Published in Proc Natl Acad Sci U S A on May 01, 1978
Chaperone-mediated autophagy: roles in disease and aging. Cell Res (2013) 1.57
Historical landmarks of autophagy research. Cell Res (2013) 1.49
Degradation of proteins microinjected into IMR-90 human diploid fibroblasts. J Cell Biol (1981) 1.40
Protein degradation in lemna with particular reference to ribulose bisphosphate carboxylase: I. The effect of light and dark. Plant Physiol (1987) 1.24
Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids. Proc Natl Acad Sci U S A (1983) 1.16
Protein Degradation in Lemna with Particular Reference to Ribulose Bisphosphate Carboxylase: II. The Effect of Nutrient Starvation. Plant Physiol (1987) 0.96
Chaperones in autophagy. Pharmacol Res (2012) 0.95
Autophagy, nutrition and immunology. Mol Aspects Med (2011) 0.94
Studies on the relationship between the degradative rates of proteins in vivo and their isoelectric points. Biochem J (1979) 0.93
Protein degradation during terminal cytodifferentiation. Studies on mammary gland in organ culture. Biochem J (1980) 0.92
Erythrocyte-mediated microinjection, a technique to study protein degradation in muscle cells. Biochem J (1983) 0.90
A releationship between protein-degradation rates in vivo, isoelectric points, and molecular weights obtained by using density labelling. Biochem J (1979) 0.90
Degradation of intra- and extrahepatic protein by livers of normal and diabetic mice: differential responses to starvation. Proc Natl Acad Sci U S A (1982) 0.90
Starvation and hypothyroidism exert an overlapping influence on rat hepatic messenger RNA activity profiles. J Clin Invest (1983) 0.89
Dietary omega 3 fatty acid alters prostaglandin synthesis, glucose transport and protein turnover in skeletal muscle of healthy and diabetic rats. Biochem J (1992) 0.85
General characteristics of normal and stress-enhanced protein degradation in Lemna minor (duckweed). Biochem J (1980) 0.83
Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models. Am J Physiol Endocrinol Metab (2014) 0.82
Selective depletion of small basic non-glycosylated proteins in diabetes. Biochem J (1981) 0.79
Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine. Biochem J (1986) 0.79
mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes. Diabetes (2014) 0.79
Role of macroautophagy in nutrient homeostasis during fungal development and pathogenesis. Cells (2012) 0.78
Effect of streptozotocin-diabetes on rat liver mitochondrial adenosine triphosphatase turnover. Biochem J (1988) 0.77
Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver. Braz J Med Biol Res (2014) 0.75
Intracellular protein degradation in mammalian and bacterial cells: Part 2. Annu Rev Biochem (1976) 12.05
Intracellular protein degradation in mammalian and bacterial cells. Annu Rev Biochem (1974) 6.05
THE IMPORTANCE OF BOTH SYNTHESIS AND DEGRADATION IN THE CONTROL OF ARGINASE LEVELS IN RAT LIVER. J Biol Chem (1964) 2.88
Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells. Biochem J (1976) 2.87
Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med (1967) 2.55
Regulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus. J Biol Chem (1977) 2.50
Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles. Am J Physiol (1976) 2.42
Protein degradation in cultured cells. The effect of fresh medium, fluoride, and iodoacetate on the digestion of cellular protein of rat fibroblasts. J Biol Chem (1973) 2.23
The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass. Biochem J (1976) 2.04
Studies on the correlation between size and relative degradation rate of soluble proteins. J Biol Chem (1973) 1.96
Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver. J Biol Chem (1969) 1.91
Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells. Biochemistry (1975) 1.71
The kinetics of disappearance of labeled leucine from the free leucine pool of rat liver and its effect on the apparent turnover of catalase and other hepatic proteins. J Biol Chem (1971) 1.70
Measurement of protein turnover in rat liver with (14C)carbonate. Protein turnover during liver regeneration. J Biol Chem (1974) 1.69
Relationship between in vivo degradative rates and isoelectric points of proteins. Proc Natl Acad Sci U S A (1975) 1.59
