Published in J Immunol on January 15, 2008
The IL-1 family: regulators of immunity. Nat Rev Immunol (2010) 4.65
How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46
Effects of air pollutants on innate immunity: the role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. J Allergy Clin Immunol (2012) 1.55
IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS One (2011) 1.37
Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis. Infect Immun (2010) 1.31
Cysteine redox potential determines pro-inflammatory IL-1beta levels. PLoS One (2009) 1.30
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med (2012) 1.27
Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal Immunol (2011) 1.26
Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest (2011) 1.25
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol (2008) 1.25
Impact of smoking on inflammation: overview of molecular mechanisms. Inflamm Res (2011) 1.24
Innate immune responses are increased in chronic obstructive pulmonary disease. PLoS One (2011) 1.23
Macrophage heterogeneity in respiratory diseases. Mediators Inflamm (2013) 1.20
New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease. Am J Pathol (2013) 1.19
TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem (2011) 1.18
Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice. Am J Respir Crit Care Med (2010) 1.08
Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. Expert Rev Clin Immunol (2012) 1.07
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem (2009) 1.07
A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. Am J Physiol Lung Cell Mol Physiol (2011) 1.06
RAGE: a new frontier in chronic airways disease. Br J Pharmacol (2012) 1.04
Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation. Respir Res (2010) 1.03
Whole cigarette smoke increased the expression of TLRs, HBDs, and proinflammory cytokines by human gingival epithelial cells through different signaling pathways. PLoS One (2012) 1.00
Regulation of wound healing and organ fibrosis by toll-like receptors. Biochim Biophys Acta (2012) 0.99
Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung. Am J Physiol Lung Cell Mol Physiol (2011) 0.97
Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med (2008) 0.97
The role of toll-like receptors in acute and chronic lung inflammation. J Inflamm (Lond) (2010) 0.97
Toll like receptors in diseases of the lung. Int Immunopharmacol (2011) 0.97
Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β - A Possible Pathway of Exacerbations in COPD. PLoS One (2013) 0.97
Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease. Respir Res (2011) 0.96
A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue. Bioinform Biol Insights (2013) 0.95
Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice. Respir Res (2012) 0.94
Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. Am J Respir Crit Care Med (2013) 0.93
Inflammation and immune response in COPD: where do we stand? Mediators Inflamm (2013) 0.92
NOD-Like Receptors in Lung Diseases. Front Immunol (2013) 0.92
Mouse models for human otitis media. Brain Res (2009) 0.92
IL-1 receptor regulates microRNA-135b expression in a negative feedback mechanism during cigarette smoke-induced inflammation. J Immunol (2013) 0.92
Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke. PLoS One (2012) 0.92
Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeutic target in Duchenne muscular dystrophy. Hum Mol Genet (2014) 0.91
Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation. PLoS One (2009) 0.91
PPARγ agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages. Respir Res (2014) 0.91
Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. J Biol Chem (2011) 0.90
Transcriptional regulation of cytokine function in airway smooth muscle cells. Pulm Pharmacol Ther (2009) 0.90
Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol (2013) 0.89
DAMPs activating innate and adaptive immune responses in COPD. Mucosal Immunol (2013) 0.89
Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am J Respir Cell Mol Biol (2014) 0.89
Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure. Respir Res (2014) 0.89
Comparison of nasal and bronchial epithelial cells obtained from patients with COPD. PLoS One (2012) 0.88
Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients. PLoS One (2012) 0.88
Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation. Respir Res (2011) 0.87
Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis. Cell Commun Signal (2015) 0.87
Anti-interleukin-33 inhibits cigarette smoke-induced lung inflammation in mice. Immunology (2013) 0.86
MyD88 provides a protective role in long-term radiation-induced lung injury. Int J Radiat Biol (2012) 0.85
Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD. PLoS One (2014) 0.85
Targeting IL-1β and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation. PLoS One (2014) 0.85
Activation of C3a receptor is required in cigarette smoke-mediated emphysema. Mucosal Immunol (2014) 0.84
Molecular Regulation of Toll-like Receptors in Asthma and COPD. Front Physiol (2015) 0.83
Effects of environmental tobacco smoke on adult rat brain biochemistry. J Mol Neurosci (2009) 0.83
Cytosolic, autocrine alpha-1 proteinase inhibitor (A1PI) inhibits caspase-1 and blocks IL-1β dependent cytokine release in monocytes. PLoS One (2012) 0.83
Second hand smoke and COPD: lessons from animal studies. Front Physiol (2013) 0.83
Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice. Respir Res (2014) 0.83
Pathogenic mechanism of second hand smoke induced inflammation and COPD. Front Physiol (2012) 0.82
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation. FASEB J (2014) 0.82
Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice. PLoS One (2014) 0.82
Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem (2015) 0.81
Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease. Am J Respir Cell Mol Biol (2016) 0.81
Airway inflammation and hypersensitivity induced by chronic smoking. Respir Physiol Neurobiol (2011) 0.80
Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas. Am J Pathol (2016) 0.79
Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients. Respir Res (2016) 0.79
TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol (2015) 0.79
Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis. Biosci Rep (2016) 0.79
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. PLoS Pathog (2014) 0.79
A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease. J Immunol (2015) 0.79
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation. Part Fibre Toxicol (2012) 0.79
Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease. J Innate Immun (2012) 0.79
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains. Inflamm Res (2015) 0.79
Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1β and tumor necrosis factor-α secretion from macrophages via substance P-mediated nuclear factor-κB activation. Am J Respir Cell Mol Biol (2010) 0.79
Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? Oncotarget (2016) 0.79
Cigarette smoke represses the innate immune response to asbestos. Physiol Rep (2015) 0.78
Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses. Nat Rev Microbiol (2016) 0.78
Lung inflammation in COPD: why does it matter? F1000 Med Rep (2012) 0.78
The dendritic cell niche in chronic obstructive pulmonary disease. Respir Res (2012) 0.78
Solitary langerhans cell histiocytosis in an adult: case report and literature review. BMC Res Notes (2016) 0.77
Inflammasome Activity in Non-Microbial Lung Inflammation. J Environ Immunol Toxicol (2014) 0.77
Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction. Laryngoscope (2013) 0.77
Experimental progressive emphysema in BALB/cJ mice as a model for chronic alveolar destruction in humans. Am J Physiol Lung Cell Mol Physiol (2015) 0.76
TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway. Int J Chron Obstruct Pulmon Dis (2015) 0.76
Leukocyte Activation in Obese Patients: Effect of Bariatric Surgery. Medicine (Baltimore) (2015) 0.75
Mucosal inflammation at the respiratory interface: a zebrafish model. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Susceptibility to Aspergillus Infections in Rats with Chronic Obstructive Pulmonary Disease via Deficiency Function of Alveolar Macrophages and Impaired Activation of TLR2. Inflammation (2016) 0.75
HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway. Mol Biol Cell (2016) 0.75
Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Lung inflammation caused by inhaled toxicants: a review. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Reduced sputum expression of interferon-stimulated genes in severe COPD. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Cigarette Smoke Induces Human Epidermal Receptor 2-Dependent Changes in Epithelial Permeability. Am J Respir Cell Mol Biol (2016) 0.75
Effects of Cigarette Smoking on Transplant Survival: Extending or Shortening It? Front Immunol (2017) 0.75
The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis. Int J Chron Obstruct Pulmon Dis (2012) 0.75
Comment on "Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent". J Immunol (2008) 0.75
HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide. Lab Anim Res (2017) 0.75
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest (2010) 2.89
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest (2007) 2.88
IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol (2007) 2.73
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med (2012) 2.71
Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J Clin Invest (2004) 2.65
Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci U S A (2007) 2.64
Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity (2007) 2.58
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med (2009) 2.45
Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum (2012) 2.43
Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity (2005) 2.35
Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am J Pathol (2004) 2.27
Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol (2002) 2.17
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc Natl Acad Sci U S A (2010) 2.09
Cutting edge: Priming of NK cells by IL-18. J Immunol (2008) 2.08
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut (2012) 1.97
Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect (2004) 1.94
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood (2004) 1.88
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med (2010) 1.84
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. Arthritis Rheum (2012) 1.83
Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity (2012) 1.82
Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J Immunol (2004) 1.81
Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun (2004) 1.77
Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response. J Biol Chem (2003) 1.71
VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases. Proc Natl Acad Sci U S A (2007) 1.68
Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol (2005) 1.59
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection. J Clin Invest (2014) 1.58
IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol (2011) 1.57
iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice. PLoS Pathog (2009) 1.53
Reactivation of latent tuberculosis infection in TNF-deficient mice. J Immunol (2003) 1.52
Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci U S A (2005) 1.50
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol (2010) 1.44
Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. Cancer Res (2012) 1.43
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol (2010) 1.43
Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J Immunol (2007) 1.41
Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. PLoS Pathog (2010) 1.39
Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol (2007) 1.38
Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am J Respir Crit Care Med (2011) 1.38
Overexpression of Toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. J Immunol (2003) 1.36
Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther (2014) 1.35
Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages. J Biol Chem (2012) 1.35
Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? J Mol Cell Biol (2011) 1.32
The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis. Respir Res (2005) 1.32
IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One (2011) 1.32
IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol (2009) 1.31
Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol (2011) 1.25
IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J Immunol (2010) 1.25
Macrophage elastase (MMP-12): a pro-inflammatory mediator? Mem Inst Oswaldo Cruz (2005) 1.23
ATP release and purinergic signaling in NLRP3 inflammasome activation. Front Immunol (2013) 1.23
The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol (2005) 1.23
All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus. PLoS One (2011) 1.20
IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol (2009) 1.17
Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int J Exp Pathol (2007) 1.15
Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs. Clin Exp Metastasis (2009) 1.15
Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan. J Biol Chem (2007) 1.15
Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells. J Immunol (2010) 1.14
Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat. Blood (2004) 1.14
Mycobacterium tuberculosis H37Ra and H37Rv differential growth and cytokine/chemokine induction in murine macrophages in vitro. J Interferon Cytokine Res (2006) 1.14
IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol (2013) 1.14
Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis (2006) 1.12