Published in J Cell Sci on August 01, 2010
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer (2011) 1.87
Deconstructing p53 transcriptional networks in tumor suppression. Trends Cell Biol (2011) 1.62
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol (2012) 1.62
Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins. Dev Cell (2015) 1.42
Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev (2017) 1.39
MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS One (2012) 1.35
Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One (2011) 1.22
The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans. Blood (2012) 1.16
Synthetic memory circuits for tracking human cell fate. Genes Dev (2012) 1.11
Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association. Invest Ophthalmol Vis Sci (2012) 0.99
Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis (2013) 0.99
p53 and mitochondrial function in neurons. Biochim Biophys Acta (2014) 0.97
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis. Transl Cancer Res (2013) 0.96
Mapping the p53 transcriptome universe using p53 natural polymorphs. Cell Death Differ (2013) 0.95
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
DBC1 functions as a tumor suppressor by regulating p53 stability. Cell Rep (2015) 0.95
The viral interferon regulatory factors of KSHV: immunosuppressors or oncogenes? Front Immunol (2011) 0.94
The Growing Complexity of Cancer Cell Response to DNA-Damaging Agents: Caspase 3 Mediates Cell Death or Survival? Int J Mol Sci (2016) 0.94
The p53 control of apoptosis and proliferation: lessons from Drosophila. Apoptosis (2014) 0.93
Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone. Front Neurosci (2012) 0.92
Not all p53 gain-of-function mutants are created equal. Cell Death Differ (2013) 0.92
The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target. Cell Cycle (2014) 0.92
Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A (2013) 0.90
p53 requires an intact C-terminal domain for DNA binding and transactivation. J Mol Biol (2011) 0.89
p53, a translational regulator: contribution to its tumour-suppressor activity. Oncogene (2015) 0.88
Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. PLoS One (2012) 0.86
Illuminating p53 function in cancer with genetically engineered mouse models. Semin Cell Dev Biol (2014) 0.86
Genome-wide expression analysis identifies a modulator of ionizing radiation-induced p53-independent apoptosis in Drosophila melanogaster. PLoS One (2012) 0.86
Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. PLoS Genet (2013) 0.85
Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. J Clin Invest (2015) 0.85
microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network. J Mol Cell Biol (2014) 0.84
Battle against cancer: an everlasting saga of p53. Int J Mol Sci (2014) 0.83
Myc-induced liver tumors in transgenic zebrafish can regress in tp53 null mutation. PLoS One (2015) 0.83
P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. PLoS One (2013) 0.83
Impaired mitochondrial metabolism and mammary carcinogenesis. J Mammary Gland Biol Neoplasia (2012) 0.82
p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget (2015) 0.81
Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination. World J Gastroenterol (2014) 0.80
Tumor suppression: p53 alters immune surveillance to restrain liver cancer. Curr Biol (2013) 0.80
RB goes mitochondrial. Genes Dev (2013) 0.80
Mimicking p14ARF phosphorylation influences its ability to restrain cell proliferation. PLoS One (2013) 0.80
Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression. Cell Death Dis (2013) 0.79
The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization. J Biol Chem (2014) 0.79
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence. EMBO J (2011) 0.79
Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing. Sci Rep (2016) 0.79
Combined Treatment of Androgen-Independent Prostate Cancer Cell Line DU145 with Chemotherapeutic Agents and Lithium Chloride: Effect on Growth Arrest and/or Apoptosis. Avicenna J Med Biotechnol (2012) 0.78
Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Rep (2015) 0.78
p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1). Oncotarget (2013) 0.78
A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression. Nucleic Acids Res (2013) 0.78
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A (2016) 0.78
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep (2015) 0.77
Chemical Variations on the p53 Reactivation Theme. Pharmaceuticals (Basel) (2016) 0.77
Guilty as CHARGED: p53's expanding role in disease. Cell Cycle (2014) 0.77
Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro. Biomed Res Int (2014) 0.77
A monoclonal antibody against p53 cross-reacts with processing bodies. PLoS One (2012) 0.77
Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma. Int J Mol Sci (2016) 0.76
Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp Ther Med (2015) 0.76
A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis. Mol Cancer Res (2014) 0.76
MDM2-mediated degradation of p14ARF: a novel mechanism to control ARF levels in cancer cells. PLoS One (2015) 0.76
Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease. Genes Cancer (2015) 0.76
Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus. Biochem Res Int (2015) 0.75
The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination. Oncotarget (2016) 0.75
Is p53 Involved in Tissue-Specific Insulin Resistance Formation? Oxid Med Cell Longev (2017) 0.75
Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells. Mol Cancer (2014) 0.75
P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia. Front Pharmacol (2016) 0.75
Adenovirus replaces mitotic checkpoint controls. J Virol (2015) 0.75
Jobelyn® Supplement Lowered Neuronal Degeneration: Significance of Altered p53 and ɤ-Enolase Protein Expressions in Prefrontal Cortex of Rat Exposed to Ethanol. Ann Neurosci (2016) 0.75
Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions. Cancer Inform (2016) 0.75
p53 gene discriminates two ecologically divergent sister species of pine voles. Heredity (Edinb) (2015) 0.75
Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer. Biomed Res Int (2016) 0.75
NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization. Oncotarget (2017) 0.75
Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene. Toxicol Rep (2014) 0.75
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33
Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol (2008) 11.05
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
Modes of p53 regulation. Cell (2009) 9.31
Senescence of activated stellate cells limits liver fibrosis. Cell (2008) 8.98
p53 has a direct apoptogenic role at the mitochondria. Mol Cell (2003) 8.98
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
Modulation of microRNA processing by p53. Nature (2009) 7.88
The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell (2004) 7.22
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell (2009) 6.64
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Modeling the therapeutic efficacy of p53 restoration in tumors. Cell (2006) 5.95
When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 5.86
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol (2004) 5.56