Effect of insulin on protein turnover in heart muscle. J Biol Chem (1975) 1.53
Comparison of turnover of several myofibrillar proteins and critical evaluation of double isotope method. J Biol Chem (1977) 1.49
On the measurement of protein turnover in animal cells. J Biol Chem (1972) 1.38
Protein catabolism and protein synthesis in perfused livers of normal and alloxan-diabetic rats. J Biol Chem (1960) 1.37
Alterations of lysosomal size and density during rat liver perfusion. Suppression by insulin and amino acids. J Biol Chem (1977) 1.13
Studies on the turnover of plasma membranes in cultured mammalian cells. II. Demonstration of heterogeneous rates of turnover for plasma membrane proteins and glycoproteins. Biochim Biophys Acta (1975) 1.10
Relative rates of degradation of mouse-liver surface-membrane proteins. Eur J Biochem (1973) 1.09
Synthesis and turnover of plasma-membrane proteins and glycoproteins in a neuroblastoma cell line. Biochem J (1976) 1.08
Structural properties of rat serum proteins which correlate with their degradative rates in vivo. Nature (1976) 1.01
Determination of trypsin by its accelerating effect on the onset of trypsinogen activation. Anal Biochem (1974) 0.93
Regulation of protein degradation in normal and transformed human cells. Effects of growth state, medium composition, and viral transformation. J Biol Chem (1977) 0.93
The dynamic state of Tetrahymena pyriformis cytosol proteins during culture development. FEBS Lett (1977) 0.85
Increased metabolic turnover rate and transcapillary escape rate of albumin in long-term juvenile diabetics. Scand J Clin Lab Invest (1975) 0.79
Intracellular protein degradation in mammalian and bacterial cells. Annu Rev Biochem (1974) 6.05
Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology (2006) 5.67
A receptor for the selective uptake and degradation of proteins by lysosomes. Science (1996) 4.89
A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science (1989) 4.58
Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci (2001) 4.36
Age-related decline in chaperone-mediated autophagy. J Biol Chem (2000) 3.22
A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J Biol Chem (1997) 2.63
Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. Am J Physiol (1995) 2.54
Unique properties of lamp2a compared to other lamp2 isoforms. J Cell Sci (2000) 2.46
Regulation of lamp2a levels in the lysosomal membrane. Traffic (2000) 2.27
Targeted disruption of the acid alpha-glucosidase gene in mice causes an illness with critical features of both infantile and adult human glycogen storage disease type II. J Biol Chem (1998) 2.24
An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J Cell Biol (1997) 2.24
Studies on the correlation between size and relative degradation rate of soluble proteins. J Biol Chem (1973) 1.96
A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci (2001) 1.86
Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J Neurosci (1997) 1.84
Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. J Biol Chem (1994) 1.69
Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J Biol Chem (1988) 1.63
IkappaB is a substrate for a selective pathway of lysosomal proteolysis. Mol Biol Cell (1998) 1.63
Lysosomes, a meeting point of proteins, chaperones, and proteases. J Mol Med (Berl) (1998) 1.59
Relationship between in vivo degradative rates and isoelectric points of proteins. Proc Natl Acad Sci U S A (1975) 1.59
Regulation of intracellular protein degradation in IMR-90 human diploid fibroblasts. J Cell Physiol (1983) 1.57
Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats. Biochem J (1991) 1.57
Etiology of infantile autism: a review of recent advances in genetic and neurobiological research. J Psychiatry Neurosci (1999) 1.54
When lysosomes get old. Exp Gerontol (2000) 1.44
Ubiquitin pools, ubiquitin mRNA levels, and ubiquitin-mediated proteolysis in aging human fibroblasts. Exp Gerontol (1993) 1.43
Polypeptide import and degradation by isolated lysosomes. J Biol Chem (1993) 1.43
Roles of molecular chaperones in protein degradation. J Cell Biol (1996) 1.42
Degradation of proteins microinjected into IMR-90 human diploid fibroblasts. J Cell Biol (1981) 1.40
Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein. J Biol Chem (1992) 1.38
