Published in J Am Chem Soc on August 23, 2011
Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod (2012) 13.27
Innate and guided C-H functionalization logic. Acc Chem Res (2011) 1.94
Multifunctionalized 3-hydroxypyrroles in a three-step, one-pot cascade process from methyl 3-TBSO-2-diazo-3-butenoate and nitrones. Org Lett (2011) 0.99
Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence. Science (2014) 0.98
Syntheses of Cyclic Guanidine-Containing Natural Products. Tetrahedron (2015) 0.92
Asymmetric synthesis of ageliferin. J Am Chem Soc (2011) 0.92
A biomimetic route for construction of the [4+2] and [3+2] core skeletons of dimeric pyrrole-imidazole alkaloids and asymmetric synthesis of ageliferins. J Am Chem Soc (2012) 0.89
Synthetic (±)-axinellamines deficient in halogen. Angew Chem Int Ed Engl (2012) 0.87
Radicals: Reactive Intermediates with Translational Potential. J Am Chem Soc (2016) 0.83
Dimeric pyrrole-imidazole alkaloids: synthetic approaches and biosynthetic hypotheses. Chem Commun (Camb) (2014) 0.83
Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem". Mar Drugs (2016) 0.83
Palladium-catalyzed amination of unprotected five-membered heterocyclic bromides. Org Lett (2014) 0.82
Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology. J Am Chem Soc (2014) 0.81
A biomimetic domino reaction for the concise synthesis of capreomycidine and epicapreomycidine. Amino Acids (2012) 0.79
Total synthesis of palau'amine. Nat Commun (2015) 0.76
11-Step Total Synthesis of Araiosamines. J Am Chem Soc (2016) 0.75
Asymmetric Synthesis of Axinellamines A and B. Angew Chem Int Ed Engl (2016) 0.75
Preparation and Diels-Alder reactions of 1'-heterosubsituted vinylimidazoles. Tetrahedron Lett (2015) 0.75
A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method. RSC Adv (2017) 0.75
Total synthesis of marine natural products without using protecting groups. Nature (2007) 3.70
Aiming for the ideal synthesis. J Org Chem (2010) 3.44
Total synthesis of palau'amine. Angew Chem Int Ed Engl (2010) 2.62
Protecting-group-free synthesis as an opportunity for invention. Nat Chem (2009) 2.11
The pursuit of palau'amine. Angew Chem Int Ed Engl (2007) 2.00
Synthesis of axinohydantoins. J Org Chem (2002) 1.99
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds. Org Lett (2000) 1.97
Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition. J Am Chem Soc (2003) 1.89
Staudinger ligation: a peptide from a thioester and azide. Org Lett (2000) 1.77
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc (2010) 1.71
Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton. J Am Chem Soc (2007) 1.65
Catalytic C-C, C-N, and C-O Ullmann-type coupling reactions. Angew Chem Int Ed Engl (2009) 1.61
Reaction mechanism and kinetics of the traceless Staudinger ligation. J Am Chem Soc (2006) 1.52
Structural assignment of tetrabromostyloguanidine: does the relative configuration of the palau'amines need revision? Angew Chem Int Ed Engl (2007) 1.44
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl (2008) 1.44
Natural products, stylissadines A and B, specific antagonists of the P2X7 receptor, an important inflammatory target. J Org Chem (2007) 1.41
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc (2011) 1.41
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl (2008) 1.39
Regiocontrol in Mn(III)-mediated oxidative heterobicyclizations: access to the core skeletons of oroidin dimers. Angew Chem Int Ed Engl (2006) 1.38
Studies toward the total synthesis of axinellamine and massadine. Org Lett (2007) 1.35
Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa. Org Lett (2003) 1.34
Sceptrin as a potential biosynthetic precursor to complex pyrrole-imidazole alkaloids: the total synthesis of ageliferin. Angew Chem Int Ed Engl (2004) 1.30
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc (2008) 1.26
High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Org Lett (2001) 1.25
Short total synthesis of (+/-)-sceptrin. J Am Chem Soc (2004) 1.23
Axinellamines A-D, Novel Imidazo-Azolo-Imidazole Alkaloids from the Australian Marine Sponge Axinella sp. J Org Chem (1999) 1.21
o-Iodoxybenzoic acid (IBX) as a viable reagent in the manipulation of nitrogen- and sulfur-containing substrates: scope, generality, and mechanism of IBX-mediated amine oxidations and dithiane deprotections. J Am Chem Soc (2004) 1.19