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science (2005) 5.49
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23
p53 and metabolism. Nat Rev Cancer (2009) 5.05
TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol (2010) 4.92
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (1994) 4.77
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell (2007) 4.75
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol (2006) 4.54
Modulation of mammalian life span by the short isoform of p53. Genes Dev (2004) 4.52
p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell (2009) 4.30
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet (2001) 4.23
p53 regulates maternal reproduction through LIF. Nature (2007) 4.12
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer (2003) 3.89
Delayed ageing through damage protection by the Arf/p53 pathway. Nature (2007) 3.87
Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat Med (2008) 3.53
Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 3.53
The expanding universe of p53 targets. Nat Rev Cancer (2009) 3.49
p53 suppresses the self-renewal of adult neural stem cells. Development (2006) 3.35
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron (2005) 3.13
A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol (2008) 3.13
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10
The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08
Stem cells: The promises and perils of p53. Nature (2009) 3.01
The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98
p53--a Jack of all trades but master of none. Nat Rev Cancer (2009) 2.96
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ (2006) 2.95
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med (2009) 2.89
MDMX: from bench to bedside. J Cell Sci (2007) 2.78
A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med (2009) 2.65
High-frequency developmental abnormalities in p53-deficient mice. Curr Biol (1995) 2.57
ROS and p53: a versatile partnership. Free Radic Biol Med (2008) 2.52
mdmx is a negative regulator of p53 activity in vivo. Cancer Res (2002) 2.40
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A (2005) 2.40
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ (2008) 2.36
Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ (2003) 2.30
Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol (2006) 2.27
Tumor suppressive functions of p53. Cold Spring Harb Perspect Biol (2009) 2.10
Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle (2008) 2.03
20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00
A dual role of p53 in the control of autophagy. Autophagy (2008) 1.88
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol (2005) 1.86
p53 in neuronal apoptosis. Biochem Biophys Res Commun (2005) 1.85
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol (2005) 1.78
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell (2006) 1.64
p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner. PLoS One (2008) 1.55
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53. Nat Genet (2009) 1.51
p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease. J Neurochem (2006) 1.41
Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome. J Mol Med (Berl) (2007) 1.40
The Arf/p53 pathway in cancer and aging. Cancer Res (2008) 1.37
p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer (2009) 1.37
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet (2009) 1.33
Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol (2009) 1.31
p53-dependent cell death signaling in neurons. Neurochem Res (2003) 1.19
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann Neurol (2002) 1.19
Lessons from p53 in non-mammalian models. Cell Death Differ (2006) 1.18
The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene (2004) 1.16
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis (2010) 1.14
Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. Mol Cell Biol (2008) 1.12
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity. J Gerontol A Biol Sci Med Sci (2007) 1.11
Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol (2006) 1.08
Structural biology of the tumor suppressor p53 and cancer-associated mutants. Adv Cancer Res (2007) 1.07
Sliding into home: facilitated p53 search for targets by the basic DNA binding domain. Cell Death Differ (2006) 0.92
Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats. Shock (2006) 0.88
Involvement of stromal p53 in tumor-stroma interactions. Semin Cell Dev Biol (2009) 0.87
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
The role of apoptosis in cancer development and treatment response. Nat Rev Cancer (2005) 4.19
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol (2004) 2.05
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
Deconstructing p53 transcriptional networks in tumor suppression. Trends Cell Biol (2011) 1.62
Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies. J Invest Dermatol (2009) 1.44
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol (2004) 1.44
Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol (2006) 1.37
Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer (2011) 1.33
Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. Biochem Biophys Res Commun (2005) 1.20
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis (2010) 1.14
Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res (2003) 1.11
Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol (2003) 1.11
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Proc Natl Acad Sci U S A (2008) 1.05
Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet (2010) 1.04
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res (2007) 1.01
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome. Am J Med Genet A (2009) 0.94
Perp-etrating p53-dependent apoptosis. Cell Cycle (2004) 0.90
Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res (2012) 0.90
Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. Cancer Res (2005) 0.90
A new Perp in the lineup: linking p63 and desmosomal adhesion. Cell Cycle (2005) 0.90
PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci (2011) 0.89
p63, cell adhesion and survival. Cell Cycle (2007) 0.88
Conquering the complexity of p53. Nat Genet (2004) 0.85
Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Am J Med Genet A (2009) 0.84
SKP-ing TAp63: stem cell depletion, senescence, and premature aging. Cell Stem Cell (2009) 0.84
Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. PLoS One (2012) 0.82
TRP53 activates a global autophagy program to promote tumor suppression. Autophagy (2013) 0.80
Tumor suppression: p53 alters immune surveillance to restrain liver cancer. Curr Biol (2013) 0.80
Engaging the p53 metabolic brake drives senescence. Cell Res (2013) 0.80
The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. J Invest Dermatol (2006) 0.79
Loss of the desmosomal component perp impairs wound healing in vivo. Dermatol Res Pract (2010) 0.78
p53QS: an old mutant teaches us new tricks. Cell Cycle (2005) 0.78
Guilty as CHARGED: p53's expanding role in disease. Cell Cycle (2014) 0.77
Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 0.76
A healthy tan? N Engl J Med (2007) 0.76