Stress, feedback and facilitation in the hypothalamo-pituitary-adrenal axis. J Neuroendocrinol (1992) 1.37
Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus. Endocrinology (1986) 1.36
Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy. Kidney Int (1999) 1.28
Anti-human immunodeficiency virus type 1 antibody complexes on platelets of seropositive thrombocytopenic homosexuals and narcotic addicts. Proc Natl Acad Sci U S A (1988) 1.23
Accuracy of whole-body low-dose multidetector CT (WBLDCT) versus skeletal survey in the detection of myelomatous lesions, and correlation of disease distribution with whole-body MRI (WBMRI). Skeletal Radiol (2008) 1.21
Regulation of protein synthesis and degradation in L8 myotubes. Effects of serum, insulin and insulin-like growth factors. Biochem J (1989) 1.19
Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids. Proc Natl Acad Sci U S A (1983) 1.16
Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis. Ann N Y Acad Sci (1994) 1.14
Human melatonin regulation is not mediated by the three cone photopic visual system. J Clin Endocrinol Metab (2001) 1.11
Feedback sensitivity of the rat hypothalamo-pituitary-adrenal axis and its capacity to adjust to exogenous corticosterone. Endocrinology (1992) 1.08
Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide. J Biol Chem (1986) 1.07
Turnover and exchange of ribosomal proteins from rat liver. J Biol Chem (1972) 1.07
Feedback and facilitation in the adrenocortical system: unmasking facilitation by partial inhibition of the glucocorticoid response to prior stress. Endocrinology (1992) 1.07
A statistical analysis of the relationship between degradative rates and molecular weights of proteins. Arch Biochem Biophys (1975) 1.06
Altered degradation of proteins microinjected into senescent human fibroblasts. J Biol Chem (1982) 1.05
Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts. J Biol Chem (1985) 1.04
How do intracellular proteolytic systems change with age? Front Biosci (1998) 1.01
Regulation of protein degradation rates in eukaryotes. Curr Opin Cell Biol (1989) 1.01
High neonatal leptin exposure enhances brain GR expression and feedback efficacy on the adrenocortical axis of developing rats. Endocrinology (2001) 1.00
Central corticotropin-releasing factor administration prevents the excessive body weight gain of genetically obese (fa/fa) rats. Endocrinology (1989) 0.99
Conditional tissue-specific expression of the acid alpha-glucosidase (GAA) gene in the GAA knockout mice: implications for therapy. Hum Mol Genet (2001) 0.98
Analysis of B-cell antigens in normal reactive lymphoid tissue using four B-cell monoclonal antibodies. Blood (1983) 0.98
Protein translocation across membranes. Biochim Biophys Acta (2001) 0.97
Microinjection of cultured cells using red-cell-mediated fusion and osmotic lysis of pinosomes: a review of methods and applications. Biosci Rep (1984) 0.96
Selective degradation of annexins by chaperone-mediated autophagy. J Biol Chem (2000) 0.95
Studies on the relationship between the degradative rates of proteins in vivo and their isoelectric points. Biochem J (1979) 0.93
Development and clinical evaluation of a recombinant-antigen-based cytomegalovirus immunoglobulin M automated immunoassay using the Abbott AxSYM analyzer. J Clin Microbiol (2000) 0.93
Protein alterations in aging WI38 cells as determined by proteolytic susceptibility. Exp Cell Res (1975) 0.92
Effects of routine pupillary dilation on functional daylight vision. Arch Ophthalmol (1988) 0.92
Chronic leptin administration in developing rats reduces stress responsiveness partly through changes in maternal behavior. Horm Behav (2000) 0.91
Increased pituitary sensitivity to glucocorticoid feedback during the stress nonresponsive period in the neonatal rat. Endocrinology (1986) 0.91
Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal. Proc Natl Acad Sci U S A (1986) 0.91
Erythrocyte-mediated microinjection, a technique to study protein degradation in muscle cells. Biochem J (1983) 0.90
Menstrual cycle dependent fluctuations in NK and T-lymphocyte subsets from non-pregnant human endometrium. Am J Reprod Immunol (2000) 0.90
Altered degradation of intracellular proteins in aging human fibroblasts. Mech Ageing Dev (1984) 0.89
Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission. Behav Neurosci (1999) 0.89
Increased fat intake during lactation modifies hypothalamic-pituitary-adrenal responsiveness in developing rat pups: a possible role for leptin. Endocrinology (1998) 0.88
Red blood cell-mediated microinjection: methodological considerations. Anal Biochem (1985) 0.88
Chronic streptozotocin diabetes in rats facilitates the acute stress response without altering pituitary or adrenal responsiveness to secretagogues. Endocrinology (1991) 0.87
Noradrenergic facilitation of the adrenocorticotropin response to stress is absent during lactation in the rat. Brain Res (1996) 0.87
Reduced noradrenergic tone to the hypothalamic paraventricular nucleus contributes to the stress hyporesponsiveness of lactation. J Neuroendocrinol (1998) 0.87
A clinical phase I and pharmacokinetic study of BBR 2778, a novel anthracenedione analogue, administered intravenously, 3 weekly. Eur J Cancer (2000) 0.87
A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. Br J Cancer (1999) 0.87
Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation. Hum Immunol (1997) 0.86
Selective release of peptides from lysosomes. J Biol Chem (1993) 0.86
Structure of cytochrome c oxidase: a comparison of the bacterial and mitochondrial enzymes. Biochim Biophys Acta (2001) 0.85
Prevention of pregnancy-induced hypertension by calcium supplementation in angiotensin II-sensitive patients. Obstet Gynecol (1994) 0.84
Forearm blood flow and local responses to peptide vasodilators: a novel pharmacodynamic measure in the phase I trial of antagonist G, a neuropeptide growth factor antagonist. Clin Cancer Res (2001) 0.83
Two related proteolipids and dolichol-linked oligosaccharides accumulate in motor neuron degeneration mice (mnd/mnd), a model for neuronal ceroid lipofuscinosis. J Biol Chem (1994) 0.82
Adrenal vasoactive intestinal peptide participates in neonatal corticosteroid production in the rat. Am J Physiol (1997) 0.82
Proteolysis in cultured cells during prolonged serum deprivation and replacement. Am J Physiol (1986) 0.82
Evidence for isopentenyladenine modification on a cell cycle-regulated protein. J Biol Chem (1991) 0.82
Intracellular protein degradation in cultures of dystrophic muscle cells and fibroblasts. Exp Cell Res (1984) 0.81
Rapid in vivo degradation of glycoproteins isolated from cytosol. J Biol Chem (1979) 0.81
Optimisation of a technique for isolating lymphocyte subsets from human endometrium. Immunol Invest (1999) 0.81
Circulating gonadotrophin surge-attenuating factor from superovulated women suppresses in vitro gonadotrophin-releasing hormone self-priming. J Endocrinol (1994) 0.80
Effect of air-supported, continuous, postural oscillation on the risk of early ICU pneumonia in nontraumatic critical illness. Chest (1993) 0.80
The synthesis and degradation of membrane proteins. Drug Metab Dispos (1974) 0.80
Cellular theories of aging as related to the liver. Hepatology (1985) 0.80
Paraventricular nucleus modulation of glycemia and insulinemia in freely moving lean rats. Am J Physiol (1989) 0.80
Selective depletion of small basic non-glycosylated proteins in diabetes. Biochem J (1981) 0.79
Regulation of catabolism of ribonuclease A microinjected into human fibroblasts. Prog Clin Biol Res (1985) 0.79
Autobiographical memory and perceptual learning: a developmental study using picture recognition, naming latency, and perceptual identification. Mem Cognit (1985) 0.79
Prediction of peripartum hysterectomy and end organ dysfunction in major obstetric haemorrhage. Eur J Obstet Gynecol Reprod Biol (2010) 0.79
Ginseng extract inhibits protein degradation and stimulates protein synthesis in human fibroblasts. Biochem Biophys Res Commun (1985) 0.78
Protein degradation in metabolic and nutritional disorders. Ciba Found Symp (1979) 0.78
Effect of serum deprivation and replacement on proteolysis in cultured human fibroblasts. Prog Clin Biol Res (1985) 0.78
N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy. J Med Chem (2001) 0.78
The morbidity of differential renal function studies. Analysis of 271 studies. JAMA (1967) 0.78
Changes in neuropeptide Y immunoreactivity in the arcuate nucleus during and after food restriction in lactating rats. Brain Res (1997) 0.78