Massadine chloride: a biosynthetic precursor of massadine and stylissadine. Angew Chem Int Ed Engl (2007) 1.19
Enantiospecific total syntheses of kapakahines B and F. J Am Chem Soc (2009) 1.17
Enantioselective synthesis of (+)-monobromophakellin and (+)-phakellin: a concise phakellin annulation strategy applicable to Palau'amine. Angew Chem Int Ed Engl (2008) 1.16
Stereocontrolled synthesis of triazacyclopenta[cd]pentalenes by intramolecular 1,3-dipolar cycloaddition reactions of azomethine imines. J Org Chem (2002) 1.16
On the structure of palau'amine: evidence for the revised relative configuration from chemical synthesis. J Am Chem Soc (2007) 1.16
Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E. Angew Chem Int Ed Engl (2006) 1.15
Stylissadines A and B: the first tetrameric pyrrole-imidazole alkaloids. Org Lett (2006) 1.14
Staudinger ligation of alpha-azido acids retains stereochemistry. J Org Chem (2002) 1.13
Synthetic access to the chlorocyclopentane cores of the proposed original and revised structures of palau'amine. Angew Chem Int Ed Engl (2008) 1.13
Facile synthesis of the trans-fused azabicyclo[3.3.0]octane core of the palau'amines and the tricyclic core of the axinellamines from a common intermediate. Org Lett (2008) 1.13
Short, enantioselective total synthesis of sceptrin and ageliferin by programmed oxaquadricyclane fragmentation. Angew Chem Int Ed Engl (2005) 1.13
Enantioselective strategy to the spirocyclic core of Palau'amine and related bisguanidine marine alkaloids. Org Lett (2001) 1.13
Revisiting the Kinnel-Scheuer hypothesis for the biosynthesis of palau'amine. Chem Commun (Camb) (2010) 1.12
Protein structures from NMR. Biochemistry (1988) 1.11
Stable 5-substituted cyclopentadienes for the Diels-Alder cycloaddition and their application to the synthesis of palau'amine. Angew Chem Int Ed Engl (2008) 1.10
Exploring symmetry-based logic for a synthesis of palau'amine. J Org Chem (2009) 1.09
Density functional theory guided design of exo-selective dehydroalanine dienophiles for application toward the synthesis of palau'amine. J Org Chem (2007) 1.06
Spirocycloisomerization of tethered alkylidene glycocyamidines: synthesis of a base template common to the palau'amine family of alkaloids. Angew Chem Int Ed Engl (2005) 1.06
Bromopyrrole alkaloids as lead compounds against protozoan parasites. Mar Drugs (2010) 1.03
Marine natural products as prototype agrochemical agents. J Agric Food Chem (2003) 1.02
Studies toward the total synthesis of the oroidin dimers. Org Biomol Chem (2009) 1.02
Highly regioselective Diels-Alder reactions toward oroidin alkaloids: use of a tosylvinyl moiety as a nitrogen masking group with adjustable electronics. Org Lett (2005) 0.99
Enantioselective total synthesis of (+)-dibromophakellstatin. J Am Chem Soc (2003) 0.99
Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon (2004) 0.98
EVALUATION OF STRATEGIES FOR THE SYNTHESIS OF THE GUANIDINE HEMIAMINAL PORTION OF PALAU'AMINE. Heterocycles (2006) 0.97
Chiral oxazaborolidine-aluminum bromide complexes are unusually powerful and effective catalysts for enantioselective Diels-Alder reactions. J Am Chem Soc (2007) 0.95
Bromosceptrin, an alkaloid from the marine sponge Agelas conifera. Z Naturforsch C (2002) 0.95
Antifouling activity of bromotyrosine-derived sponge metabolites and synthetic analogues. Mar Biotechnol (NY) (2007) 0.94
Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines. ACS Chem Biol (2010) 0.94
Synthetic Studies on Palau'amine. Construction of the Cyclopentane Core via an Asymmetric 1,3-Dipolar Cycloaddition. Tetrahedron Lett (2010) 0.93
Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. J Am Chem Soc (2008) 0.93
Determining stereo-specific 1H nuclear magnetic resonance assignments from distance geometry calculations. J Mol Biol (1988) 0.91
A Diels-Alder approach to (-)-ovalicin. Angew Chem Int Ed Engl (2007) 0.90
Extending Pummerer reaction chemistry: studies in the palau'amine synthesis area. J Org Chem (2011) 0.90
Molecular dynamics simulation techniques for determination of molecular structures from nuclear magnetic resonance data. Methods Enzymol (1989) 0.90
Ugi-4-component reaction enabling rapid access to the core fragment of massadine. Org Lett (2010) 0.90
A study on the mechanism of action of sceptrin, an antimicrobial agent isolated from the South Pacific sponge Agelas mauritiana. J Antimicrob Chemother (1993) 0.90
