Published in Biochem J on June 15, 1976
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A (1982) 8.71
A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. Proc Natl Acad Sci U S A (1977) 4.17
Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes. J Cell Biol (1990) 2.84
Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids. Proc Natl Acad Sci U S A (1979) 2.54
Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway. Biochem J (1977) 1.93
Inhibition of protein degradation in isolated rat hepatocytes. Biochem J (1977) 1.68
Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysis. Biochem J (1979) 1.47
Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes. Biochem J (1978) 1.45
Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. Proc Natl Acad Sci U S A (1980) 1.43
Degradation of proteins microinjected into IMR-90 human diploid fibroblasts. J Cell Biol (1981) 1.40
Effects of weak bases on the degradation of endogenous and exogenous proteins by rat yolk sacs. Biochem J (1980) 1.40
General characteristics of protein degradation in diabetes and starvation. Proc Natl Acad Sci U S A (1978) 1.24
Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3':5'-cyclic monophosphate and insulin. Biochem J (1980) 1.18
Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids. Proc Natl Acad Sci U S A (1983) 1.16
Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle. Proc Natl Acad Sci U S A (1978) 1.15
Model for Stress-induced Protein Degradation in Lemna minor. Plant Physiol (1980) 1.06
Regulation of protein accumulation in cultured cells. Biochem J (1982) 1.04
Metabolism of native and of lactosylated human low density lipoprotein: evidence for two pathways for catabolism of exogenous proteins in rat hepatocytes. Proc Natl Acad Sci U S A (1980) 1.02
Intracellular protein degradation in serum-deprived human fibroblasts. Biochem J (1986) 1.02
Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes. Biochem J (1985) 1.01
Stimulation by glucocorticoids of protein degradation in hepatocyte monolayers. Biochem J (1981) 0.96
Distribution and degradation of biotin-containing carboxylases in human cell lines. Biochem J (1985) 0.96
Cellular and lysosomal uptake of methylamine in isolated rat hepatocytes. Biochem J (1983) 0.94
Studies on the relationship between the degradative rates of proteins in vivo and their isoelectric points. Biochem J (1979) 0.93
Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J (1980) 0.93
Degradation of smooth-muscle myosin by trypsin-like serine proteinases. Biochem J (1982) 0.92
Protein degradation during terminal cytodifferentiation. Studies on mammary gland in organ culture. Biochem J (1980) 0.92
Decreased protein and puromycinyl-peptide degradation in livers of senescent mice. Biochem J (1982) 0.92
Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal. Proc Natl Acad Sci U S A (1986) 0.91
Inhibition of pyruvate carboxylase degradation and total protein breakdown by lysosomotropic agents in 3T3-L1 cells. Biochem J (1983) 0.91
Degradation of erythrocyte-microinjected and scrape-loaded homologous cytosolic proteins by 3T3-L1 cells. Biochem J (1985) 0.90
Effects of microbial proteinase inhibitors on the degradation of endogenous and internalized proteins by rat yolk sacs. Biochem J (1981) 0.90
Degradation of transplanted rat liver mitochondrial-outer-membrane proteins in hepatoma cells. Biochem J (1983) 0.89
Inhibition of protein breakdown by epidermal growth factor in IMR90 human fibroblasts and other mammalian cell lines. Biochem J (1983) 0.86
Distribution and partial purification of a liver membrane protein capable of inactivating cytosol enzymes. Biochem J (1980) 0.86
Proinsulin modified by analogues of arginine and lysine is degraded rapidly in pancreatic B-cells. Biochem J (1984) 0.85
Inhibition by cycloheximide of degradation of cytochrome P-450 in primary cultures of adult rat liver parenchymal cells and in vivo. Biochem J (1979) 0.85
Protein catabolism in fibroblasts cultured from patients with mucolipidosis II and other lysosomal disorders. Biochem J (1993) 0.84
Mechanisms of protein degradation in growing and non-growing L-cell cultures. Biochem J (1979) 0.84
Accelerated breakdown of reticulocyte protein formed under conditions of amino acid depletion. Biochem J (1978) 0.83
General characteristics of normal and stress-enhanced protein degradation in Lemna minor (duckweed). Biochem J (1980) 0.83
Degradation of native and modified forms of fructose-bisphosphate aldolase microinjected into HeLa cells. Biochem J (1988) 0.82
