Published in Cell on November 30, 2007
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell (2011) 2.65
Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae. Genetics (2013) 1.20
Cellular dynamics of tRNAs and their genes. FEBS Lett (2010) 1.17
Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Cell Cycle (2012) 1.16
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab (2015) 1.05
Checkpoint kinases regulate a global network of transcription factors in response to DNA damage. Cell Rep (2013) 1.02
Retrograde transfer RNA nuclear import provides a new level of tRNA quality control in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2013) 1.01
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tRNAs: cellular barcodes for amino acids. FEBS Lett (2010) 0.99
The DNA damage checkpoint response to replication stress: A Game of Forks. Front Genet (2013) 0.94
Utp9p facilitates Msn5p-mediated nuclear reexport of retrograded tRNAs in Saccharomyces cerevisiae. Mol Biol Cell (2009) 0.94
Disrupted tRNA gene diversity and possible evolutionary scenarios. J Mol Evol (2009) 0.93
Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses. RNA Biol (2015) 0.92
Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex. Mol Biol Cell (2010) 0.92
Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing. J Biol Chem (2011) 0.92
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA (2011) 0.89
The ins and outs of nuclear re-export of retrogradely transported tRNAs in Saccharomyces cerevisiae. Nucleus (2010) 0.86
Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p. Mol Biol Cell (2011) 0.86
Developmental roles of Drosophila tRNA processing endonuclease RNase ZL as revealed with a conditional rescue system. Dev Biol (2013) 0.85
PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression. EMBO J (2012) 0.84
The intron of tRNA-TrpCCA is dispensable for growth and translation of Saccharomyces cerevisiae. RNA (2011) 0.82
Circularly permuted tRNA genes: their expression and implications for their physiological relevance and development. Front Genet (2014) 0.82
An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control. BMC Genomics (2012) 0.81
Identification of highly-disrupted tRNA genes in nuclear genome of the red alga, Cyanidioschyzon merolae 10D. Sci Rep (2013) 0.81
Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport. Mol Biol Cell (2014) 0.81
Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC 724998, a novel topoisomerase I inhibitor. J Proteome Res (2010) 0.80
Degradation of initiator tRNAMet by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells. Nucleic Acids Res (2013) 0.80
Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm. Nucleic Acids Res (2013) 0.78
Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle. PLoS One (2014) 0.78
Kinetic CRAC uncovers a role for Nab3 in determining gene expression profiles during stress. Nat Commun (2017) 0.77
Differential chromatin proteomics of the MMS-induced DNA damage response in yeast. Proteome Sci (2011) 0.77
Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation. PLoS One (2012) 0.77
tRNA traffic meets a cell-cycle checkpoint. Cell (2007) 0.76
Nup100 regulates Saccharomyces cerevisiae replicative life span by mediating the nuclear export of specific tRNAs. RNA (2016) 0.75
A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan. PLoS Genet (2015) 0.75
An La-related protein controls cell cycle arrest by nuclear retrograde transport of tRNAs during diapause formation in Artemia. BMC Biol (2016) 0.75
Multiple Layers of Stress-Induced Regulation in tRNA Biology. Life (Basel) (2016) 0.75
The essential function of the Trypanosoma brucei Trl1 homolog in procyclic cells is maturation of the intron-containing tRNATyr. RNA (2016) 0.75
Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment. PLoS One (2017) 0.75
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07
Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science (2010) 11.37
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med (2008) 10.12
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature (2005) 8.19
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Online predicted human interaction database. Bioinformatics (2005) 6.83
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One (2010) 6.61
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med (2011) 5.24
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer. J Clin Oncol (2010) 4.19
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice. Circulation (2002) 3.93
A census of human soluble protein complexes. Cell (2012) 3.90
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science (2011) 3.89
Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. Cancer Res (2002) 3.68
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat Methods (2012) 3.17
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol (2009) 3.03
eSGA: E. coli synthetic genetic array analysis. Nat Methods (2008) 3.01
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal (2010) 2.95
Prognostic gene signatures for non-small-cell lung cancer. Proc Natl Acad Sci U S A (2009) 2.84
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas. Clin Cancer Res (2010) 2.79
Evaluation of linguistic features useful in extraction of interactions from PubMed; application to annotating known, high-throughput and predicted interactions in I2D. Bioinformatics (2009) 2.78
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood (2003) 2.73
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell (2006) 2.71
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol (2010) 2.70
Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J Am Chem Soc (2012) 2.55
Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc (2006) 2.52
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res (2006) 2.50
Unequal evolutionary conservation of human protein interactions in interologous networks. Genome Biol (2007) 2.45
Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest (2009) 2.43
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
NAViGaTOR: Network Analysis, Visualization and Graphing Toronto. Bioinformatics (2009) 2.34
Informatics platform for global proteomic profiling and biomarker discovery using liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics (2004) 2.25
Statistical and computational methods for comparative proteomic profiling using liquid chromatography-tandem mass spectrometry. Mol Cell Proteomics (2005) 2.24
mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnol (2011) 2.20
Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses. Circulation (2002) 2.18
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. ACS Nano (2014) 2.17
Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell (2004) 2.17
Sequential Peptide Affinity (SPA) system for the identification of mammalian and bacterial protein complexes. J Proteome Res (2004) 2.16
Three-gene prognostic classifier for early-stage non small-cell lung cancer. J Clin Oncol (2007) 2.10
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol (2008) 2.05
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae. Nature (2012) 2.05
Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. Hum Mol Genet (2009) 2.00
Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab (2005) 1.98
Identifying functional modules in the physical interactome of Saccharomyces cerevisiae. Proteomics (2007) 1.96
PRISM, a generic large scale proteomic investigation strategy for mammals. Mol Cell Proteomics (2003) 1.91
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res (2005) 1.89
Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci U S A (2011) 1.88
The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Mol Cell Biol (2004) 1.87
Integrating gene and protein expression data: pattern analysis and profile mining. Methods (2005) 1.83
H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Mol Cell Biol (2005) 1.82
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80
A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers. J Proteome Res (2007) 1.80
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol Syst Biol (2009) 1.75
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72
PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC Bioinformatics (2006) 1.71
Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci U S A (2010) 1.71
Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell (2005) 1.66
Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin Cancer Res (2006) 1.65
Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo. Mol Cell Biol (2005) 1.64
Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma. J Clin Invest (2012) 1.57
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal (2009) 1.54
beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J (2007) 1.52
Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. Mol Syst Biol (2007) 1.50
Conserved network of proteins essential for bacterial viability. J Bacteriol (2009) 1.48
The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes. Mol Cell (2008) 1.44
The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Res (2008) 1.44
Genome-scale genetic manipulation methods for exploring bacterial molecular biology. Mol Biosyst (2012) 1.44
Automatic classification of sub-microlitre protein-crystallization trials in 1536-well plates. Acta Crystallogr D Biol Crystallogr (2003) 1.43
Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res (2011) 1.42
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41
Knowledge Discovery and interactive Data Mining in Bioinformatics--State-of-the-Art, future challenges and research directions. BMC Bioinformatics (2014) 1.41
Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell (2012) 1.37
Identification of pathways associated with invasive behavior by ovarian cancer cells using multidimensional protein identification technology (MudPIT). Mol Biosyst (2008) 1.37
Optimized application of penalized regression methods to diverse genomic data. Bioinformatics (2011) 1.37