Published in Int J Biochem Cell Biol on January 11, 2008
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med (2010) 4.07
Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci (2012) 3.11
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol (2011) 2.76
Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol (2010) 2.38
Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology (2010) 2.29
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86
Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior. J Immunol (2009) 1.77
Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis. J Immunol (2010) 1.22
Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia. Schizophr Bull (2010) 1.18
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Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Res (2009) 1.13
Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO). PLoS One (2011) 1.11
Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res (2014) 1.10
Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers. PLoS One (2013) 1.08
Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. Infect Immun (2010) 1.04
The possible role of the kynurenine pathway in anhedonia in adolescents. J Neural Transm (Vienna) (2011) 0.99
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance. Trends Immunol (2016) 0.96
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PLoS One (2012) 0.96
Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis. J Histochem Cytochem (2012) 0.95
The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells. J Immunol (2014) 0.89
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state. J Biol Chem (2010) 0.89
The importance of NAD in multiple sclerosis. Curr Pharm Des (2009) 0.89
Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide. J Neuroinflammation (2011) 0.89
Vascular endothelial expression of indoleamine 2,3-dioxygenase 1 forms a positive gradient towards the feto-maternal interface. PLoS One (2011) 0.89
Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases. Mediators Inflamm (2013) 0.88
Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. Am J Physiol Heart Circ Physiol (2011) 0.87
Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells. Immun Ageing (2011) 0.87
IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease. Int J Tryptophan Res (2010) 0.86
Understanding the roles of the kynurenine pathway in multiple sclerosis progression. Int J Tryptophan Res (2010) 0.85
In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1. Cancer Biol Ther (2013) 0.85
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem (2015) 0.84
Learning from other diseases: protection and pathology in chronic fungal infections. Semin Immunopathol (2015) 0.84
Aryl hydrocarbon receptor ligand effects in RBL2H3 cells. J Immunotoxicol (2012) 0.83
Species and cell types difference in tryptophan metabolism. Int J Tryptophan Res (2013) 0.82
Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases. J Mol Evol (2010) 0.81
Cerebral malaria: gamma-interferon redux. Front Cell Infect Microbiol (2014) 0.81
Understanding the role of the kynurenine pathway in human breast cancer immunobiology. Oncotarget (2016) 0.80
Clinical significance of T cell metabolic reprogramming in cancer. Clin Transl Med (2016) 0.79
Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity. Int J Tryptophan Res (2013) 0.78
The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals. Front Immunol (2015) 0.78
Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection. J Interferon Cytokine Res (2015) 0.78
Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice. Cancer Sci (2015) 0.77
The potential role of indoleamine 2,3 dioxygenase (IDO) as a predictive and therapeutic target for diabetes treatment: a mythical truth. EPMA J (2010) 0.77
The role of indoleamine 2,3 dioxygenase in beneficial effects of stem cells in hind limb ischemia reperfusion injury. PLoS One (2014) 0.77
Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase. Antimicrob Agents Chemother (2015) 0.75
Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases. Brain Behav Immun (2017) 0.75
Indoleamine 2,3-Dioxygenase Is Not a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation through Adipose-Derived Stem Cells. PLoS One (2016) 0.75
Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects. Int J Tryptophan Res (2017) 0.75
Sea lampreys elicit strong transcriptomic responses in the lake trout liver during parasitism. BMC Genomics (2016) 0.75
Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease. J Huntingtons Dis (2015) 0.75
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases. Cell Mol Life Sci (2017) 0.75
Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma. World J Gastroenterol (2017) 0.75
Tryptophan oxidative metabolism catalyzed by geobacillus stearothermophilus: a thermophile isolated from kuwait soil contaminated with petroleum hydrocarbons. Int J Tryptophan Res (2011) 0.75
Docking Studies and Molecular Dynamic Simulations Reveal Different Features of IDO1 Structure. Mol Inform (2016) 0.75
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett (2017) 0.75
Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice. Infect Immun (2017) 0.75
Placental expression of indoleamine 2,3-dioxygenase. Wien Med Wochenschr (2012) 0.75
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina. Invest Ophthalmol Vis Sci (2017) 0.75
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene (2007) 2.24
Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12
Current perspectives on the mechanism of action of artemisinins. Int J Parasitol (2006) 1.80
Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One (2012) 1.59
Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol (2008) 1.42
Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int J Parasitol (2006) 1.35
Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun (2005) 1.32
The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation. Cell Res (2008) 1.26
Murine cerebral malaria: the whole story. Trends Parasitol (2010) 1.24
Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma. J Cell Physiol (2008) 1.18
Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. Analyst (2011) 1.17
Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma? J Allergy Clin Immunol (2004) 1.16
Cerebral malaria -- a neurovascular pathology with many riddles still to be solved. Curr Neurovasc Res (2004) 1.14
CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle. J Allergy Clin Immunol (2005) 1.08
Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. J Biol Chem (2008) 1.08
Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. FASEB J (2004) 1.06
Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. Int J Parasitol (2010) 1.03
The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria. J Infect Dis (2002) 1.03
Technical advance: autofluorescence as a tool for myeloid cell analysis. J Leukoc Biol (2010) 1.02
Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis. Prog Neurobiol (2010) 1.02
The microcirculation in severe malaria. Microcirculation (2004) 1.02
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria. J Infect Dis (2003) 1.01
Heme moves to center stage in cerebral malaria. Nat Med (2007) 1.01
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. Int J Parasitol (2004) 0.98
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids (2013) 0.98
Probucol promotes functional reendothelialization in balloon-injured rabbit aortas. Circulation (2003) 0.96
Placental hypoxia during placental malaria. J Infect Dis (2008) 0.96
Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine (2007) 0.96
Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Res Brain Res Protoc (2002) 0.96
Gp91(phox) contributes to the development of experimental inflammatory bowel disease. Immunol Cell Biol (2011) 0.95
Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. J Infect Dis (2004) 0.95
A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury. Mol Diagn Ther (2012) 0.93
Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis. J Immunol (2012) 0.93
1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan. Comp Biochem Physiol B Biochem Mol Biol (2010) 0.93
Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Antimicrob Agents Chemother (2011) 0.92
The correlation between proinflammatory cytokines, MAdCAM-1 and cellular infiltration in the inflamed colon from TNF-alpha gene knockout mice. Immunol Cell Biol (2007) 0.91
Differential microRNA expression in experimental cerebral and noncerebral malaria. Infect Immun (2011) 0.91
Role of the gut in visceral fat inflammation and metabolic disorders. Obesity (Silver Spring) (2011) 0.91
A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. J Neuroimmunol (2006) 0.91
Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1. Amino Acids (2014) 0.90
Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. Int J Clin Exp Pathol (2011) 0.90
Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. Int J Parasitol (2010) 0.89
Comparison of the sequences of Turbo and Sulculus indoleamine dioxygenase-like myoglobin genes. Gene (2003) 0.88
Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infect Immun (2008) 0.88
Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One (2008) 0.88
Differential effects of the antioxidant alpha-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells. Mol Immunol (2002) 0.86
The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. Am J Pathol (2006) 0.85
The effect of restraint stress on experimental colitis is IFN-gamma independent. J Neuroimmunol (2008) 0.84
Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.83
The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends Parasitol (2012) 0.83
Identification of Ca2+-dependent calmodulin-binding proteins in rat spermatogenic cells as complexes of the heat-shock proteins. Mol Reprod Dev (2004) 0.83
The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis. Stem Cells (2015) 0.82
Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets. Am J Pathol (2013) 0.82
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorg Med Chem Lett (2012) 0.81
Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino Acids (2008) 0.81
Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A. Chemistry (2011) 0.80
Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria. Int J Parasitol (2006) 0.80
FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry. ACS Chem Neurosci (2012) 0.80
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. Int J Parasitol (2008) 0.79
Hepcidin bound to α2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels. J Biol Chem (2013) 0.79
Effects of a redox-active agent on lymphocyte activation and early gene expression patterns. Free Radic Biol Med (2004) 0.79
Total synthesis and antimalarial activity of symplostatin 4. Org Lett (2010) 0.78
Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem (2014) 0.78
Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.78
Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria. PLoS One (2013) 0.78
Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells. J Synchrotron Radiat (2013) 0.76
A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation. J Cereb Blood Flow Metab (2005) 0.76
Probing for antiparasitic drugs. Mini Rev Med Chem (2006) 0.75
Improved spectrophotometric human interferon-gamma bioassay. J Immunol Methods (2013) 0.75