Published in EMBO Rep on February 15, 2008
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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell (2008) 6.07
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 2.19
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell (2009) 1.98
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Mechanism of hypoxia-induced NF-kappaB. Mol Cell Biol (2010) 1.74
Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep (2009) 1.48
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Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid Redox Signal (2014) 1.06
Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem (2011) 1.06
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry (2008) 1.03
The expanding universe of ubiquitin and ubiquitin-like modifiers. Plant Physiol (2012) 1.02
Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. Mol Cell Proteomics (2011) 1.02
Scission of the p53-MDM2 Loop by Ribosomal Proteins. Genes Cancer (2012) 1.00
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The p53 isoforms are differentially modified by Mdm2. Cell Cycle (2012) 0.94
Deletion of mitochondrial associated ubiquitin fold modifier protein Ufm1 in Leishmania donovani results in loss of β-oxidation of fatty acids and blocks cell division in the amastigote stage. Mol Microbiol (2012) 0.93
Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics (2012) 0.93
MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants. Plant Physiol (2011) 0.91
Neddylation and deneddylation in cardiac biology. Am J Cardiovasc Dis (2014) 0.90
Regulation of parkin and PINK1 by neddylation. Hum Mol Genet (2012) 0.90
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Suppression of glioblastoma by targeting the overactivated protein neddylation pathway. Neuro Oncol (2015) 0.87
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The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway. Oncogene (2015) 0.85
New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol Cell Biol (2010) 0.85
Early transcriptional changes in the reef-building coral Acropora aspera in response to thermal and nutrient stress. BMC Genomics (2014) 0.83
The NEDD8 modification pathway in plants. Front Plant Sci (2014) 0.83
Modification by ubiquitin-like proteins: significance in apoptosis and autophagy pathways. Int J Mol Sci (2012) 0.82
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Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins. DNA Repair (Amst) (2015) 0.80
Brap2 regulates temporal control of NF-κB localization mediated by inflammatory response. PLoS One (2013) 0.80
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Ribosomal Protein Rps26 Influences 80S Ribosome Assembly in Saccharomyces cerevisiae. mSphere (2016) 0.76
ML3 is a NEDD8- and ubiquitin-modified protein. Plant Physiol (2013) 0.76
Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications. Cytotechnology (2015) 0.76
Stress, specificity and the NEDD8 proteome. Cell Cycle (2012) 0.76
Nedd8 processing enzymes in Schizosaccharomyces pombe. BMC Biochem (2013) 0.76
NEDDylation promotes stress granule assembly. Nat Commun (2016) 0.75
Protein neddylation pathway in Trypanosoma brucei: functional characterization and substrate identification. J Biol Chem (2016) 0.75
SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function. Elife (2017) 0.75
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. PLoS One (2013) 0.75
A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation. Sci Rep (2017) 0.75
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Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol (2006) 10.74
Nucleolar proteome dynamics. Nature (2005) 7.32
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46
Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins. Curr Biol (2007) 3.55
Nedd8 on cullin: building an expressway to protein destruction. Oncogene (2004) 3.29
Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells. J Cell Biol (2001) 2.70
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics. Nat Cell Biol (2005) 2.62
Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J (2004) 2.59
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene (2001) 2.14
Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Mol Cell Biol (2000) 2.00
The moving parts of the nucleolus. Histochem Cell Biol (2005) 1.81
NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem (2003) 1.64
Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat Cell Biol (2006) 1.62
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J (2005) 1.48
pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol (2004) 1.45
Nucleolus: from structure to dynamics. Histochem Cell Biol (2005) 1.44
Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem (2006) 1.42
Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. J Mol Biol (2005) 1.28
Protection of cullin-RING E3 ligases by CSN-UBP12. Trends Cell Biol (2006) 1.17
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem (2006) 1.17
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Arch Biochem Biophys (2006) 0.98
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46
P300 transcriptional repression is mediated by SUMO modification. Mol Cell (2003) 3.67
System-wide changes to SUMO modifications in response to heat shock. Sci Signal (2009) 3.50
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature (2012) 2.86
Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics (2006) 2.64
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol (2009) 2.27
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites. Nat Methods (2012) 2.12
The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest (2003) 2.10
SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol (2010) 1.95
Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. Mol Cell Proteomics (2007) 1.95
A mechanism for inhibiting the SUMO pathway. Mol Cell (2004) 1.93
A proteomic study of SUMO-2 target proteins. J Biol Chem (2004) 1.92
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev (2012) 1.90
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol (2004) 1.90
SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol (2006) 1.89
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
SUMO and transcriptional regulation. Semin Cell Dev Biol (2004) 1.82
Mechanism of hypoxia-induced NF-kappaB. Mol Cell Biol (2010) 1.74