Vanadate inhibits degradation of short-lived, but not of long-lived, proteins in L-132 human cells. Biochem J (1989) 0.82
Effect of a nutritional shift on the degradation of abnormal proteins in the mouse liver. Decreased degradation during rapid liver growth. Biochem J (1977) 0.81
Mechanisms of intracellular protein catabolism. Intracellular fate of microinjected polypeptides translated in vitro. Biochem J (1987) 0.79
Use of 18O-labelled leucine and phenylalanine to measure protein turnover in muscle cell cultures and possible futile cycling during aminoacylation. Biochem J (1993) 0.78
Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting. Rambam Maimonides Med J (2012) 0.78
Degradation of myofibrillar proteins by trypsin-like serine proteinases. Biochem J (1982) 0.78
A low-molecular-weight inhibitor of the neutral proteinase from rat intestinal smooth muscle. Biochem J (1980) 0.78
Effects of inhibitors on aldolase breakdown after its microinjection into HeLa cells. Biochem J (1989) 0.77
A comparison of lysosomal involvements in the degradation of normal and abnormal endogenous proteins of differing half-lives in MRC5 cells. Biochem J (1983) 0.75
Protein degradation in cat liver cells. Biochem J (1986) 0.75
The breakdown of Tetrahymena ribosomes in vivo. The effects of inhibitors. Biochem J (1982) 0.75
Protein degradation in cultured fetal hepatocytes. Absence of an inhibitory effect of insulin. Biochem J (1990) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Amino acid metabolism in mammalian cell cultures. Science (1959) 55.21
Cytoplasmic components in hepatic cell lysosomes. J Cell Biol (1962) 6.57
Intracellular protein degradation in mammalian and bacterial cells. Annu Rev Biochem (1974) 6.05
HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO. Natl Cancer Inst Monogr (1964) 3.53
Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin). Proc Natl Acad Sci U S A (1972) 3.53
Focal cytoplasmic degradation. Am J Pathol (1963) 3.32
Response of intracellular proteolysis to alteration of bacterial protein and the implications in metabolic regulation. J Bacteriol (1967) 2.62
Protein degradation in cultured cells. The effect of fresh medium, fluoride, and iodoacetate on the digestion of cellular protein of rat fibroblasts. J Biol Chem (1973) 2.23
Insulin in the regulation of protein turnover in heart and skeletal muscle. Fed Proc (1974) 2.18
Degradation of abnormal proteins in Escherichia coli. Formation of protein inclusions in cells exposed to amino acid analogs. J Biol Chem (1975) 2.03
Role of individual cathepsins in lysosomal protein digestion as tested by specific inhibitors. Biochim Biophys Acta (1974) 1.38
Biological activities of leupeptins. J Antibiot (Tokyo) (1969) 1.33
Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin. J Antibiot (Tokyo) (1972) 1.26
Studies on cellular autophagocytosis. A histochemical study on sequential alterations of mitochondria in the glucagon-induced autophagic vacuoles of rat liver. Lab Invest (1972) 1.26
Increased degradation rates of protein synthesized in hepatoma cells in the presence of amino acid analogues. Biochem J (1975) 1.23
Fate of abnormal proteins in E. coli accumulation in intracellular granules before catabolism. Nat New Biol (1972) 1.21
Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo) (1972) 1.21
Degradation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in vivo and in vitro. Biochem J (1974) 1.21
A comparison of the proteolytic susceptibility of several rat liver enzymes. Biochem Biophys Res Commun (1971) 1.18
Factors affecting the secretion of insulin and glucagon by the rat fetus. Diabetes (1974) 1.16
The relative stability of liver cytosol enzymes incubated in vitro. Biochem J (1974) 1.09
Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues. Biochem J (1975) 0.95
Comparative studies in vivo and in vitro of rat-liver enzymes. Eur J Biochem (1974) 0.93
[Intracellular protein breakdown. 3. Intracellular distribution of proteolytic degradation of cytosol proteins at neutral pH]. Acta Biol Med Ger (1971) 0.92
Inactivation of phosphoenolypyruvate carboxykinase (GTP) by liver extracts. Biochem J (1976) 0.91
Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Biochem J (1967) 2.98
Ketohexokinase, isoenzymes of glucokinase and glycogen synthesis from hexoses in neonatal rat liver. Biochem J (1964) 2.55
Intracellular protein degradation. Essays Biochem (1977) 2.00
Phosphoenolpyruvate carboxykinase and the synthesis of glyceride-glycerol from pyruvate in adipose tissue. J Biol Chem (1967) 1.69
