Published in Cell on March 11, 2005
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer (2010) 6.81
Differential network biology. Mol Syst Biol (2012) 3.74
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet (2009) 3.06
Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90. Structure (2008) 2.98
Integrating physical and genetic maps: from genomes to interaction networks. Nat Rev Genet (2007) 2.77
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Curr Biol (2009) 2.50
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci U S A (2009) 2.35
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. Mol Cell (2008) 2.26
Heat shock proteins as emerging therapeutic targets. Br J Pharmacol (2005) 2.25
Integrative approaches for finding modular structure in biological networks. Nat Rev Genet (2013) 2.19
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol Cell (2010) 2.07
The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol (2008) 1.95
The BAR domain proteins: molding membranes in fission, fusion, and phagy. Microbiol Mol Biol Rev (2006) 1.94
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol (2008) 1.92
Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol Mol Biol Rev (2011) 1.90
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res (2008) 1.88
The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem (2008) 1.82
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia. Nat Genet (2012) 1.78
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS Pathog (2009) 1.76
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol Syst Biol (2009) 1.75
Hsp90 and co-chaperones twist the functions of diverse client proteins. Biopolymers (2010) 1.67
PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. PLoS Pathog (2010) 1.63
The interaction network of the chaperonin CCT. EMBO J (2008) 1.63
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62
Conformational dynamics of the molecular chaperone Hsp90. Q Rev Biophys (2011) 1.61
Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses. Plant Cell (2007) 1.61
Hsp90 selectively modulates phenotype in vertebrate development. PLoS Genet (2007) 1.60
Genotype to phenotype: lessons from model organisms for human genetics. Nat Rev Genet (2013) 1.58
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell (2014) 1.52
The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (2008) 1.52
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50
Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiol Mol Biol Rev (2012) 1.48
The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harb Perspect Biol (2011) 1.48
Hsp90: A New Player in DNA Repair? Biomolecules (2015) 1.45
Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer. PLoS Comput Biol (2009) 1.43
Potential Application of the Oryza sativa Monodehydroascorbate Reductase Gene (OsMDHAR) to Improve the Stress Tolerance and Fermentative Capacity of Saccharomyces cerevisiae. PLoS One (2016) 1.41
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J (2012) 1.36
Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. Proc Natl Acad Sci U S A (2009) 1.31
HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast. Proc Natl Acad Sci U S A (2008) 1.31
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods (2013) 1.30
Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation. J Cell Biol (2007) 1.29
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat (2009) 1.27
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine. PLoS One (2011) 1.27
The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol (2005) 1.25
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. Methods (2009) 1.24
SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae. Cell Stress Chaperones (2007) 1.22
Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting. Nat Rev Drug Discov (2009) 1.21
p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity. Mol Cell Biol (2008) 1.20
Definition of the minimal fragments of Sti1 required for dimerization, interaction with Hsp70 and Hsp90 and in vivo functions. Biochem J (2007) 1.20
pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation. J Mol Biol (2009) 1.19
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A (2013) 1.19
Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide. Protein Sci (2009) 1.19
A systematic survey of an intragenic epistatic landscape. Mol Biol Evol (2014) 1.18
Hsp90 orchestrates stress response signaling governing fungal drug resistance. PLoS Pathog (2009) 1.17
Making the most of high-throughput protein-interaction data. Genome Biol (2007) 1.17
Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol Cell (2014) 1.17
Coverage and error models of protein-protein interaction data by directed graph analysis. Genome Biol (2007) 1.15
Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease. Circulation (2010) 1.13
The 'active life' of Hsp90 complexes. Biochim Biophys Acta (2011) 1.13
Nitration of Hsp90 induces cell death. Proc Natl Acad Sci U S A (2013) 1.13
Hierarchy, causation and explanation: ubiquity, locality and pluralism. Interface Focus (2011) 1.12
Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response. Mol Cell Proteomics (2011) 1.12
Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms. Cell Stress Chaperones (2008) 1.11
Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot Cell (2012) 1.11
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Mol Cell Proteomics (2009) 1.11
Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells. Cell Stress Chaperones (2010) 1.10
A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol Cell Biol (2007) 1.10
Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila. Curr Genomics (2008) 1.09
Novel Hsp90 partners discovered using complementary proteomic approaches. Cell Stress Chaperones (2009) 1.09
Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol Cell (2011) 1.09
