Published in Curr Opin Chem Biol on March 07, 2008
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Identification of direct protein targets of small molecules. ACS Chem Biol (2010) 1.44
High-throughput screening and small animal models, where are we? Br J Pharmacol (2010) 1.37
Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov (2009) 1.21
Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mech Dev (2009) 1.17
Identifying compound-target associations by combining bioactivity profile similarity search and public databases mining. J Chem Inf Model (2011) 1.12
Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response. Mol Cell Proteomics (2011) 1.12
Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache. J Headache Pain (2013) 1.09
Energetics-based discovery of protein-ligand interactions on a proteomic scale. J Mol Biol (2011) 0.96
Rapid label-free identification of estrogen-induced differential protein expression in vivo from mouse brain and uterine tissue. J Proteome Res (2009) 0.95
Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen. PLoS One (2012) 0.91
Knowledge-guided inference of domain-domain interactions from incomplete protein-protein interaction networks. Bioinformatics (2009) 0.91
Systematizing serendipity for cardiovascular drug discovery. Circulation (2009) 0.88
Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins. Antimicrob Agents Chemother (2010) 0.86
Photoaffinity labeling in target- and binding-site identification. Future Med Chem (2015) 0.84
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium. ACS Chem Biol (2014) 0.83
New tools and new biology: recent miniaturized systems for molecular and cellular biology. Mol Cells (2013) 0.81
Methods for investigation of targeted kinase inhibitor therapy using chemical proteomics and phosphorylation profiling. Biochem Pharmacol (2010) 0.78
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The omics in migraine. J Headache Pain (2013) 0.76
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature (2005) 8.19
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One (2010) 6.61
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
A census of human soluble protein complexes. Cell (2012) 3.90
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol (2009) 3.03
eSGA: E. coli synthetic genetic array analysis. Nat Methods (2008) 3.01
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood (2003) 2.73
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell (2006) 2.71
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol (2010) 2.70
Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J Am Chem Soc (2012) 2.55
Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc (2006) 2.52
Informatics platform for global proteomic profiling and biomarker discovery using liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics (2004) 2.25
Statistical and computational methods for comparative proteomic profiling using liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics (2005) 2.24
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. ACS Nano (2014) 2.17
Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell (2004) 2.17
Sequential Peptide Affinity (SPA) system for the identification of mammalian and bacterial protein complexes. J Proteome Res (2004) 2.16
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol (2008) 2.05
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae. Nature (2012) 2.05
Identifying functional modules in the physical interactome of Saccharomyces cerevisiae. Proteomics (2007) 1.96
Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint. Cell (2007) 1.94
PRISM, a generic large scale proteomic investigation strategy for mammals. Mol Cell Proteomics (2003) 1.91
The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Mol Cell Biol (2004) 1.87
Integrating gene and protein expression data: pattern analysis and profile mining. Methods (2005) 1.83
H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Mol Cell Biol (2005) 1.82
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol Syst Biol (2009) 1.75
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72
PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC Bioinformatics (2006) 1.71
Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell (2005) 1.66
Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo. Mol Cell Biol (2005) 1.64
beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J (2007) 1.52
Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. Mol Syst Biol (2007) 1.50
Conserved network of proteins essential for bacterial viability. J Bacteriol (2009) 1.48
The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Res (2008) 1.44
Genome-scale genetic manipulation methods for exploring bacterial molecular biology. Mol Biosyst (2012) 1.44
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41
Proteome dynamics during C2C12 myoblast differentiation. Mol Cell Proteomics (2005) 1.36
A role for SlyD in the Escherichia coli hydrogenase biosynthetic pathway. J Biol Chem (2004) 1.32
Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Mol Cell Proteomics (2007) 1.31
