Published in Hum Genet on February 05, 2008
A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr (2008) 1.22
A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 0.99
Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. Birth Defects Res A Clin Mol Teratol (2010) 0.83
Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304). Cancer (2014) 0.80
Folate-related gene variants in Irish families affected by neural tube defects. Front Genet (2013) 0.80
Dihydrofolate reductase gene variations in susceptibility to disease and treatment outcomes. Curr Genomics (2010) 0.79
The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake. J Nutr (2015) 0.77
Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. Am J Clin Nutr (2015) 0.76
The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role. J Appl Oral Sci (2015) 0.75
DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome. Genet Test Mol Biomarkers (2013) 0.75
A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ (2002) 7.14
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation (1996) 4.62
Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet (1995) 3.70
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. QJM (1996) 3.31
Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab (2000) 2.61
Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr (1998) 2.41
Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr (1991) 2.41
Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol (1997) 2.40
Spina bifida. Lancet (2004) 2.02
Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. Eur J Hum Genet (2006) 1.74
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood (2003) 1.57
New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? Am J Med Genet A (2004) 1.53
C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes (2005) 1.48
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis (2006) 1.42
Coronary risk factors in schoolchildren. Arch Dis Child (1993) 1.37
The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population. Am J Med Genet A (2007) 1.05
Tracking of physical activity, fitness, body composition and diet from adolescence to young adulthood: The Young Hearts Project, Northern Ireland. Int J Behav Nutr Phys Act (2004) 1.03
Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene. Genomics (2005) 1.00
Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. Mol Genet Metab (2007) 0.95
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. Biochem J (1997) 0.95
Intron 1 and the 5'-flanking region of the human thymidylate synthase gene as a regulatory determinant of growth-dependent expression. Nucleic Acids Res (1992) 0.89
Evidence for sex differences in the determinants of homocysteine concentrations. Mol Genet Metab (2008) 0.85
Intronic enhancement of angiotensin II type 2 receptor transgene expression in vitro and in vivo. Biochem Biophys Res Commun (2005) 0.84
A longitudinal study through adolescence to adulthood: the Young Hearts Project, Northern Ireland. Public Health (2002) 0.81
Efficient transcription of the human angiotensin II type 2 receptor gene requires intronic sequence elements. Biochem J (1999) 0.79
The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem (1996) 28.76
Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol (1999) 5.81
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem (2004) 4.31
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet (2010) 3.63
Accuracy of weighed dietary records in studies of diet and health. BMJ (1990) 3.45
The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med (2010) 2.84
Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol (2006) 2.82
Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet (2010) 2.78
Total synthesis of palau'amine. Angew Chem Int Ed Engl (2010) 2.62
Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr (2003) 2.47
The incidence of esophageal cancer and high-grade dysplasia in Barrett's esophagus: a systematic review and meta-analysis. Am J Epidemiol (2008) 2.34
Screening for organic mental syndromes in the medically ill. Ann Intern Med (1977) 2.28
Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease. Lancet (2002) 2.25
Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004. Environ Health Perspect (2010) 2.16
Operationalizing a bedside pen entry notebook clinical database system in consultation-liaison psychiatry. Gen Hosp Psychiatry (1995) 2.15
Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur Heart J (2008) 2.15
Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters. Am J Clin Nutr (2013) 2.08
The relationship between active travel to school and health-related fitness in children and adolescents: a systematic review. Int J Behav Nutr Phys Act (2011) 2.03
Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia. Chest (2013) 2.03
Spina bifida. Lancet (2004) 2.02
Reduced risk of atopic disorders in adults with Helicobacter pylori infection. Eur J Gastroenterol Hepatol (2003) 1.87
Validation of estimates of energy intake by weighed dietary record and diet history in children and adolescents. Am J Clin Nutr (1992) 1.84
Clustering of metabolic syndrome risk factors and arterial stiffness in young adults: the Northern Ireland Young Hearts Project. J Hypertens (2007) 1.84
Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy. Neurotoxicology (2008) 1.82
Fruit and vegetable consumption and bone mineral density: the Northern Ireland Young Hearts Project. Am J Clin Nutr (2004) 1.77
