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Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse. Mol Cell Proteomics (2013) 1.60

Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell (2015) 1.50

Recent advances in quantitative neuroproteomics. Methods (2013) 1.23

Global subcellular characterization of protein degradation using quantitative proteomics. Mol Cell Proteomics (2012) 1.17

Comparative proteomics of two life cycle stages of stable isotope-labeled Trypanosoma brucei reveals novel components of the parasite's host adaptation machinery. Mol Cell Proteomics (2012) 1.14

Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse. Mol Cell Proteomics (2013) 1.05

Isotopic ratio outlier analysis global metabolomics of Caenorhabditis elegans. Anal Chem (2013) 1.04

Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism. EMBO J (2014) 1.02

Cell-specific proteomic analysis in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2015) 0.95

Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cell Mol Life Sci (2014) 0.94

Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem (2012) 0.92

Chemical tools for temporally and spatially resolved mass spectrometry-based proteomics. Ann Biomed Eng (2013) 0.85

Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Mol Cell Proteomics (2013) 0.84

Parasites, proteomes and systems: has Descartes' clock run out of time? Parasitology (2012) 0.84

Transcriptome analyses reveal protein and domain families that delineate stage-related development in the economically important parasitic nematodes, Ostertagia ostertagi and Cooperia oncophora. BMC Genomics (2013) 0.83

Plant SILAC: stable-isotope labelling with amino acids of arabidopsis seedlings for quantitative proteomics. PLoS One (2013) 0.83

Strength in numbers: "Omics" studies of C. elegans innate immunity. Virulence (2012) 0.83

Insights from quantitative metaproteomics and protein-stable isotope probing into microbial ecology. ISME J (2013) 0.83

Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Mol Cell Proteomics (2012) 0.82

Quantitation of endogenous peptides using mass spectrometry based methods. Curr Opin Chem Biol (2013) 0.80

Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nat Protoc (2014) 0.80

Global Proteomics Analysis of the Response to Starvation in C. elegans. Mol Cell Proteomics (2015) 0.80

A Biologist's Field Guide to Multiplexed Quantitative Proteomics. Mol Cell Proteomics (2016) 0.79

RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Open Biol (2013) 0.78

Quantitative proteomics by amino acid labeling identifies novel NHR-49 regulated proteins in C. elegans. Worm (2012) 0.78

Deep Proteome Analysis Identifies Age-Related Processes in C. elegans. Cell Syst (2016) 0.78

Micro-proteomics with iterative data analysis: Proteome analysis in C. elegans at the single worm level. Proteomics (2016) 0.77

Deletion of Genes Encoding Arginase Improves Use of "Heavy" Isotope-Labeled Arginine for Mass Spectrometry in Fission Yeast. PLoS One (2015) 0.77

NeuCode Labeling in Nematodes: Proteomic and Phosphoproteomic Impact of Ascaroside Treatment in Caenorhabditis elegans. Mol Cell Proteomics (2015) 0.77

Approaches for assessing and discovering protein interactions in cancer. Mol Cancer Res (2013) 0.76

Emerging proteomic technologies for elucidating context-dependent cellular signaling events: A big challenge of tiny proportions. Proteomics (2015) 0.76

Natural Genetic Variation Differentially Affects the Proteome and Transcriptome in Caenorhabditis elegans. Mol Cell Proteomics (2016) 0.76

Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. Genetics (2016) 0.76

New techniques and tools in 2011. Worm (2012) 0.75

Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Worm (2013) 0.75

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Dev Cell (2017) 0.75

Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans. PLoS One (2017) 0.75

The genetics of Caenorhabditis elegans. Genetics (1974) 102.14

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A (2000) 96.90

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol (2000) 9.01

Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics (2006) 4.25

Enhanced neuronal RNAi in C. elegans using SID-1. Nat Methods (2010) 2.50

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37

HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol Cell (2010) 2.07

A quantitative proteomics analysis of subcellular proteome localization and changes induced by DNA damage. Mol Cell Proteomics (2009) 1.74

The SILAC fly allows for accurate protein quantification in vivo. Mol Cell Proteomics (2010) 1.60

A genetic engineering solution to the "arginine conversion problem" in stable isotope labeling by amino acids in cell culture (SILAC). Mol Cell Proteomics (2010) 1.17

Mass spectrometric proteome analysis for profiling temperature-dependent changes of protein expression in wild-type Caenorhabditis elegans. Proteomics (2003) 0.96

Nucleolar proteome dynamics. Nature (2005) 7.32

The multifunctional nucleolus. Nat Rev Mol Cell Biol (2007) 7.08

Directed proteomic analysis of the human nucleolus. Curr Biol (2002) 7.04

p53 isoforms can regulate p53 transcriptional activity. Genes Dev (2005) 6.76

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90

Large-scale proteomic analysis of the human spliceosome. Genome Res (2002) 5.75

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46

Paraspeckles: a novel nuclear domain. Curr Biol (2002) 4.19

Combined functional genomic maps of the C. elegans DNA damage response. Science (2002) 3.74

