Published in Genome Biol on January 31, 2008
Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila. Development (2011) 1.34
The Capicua repressor--a general sensor of RTK signaling in development and disease. J Cell Sci (2012) 1.29
A method for WD40 repeat detection and secondary structure prediction. PLoS One (2013) 1.14
Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535. PLoS One (2014) 1.06
Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression. Mol Cell (2011) 1.05
Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression. EMBO J (2011) 1.05
SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest. J Cell Biol (2012) 1.03
Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A (2013) 0.98
Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear. Dev Dyn (2011) 0.98
Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1. PLoS One (2009) 0.97
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol Cell (2012) 0.95
FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation. Development (2010) 0.95
The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation. Development (2012) 0.93
Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem (2009) 0.93
TLE3 as a candidate biomarker of response to taxane therapy. Breast Cancer Res (2009) 0.92
Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Proc Natl Acad Sci U S A (2013) 0.91
Homeodomain proteins: an update. Chromosoma (2015) 0.91
AES/GRG5: more than just a dominant-negative TLE/GRG family member. Dev Dyn (2010) 0.90
Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Res (2012) 0.89
Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant Stress Responses. Front Plant Sci (2012) 0.89
Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors. Sci Adv (2015) 0.88
Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Front Cell Neurosci (2015) 0.87
The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription. PLoS Genet (2014) 0.86
The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone development. PLoS One (2014) 0.83
Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction. Stem Cells Dev (2011) 0.82
TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway. Oncotarget (2016) 0.81
p15RS/RPRD1A (p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/β-catenin signaling pathway. J Biol Chem (2015) 0.81
New insights into the Orange domain of E(spl)-M8, and the roles of the C-terminal domain in autoinhibition and Groucho recruitment. Mol Cell Biochem (2011) 0.81
Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation. Cell Death Differ (2013) 0.81
Origins of context-dependent gene repression by capicua. PLoS Genet (2015) 0.80
Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance. Mol Cell Biol (2013) 0.80
Pericentral activity of alpha-fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β-catenin in mice. Hepatology (2012) 0.80
O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling. J Biol Chem (2014) 0.80
The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. J Biol Chem (2013) 0.79
Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells. Stem Cells Int (2016) 0.79
Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2. Structure (2013) 0.78
Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning. Mech Dev (2014) 0.77
Transcript levels of ten caste-related genes in adult diploid males of Melipona quadrifasciata (Hymenoptera, Apidae) - A comparison with haploid males, queens and workers. Genet Mol Biol (2011) 0.77
TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways. J Exp Clin Cancer Res (2016) 0.77
Recent insights into Groucho co-repressor recruitment and function. Transcription (2015) 0.76
Uncovering the pathways underlying whole body regeneration in a chordate model, Botrylloides leachi using de novo transcriptome analysis. BMC Genomics (2016) 0.76
Characterization of Aes nuclear foci in colorectal cancer cells. J Biochem (2015) 0.76
Aberrant regulation of Wnt signaling in hepatocellular carcinoma. World J Gastroenterol (2016) 0.76
Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog (2016) 0.75
The Transcriptional Coregulator LEUNIG_HOMOLOG Inhibits Light-Dependent Seed Germination in Arabidopsis. Plant Cell (2015) 0.75
Molecular mechanism underlying juvenile hormone-mediated repression of precocious larval-adult metamorphosis. Proc Natl Acad Sci U S A (2017) 0.75
Developmental Progression in the Coral Acropora digitifera Is Controlled by Differential Expression of Distinct Regulatory Gene Networks. Genome Biol Evol (2016) 0.75
TLE1 function and therapeutic potential in cancer. Oncotarget (2016) 0.75
The Unicellular Ancestry of Groucho-Mediated Repression and the Origins of Metazoan Transcription Factors. Genome Biol Evol (2016) 0.75
Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types. Development (2013) 0.75
GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PLoS One (2013) 0.75
The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor. J Biol Chem (2017) 0.75
Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol Cell (2017) 0.75
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol (1987) 266.90
BLAT--the BLAST-like alignment tool. Genome Res (2002) 126.78
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res (2006) 48.10
The UCSC Genome Browser Database. Nucleic Acids Res (2003) 32.84
GeneWise and Genomewise. Genome Res (2004) 17.87
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature (1998) 5.16
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell (1994) 4.95
A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev (1999) 3.91
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol (2005) 3.41
Groucho/TLE family proteins and transcriptional repression. Gene (2000) 3.31
The multifaceted role of Notch in cancer. Curr Opin Genet Dev (2006) 3.07
Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev (1998) 2.92
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet (1992) 2.71
