Published in Cell Death Differ on January 25, 2008
Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer (2009) 5.12
The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08
Translating p53 into the clinic. Nat Rev Clin Oncol (2010) 2.55
Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell (2009) 2.28
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Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev (2011) 1.11
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Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. J Biol Chem (2010) 1.00
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage. Mol Cell Biol (2011) 1.00
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J Biol Chem (2010) 0.99
Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation. Nucleic Acids Res (2011) 0.99
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The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. Hum Mutat (2014) 0.97
Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia (2013) 0.96
Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism. J Biol Chem (2013) 0.96
MDM4 (MDMX) and its Transcript Variants. Curr Genomics (2009) 0.94
Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Mol Cell Biol (2012) 0.94
Abnormal MDMX degradation in tumor cells due to ARF deficiency. Oncogene (2011) 0.90
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif. J Chem Biol (2009) 0.90
MDMX contains an autoinhibitory sequence element. Proc Natl Acad Sci U S A (2013) 0.89
The p53-MDM2/MDMX axis - A chemotype perspective. Medchemcomm (2011) 0.88
MDMX exerts its oncogenic activity via suppression of retinoblastoma protein. Oncogene (2015) 0.88
c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation. J Biol Chem (2010) 0.87
MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4. PLoS One (2015) 0.87
An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus trossulus haemocytes. Comp Biochem Physiol B Biochem Mol Biol (2010) 0.87
Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex. Nucleic Acids Res (2011) 0.86
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. J Biol Chem (2010) 0.86
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J (2014) 0.84
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem (2014) 0.84
BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nat Commun (2015) 0.84
Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. Curr Pharm Des (2013) 0.84
Autoinhibition of MDMX by intramolecular p53 mimicry. Proc Natl Acad Sci U S A (2015) 0.84
The MDM2 gene family. Biomol Concepts (2014) 0.83
Autoactivation of the MDM2 E3 ligase by intramolecular interaction. Mol Cell Biol (2014) 0.83
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. J Biol Chem (2015) 0.83
Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops. Genes Cancer (2012) 0.83
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene (2012) 0.82
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Mol Cancer (2015) 0.81
Alterations of p63 and p73 in human cancers. Subcell Biochem (2014) 0.81
p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling. Genes Cancer (2012) 0.81
The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53. Genes Cancer (2012) 0.81
MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac. PLoS One (2014) 0.81
Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay. Proc Natl Acad Sci U S A (2012) 0.80
Therapeutic considerations for Mdm2: not just a one trick pony. Expert Opin Drug Discov (2008) 0.79
Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity. J Biol Chem (2013) 0.79
Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition. Cell Cycle (2015) 0.79
How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures. ChemMedChem (2015) 0.78
Regulation of the DNA damage response by ubiquitin conjugation. Front Genet (2015) 0.78
Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J Biol Chem (2015) 0.78
Thermodynamic and kinetic analysis of peptides derived from CapZ, NDR, p53, HDM2, and HDM4 binding to human S100B. Biochemistry (2012) 0.77
Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget (2016) 0.77
Allosteric Interactions by p53 mRNA Govern HDM2 E3 Ubiquitin Ligase Specificity under Different Conditions. Mol Cell Biol (2016) 0.76
Structure of the yeast Bre1 RING domain. Proteins (2015) 0.76
FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Oncogene (2016) 0.76
Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis (2015) 0.76
MDM2 oligomers: antagonizers of the guardian of the genome. Oncogene (2016) 0.76
Length matters: C-terminal tails regulate Mdm2-MdmX complexes. Cell Cycle (2012) 0.76
The Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic Target. Int J Mol Sci (2016) 0.75
Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB. Genes Cancer (2016) 0.75
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125. Sci Rep (2016) 0.75
Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. J Biol Chem (2016) 0.75
Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4. Cell Cycle (2017) 0.75
Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity. Oncotarget (2016) 0.75
Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner. Dev Biol (2017) 0.75
Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol (2014) 0.75
5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. Bioorg Med Chem (2013) 0.75
MDM2-MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance. Int J Nanomedicine (2016) 0.75
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens. Sci Rep (2016) 0.75
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat Struct Mol Biol (2017) 0.75
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