Published in Genetics on November 01, 1991
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol Cell Biol (1996) 3.06
Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev (1997) 2.38
Groucho-dependent and -independent repression activities of Runt domain proteins. Mol Cell Biol (1997) 2.27
Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev (2000) 2.24
Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. Genetics (1996) 2.05
Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins. Genetics (1992) 1.87
The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc Natl Acad Sci U S A (1992) 1.76
eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins. Genes Dev (1997) 1.69
Hairy transcriptional repression targets and cofactor recruitment in Drosophila. PLoS Biol (2004) 1.63
Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol Cell Biol (2005) 1.55
The Groucho/TLE/Grg family of transcriptional co-repressors. Genome Biol (2008) 1.46
A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. Mol Cell Biol (1999) 1.39
The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. Mol Cell Biol (2001) 1.32
Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics (1996) 1.29
Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins. Mol Cell Biol (1999) 1.26
Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression. Mol Cell Biol (2002) 1.24
A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system. Proc Natl Acad Sci U S A (1997) 1.19
Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions. Biochem J (1996) 1.17
The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics (1996) 1.12
In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters. EMBO J (1996) 1.12
Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS Genet (2013) 1.03
A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. Mol Cell Biol (1997) 0.94
The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee. BMC Evol Biol (2005) 0.92
NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. PLoS One (2007) 0.91
Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor. Proc Natl Acad Sci U S A (2009) 0.88
Drosophila evolution challenges postulated redundancy in the E(spl) gene complex. Proc Natl Acad Sci U S A (1993) 0.87
Position dependent responses to discontinuities in the retinal determination network. Dev Biol (2008) 0.86
A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics (2010) 0.80
Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling. PLoS Genet (2016) 0.79
Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression. Mol Cell Biol (2012) 0.79
On the mechanism underlying the divergent retinal and bristle defects of M8* (E(spl)D) in Drosophila. Genesis (2009) 0.79
bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability. Nucleic Acids Res (2015) 0.76
Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression. J Mol Med (Berl) (2014) 0.76
The Enhancer of split complex arose prior to the diversification of schizophoran flies and is strongly conserved between Drosophila and stalk-eyed flies (Diopsidae). BMC Evol Biol (2011) 0.75
The Conserved MAPK Site in E(spl)-M8, an Effector of Drosophila Notch Signaling, Controls Repressor Activity during Eye Development. PLoS One (2016) 0.75
Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche. Development (2016) 0.75
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71
Genetic transformation of Drosophila with transposable element vectors. Science (1982) 27.36
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell (1989) 14.24
Analysis of P transposable element functions in Drosophila. Cell (1984) 11.95
The myoD gene family: nodal point during specification of the muscle cell lineage. Science (1991) 9.53
Vectors for P element-mediated gene transfer in Drosophila. Nucleic Acids Res (1983) 7.33
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b. J Biol Chem (1985) 6.32
A position-effect assay for boundaries of higher order chromosomal domains. Cell (1991) 6.04
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc Natl Acad Sci U S A (1982) 3.73
extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins. Cell (1990) 3.15
The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein. Cell (1990) 3.08
Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome. Genetics (1989) 2.99
Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. EMBO J (1989) 2.54
The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J (1987) 2.23
Genetic interactions in early neurogenesis of Drosophila melanogaster. J Neurogenet (1985) 2.11
Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells. Dev Biol (1985) 2.04
A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell (1988) 2.01
PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Mol Cell Biol (1989) 1.95
From DNA to form: the achaete-scute complex. Genes Dev (1988) 1.71
Functional interactions of neurogenic genes of Drosophila melanogaster. Genetics (1988) 1.65
The enhancer of split locus and neurogenesis in Drosophila melanogaster. Dev Biol (1987) 1.54
The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Genes Dev (1990) 1.51
The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila. EMBO J (1988) 1.48
Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development. Genes Dev (1989) 1.43
Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster. EMBO J (1987) 1.42
Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster. Neuron (1990) 1.37
Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev (1990) 1.28
The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J Cell Biol (1989) 1.25
A tripartite interaction among alleles of Notch, Delta, and Enhancer of split during imaginal development of Drosophila melanogaster. Genetics (1989) 1.12
Notch and the choice of cell fate in Drosophila neuroepithelium. Trends Genet (1990) 1.01
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell (1985) 5.71
A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell (1986) 4.39
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell (1991) 4.37
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell (1990) 4.07
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
The suppressor of hairless protein participates in notch receptor signaling. Cell (1994) 3.81
Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science (1999) 3.74
Genetic and molecular analysis of the 87A7 and 87C1 heat-inducible loci of D. melanogaster. Cell (1979) 3.68
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell (1997) 3.47
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell (1993) 3.35
Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A (1995) 3.33
Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol (2000) 3.15
A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development (1994) 2.78
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet (1992) 2.71
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J Cell Biol (1995) 2.69