Differences in exposure assignment between conception and delivery: the impact of maternal mobility. Paediatr Perinat Epidemiol (2010) 1.76
Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight. Clin Chem (2004) 1.74
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. Circulation (2005) 1.70
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements. Am J Clin Nutr (2002) 1.68
The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study. Am J Clin Nutr (2002) 1.66
Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr (2008) 1.65
Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B₁₂ status in the elderly. Clin Chem (2011) 1.59
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood (2003) 1.57
A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy. Am J Clin Nutr (2010) 1.55
Prediction of Recurrent Events by D-Dimer and Inflammatory Markers in Patients with Normal Cardiac Troponin I (PREDICT) Study. Am Heart J (2003) 1.54
Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age. Am J Clin Nutr (2009) 1.54
Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain. Am J Cardiol (2008) 1.53
Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet (2006) 1.52
C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism. J Vasc Surg (2008) 1.48
Dietary patterns and breast cancer risk: a systematic review and meta-analysis. Am J Clin Nutr (2010) 1.46
Adipose tissue trans fatty acids and breast cancer in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Cancer Epidemiol Biomarkers Prev (1997) 1.46
Antioxidants and oxidative stress in BAL fluid of atopic asthmatic children. Pediatr Res (2003) 1.45
Daily energy expenditure in free-living children: comparison of heart-rate monitoring with the doubly labeled water (2H2(18)O) method. Am J Clin Nutr (1992) 1.45
Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis. Liver Int (2013) 1.45
Troponin T is an independent predictor of mortality in renal transplant recipients. Nephrol Dial Transplant (2007) 1.45
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics (2009) 1.44
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl (2008) 1.44
The role of smoking in abdominal aortic aneurysm development. Angiology (2008) 1.41
Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension (2002) 1.40
Patient noncompliance with self-administered chemotherapy. Cancer (1990) 1.40
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl (2008) 1.39
Variants of folate metabolism genes and the risk of conotruncal cardiac defects. Circ Cardiovasc Genet (2008) 1.38
The sequencing of psychiatric recommendations. Concordance during the process of a psychiatric consultation. Psychosomatics (1993) 1.38
Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Am J Clin Nutr (2007) 1.37
Guidelines for the design, conduct and reporting of human intervention studies to evaluate the health benefits of foods. Br J Nutr (2011) 1.35
Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity. Pharmacogenomics (2007) 1.34
Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr J (2013) 1.34
Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull (2008) 1.33
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
MTRR and MTHFR polymorphism: link to Down syndrome? Am J Med Genet (2002) 1.30
Genetic and environmental determinants of peak bone mass in young men and women. J Bone Miner Res (2002) 1.27
Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. Ophthalmology (2007) 1.26
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc (2008) 1.26
Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines. J Am Chem Soc (2011) 1.25
Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis. Arthritis Rheum (2004) 1.25
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. BMJ (2004) 1.24
Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations. J Nutr (2003) 1.24
Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring. J Nutr (2007) 1.23
The immune system as a physiological indicator of marginal copper status? Br J Nutr (2002) 1.23
Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache. J Cereb Blood Flow Metab (2006) 1.22
Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. Mol Genet Metab (2009) 1.21
Sunlight exposure, antioxidants, and age-related macular degeneration. Arch Ophthalmol (2008) 1.21
Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. QJM (1997) 1.21
Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc Natl Acad Sci U S A (1998) 1.21
Nutrient and methyl mercury exposure from consuming fish. J Nutr (2007) 1.20
Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Am J Hum Genet (2002) 1.20
Inflammation markers are associated with cardiovascular diseases risk in adolescents: the Young Hearts project 2000. J Adolesc Health (2010) 1.20
Fitness, fatness, and coronary heart disease risk in adolescents: the Northern Ireland Young Hearts Project. Med Sci Sports Exerc (2001) 1.20
Randomised controlled trial of home-based walking programmes at and below current recommended levels of exercise in sedentary adults. J Epidemiol Community Health (2007) 1.19
Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers. Br J Nutr (2008) 1.19
Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people. Am J Epidemiol (2011) 1.19
Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study. Neurotoxicology (2011) 1.18