Published in Pflugers Arch on October 24, 2007
A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions. J Physiol (2009) 1.23
Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. J Endocrinol (2009) 1.00
Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction. J Appl Physiol (1985) (2014) 0.90
Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells. J Physiol (2009) 0.88
Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. J Proteomics (2014) 0.85
Training in the fasted state facilitates re-activation of eEF2 activity during recovery from endurance exercise. Eur J Appl Physiol (2010) 0.80
Leucine-enriched essential amino acids attenuate muscle soreness and improve muscle protein synthesis after eccentric contractions in rats. Amino Acids (2015) 0.79
Role of AMP-activated protein kinase in metabolic depression in animals. J Comp Physiol B (2015) 0.77
SPECHT - single-stage phosphopeptide enrichment and stable-isotope chemical tagging: quantitative phosphoproteomics of insulin action in muscle. J Proteomics (2014) 0.76
eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells. PLoS One (2015) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem (1998) 8.46
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci (2006) 5.11
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur J Biochem (1989) 4.65
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J (2007) 4.48
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem (2002) 3.81
Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J (2007) 3.28
Assays of protein kinase. Methods Enzymol (1983) 3.27
Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci (1999) 3.25
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda) (2006) 2.91
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol (2002) 2.73
Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J Clin Invest (1987) 2.68
Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. FASEB J (2005) 2.48
A hierarchy of ATP-consuming processes in mammalian cells. Biochem J (1995) 2.32
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem (2004) 2.26
Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest (1995) 2.12
5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J Biol Chem (2001) 1.97
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem (2004) 1.89
Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem (2002) 1.72
Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci (2005) 1.59
Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol (1985) (2002) 1.58
Effect of exercise and recovery on muscle protein synthesis in human subjects. Am J Physiol (1990) 1.48
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J Physiol (2005) 1.47
Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valine. Am J Physiol (1992) 1.46
Protein synthesis versus energy state in contracting muscles of perfused rat hindlimb. Am J Physiol (1984) 1.44
Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Am J Physiol Endocrinol Metab (2006) 1.42
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. J Biol Chem (2007) 1.41
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur J Biochem (2002) 1.38
Effects of insulin in vitro on protein turnover in rat epitrochlearis muscle. Biochem J (1983) 1.21
Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons. J Neurosci (1997) 1.19
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1. J Biol Chem (2000) 1.16
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. J Biol Chem (2003) 1.10
Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology (2004) 1.05
Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase. J Biol Chem (1996) 1.04
Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation. Comp Biochem Physiol B Biochem Mol Biol (2005) 0.97
Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase. FEBS Lett (2002) 0.93
Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects. Biochem J (2001) 0.89
Effects of epinephrine on glucose metabolism in contracting rat skeletal muscles. Am J Physiol (1998) 0.89
Elongation factor-2 kinase: immunological evidence for the existence of tissue-specific isoforms. FEBS Lett (1996) 0.85
Protein and amino acid metabolism in human muscle. Adv Exp Med Biol (1998) 0.84
Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle. Biochem J (2000) 0.78
Stress-induced activation of the AMP-activated protein kinase in the freeze-tolerant frog Rana sylvatica. Cryobiology (2006) 0.77
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol (2002) 2.73
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol (2006) 2.47
Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. J Biol Chem (2003) 2.45
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. Cell Metab (2010) 1.87
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem (2002) 1.78
Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle. Am J Physiol Endocrinol Metab (2007) 1.77
A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J Am Soc Nephrol (2003) 1.77
Identification of a dehydrogenase acting on D-2-hydroxyglutarate. Biochem J (2004) 1.72
PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli. Biochem J (2013) 1.60
The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS J (2013) 1.58
Insulin signalling in the heart. Cardiovasc Res (2008) 1.55
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J Physiol (2005) 1.47
Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem (2003) 1.46
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Biochem J (2004) 1.45
Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. FEBS Lett (2002) 1.41
Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization. Biophys J (2004) 1.40
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur J Biochem (2002) 1.38
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside. Biochem J (2007) 1.30
Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.26
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res (2011) 1.24
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. EMBO J (2005) 1.23
A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions. J Physiol (2009) 1.23
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J Biol Chem (2008) 1.19
Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis. Proc Natl Acad Sci U S A (2008) 1.18
Molecular nutrition research: the modern way of performing nutritional science. Nutrients (2012) 1.18
Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol (2002) 1.16
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B. Am J Physiol Heart Circ Physiol (2006) 1.14
Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life (2009) 1.14
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes. Eur J Biochem (2002) 1.12
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol (2006) 1.11
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. J Biol Chem (2003) 1.10
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline. Cell Signal (2005) 1.09
High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites. J Mol Biol (2006) 1.08
A novel hemotropic Mycoplasma (hemoplasma) in a patient with hemolytic anemia and pyrexia. Clin Infect Dis (2011) 1.05
Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia. Am J Physiol Heart Circ Physiol (2006) 1.04
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity. J Biol Chem (2005) 1.03
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochem J (2012) 1.03
Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways. J Mol Cell Cardiol (2002) 1.02
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovasc Res (2011) 1.01
Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. J Biol Chem (2004) 1.01
Promiscuous affairs of PKB/AKT isoforms in metabolism. Arch Physiol Biochem (2011) 1.00
Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells. PLoS One (2013) 0.99
The AMP-activated protein kinase: more than an energy sensor. Essays Biochem (2007) 0.98
Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats. Hypertension (2010) 0.98
Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. Am J Physiol Endocrinol Metab (2010) 0.98
Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation. Comp Biochem Physiol B Biochem Mol Biol (2005) 0.97
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states. Am J Physiol Heart Circ Physiol (2013) 0.97
AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells. Biochem Biophys Res Commun (2010) 0.97
Plasma Norepinephrine in Hypertensive Rats Reflects α(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited. Front Neurol (2012) 0.95
Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1. Cell Transplant (2007) 0.94
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochem J (2012) 0.94
Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. Br J Nutr (2009) 0.94
Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes. FEBS Lett (2008) 0.93
Sprint interval running increases insulin sensitivity in young healthy subjects. Arch Physiol Biochem (2012) 0.93
Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK. Cell Signal (2007) 0.92
Attenuated adrenergic responses to exercise in women with fibromyalgia--a controlled study. Eur J Pain (2007) 0.92
Simultaneous parasympathetic and sympathetic activation reveals altered autonomic control of heart rate, vascular tension, and epinephrine release in anesthetized hypertensive rats. Front Neurol (2011) 0.90
Are cultured human myotubes far from home? Cell Tissue Res (2013) 0.90
A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle. Biochem J (2012) 0.88
Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat. Diabetes (2002) 0.88
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation. J Hepatol (2008) 0.88
Glycogen content and contraction regulate glycogen synthase phosphorylation and affinity for UDP-glucose in rat skeletal muscles. Am J Physiol Endocrinol Metab (2007) 0.88
Tyramine Reveals Failing α2-Adrenoceptor Control of Catecholamine Release and Total Peripheral Vascular Resistance in Hypertensive Rats. Front Neurol (2013) 0.88
[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases]. Med Sci (Paris) (2006) 0.87
Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways. Am J Physiol Cell Physiol (2007) 0.87
AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol. Biochem Biophys Res Commun (2008) 0.87
Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle. Cell Signal (2013) 0.87
Dynamic monitoring of cytosolic glucose in single astrocytes. Glia (2011) 0.86
Regulation of follistatin-like protein 1 expression and secretion in primary human skeletal muscle cells. Arch Physiol Biochem (2013) 0.86
Electrical stimulation improves insulin responses in a human skeletal muscle cell model of hyperglycemia. Ann N Y Acad Sci (2002) 0.86
HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome. Cardiovasc Res (2013) 0.86
Effect of whey protein hydrolysate on performance and recovery of top-class orienteering runners. Int J Sport Nutr Exerc Metab (2014) 0.85
Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents. J Appl Physiol (1985) (2010) 0.85
The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism. FEBS Lett (2002) 0.84
Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing. Cell Signal (2004) 0.84
The crystal structure of Trypanosoma brucei enolase: visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition. J Mol Biol (2003) 0.84
Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA. Br J Pharmacol (2010) 0.83
Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform. Crit Care Med (2013) 0.83
Astrocytes and energy metabolism. Arch Physiol Biochem (2011) 0.82
Regulation of PIKfyve phosphorylation by insulin and osmotic stress. Biochem Biophys Res Commun (2010) 0.82