Production of phenocopies by Krüppel antisense RNA injection into Drosophila embryos. Nature (1985) 2.62
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature (1993) 2.49
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol (1997) 2.48
Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science (1996) 2.31
slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev (1990) 2.25
Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo. Nature (1985) 2.25
Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A (1983) 2.17
Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein. Cell (1978) 2.10
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development (1995) 2.09
The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development (1994) 2.07
Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol (1991) 2.05
The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood (1998) 2.05
A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell (1988) 2.01
Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99
Cell proliferation control by Notch signaling in Drosophila development. Development (1998) 1.98
The 5S genes of Drosophila melanogaster. Cell (1977) 1.94
Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell (1979) 1.80
Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Curr Biol (2001) 1.78
The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc Natl Acad Sci U S A (1992) 1.76
Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development (1996) 1.75
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development (1994) 1.73
Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos. Nature (1985) 1.73
Molecular genetics of Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol (1985) 1.68
Genes for the 70,000 dalton heat shock protein in two cloned D. melanogaster DNA segments. Cell (1979) 1.66
The involvement of the Notch locus in Drosophila oogenesis. Development (1992) 1.65
A cytological map of the human X chromosome--evidence for non-random recombination. Nucleic Acids Res (1984) 1.64
The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev (1990) 1.61
Human deltex is a conserved regulator of Notch signalling. Nat Genet (1998) 1.55
Organization of the multiple genes for the 70,000-dalton heat-shock protein in Drosophila melanogaster. Proc Natl Acad Sci U S A (1979) 1.55
The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev (1990) 1.53
The molecular genetics of the Notch locus in Drosophila melanogaster. Dev Biol (1985) 1.49
slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell (1988) 1.48
The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila. EMBO J (1988) 1.48
The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development (1996) 1.46
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development (1997) 1.39
Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development (1997) 1.37
Notch: neurogenesis is only part of the picture. Cell (1993) 1.35
Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J Biol Chem (1995) 1.34
Human ligands of the Notch receptor. Am J Pathol (1999) 1.32
The gooseberry-zipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo. EMBO J (1987) 1.31
The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet (1988) 1.29
Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics (1996) 1.29
Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos. Development (1993) 1.27
The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J Cell Biol (1989) 1.25
Transfer RNA genes of Drosophila melanogaster. Nucleic Acids Res (1980) 1.25
deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics (1990) 1.23
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Genetics (1999) 1.20
Primary structure of triosephosphate isomerase from Bacillus stearothermophilus. Eur J Biochem (1980) 1.19
Endogenous plant hormones of the broad bean, Vicia faba L. (-)-jasmonic acid, a plant growth inhibitor in pericarp. Planta (1981) 1.18
Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein. Mech Dev (1992) 1.13
Regulation of the segmentation gene fushi tarazu has been functionally conserved in Drosophila. EMBO J (1990) 1.13
Notch signaling and the determination of appendage identity. Proc Natl Acad Sci U S A (2000) 1.12
The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. J Mol Biol (1994) 1.12
Comparative aspects of Notch signaling in lower and higher eukaryotes. Perspect Dev Neurobiol (1997) 1.12
Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics (1998) 1.12
Comparative studies of the leachate of an industrial landfill by gas chromatography-mass spectrometry, liquid chromatography-nuclear magnetic resonance and liquid chromatography-mass spectrometry. J Chromatogr A (1999) 1.09
A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Genetics (1994) 1.08
The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes. Mech Dev (1999) 1.07
Identification of a divergent actin-related protein in Drosophila. J Mol Biol (1994) 1.06
In vivo structure-function analysis of Drosophila Hairless. Mech Dev (1997) 1.06
Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells. Mech Dev (1995) 1.05
Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. Genomics (1996) 1.04
The NOTCH receptor and its ligands. Trends Cell Biol (1997) 1.04
Time-related bisphenol-A content and estrogenic activity in saliva samples collected in relation to placement of fissure sealants. Clin Oral Investig (1999) 1.03
Physical and functional definition of the Drosophila Notch locus by P element transformation. Genetics (1989) 1.03
Distinct expression patterns of different enhancer of split bHLH genes during embryogenesis of Drosophila melanogaster. Dev Genes Evol (1999) 1.02
Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila. Mech Dev (2000) 1.02
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet (1992) 1.01
DNA sequences flanking the starts of the hsp 70 and alpha beta heat shock genes are homologous. Dev Biol (1981) 0.99
Modulation of wingless signaling by Notch in Drosophila. Mech Dev (1994) 0.99
An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin. J Cell Sci (1997) 0.98
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int J Dev Neurosci (2001) 0.96
The role of the enhancer of split complex during cell fate determination in Drosophila. Dev Suppl (1993) 0.96
Subcellular localization of Hairless protein shows a major focus of activity within the nucleus. Mech Dev (1999) 0.96
Molecular analysis of Krüppel, a segmentation gene of Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1985) 0.96
Modularity of the slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions. J Mol Biol (1992) 0.94
A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo. Proc Natl Acad Sci U S A (1998) 0.93
Bisphenol-A content of resin monomers and related degradation products. Clin Oral Investig (1999) 0.91
Inhibition of cell fate in Drosophila by Enhancer of split genes. Mech Dev (1995) 0.91