Purification and identification of endogenous polySUMO conjugates. EMBO Rep (2011) 1.72
Identification of a substrate recognition site on Ubc9. J Biol Chem (2002) 1.71
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry (2003) 1.70
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol (2003) 1.69
Detection of protein SUMOylation in vivo. Nat Protoc (2009) 1.66
NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem (2003) 1.64
Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol (2011) 1.59
Reliable, verifiable and efficient monitoring of biodiversity via metabarcoding. Ecol Lett (2013) 1.56
Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal (2011) 1.54
Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J (2009) 1.51
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J (2006) 1.49
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J (2005) 1.48
Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol (2003) 1.39
Sentinel node sampling limits lymphadenectomy in stage I non-small cell lung cancer. Eur J Cardiothorac Surg (2007) 1.38
Stable-isotope labeling with amino acids in nematodes. Nat Methods (2011) 1.28
Post-translational modification by SUMO. Toxicology (2010) 1.26
Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc Natl Acad Sci U S A (2007) 1.22
Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Biochem J (2011) 1.16
Video-assisted thoracic surgery lobectomy reduces the morbidity after surgery for stage I non-small cell lung cancer. Jpn J Thorac Cardiovasc Surg (2006) 1.16
Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14. Epilepsy Res (2002) 1.14
The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation. Cell Cycle (2005) 1.12
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum (2005) 1.11
Detection of modification by ubiquitin-like proteins. Methods (2006) 1.10
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2. FEBS Lett (2002) 1.10
The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice. Proc Natl Acad Sci U S A (2008) 1.10
A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing. Anal Biochem (2007) 1.10
Ube2W conjugates ubiquitin to α-amino groups of protein N-termini. Biochem J (2013) 1.07
Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Mol Biol Cell (2010) 1.07
Anterior chest wall reconstruction with titanium plate sandwiched between two polypropylene sheets. Gen Thorac Cardiovasc Surg (2012) 1.05
Induction of protein conformational change in mouse senile amyloidosis. J Biol Chem (2002) 1.04
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells. Clin Exp Metastasis (2007) 1.04
Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. Eur J Immunol (2002) 1.02
SUMOylation of HNF4α regulates protein stability and hepatocyte function. J Cell Sci (2012) 1.01
Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway. Protein Sci (2008) 1.00
Novel MHC class I structures on exosomes. J Immunol (2009) 0.99
FRET-based in vitro assays for the analysis of SUMO protease activities. Methods Mol Biol (2009) 0.99
Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity. Cancer Res (2008) 0.99
Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach. Anal Chem (2004) 0.99
Phase-specific central regulatory systems of hibernation in Syrian hamsters. Brain Res (2005) 0.97
Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex. Biochemistry (2003) 0.96
Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes Dev (2008) 0.96
Medical risks in epilepsy: a review with focus on physical injuries, mortality, traffic accidents and their prevention. Epilepsy Res (2004) 0.96
Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem (2005) 0.93
Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas. Hepatol Res (2003) 0.93
NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. J Hepatol (2008) 0.92
Amyloid protofibril is highly voluminous and compressible. Biochemistry (2007) 0.92
Absolute SILAC-compatible expression strain allows Sumo-2 copy number determination in clinical samples. J Proteome Res (2011) 0.92
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Biochem J (2013) 0.91
The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Mol Biol Cell (2010) 0.91
A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC. Mediators Inflamm (2009) 0.91
Age-related difference of site-specific histone modifications in rat liver. Biogerontology (2008) 0.90
Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. Biochem J (2007) 0.90
Retinoic acid increases proliferation of human osteoclast progenitors and inhibits RANKL-stimulated osteoclast differentiation by suppressing RANK. PLoS One (2010) 0.89
BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression. Cell Oncol (Dordr) (2011) 0.89
Vitamin a is a negative regulator of osteoblast mineralization. PLoS One (2013) 0.89
Occurrence of cardiovascular events after the 2011 Great East Japan Earthquake and tsunami disaster. Int Heart J (2013) 0.88
Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cells. Biochim Biophys Acta (2003) 0.87
A role for paralog-specific sumoylation in histone deacetylase 1 stability. J Mol Cell Biol (2013) 0.87
Advantages of thoracoabdominal approach by oblique incision for right-side hepatectomy. Hepatogastroenterology (2007) 0.87
VEGF 164 gene transfer by electroporation improves diabetic sensory neuropathy in mice. J Gene Med (2006) 0.87
BC-box protein domain-related mechanism for VHL protein degradation. Proc Natl Acad Sci U S A (2013) 0.86
CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte. Biol Open (2012) 0.86
SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression. Mol Cell Biol (2007) 0.86
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Modifying NEMO. Nat Cell Biol (2004) 0.85
Inhibition of NF-kappa B by a cell permeable form of I kappa B alpha induces apoptosis in eosinophils. Biochem Biophys Res Commun (2005) 0.85
High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats. Bone (2010) 0.84
Video-assisted thoracoscopic resection for intralobar pulmonary sequestration. Gen Thorac Cardiovasc Surg (2009) 0.84
Use of Pharmacist Consultations for Nonprescription Laxatives in Japan: An Online Survey. Biol Pharm Bull (2016) 0.83
PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation. J Cell Sci (2013) 0.83
High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties. Nat Protoc (2010) 0.83
Glial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain. Free Radic Res (2002) 0.83