The Hsp90 chaperone complex regulates GDI-dependent Rab recycling. Mol Biol Cell (2006) 1.09
Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry. PLoS Genet (2012) 1.07
Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle. Nat Struct Mol Biol (2013) 1.06
The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem (2010) 1.05
Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. J Immunol (2009) 1.05
Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. Protein Sci (2006) 1.04
Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects. Cell Death Differ (2008) 1.04
Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes. Philos Trans R Soc Lond B Biol Sci (2013) 1.03
The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension. J Biol Chem (2007) 1.03
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryot Cell (2006) 1.02
Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos. PLoS One (2010) 1.02
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci U S A (2012) 1.01
Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism. Hepatology (2009) 1.00
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Structure (2014) 1.00
The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol (2013) 1.00
Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. PLoS One (2012) 0.99
Hsp90 and client protein maturation. Methods Mol Biol (2011) 0.98
The heat shock protein 70 cochaperone YDJ1 is required for efficient membrane-specific flock house virus RNA replication complex assembly and function in Saccharomyces cerevisiae. J Virol (2007) 0.98
Reduction and expansion in microsporidian genome evolution: new insights from comparative genomics. Genome Biol Evol (2013) 0.98
Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochem J (2008) 0.98
Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A. BMC Bioinformatics (2011) 0.97
Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs. Nat Rev Microbiol (2012) 0.96
Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis. J Mol Neurosci (2010) 0.96
Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases. Nucleic Acids Res (2014) 0.96
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics (2014) 0.96
An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics (2012) 0.96
Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses. Planta (2009) 0.96
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
The genetic landscape of a cell. Science (2010) 16.52
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Computational methods for the comparative quantification of proteins in label-free LCn-MS experiments. Brief Bioinform (2007) 8.26
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature (2005) 8.19
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One (2010) 6.61
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol (2006) 4.45
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell (2003) 4.04
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
A census of human soluble protein complexes. Cell (2012) 3.90
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. Angew Chem Int Ed Engl (2007) 3.41
Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
Functional organization of the S. cerevisiae phosphorylation network. Cell (2009) 3.15
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol (2009) 3.03
eSGA: E. coli synthetic genetic array analysis. Nat Methods (2008) 3.01
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell (2008) 2.96
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.95
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol (2010) 2.92
Genotype to phenotype: a complex problem. Science (2010) 2.92
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol (2003) 2.84
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood (2003) 2.73
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell (2006) 2.71
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol (2010) 2.70
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol (2005) 2.68
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
Bridging structural biology and genomics: assessing protein interaction data with known complexes. Trends Genet (2002) 2.65
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet (2007) 2.58
Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J Am Chem Soc (2012) 2.55
Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc (2006) 2.52
HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic (2010) 2.47
Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol (2003) 2.46
Systematic mapping of genetic interaction networks. Annu Rev Genet (2009) 2.43
Regulation of transcription elongation by phosphorylation. Biochim Biophys Acta (2002) 2.41
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol (2012) 2.40
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J (2005) 2.34
Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell (2004) 2.34
Formins: signaling effectors for assembly and polarization of actin filaments. J Cell Sci (2003) 2.31
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet (2006) 2.30
Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall cell lung cancer. Int J Cancer (2006) 2.27
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.27
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol (2011) 2.26
Informatics platform for global proteomic profiling and biomarker discovery using liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics (2004) 2.25
Statistical and computational methods for comparative proteomic profiling using liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics (2005) 2.24
Mechanism of formin-induced nucleation of actin filaments. Biochemistry (2003) 2.18
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. ACS Nano (2014) 2.17
Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell (2004) 2.17