PubRank

Josefina Casas

Author PubWeight™ 52.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. PLoS Biol 2012 1.79
2 Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett 2009 1.35
3 Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Prog Lipid Res 2010 1.28
4 Inhibitors of sphingolipid metabolism enzymes. Biochim Biophys Acta 2006 1.14
5 Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem 2008 1.03
6 Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase. J Org Chem 2003 1.01
7 Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Prog Lipid Res 2011 1.01
8 Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. Bioorg Med Chem 2008 0.98
9 Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids 2006 0.96
10 Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem 2007 0.96
11 Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy. Int J Biochem Cell Biol 2012 0.95
12 Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna. Environ Health Perspect 2015 0.94
13 On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem 2014 0.94
14 Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med 2013 0.94
15 Synthesis and phospholipase C inhibitory activity of D609 diastereomers. Lipids 2002 0.93
16 C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth. Breast Cancer Res Treat 2011 0.92
17 Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease. ChemMedChem 2007 0.92
18 Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem 2011 0.91
19 Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains. Chem Biol 2010 0.91
20 Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide. Prostate 2010 0.90
21 Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry. Environ Sci Pollut Res Int 2014 0.89
22 The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J 2012 0.87
23 Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease. Blood Cells Mol Dis 2009 0.87
24 Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res 2012 0.87
25 Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities. Org Biomol Chem 2005 0.87
26 Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. J Lipid Res 2010 0.87
27 Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochim Biophys Acta 2013 0.86
28 Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. Chembiochem 2009 0.86
29 Specific sphingolipid content decrease in Cerkl knockdown mouse retinas. Exp Eye Res 2013 0.86
30 Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides. Chem Phys Lipids 2008 0.85
31 Acid ceramidase as a therapeutic target in metastatic prostate cancer. J Lipid Res 2013 0.84
32 Sphingolipid modulation: a strategy for cancer therapy. Anticancer Agents Med Chem 2012 0.84
33 Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues. Chembiochem 2008 0.84
34 A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors. Oncotarget 2013 0.83
35 Generation of a human neuronal stable cell model for niemann-pick C disease by RNA interference. JIMD Rep 2011 0.82
36 Fructose-6-phosphate aldolase in organic synthesis: preparation of D-fagomine, N-alkylated derivatives, and preliminary biological assays. Org Lett 2006 0.82
37 Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues. Org Biomol Chem 2007 0.81
38 Chemical tools to investigate sphingolipid metabolism and functions. ChemMedChem 2007 0.81
39 Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. Ann Surg 2013 0.81
40 Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. Chem Phys Lipids 2012 0.80
41 Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. Prostaglandins Leukot Essent Fatty Acids 2013 0.80
42 Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii. Mol Biochem Parasitol 2012 0.80
43 Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells. Biophys J 2012 0.79
44 Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells. J Org Chem 2013 0.79
45 2-aminohydroxamic acid derivatives as inhibitors of Bacillus cereus phosphatidylcholine preferred phospholipase C PC-PLC(Bc). Bioorg Med Chem 2010 0.79
46 Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells. Bioorg Med Chem 2006 0.79
47 Natural products as platforms for the design of sphingolipid-related anticancer agents. Adv Cancer Res 2013 0.79
48 Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii. J Biol Chem 2009 0.79
49 Ceramidases in hematological malignancies: senseless or neglected target? Anticancer Agents Med Chem 2011 0.79
50 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem 2012 0.78
51 Natural grape extracts regulate colon cancer cells malignancy. Nutr Cancer 2015 0.78
52 New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. J Med Chem 2011 0.78
53 Practical synthesis of (-)-1-amino-1-deoxy-myo-inositol from achiral precursors. Carbohydr Res 2007 0.78
54 Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. J Med Chem 2010 0.78
55 Synthesis and evaluation of xylopyranoside derivatives as "decoy acceptors" of human β-1,4-galactosyltransferase 7. Mol Biosyst 2011 0.77
56 The first cytochrome P450 in ferns. Evidence for its involvement in phytoecdysteroid biosynthesis in Polypodium vulgare. FEBS J 2005 0.77
57 Dihydroxyacetone phosphate aldolase catalyzed synthesis of structurally diverse polyhydroxylated pyrrolidine derivatives and evaluation of their glycosidase inhibitory properties. Chemistry 2009 0.77
58 Synthesis of antimitotic thioglycosides: in vitro and in vivo evaluation of their anticancer activity. J Med Chem 2011 0.77
59 Lipid and ganglioside alterations in tumor cells treated with antimitotic oleyl glycoside. Mol Biosyst 2010 0.76
60 New aminocyclitols as modulators of glucosylceramide metabolism. Org Biomol Chem 2005 0.75
61 Correction: Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity. Org Biomol Chem 2017 0.75
62 Absorption and metabolization of cytoprotective epicatechin thio conjugates in rats. Drug Metab Dispos 2010 0.75
63 Parallel synthesis and yeast growth inhibition screening of succinamic acid libraries. J Comb Chem 2007 0.75
64 Azide-tagged sphingolipids: new tools for metabolic flux analysis. Chembiochem 2015 0.75
65 Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases. Angew Chem Int Ed Engl 2004 0.75
66 Glucocerebrosidase enhancers for selected Gaucher disease genotypes by modification of α-1-C-substituted imino-D-xylitols (DIXs) by click chemistry. ChemMedChem 2014 0.75
67 De novo ceramide synthesis is involved in acute inflammation during labor. Biol Chem 2016 0.75
68 Combinatorial approach to N-substituted aminocyclitol libraries by solution-phase parallel synthesis and preliminary evaluation as glucocerebrosidase inhibitors. J Comb Chem 2007 0.75
69 Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity. Org Biomol Chem 2017 0.75
70 From the configurational preference of dihydroceramide desaturase-1 towards Δ(6)-unsaturated substrates to the discovery of a new inhibitor. Chem Commun (Camb) 2017 0.75
71 3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells. Mol Biosyst 2016 0.75