Inhibition of protein degradation in isolated rat hepatocytes. Biochem J (1977) 1.68
Production and utilization of acetate in mammals. Biochem J (1974) 1.61
Synthesis and degradation of phosphoenolpyruvate carboxylase in rat liver and adipose tissue. Changes during a starvation-re-feeding cycle. Biochem J (1973) 1.55
A possible physiological role for glyceroneogenesis in rat adipose tissue. J Biol Chem (1970) 1.49
Citrate, pyruvate, and lactate contaminants of commercial serum albumin. J Lipid Res (1968) 1.49
The initial synthesis of proteins during development. Phosphoenolpyruvate carboxylase in rat liver at birth. Biochem J (1972) 1.47
Supply and utilization of acetate in mammals. Am J Clin Nutr (1972) 1.46
Glyceride-glycerol synthesis from pyruvate. Adaptive changes in phosphoenolpyruvate carboxykinase and pyruvate carboxylase in adipose tissue and liver. J Biol Chem (1969) 1.44
The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants. Biochem J (1967) 1.40
Effects of weak bases on the degradation of endogenous and exogenous proteins by rat yolk sacs. Biochem J (1980) 1.40
The development of gluconeogenesis in rat liver: experiments in vivo. Biochem J (1969) 1.39
Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts. Biochem J (1986) 1.32
Insulin-like growth factors 1 and 2 in bovine colostrum. Sequences and biological activities compared with those of a potent truncated form. Biochem J (1988) 1.30
Rapid loss of translatable messenger RNA of phosphoenolpyruvate carboxykinase during glucose repression in liver. Proc Natl Acad Sci U S A (1974) 1.29
Reduced rates of proteolysis in transformed cells. Nature (1977) 1.26
Gluconeogenesis and lipogenesis in tissue from ruminant and nonruminant animals. Fed Proc (1969) 1.25
The development of gluconeogenesis in rat liver. Effects of glucagon and ether. Biochem J (1970) 1.23
Insulin inhibition of protein degradation in cell monolayers. J Cell Physiol (1980) 1.23
Increased degradation rates of protein synthesized in hepatoma cells in the presence of amino acid analogues. Biochem J (1975) 1.23
Degradation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in vivo and in vitro. Biochem J (1974) 1.21
Effects of cyclic adenosine monophosphate, dexamethasone and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells. Biochemistry (1975) 1.20
The development of gluconeogenesis in rat liver. Controlling factors in the newborn. Biochem J (1971) 1.19
Phosphopyruvate carboxylase induction by L-tryptophan. Effects on synthesis and degradation of the enzyme. Biochem J (1973) 1.19
The effect of concentration on glucose phosphorylation and incorporation into glycogen in the livers of foetal and adult rats and sheep. Biochem J (1964) 1.19
Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3':5'-cyclic monophosphate and insulin. Biochem J (1980) 1.18
Purification and properties of rat liver fructokinase. J Biol Chem (1967) 1.17
Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions. Biochem J (1971) 1.13
The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids. J Biol Chem (1975) 1.11
Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. J Mol Endocrinol (1992) 1.10
Regulation of the breakdown rates of biotin-containing proteins in Swiss 3T3-L1 cells. Biochem J (1988) 1.10
Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Biochem J (1986) 1.09
The relative stability of liver cytosol enzymes incubated in vitro. Biochem J (1974) 1.09
Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1. Biochem J (1989) 1.05
Adenine nucleotides and the adenylate kinase equilibrium in livers of foetal and newborn rats. Biochem J (1970) 1.05
Glucocorticoids and the regulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in the rat. Biochem J (1975) 1.04
Kinetic studies with liver galactokinase. Biochem J (1966) 1.04
Regulation of protein accumulation in cultured cells. Biochem J (1982) 1.04
IGF-I and the truncated analogue des-(1-3)IGF-I enhance growth in rats after gut resection. Am J Physiol (1991) 1.03
Inhibition of protein breakdown in cultured cells is a consistent response to growth factors. FEBS Lett (1980) 1.02
The role of the adrenals in the regulation of phosphoenolpyruvate carboxykinase of rat adipose tissue. J Biol Chem (1969) 1.01
Kinetic studies with cytosol and mitochondrial phosphoenolpyruvate carboxykinases. Biochem J (1970) 1.00
3-Methylhistidine as a measure of skeletal muscle protein breakdown in human subjects: the case for its continued use. Clin Sci (Lond) (1983) 1.00
Alterations in translatable messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat liver cytosol during deinduction. J Biol Chem (1978) 0.99