Toward palau'amine: Hg(OTf)2-catalyzed synthesis of the cyclopentane core. Chemistry (2009) 0.89
Synthesis of Mauritiamine. J Org Chem (1997) 0.88
Intramolecular Staudinger ligation: a powerful ring-closure method to form medium-sized lactams. Angew Chem Int Ed Engl (2003) 0.87
Enantioselective total synthesis of cyathin A3. Org Lett (2007) 0.86
New bromopyrrole alkaloids from the Indopacific sponge Agelas nakamurai. J Nat Prod (1999) 0.86
Total syntheses of the Securinega alkaloids (+)-14,15-dihydronorsecurinine, (-)-norsecurinine, and phyllanthine. J Org Chem (2000) 0.85
Highly diastereoselective desymmetrizations of cyclo(Pro,Pro): an enantioselective strategy toward phakellstatin and phakellin. Org Lett (2002) 0.84
A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type reaction. Angew Chem Int Ed Engl (2009) 0.84
Synthesis of 3'-deoxy-3'-difluoromethyl azanucleosides from trans-4-hydroxy-l-proline. J Org Chem (2005) 0.84
Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges. Experientia (1992) 0.83
Enantioselective synthesis of the carbocyclic D-ring subunit of massadine. Angew Chem Int Ed Engl (2008) 0.81
Oxidation of secondary amines catalyzed by dirhodium caprolactamate. Chem Commun (Camb) (2007) 0.79
Rational design of highly effective asymmetric Diels-Alder catalysts bearing 4,4'-sulfonamidomethyl groups. J Am Chem Soc (2009) 0.78
Synthesis of slagenins A, B, and C. Org Lett (2000) 0.76
Aiming for the ideal synthesis. J Org Chem (2010) 3.44
Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol (2006) 2.82
Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet (2010) 2.78
Redox economy in organic synthesis. Angew Chem Int Ed Engl (2009) 2.74
Total synthesis of eudesmane terpenes by site-selective C-H oxidations. Nature (2009) 2.65
Total synthesis of palau'amine. Angew Chem Int Ed Engl (2010) 2.62
Innate C-H trifluoromethylation of heterocycles. Proc Natl Acad Sci U S A (2011) 2.52
Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur Heart J (2008) 2.15
The economies of synthesis. Chem Soc Rev (2009) 2.15
Protecting-group-free synthesis as an opportunity for invention. Nat Chem (2009) 2.11
Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach. J Am Chem Soc (2008) 2.10
If C-H bonds could talk: selective C-H bond oxidation. Angew Chem Int Ed Engl (2011) 2.09
Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia. Chest (2013) 2.03
C-H functionalization logic in total synthesis. Chem Soc Rev (2011) 2.00
The pursuit of palau'amine. Angew Chem Int Ed Engl (2007) 2.00
Discovery of chemical reactions through multidimensional screening. J Am Chem Soc (2007) 1.97
Innate and guided C-H functionalization logic. Acc Chem Res (2011) 1.94
Clustering of metabolic syndrome risk factors and arterial stiffness in young adults: the Northern Ireland Young Hearts Project. J Hypertens (2007) 1.84
Practical and innate carbon-hydrogen functionalization of heterocycles. Nature (2012) 1.83
A concise approach to vinigrol. Angew Chem Int Ed Engl (2008) 1.78
Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. J Am Chem Soc (2010) 1.71
A new reagent for direct difluoromethylation. J Am Chem Soc (2012) 1.70
Modern synthetic efforts toward biologically active terpenes. Nat Chem Biol (2007) 1.68
Intermolecular enolate heterocoupling: scope, mechanism, and application. J Am Chem Soc (2008) 1.66
Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton. J Am Chem Soc (2007) 1.65
EGFR gene alterations in a Norwegian cohort of lung cancer patients selected for surgery. J Thorac Oncol (2011) 1.58
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood (2003) 1.57
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol Pharmacol (2007) 1.56
Prediction of Recurrent Events by D-Dimer and Inflammatory Markers in Patients with Normal Cardiac Troponin I (PREDICT) Study. Am Heart J (2003) 1.54
Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain. Am J Cardiol (2008) 1.53
Synthesis of (+)-cortistatin A. J Am Chem Soc (2008) 1.48
C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism. J Vasc Surg (2008) 1.48
A practical and catalytic reductive olefin coupling. J Am Chem Soc (2014) 1.46
Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis. Liver Int (2013) 1.45
Antioxidants and oxidative stress in BAL fluid of atopic asthmatic children. Pediatr Res (2003) 1.45
Troponin T is an independent predictor of mortality in renal transplant recipients. Nephrol Dial Transplant (2007) 1.45