Groucho-dependent and -independent repression activities of Runt domain proteins. Mol Cell Biol (1997) 2.27
Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell (2007) 2.12
PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev (1999) 2.09
Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. J Cell Sci (2000) 2.08
A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell (1988) 2.01
TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol (2007) 1.94
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell (2006) 1.91
Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev (2004) 1.80
The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans. Development (1997) 1.77
hairy mediates dominant repression in the Drosophila embryo. EMBO J (1997) 1.74
The 'Marx' of Groucho on development and disease. Trends Cell Biol (2007) 1.73
A role for Groucho tetramerization in transcriptional repression. Mol Cell Biol (1998) 1.70
Groucho: making its Marx as a transcriptional co-repressor. Trends Genet (1998) 1.58
Mammalian Groucho homologs: redundancy or specificity? J Cell Biochem (2005) 1.48
Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics (1991) 1.47
Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Am J Pathol (2002) 1.46
EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output. Nat Genet (2004) 1.44
Groucho oligomerization is required for repression in vivo. Mol Cell Biol (2004) 1.36
Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. Eur J Biochem (1998) 1.33
Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res (2005) 1.33
Novel molecular signaling and classification of human clinically nonfunctional pituitary adenomas identified by gene expression profiling and proteomic analyses. Cancer Res (2005) 1.33
Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res (2006) 1.31
TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination. Mech Dev (1995) 1.27
Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Mech Dev (1996) 1.21
Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression. Nucleic Acids Res (2000) 1.20
A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc Natl Acad Sci U S A (2007) 1.16
Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures. Dev Dyn (1997) 1.15
Cloning and developmental expression of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Mech Dev (1993) 1.13
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. Structure (2002) 1.12
Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation. Mol Cell Biol (2004) 1.11
Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho. J Biol Chem (2005) 1.11
Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis. Development (2008) 1.09
Differential in vivo requirements for oligomerization during Groucho-mediated repression. EMBO Rep (2007) 1.05
In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein. Genes Dev (2003) 1.02
Activation and repression by the C-terminal domain of Dorsal. Development (2001) 1.00
Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex. Genetics (2002) 0.98
Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. J Neuropathol Exp Neurol (2006) 0.98
Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Mol Cell Biol (2005) 0.97
A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. J Biol Chem (2002) 0.96
Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mech Dev (2000) 0.91
Duplicated members of the Groucho/Tle gene family in fish. Dev Dyn (2005) 0.90
Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression. Endocrine (2006) 0.89
Evolution of the Groucho/Tle gene family: gene organization and duplication events. Dev Genes Evol (2007) 0.85
Expression of avian Groucho-related genes (Grgs) during embryonic development. Gene Expr Patterns (2005) 0.78
Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons. Brain Res Mol Brain Res (2005) 0.78
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol (2004) 2.63
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell (2006) 1.91
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev Cell (2002) 1.44
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport. EMBO J (2003) 1.21
A'-form RNA helices are required for cytoplasmic mRNA transport in Drosophila. Nat Struct Mol Biol (2010) 1.19
Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution. Development (2004) 1.10
Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Curr Biol (2004) 1.08
Differential in vivo requirements for oligomerization during Groucho-mediated repression. EMBO Rep (2007) 1.05
Inscuteable mRNA localization is dynein-dependent and regulates apicobasal polarity and spindle length in Drosophila neuroblasts. Curr Biol (2004) 0.93
Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes. Proc Natl Acad Sci U S A (2013) 0.91
Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock. Development (2014) 0.88
Upregulation of chicken p15INK4b at senescence and in the developing brain. J Cell Sci (2006) 0.86
The epsilon-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions. Genetics (2005) 0.85
Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis. Development (2010) 0.85
Notch activity is required to maintain floorplate identity and to control neurogenesis in the chick hindbrain and spinal cord. Int J Dev Biol (2003) 0.84
Receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm. Development (2004) 0.84
Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS One (2009) 0.83
A genetic screen based on in vivo RNA imaging reveals centrosome-independent mechanisms for localizing gurken transcripts in Drosophila. G3 (Bethesda) (2014) 0.80
Modifying transcript lengths of cycling mouse segmentation genes. Mech Dev (2012) 0.78
Cell polarity: Oskar seeks PARtner for a stable relationship. Nat Cell Biol (2002) 0.76
Chick receptor tyrosine phosphatase Psi is dynamically expressed during somitogenesis. Gene Expr Patterns (2003) 0.75
Identification and mapping of induced chromosomal deletions using sequence polymorphisms. Biotechniques (2010) 0.75