation: testis, brain, and beyond. Wiley Interdiscip Rev RNA (2011) 1.09
To polyadenylate or to deadenylate: that is the question. Cell Cycle (2010) 1.09
PARP1 represses PAP and inhibits polyadenylation during heat shock. Mol Cell (2012) 1.05
A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. Neuropharmacology (2010) 1.05
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene (2011) 0.99
Genetics and regulatory impact of alternative polyadenylation in human B-lymphoblastoid cells. PLoS Genet (2012) 0.96
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer (2011) 0.96
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Mol Cell Biol (2014) 0.96
Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing. RNA (2013) 0.95
Structural biology of poly(A) site definition. Wiley Interdiscip Rev RNA (2011) 0.94
Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Development (2010) 0.94
Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol (2009) 0.92
Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy. BMC Genomics (2013) 0.92
Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Wiley Interdiscip Rev RNA (2013) 0.91
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. J Mol Med (Berl) (2013) 0.90
αCP Poly(C) binding proteins act as global regulators of alternative polyadenylation. Mol Cell Biol (2013) 0.90
An RNA-protein complex links enhanced nuclear 3' processing with cytoplasmic mRNA stabilization. EMBO J (2011) 0.90
The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Nucleic Acids Res (2011) 0.89
cpsf1 is required for definitive HSC survival in zebrafish. Blood (2011) 0.89
Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. Mol Cell Biol (2015) 0.88
A meta-analysis of single base-pair substitutions in translational termination codons ('nonstop' mutations) that cause human inherited disease. Hum Genomics (2011) 0.88
The long and the short of it: the role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail length. Biochim Biophys Acta (2012) 0.88
Analyses of zebrafish and Xenopus oocyte maturation reveal conserved and diverged features of translational regulation of maternal cyclin B1 mRNA. BMC Dev Biol (2009) 0.87
Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1. PLoS One (2009) 0.87
A complex immunodeficiency is based on U1 snRNP-mediated poly(A) site suppression. EMBO J (2012) 0.86
Gross deletions in TCOF1 are a cause of Treacher-Collins-Franceschetti syndrome. Eur J Hum Genet (2012) 0.86
Reconstitution of CF IA from overexpressed subunits reveals stoichiometry and provides insights into molecular topology. Biochemistry (2011) 0.86
Connections between 3'-end processing and DNA damage response. Wiley Interdiscip Rev RNA (2010) 0.85
Enzymatic processing of platinated RNAs. J Am Chem Soc (2010) 0.85
mRNA 3'end processing: A tale of the tail reaches the clinic. EMBO Mol Med (2014) 0.84
RNA sequencing: from tag-based profiling to resolving complete transcript structure. Cell Mol Life Sci (2014) 0.83
The Rift Valley Fever virus protein NSm and putative cellular protein interactions. Virol J (2012) 0.83
Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies. Plant Physiol (2009) 0.83
The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation. J Zhejiang Univ Sci B (2014) 0.82
U2 snRNP is required for expression of the 3' end of genes. PLoS One (2014) 0.82
Seed Dormancy in Arabidopsis Is Controlled by Alternative Polyadenylation of DOG1. Plant Physiol (2015) 0.81
U1 snRNP-mediated poly(A) site suppression: beneficial and deleterious for mRNA fate. RNA Biol (2013) 0.81
Alterations in polyadenylation and its implications for endocrine disease. Front Endocrinol (Lausanne) (2013) 0.81
Integrin α3β1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells. J Cell Sci (2014) 0.81
Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. RNA (2012) 0.81
Single nucleotide polymorphisms can create alternative polyadenylation signals and affect gene expression through loss of microRNA-regulation. PLoS Comput Biol (2012) 0.81
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Mol Ther Nucleic Acids (2013) 0.81
Orphan nuclear bodies. Cold Spring Harb Perspect Biol (2010) 0.80
Alternative Polyadenylation of mRNAs: 3'-Untranslated Region Matters in Gene Expression. Mol Cells (2016) 0.79
U1snRNP-mediated suppression of polyadenylation in conjunction with the RNA structure controls poly (A) site selection in foamy viruses. Retrovirology (2013) 0.79
Juxtaposition of two distant, serine-arginine-rich protein-binding elements is required for optimal polyadenylation in Rous sarcoma virus. J Virol (2011) 0.79
Structural and biochemical analysis of the assembly and function of the yeast pre-mRNA 3' end processing complex CF I. Proc Natl Acad Sci U S A (2012) 0.79
A novel plant in vitro assay system for pre-mRNA cleavage during 3'-end formation. Plant Physiol (2011) 0.79
RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases. Mol Med (2009) 0.79
Novel upstream and downstream sequence elements contribute to polyadenylation efficiency. RNA Biol (2012) 0.79
Crystal Structure of the SPOC Domain of the Arabidopsis Flowering Regulator FPA. PLoS One (2016) 0.78
Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation. PLoS One (2016) 0.78
The nucleosome regulates the usage of polyadenylation sites in the human genome. BMC Genomics (2013) 0.78
Ectopic 5' splice sites inhibit gene expression by engaging RNA surveillance and silencing pathways in plants. Plant Physiol (2009) 0.76
Cleavage and polyadenylation: Ending the message expands gene regulation. RNA Biol (2017) 0.75
The 3' end prothrombin gene variants in serbian patients with idiopathic thrombophilia. Balkan J Med Genet (2015) 0.75
Increased expression of Ero1L-alpha in healing fetal wounds. BMC Res Notes (2011) 0.75
Alternative polyadenylation of tumor suppressor genes in small intestinal neuroendocrine tumors. Front Endocrinol (Lausanne) (2014) 0.75
Dynamic landscape of alternative polyadenylation during retinal development. Cell Mol Life Sci (2016) 0.75
Ribonucleic acid (RNA) biosynthesis in human cancer. Cancer Cell Int (2015) 0.75
Alternative polyadenylation in a family of paralogous epb41 genes generates protein 4.1 diversity. RNA Biol (2016) 0.75
Oxidative stress controls the choice of alternative last exons via a Brahma-BRCA1-CstF pathway. Nucleic Acids Res (2016) 0.75
The drive to generate multiple forms of oncogenic cyclin D1 transcripts in mantle cell lymphoma. Biomark Res (2017) 0.75
RAX2: a genome-wide detection method of condition-associated transcription variation. Nucleic Acids Res (2015) 0.75
Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD). Genes (Basel) (2017) 0.75
Genome-wide dynamics of alternative polyadenylation in rice. Genome Res (2016) 0.75
Processing and transcriptome expansion at the mRNA 3' end in health and disease: finding the right end. Pflugers Arch (2016) 0.75
Cloning and characterization of buffalo NANOG gene: alternative transcription start sites, splicing, and polyadenylation in embryonic stem cell-like cells. DNA Cell Biol (2011) 0.75
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
The functions of animal microRNAs. Nature (2004) 64.85
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med (2005) 26.02
Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem (2003) 21.11
Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science (2006) 18.14
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
miRNAs, cancer, and stem cell division. Cell (2005) 12.15
An extensive network of coupling among gene expression machines. Nature (2002) 11.84
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol (2004) 11.39
Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Microbiol Mol Biol Rev (1999) 11.32
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med (2003) 11.17
Alternative splicing: increasing diversity in the proteomic world. Trends Genet (2001) 10.44
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
Integrating mRNA processing with transcription. Cell (2002) 9.74
Mechanism and regulation of mRNA polyadenylation. Genes Dev (1997) 7.48
A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res (2005) 7.24
Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell (1997) 7.15
Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation. Annu Rev Genet (1998) 7.15
A perfect message: RNA surveillance and nonsense-mediated decay. Cell (1999) 7.08
Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences. Nature (1988) 6.35
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res (2006) 6.22
RNA polymerase II and the integration of nuclear events. Genes Dev (2000) 6.16
Alternative poly(A) site selection in complex transcription units: means to an end? Nucleic Acids Res (1997) 5.64
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell (1998) 5.60
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell (2000) 5.16
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing. Mol Cell (2004) 5.01
The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell (1996) 4.93
RNA polymerase II is an essential mRNA polyadenylation factor. Nature (1998) 4.87
Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol (2003) 4.45
Alpha-thalassaemia caused by a polyadenylation signal mutation. Nature (1984) 4.41
New perspectives on connecting messenger RNA 3' end formation to transcription. Curr Opin Cell Biol (2004) 4.04
Influenza virus structural and nonstructural proteins in infected cells and their plasma membranes. Virology (1971) 3.96
A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell (2002) 3.88
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature (1998) 3.86
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82
In vitro polyadenylation is stimulated by the presence of an upstream intron. Genes Dev (1990) 3.73
Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells. Immunity (1999) 3.69
Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nat Genet (1998) 3.62
A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing. Genes Dev (1992) 3.44
Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Genes Dev (2005) 3.43
U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell (1998) 3.39
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. EMBO J (1999) 3.35
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J (1994) 3.26
Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat Rev Genet (2001) 3.15
Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation. RNA (2005) 3.08
Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Mol Cell (1998) 3.02
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol Cell Biol (1992) 2.99
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature (2006) 2.95
A history of poly A sequences: from formation to factors to function. Prog Nucleic Acid Res Mol Biol (2002) 2.93
hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells. Mol Cell Biol (2001) 2.91
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Genes Dev (1995) 2.83
Cell signalling and the control of pre-mRNA splicing. Nat Rev Mol Cell Biol (2004) 2.78
The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation. Proc Natl Acad Sci U S A (1991) 2.77
SRm160 splicing coactivator promotes transcript 3'-end cleavage. Mol Cell Biol (2002) 2.73
The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. Cell (1994) 2.70
Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequences. Curr Opin Cell Biol (2002) 2.68
The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev (1994) 2.64
Cleavage site determinants in the mammalian polyadenylation signal. Nucleic Acids Res (1995) 2.63
The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Genes Dev (1998) 2.56
Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. Genes Dev (2005) 2.52
mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription. Curr Opin Cell Biol (1999) 2.51
The double lives of shuttling mRNA binding proteins. Cell (2000) 2.51
A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. Genes Dev (1996) 2.50
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. Genes Dev (2007) 2.49
Arylsulfatase A pseudodeficiency: loss of a polyadenylylation signal and N-glycosylation site. Proc Natl Acad Sci U S A (1989) 2.47
Connections between mRNA 3' end processing and transcription termination. Curr Opin Cell Biol (2005) 2.46
The polyadenylation factor CPSF-73 is involved in histone-pre-mRNA processing. Cell (2005) 2.37
CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition. Genes Dev (1995) 2.37
Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes Dev (1996) 2.33
A comparison of mammalian and yeast pre-mRNA 3'-end processing. Curr Opin Cell Biol (1997) 2.32
Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing. J Virol (1992) 2.29
Structure and function of poly(A) binding proteins. Biochim Biophys Acta (2004) 2.28
The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing. Genes Dev (2000) 2.27
Sequence determinants in human polyadenylation site selection. BMC Genomics (2003) 2.26
The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. Genes Dev (1996) 2.25
Cotranscriptional processes and their influence on genome stability. Genes Dev (2006) 2.23