Chemoselectivity: the mother of invention in total synthesis. Acc Chem Res (2009) 1.44
Structural assignment of tetrabromostyloguanidine: does the relative configuration of the palau'amines need revision? Angew Chem Int Ed Engl (2007) 1.44
Total synthesis of (+/-)-axinellamines A and B. Angew Chem Int Ed Engl (2008) 1.44
The role of smoking in abdominal aortic aneurysm development. Angiology (2008) 1.41
Total synthesis of (+/-)-psychotrimine. J Am Chem Soc (2008) 1.41
Practical C-H functionalization of quinones with boronic acids. J Am Chem Soc (2011) 1.41
Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension (2002) 1.40
Scalable enantioselective total synthesis of taxanes. Nat Chem (2011) 1.40
Synthesis of 1,9-dideoxy-pre-axinellamine. Angew Chem Int Ed Engl (2008) 1.39
[A 67-year old man with right arm paresthesias]. Tidsskr Nor Laegeforen (2009) 1.38
Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide. Science (2013) 1.35
Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr J (2013) 1.34
Scalable synthesis of cortistatin A and related structures. J Am Chem Soc (2011) 1.30
Sceptrin as a potential biosynthetic precursor to complex pyrrole-imidazole alkaloids: the total synthesis of ageliferin. Angew Chem Int Ed Engl (2004) 1.30
14-step synthesis of (+)-ingenol from (+)-3-carene. Science (2013) 1.26
Total syntheses of (+/-)-massadine and massadine chloride. J Am Chem Soc (2008) 1.26
Short total synthesis of (+/-)-sceptrin. J Am Chem Soc (2004) 1.23
A synthesis of the carbon skeleton of maoecrystal V. Org Lett (2009) 1.22
Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache. J Cereb Blood Flow Metab (2006) 1.22
1,3-Diol synthesis via controlled, radical-mediated C-H functionalization. J Am Chem Soc (2008) 1.21
Sunlight exposure, antioxidants, and age-related macular degeneration. Arch Ophthalmol (2008) 1.21
Inflammation markers are associated with cardiovascular diseases risk in adolescents: the Young Hearts project 2000. J Adolesc Health (2010) 1.20
It all began with an error: the nomofungin/communesin story. Angew Chem Int Ed Engl (2008) 1.20
Randomised controlled trial of home-based walking programmes at and below current recommended levels of exercise in sedentary adults. J Epidemiol Community Health (2007) 1.19
Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B. J Am Chem Soc (2011) 1.19
Synthesis: A constructive debate. Nature (2012) 1.19
Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people. Am J Epidemiol (2011) 1.19
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A (2012) 1.19
Massadine chloride: a biosynthetic precursor of massadine and stylissadine. Angew Chem Int Ed Engl (2007) 1.19
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. Hum Mutat (2011) 1.17
Enantiospecific total syntheses of kapakahines B and F. J Am Chem Soc (2009) 1.17
Direct proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones. J Org Chem (2004) 1.16
Viscosamine: the first naturally occurring trimeric 3-alkyl pyridinium alkaloid. Org Lett (2003) 1.16
Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness? Am J Physiol Regul Integr Comp Physiol (2009) 1.16
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Mol Pharmacol (2013) 1.15
Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E. Angew Chem Int Ed Engl (2006) 1.15
Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F. J Am Chem Soc (2010) 1.15
Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am J Physiol Heart Circ Physiol (2004) 1.14
Saturated and trans fatty acids and coronary heart disease. Curr Atheroscler Rep (2008) 1.14
Stylissadines A and B: the first tetrameric pyrrole-imidazole alkaloids. Org Lett (2006) 1.14
High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability. J Physiol (2010) 1.14
High density lipoprotein subfractions: isolation, composition, and their duplicitous role in oxidation. J Lipid Res (2006) 1.13
Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylation. J Am Chem Soc (2011) 1.13
Short, enantioselective total synthesis of sceptrin and ageliferin by programmed oxaquadricyclane fragmentation. Angew Chem Int Ed Engl (2005) 1.13
Two-phase synthesis of (-)-taxuyunnanine D. J Am Chem Soc (2014) 1.12
Bioactive metabolites from the Caribbean sponge Aka coralliphagum. J Nat Prod (2007) 1.09
Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues. Angew Chem Int Ed Engl (2009) 1.09