P300 transcriptional repression is mediated by SUMO modification. Mol Cell (2003) 3.67

The nucleolus under stress. Mol Cell (2010) 3.63

Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins. Curr Biol (2007) 3.55

System-wide changes to SUMO modifications in response to heat shock. Sci Signal (2009) 3.50

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43

Cajal body dynamics and association with chromatin are ATP-dependent. Nat Cell Biol (2002) 3.28

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J Cell Biol (2006) 3.27

Nuclear speckles. Cold Spring Harb Perspect Biol (2011) 3.04

Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. Endocr Relat Cancer (2004) 3.03

Cajal bodies: a long history of discovery. Annu Rev Cell Dev Biol (2005) 2.92

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature (2012) 2.86

Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics (2006) 2.64

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. Mol Biol Cell (2005) 2.53

Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol (2006) 2.33

Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans. Chromosoma (2003) 2.29

An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol (2009) 2.27

A quantitative spatial proteomics analysis of proteome turnover in human cells. Mol Cell Proteomics (2011) 2.22

Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell (2005) 2.21

Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One (2008) 2.18

Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol (2006) 2.16

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12

Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites. Nat Methods (2012) 2.12

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging. Proc Natl Acad Sci U S A (2008) 2.09

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07

Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol (2002) 2.06

Human miRNA precursors with box H/ACA snoRNA features. PLoS Comput Biol (2009) 2.06

Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Mol Biol Cell (2004) 2.02

Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res (2009) 1.98

Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells. J Cell Biol (2004) 1.98

Role of the Escherichia coli Tat pathway in outer membrane integrity. Mol Microbiol (2003) 1.96

SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol (2010) 1.95

Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer (2007) 1.94

Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Cell (2002) 1.94

A mechanism for inhibiting the SUMO pathway. Mol Cell (2004) 1.93

NOPdb: Nucleolar Proteome Database--2008 update. Nucleic Acids Res (2008) 1.93

A proteomic study of SUMO-2 target proteins. J Biol Chem (2004) 1.92

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev (2012) 1.90

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol (2004) 1.90

SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol (2006) 1.89

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87

Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep (2008) 1.84

The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitors. J Bacteriol (2011) 1.82

SUMO and transcriptional regulation. Semin Cell Dev Biol (2004) 1.82

Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell (2003) 1.78

A quantitative proteomics analysis of subcellular proteome localization and changes induced by DNA damage. Mol Cell Proteomics (2009) 1.74

Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci U S A (2005) 1.73

Coordinating assembly and export of complex bacterial proteins. EMBO J (2004) 1.73

Purification and identification of endogenous polySUMO conjugates. EMBO Rep (2011) 1.72

Identification of a substrate recognition site on Ubc9. J Biol Chem (2002) 1.71

Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry (2003) 1.70

Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. J Natl Cancer Inst (2013) 1.70

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol (2003) 1.69

Cajal bodies and coilin--moving towards function. J Cell Biol (2002) 1.69

NOPdb: Nucleolar Proteome Database. Nucleic Acids Res (2006) 1.68

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology (2012) 1.66

Detection of protein SUMOylation in vivo. Nat Protoc (2009) 1.66

NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem (2003) 1.64

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. J Biol Chem (2004) 1.61

A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease. Int J Cancer (2012) 1.60

Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol (2011) 1.59

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol (2007) 1.58

High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli. Mol Biol Cell (2010) 1.56

Mitotic phosphatases: no longer silent partners. Curr Opin Cell Biol (2006) 1.55

Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal (2011) 1.54

Guidelines for reporting the use of gel electrophoresis in proteomics. Nat Biotechnol (2008) 1.54

BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Curr Biol (2004) 1.52

Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J (2009) 1.51

The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J (2006) 1.49

Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep (2009) 1.48

Paraspeckles. Cold Spring Harb Perspect Biol (2010) 1.48

Conserved network of proteins essential for bacterial viability. J Bacteriol (2009) 1.48

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J (2005) 1.48

3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res (2004) 1.48

Behaviour of topological marker proteins targeted to the Tat protein transport pathway. Mol Microbiol (2002) 1.47

Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo. J Cell Sci (2003) 1.44

The nucleolus. J Cell Sci (2005) 1.42

C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev (2008) 1.41

Characterization and prediction of protein nucleolar localization sequences. Nucleic Acids Res (2010) 1.40

Identification of human miRNA precursors that resemble box C/D snoRNAs. Nucleic Acids Res (2011) 1.35

UV-induced fragmentation of Cajal bodies. J Cell Biol (2006) 1.34

Bioinformatic analysis of the nucleolus. Biochem J (2003) 1.30

Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A (2008) 1.29

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system. Proc Natl Acad Sci U S A (2009) 1.29

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27

Post-translational modification by SUMO. Toxicology (2010) 1.26

Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners. Mol Cell Proteomics (2009) 1.24