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. RNA (2004) 2.10
Nuclear RNA export. Genes Dev (1998) 2.04
Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation. Genes Dev (1997) 2.03
Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. Proc Natl Acad Sci U S A (1998) 2.01
A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer (2004) 2.01
A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. Mol Cell (2003) 2.00
Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat Genet (1992) 1.98
The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell (2001) 1.95
The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation. Cold Spring Harb Symp Quant Biol (2001) 1.94
The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. RNA (2001) 1.94
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. EMBO J (2004) 1.92
Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation. Mol Cell Biol (2002) 1.92
Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Res (2004) 1.91
Computational analysis of 3'-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat. Genome Res (2005) 1.88
Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing. Mol Cell (2006) 1.86
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell (2012) 6.71
Molecular mechanisms of translational control. Nat Rev Mol Cell Biol (2004) 6.39
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell (2012) 6.22
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell (2012) 6.07
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature (2007) 3.77
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA (2006) 3.71
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Nat Struct Mol Biol (2007) 3.62
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood (2006) 3.38
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. J Clin Oncol (2011) 3.33
Y14 and hUpf3b form an NMD-activating complex. Mol Cell (2003) 3.17
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell (2011) 3.11
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr (2008) 2.98
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell (2006) 2.77
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med (2011) 2.59
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet (2003) 2.43
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet (2013) 2.42
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Molecular staging of intracranial ependymoma in children and adults. J Clin Oncol (2010) 2.27
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) (2009) 2.15
The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Mol Cell (2010) 2.14
The RNA-binding protein repertoire of embryonic stem cells. Nat Struct Mol Biol (2013) 2.12
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood (2006) 2.10
NMD: RNA biology meets human genetic medicine. Biochem J (2010) 2.09
Adult medulloblastoma comprises three major molecular variants. J Clin Oncol (2011) 2.07
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 2.02
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol (2002) 1.98
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol (2007) 1.96
Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol (2003) 1.95
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol (2012) 1.91
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell (2005) 1.91
Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol (2011) 1.90
TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol (2010) 1.83
Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol (2010) 1.82
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Mol Cell (2009) 1.82
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A (2002) 1.77
Translational control via protein-regulated upstream open reading frames. Cell (2011) 1.76
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem J (2003) 1.74
Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin. J Clin Invest (2007) 1.73
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med (2007) 1.73
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl) (2008) 1.71
Disassembly of exon junction complexes by PYM. Cell (2009) 1.69
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet (2004) 1.68
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One (2009) 1.67
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification. J Clin Oncol (2010) 1.65
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood (2005) 1.59
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol (2004) 1.59
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol (2002) 1.58
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab (2008) 1.54
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Nucleic Acids Res (2007) 1.53
Using the lambdaN peptide to tether proteins to RNAs. Methods Mol Biol (2004) 1.52
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
The efficiency of nonsense-mediated mRNA decay is an inherent character and varies among different cells. Eur J Hum Genet (2007) 1.48
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. RNA (2010) 1.46
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA (2006) 1.46
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay. Blood (2002) 1.43
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Nat Protoc (2008) 1.43
RNA-binding proteins in Mendelian disease. Trends Genet (2013) 1.38
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Proc Natl Acad Sci U S A (2005) 1.36
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Mol Cell (2004) 1.36
Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers. Acta Neuropathol (2015) 1.35
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood (2009) 1.33
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma. Acta Neuropathol (2011) 1.32
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol (2012) 1.28
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J (2007) 1.27
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem (2006) 1.25
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. PLoS Biol (2009) 1.24
NMD: multitasking between mRNA surveillance and modulation of gene expression. Adv Genet (2008) 1.23
The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. Mol Cell (2009) 1.23
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev (2006) 1.22
Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon. RNA (2011) 1.19
The human intronless melanocortin 4-receptor gene is NMD insensitive. Hum Mol Genet (2002) 1.19
Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA. Mol Cell (2003) 1.18
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem (2005) 1.17