Difference detection in LC-MS data for protein biomarker discovery. Bioinformatics (2007) 1.30
Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps. Proteomics (2010) 1.29
An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Nat Struct Mol Biol (2009) 1.27
Computational prediction of cancer-gene function. Nat Rev Cancer (2006) 1.25
Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proc Natl Acad Sci U S A (2006) 1.24
In silico proteome analysis to facilitate proteomics experiments using mass spectrometry. Proteome Sci (2003) 1.24
Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains. Dev Cell (2011) 1.21
Interactions of elongation factor EF-P with the Escherichia coli ribosome. FEBS J (2008) 1.20
JlpA of Campylobacter jejuni interacts with surface-exposed heat shock protein 90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38 MAP kinase in epithelial cells. Cell Microbiol (2003) 1.19
Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism. Structure (2010) 1.19
Cardiovascular proteomics: tools to develop novel biomarkers and potential applications. J Am Coll Cardiol (2006) 1.19
Multidimensional protein identification technology (MudPIT): technical overview of a profiling method optimized for the comprehensive proteomic investigation of normal and diseased heart tissue. J Am Soc Mass Spectrom (2005) 1.13
Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol (2006) 1.12
Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase. J Biol Chem (2005) 1.10
Recent advances and method development for drug target identification. Trends Pharmacol Sci (2009) 1.09
Human tissue profiling with multidimensional protein identification technology. J Proteome Res (2005) 1.07
Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca(2+)-ATPases. Proc Natl Acad Sci U S A (2004) 1.06
Bacteriome.org--an integrated protein interaction database for E. coli. Nucleic Acids Res (2007) 1.06
Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles. ACS Nano (2014) 1.05
Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways. PLoS Genet (2011) 1.05
Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. BMC Biol (2007) 1.05
ComplexQuant: high-throughput computational pipeline for the global quantitative analysis of endogenous soluble protein complexes using high resolution protein HPLC and precision label-free LC/MS/MS. J Proteomics (2012) 1.05
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Mol Syst Biol (2013) 1.03
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B. Proc Natl Acad Sci U S A (2010) 1.03
Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae. Mol Cell Biol (2005) 1.02
De novo peptide sequencing and quantitative profiling of complex protein mixtures using mass-coded abundance tagging. Nat Biotechnol (2002) 1.01
Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. Methods Mol Biol (2009) 1.00
A skeleton of the human protein interactome. Cell (2005) 1.00
Evaluation of data-dependent versus targeted shotgun proteomic approaches for monitoring transcription factor expression in breast cancer. J Proteome Res (2008) 1.00
Retention of protein complex membership by ancient duplicated gene products in budding yeast. Trends Genet (2007) 0.99
Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription (2012) 0.99
DAnCER: disease-annotated chromatin epigenetics resource. Nucleic Acids Res (2010) 0.98
Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol (2003) 0.96
Systems-level approaches for identifying and analyzing genetic interaction networks in Escherichia coli and extensions to other prokaryotes. Mol Biosyst (2009) 0.96
Sequential peptide affinity purification system for the systematic isolation and identification of protein complexes from Escherichia coli. Methods Mol Biol (2009) 0.95
hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression. Retrovirology (2007) 0.94
The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. PLoS Pathog (2013) 0.94
A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300. RNA (2009) 0.94
Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics. Proc Natl Acad Sci U S A (2004) 0.92
Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway. PLoS One (2009) 0.92
Interpretation of large-scale quantitative shotgun proteomic profiles for biomarker discovery. Curr Opin Mol Ther (2008) 0.91
Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome. FEMS Microbiol Rev (2008) 0.90
Predict, prevent and personalize: Genomic and proteomic approaches to cardiovascular medicine. Can J Cardiol (2007) 0.90
Interactions of the Escherichia coli hydrogenase biosynthetic proteins: HybG complex formation. FEBS Lett (2005) 0.88
Biosynthesis of the respiratory formate dehydrogenases from Escherichia coli: characterization of the FdhE protein. Arch Microbiol (2008) 0.88
The evolutionary landscape of the chromatin modification machinery reveals lineage specific gains, expansions, and losses. Proteins (2010) 0.87
Multidimensional protein identification technology: current status and future prospects. Expert Rev Proteomics (2005) 0.87