Published in Chimia (Aarau) on January 01, 2010
Mitochondrial CB₁ receptors regulate neuronal energy metabolism. Nat Neurosci (2012) 2.15
Extended kinase profile and properties of the protein kinase inhibitor nilotinib. Biochim Biophys Acta (2009) 2.04
AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res (2004) 1.82
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells. Cancer Res (2007) 1.65
Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. J Biol Chem (2006) 1.54
Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib. Bioorg Med Chem (2010) 1.46
The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer. Cancer Res (2008) 1.38
Cross-cultural comparisons of medicinal floras--what are the implications for bioprospecting? J Ethnopharmacol (2011) 1.38
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake. Clin Cancer Res (2003) 1.27
Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep (2007) 1.24
Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther (2010) 1.22
Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. J Biol Chem (2011) 1.11
Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media. Angew Chem Int Ed Engl (2005) 1.10
Yucatec Mayan medicinal plants: evaluation based on indigenous uses. J Ethnopharmacol (2002) 1.06
Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. Clin Cancer Res (2005) 1.06
Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo. Anticancer Drugs (2011) 1.03
Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET. J Cell Sci (2012) 1.03
In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta Med (2008) 1.02
The major central endocannabinoid directly acts at GABA(A) receptors. Proc Natl Acad Sci U S A (2011) 1.02
A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Cancer Res (2011) 1.02
Chiral (acyclic diaminocarbene)gold(I)-catalyzed dynamic kinetic asymmetric transformation of propargyl esters. J Am Chem Soc (2011) 0.99
Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. Chem Biol (2011) 0.99
Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin. Org Lett (2010) 0.97
Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo. Prostate (2005) 0.97
Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int Immunopharmacol (2009) 0.96
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother Pharmacol (2008) 0.96
Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors. J Biol Chem (2012) 0.96
Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg Med Chem (2010) 0.95
The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS One (2013) 0.95
Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? J Pharm Pharmacol (2009) 0.94
Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla. Phytochemistry (2002) 0.94
Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. J Immunol Methods (2011) 0.93
Plant volatiles: production, function and pharmacology. Nat Prod Rep (2011) 0.93
Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity. Org Lett (2008) 0.92
Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine. Angew Chem Int Ed Engl (2010) 0.92
Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Acc Chem Res (2007) 0.91
Molecular design and chemical synthesis of a highly potent epothilone. ChemMedChem (2006) 0.91
Evidence for bidirectional endocannabinoid transport across cell membranes. J Biol Chem (2012) 0.91
Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo. Clin Cancer Res (2005) 0.89
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors. J Med Chem (2012) 0.89
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. J Med Chem (2010) 0.88
Conformational preferences of natural and C3-modified epothilones in aqueous solution. J Med Chem (2008) 0.88
Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives. Chemistry (2012) 0.87
The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue. Chemistry (2009) 0.86
Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol (2010) 0.86
Stereoselective synthesis of a monocyclic peloruside a analogue. Org Lett (2010) 0.85
EPO906 (epothilone B): a promising novel microtubule stabilizer. Semin Oncol (2003) 0.85
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo. Blood (2004) 0.85
β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radic Biol Med (2012) 0.85
Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL. ACS Chem Neurosci (2014) 0.84
Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. J Immunol (2011) 0.84
A ring-closing metathesis (RCM)-based approach to mycolactones A/B. Chemistry (2011) 0.81
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol (2011) 0.81
Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem (2009) 0.81
Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochem Pharmacol (2012) 0.81
Cellular BRET assay suggests a conformational rearrangement of preformed TrkB/Shc complexes following BDNF-dependent activation. Cell Signal (2009) 0.81
Total synthesis of the marine diterpenoid blumiolide C. Angew Chem Int Ed Engl (2008) 0.80
New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima. Bioorg Med Chem Lett (2008) 0.80
Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS Chem Biol (2014) 0.79
Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom? ChemMedChem (2006) 0.78
Design, synthesis, and biological properties of highly potent epothilone B analogues. Angew Chem Int Ed Engl (2003) 0.78
Cytotoxic steroidal saponins from the rhizomes of Tacca integrifolia. Chem Biodivers (2010) 0.78
Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii. J Nat Prod (2014) 0.78
Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. J Nat Prod (2007) 0.78
Synthesis and biological activity of 7,8,9-trideoxy- and 7R desTHP-peloruside A. Chemistry (2013) 0.78
Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin. Chemistry (2009) 0.78
Stereoselective synthesis, natural occurrence and CB(2) receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp. Org Biomol Chem (2006) 0.78
The binding mode of side chain- and C3-modified epothilones to tubulin. ChemMedChem (2010) 0.77
Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition. Chembiochem (2006) 0.77
4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. Prog Med Chem (2004) 0.76
Bioprospecting: evolutionary implications from a post-olmec pharmacopoeia and the relevance of widespread taxa. J Ethnopharmacol (2013) 0.76
Scaffolds for microtubule inhibition through extensive modification of the epothilone template. Angew Chem Int Ed Engl (2005) 0.76
Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent N12-aza-epothilone (azathilone). Chembiochem (2009) 0.76
Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors? PeerJ (2013) 0.76
Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. Bioorg Med Chem Lett (2009) 0.76
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. Bioorg Med Chem (2011) 0.76
Total synthesis and reassessment of the phosphatase-inhibitory activity of the antitumor agent TMC-69-6H. Angew Chem Int Ed Engl (2003) 0.76
Biodiversity and chemodiversity: future perspectives in bioprospecting. Curr Drug Targets (2011) 0.75
Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity. Angew Chem Int Ed Engl (2006) 0.75
Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus. J Nat Prod (2006) 0.75
Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants. Org Lett (2011) 0.75
A pterocarpan from the seeds of Bituminaria morisiana. J Nat Med (2010) 0.75
New cytotoxic prenylated isoflavonoids from Bituminaria morisiana. Planta Med (2005) 0.75
Total synthesis and configurational assignment of the marine natural product haliclamide. J Org Chem (2013) 0.75
Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives. Bioorg Med Chem Lett (2012) 0.75
Natural products in chemical biology. Curr Drug Targets (2011) 0.75
Total synthesis and biological evaluation of a C(10)/C(12)-phenylene-bridged analog of epothilone D. Chem Biodivers (2004) 0.75
Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting. Chimia (Aarau) (2010) 0.75
An endocannabinoid uptake inhibitor from black pepper exerts pronounced anti-inflammatory effects in mice. J Agric Food Chem (2017) 0.75
Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands. Org Biomol Chem (2015) 0.75
Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones. Bioorg Med Chem (2003) 0.75
Synthesis, conformational analysis, and bioassay of 9,10-didehydroepothilone D. Org Lett (2002) 0.75