Published in Proc Natl Acad Sci U S A on February 11, 2008
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The Fip35 WW domain folds with structural and mechanistic heterogeneity in molecular dynamics simulations. Biophys J (2009) 1.58
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Tackling force-field bias in protein folding simulations: folding of Villin HP35 and Pin WW domains in explicit water. Biophys J (2010) 1.47
Exploring one-state downhill protein folding in single molecules. Proc Natl Acad Sci U S A (2011) 1.42
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Evaluating beta-turn mimics as beta-sheet folding nucleators. Proc Natl Acad Sci U S A (2009) 1.07
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A survey of lambda repressor fragments from two-state to downhill folding. J Mol Biol (2010) 1.06
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Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics. J Am Chem Soc (2010) 0.93
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Probing the origins of two-state folding. J Chem Phys (2013) 0.90
High resolution approach to the native state ensemble kinetics and thermodynamics. Biophys J (2008) 0.88
Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS One (2009) 0.87
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Exploiting the downhill folding regime via experiment. HFSP J (2008) 0.82
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Characterization of folding mechanisms of Trp-cage and WW-domain by network analysis of simulations with a hybrid-resolution model. J Phys Chem B (2013) 0.81
How to mark off paths on the protein energy landscape. Proc Natl Acad Sci U S A (2009) 0.80
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Comparing Fast Pressure Jump and Temperature Jump Protein Folding Experiments and Simulations. J Am Chem Soc (2015) 0.79
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A semi-analytical description of protein folding that incorporates detailed geometrical information. J Chem Phys (2011) 0.79
The Role of Electrostatic Interactions in Folding of β-Proteins. J Am Chem Soc (2016) 0.79
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Folding Proteins at 500 ns/hour with Work Queue. Proc IEEE Int Conf Escience (2012) 0.78
Structural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein. Sci Rep (2016) 0.77
Preventing fibril formation of a protein by selective mutation. Proc Natl Acad Sci U S A (2015) 0.77
High-resolution visualisation of the states and pathways sampled in molecular dynamics simulations. Sci Rep (2014) 0.76
Protein dynamics: from molecules, to interactions, to biology. Int J Mol Sci (2009) 0.75
The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate. J Am Chem Soc (2016) 0.75
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Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation. Proc Natl Acad Sci U S A (2003) 2.15
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Downhill protein folding: evolution meets physics. C R Biol (2005) 1.50
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The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c. Proc Natl Acad Sci U S A (2003) 1.43
Tuning lambda6-85 towards downhill folding at its melting temperature. J Mol Biol (2007) 1.36
Robustness of downhill folding: guidelines for the analysis of equilibrium folding experiments on small proteins. Biochemistry (2005) 1.18
Solvent-tuning the collapse and helix formation time scales of lambda(6-85)*. Protein Sci (2006) 1.16
Exponential decay kinetics in "downhill" protein folding. Proteins (2003) 1.15
Expedient synthesis of the alpha-C-glycoside analogue of the immunostimulant galactosylceramide (KRN7000). Org Lett (2006) 1.10
Structural biology: analysis of 'downhill' protein folding. Nature (2007) 1.07
Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies. J Am Chem Soc (2006) 1.06
Excluded volume, local structural cooperativity, and the polymer physics of protein folding rates. Proc Natl Acad Sci U S A (2007) 1.06
Low barrier kinetics: dependence on observables and free energy surface. J Comput Chem (2006) 1.02
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Variationally determined free energy profiles for structural models of proteins: characteristic temperatures for folding and trapping. J Phys Chem B (2008) 0.95
Downhill versus two-state protein folding in a statistical mechanical model. J Chem Phys (2007) 0.86
Adapting proteostasis for disease intervention. Science (2008) 13.22
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (2003) 6.68
Opposing activities protect against age-onset proteotoxicity. Science (2006) 5.85
Absolute comparison of simulated and experimental protein-folding dynamics. Nature (2002) 5.68
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
Semen-derived amyloid fibrils drastically enhance HIV infection. Cell (2007) 5.23
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell (2006) 5.01
Therapeutic approaches to protein-misfolding diseases. Nature (2003) 4.57
Functional amyloid--from bacteria to humans. Trends Biochem Sci (2007) 4.50
Folding at the speed limit. Nature (2003) 4.23
Functional amyloid formation within mammalian tissue. PLoS Biol (2006) 3.92
Ten-microsecond molecular dynamics simulation of a fast-folding WW domain. Biophys J (2008) 3.81
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res (2009) 3.59
Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial. Neurology (2012) 3.48
Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell (2008) 3.11
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell (2009) 2.87
The biological and chemical basis for tissue-selective amyloid disease. Cell (2005) 2.76
Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proc Natl Acad Sci U S A (2002) 2.71
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
Metamorphic enzyme assembly in polyketide diversification. Nature (2009) 2.64
Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science (2003) 2.63
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat Chem Biol (2007) 2.57
Folding lambda-repressor at its speed limit. Biophys J (2004) 2.44
Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics. Nature (2004) 2.44
Structure-function-folding relationship in a WW domain. Proc Natl Acad Sci U S A (2006) 2.28
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A (2012) 2.27
Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses. Acc Chem Res (2005) 2.25
Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity. Proc Natl Acad Sci U S A (2002) 2.25
Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants. ACS Chem Biol (2006) 2.25
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther (2004) 2.25
Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation. Proc Natl Acad Sci U S A (2003) 2.15
Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc Natl Acad Sci U S A (2004) 2.14
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Targeting mitochondria. Acc Chem Res (2008) 2.03
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med (2009) 2.00
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Rep (2013) 1.87
An adaptable standard for protein export from the endoplasmic reticulum. Cell (2007) 1.86
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. J Mol Biol (2003) 1.82
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. J Med Chem (2005) 1.80
Protein folding stability and dynamics imaged in a living cell. Nat Methods (2010) 1.77
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chem Biol (2004) 1.76
Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding. Proc Natl Acad Sci U S A (2010) 1.75
Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem (2008) 1.74
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A (2013) 1.73
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell (2006) 1.71
Nanoparticles in cellular drug delivery. Bioorg Med Chem (2009) 1.70
The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug. J Mol Biol (2012) 1.70
Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles. Chem Biol (2005) 1.68
Therapeutic strategies for human amyloid diseases. Nat Rev Drug Discov (2002) 1.63
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Curr Opin Struct Biol (2010) 1.62
Exploring the energy landscape of a small RNA hairpin. J Am Chem Soc (2006) 1.62
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med (2011) 1.62
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol (2006) 1.60
An extended dynamical hydration shell around proteins. Proc Natl Acad Sci U S A (2007) 1.59
Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nat Neurosci (2012) 1.58
Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. J Med Chem (2007) 1.58
Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 1.55
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Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J Med Chem (2004) 1.54
The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability. Proc Natl Acad Sci U S A (2009) 1.54
Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. J Biol Chem (2004) 1.51
Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry (2008) 1.51
Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Lab Invest (2004) 1.50
Engineering a beta-sheet protein toward the folding speed limit. J Phys Chem B (2005) 1.49
Kinetics are probe-dependent during downhill folding of an engineered lambda6-85 protein. Proc Natl Acad Sci U S A (2005) 1.49
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The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther (2005) 1.46
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Optoelectronic Switching of a Carbon Nanotube Chiral Junction Imaged with Nanometer Spatial Resolution. ACS Nano (2015) 1.40
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proc Natl Acad Sci U S A (2012) 1.39
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A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation. Int J Radiat Oncol Biol Phys (2008) 1.39
Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins. Nat Struct Mol Biol (2009) 1.37
Tuning lambda6-85 towards downhill folding at its melting temperature. J Mol Biol (2007) 1.36
Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides. J Pharmacol Exp Ther (2006) 1.36
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Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis. Amyloid (2006) 1.34
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The pathway by which the tetrameric protein transthyretin dissociates. Biochemistry (2005) 1.32
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Pharmacologic chaperoning as a strategy to treat Gaucher disease. FEBS J (2007) 1.29
Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators. Int J Radiat Oncol Biol Phys (2011) 1.29
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