Intermediary metabolism of carbon compounds by nitrifying bacteria. Arch Mikrobiol (1970) 0.98
Measurement of adipose-tissue metabolites in vivo. Biochem J (1969) 0.98
The bovine insulin-like growth factor (IGF) binding protein purified from conditioned medium requires the N-terminal tripeptide in IGF-1 for binding. Biochem Biophys Res Commun (1988) 0.97
Stimulation by glucocorticoids of protein degradation in hepatocyte monolayers. Biochem J (1981) 0.96
Distribution and degradation of biotin-containing carboxylases in human cell lines. Biochem J (1985) 0.96
Multiple biotin-containing proteins in 3T3-L1 cells. Biochem J (1986) 0.96
Changes in the growth-promoting activity of human milk during lactation. Pediatr Res (1984) 0.96
Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues. Biochem J (1975) 0.95
Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem J (1991) 0.94
Purification and properties of galactokinase from pig liver. Biochem J (1966) 0.94
A rapid method for the analysis of N tau-methylhistidine in human urine. Anal Biochem (1981) 0.94
The relationship between the insulin content and inhibitory effects of bovine colostrum on protein breakdown in cultured cells. J Cell Physiol (1982) 0.94
Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate. Growth Factors (1998) 0.94
Infulence of hormones and medium composition on the degradation of phosphoenolpyruvate carboxykinase (GTP) and total protein in Reuber H35 cells. J Biol Chem (1976) 0.94
Enzyme inactivation via disulphide-thiol exchange as catalysed by a rat liver membrane protein. Biochem J (1980) 0.93
Effects of carbohydrate availability on lipogenesis in sheep. Biochem J (1972) 0.92
Comparative binding of bovine, human and rat insulin-like growth factors to membrane receptors and to antibodies against human insulin-like growth factor-1. Biochem J (1986) 0.92
Pyruvate dehydrogenase activity in rat liver during development. Biol Neonate (1974) 0.92
Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu3, following their expression in Escherichia coli as fusion proteins. J Mol Endocrinol (1992) 0.91
Inactivation of phosphoenolypyruvate carboxykinase (GTP) by liver extracts. Biochem J (1976) 0.91
Insulin-like growth factor (IGF)-II binding to IGF-binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II. Biochem J (1993) 0.91
Inhibition of pyruvate carboxylase degradation and total protein breakdown by lysosomotropic agents in 3T3-L1 cells. Biochem J (1983) 0.91
Effects of microbial proteinase inhibitors on the degradation of endogenous and internalized proteins by rat yolk sacs. Biochem J (1981) 0.90
The appearance of gluconeogenesis at birth in sheep. Activation of the pathway associated with blood oxygenation. Biochem J (1977) 0.90
Physiological role and regulation of glyceroneogenesis in rat adipose tissue. Isr J Med Sci (1972) 0.89
Phosphoenolpyruvate synthesis and release by mitochondria from guinea pig liver. J Biol Chem (1969) 0.89
Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I), IGF-II and des(1-3)IGF-I in rats. J Endocrinol (1991) 0.88
Effects of full-length and truncated insulin-like growth factor-I on nitrogen balance and muscle protein metabolism in nitrogen-restricted rats. J Endocrinol (1991) 0.88
Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochem J (1992) 0.88
Metabolism of glucose, fructose and lactate in vivo in chronically cannulated foetuses and in suckling lambs. Biochem J (1977) 0.88
A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide. Biochem J (1989) 0.88
The effect of insulin and glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP) in rat adipose tissue cultured in vitro. Biochem J (1976) 0.88
Pathway of carbon flow during fatty acid synthesis from lactate and pyruvate in rat adipose tissue. J Lipid Res (1971) 0.87
The regulation of phosphoenolpyruvate carboxykinase in fetal rat liver. Enzyme (1973) 0.87
Transforming growth factor beta in bovine milk: concentration, stability and molecular mass forms. J Endocrinol (1996) 0.87
Factors controlling the concentration of mitochondrial oxaloacetate in liver during spontaneous bovine ketosis. Biochem Biophys Res Commun (1968) 0.87
Purification, amino acid sequences and assay cross-reactivities of porcine insulin-like growth factor-I and -II. J Endocrinol (1989) 0.87
Utilization of oxidizable substrates by the sheep hind limb: effects of starvation and exercise. Metabolism (1976) 0.86
Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin. Biochem J (1976) 0.86